Immunohistochemical localization of human kallikreins 6, 10 and 13 in benign and malignant prostatic tissues

Prostate Cancer and Prostatic Diseases

Volumn 6, Issue 3, 2003, Pages 223-227

  Petraki, C D ^a   Gregorakis, A K ^a   Papanastasiou, P A ^a   Karavana, V N ^a   Luo, L Y ^b,c   Diamandis, E P ^b,c  

^a EVANGELISMOS HOSPITAL   (Greece)

^b MOUNT SINAI HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cancer biomarkers; Human kallikreins; Immunohistochemistry; Prognostic marker

Indexed keywords

BIOTIN; KALLIKREIN; KALLIKREIN 10; KALLIKREIN 13; KALLIKREIN 6; MONOCLONAL ANTIBODY; PEROXIDASE; POLYCLONAL ANTIBODY; PROSTATE SPECIFIC ANTIGEN; STREPTAVIDIN; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CANCER GRADING; CANCER GROWTH; CANCER INHIBITION; CANCER RECURRENCE; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DOWN REGULATION; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROSTATE EPITHELIUM; PROSTATE HYPERTROPHY; PROSTATECTOMY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SCORING SYSTEM; TRANSURETHRAL RESECTION;

HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MALE; PROSTATE; PROSTATIC NEOPLASMS; TISSUE KALLIKREINS;

EID: 0141502325     PISSN: 13657852     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500674     Document Type: Article

References (24)

1. Diamandis EP et al. The human kallikrein gene family: implications in carcinogenesis. Trends Endocrinol Metab 2000; 11: 54-60.
2. Yousef GM, Diamandis EP. The new human tissue kallikrein gene family: structure, function, and association to disease. Endocr Rev 2001; 22: 184-204.
3. Petraki C et al. The spectrum of human kallikrein 6 (zyme/protease M/neurosin) expression in human tissues, as assessed by immunohistochemistry. J Histochem Cytochem 2001; 49: 1431-1442.
4. Petraki C et al. Human kallikrein 10 expression in normal tissues by immunohistochemistry. J Histochem Cytochem 2002; 50: 1247-1261.
5. Petraki CD, Karavana VN, Diamandis EP. Human kallikrein 13 expression in normal tissues: an immunohistochemical study. J Histochem Cytochem 2003; 51: 493-501.
6. Gleason DF. Histologic grading of prostatic carcinoma. In: Bostwick, DG (ed). Pathology of the Prostate. Churchill Livingstone, New York, Edinburgh, London, Melbourne, 1990, pp 83-93.
7. Diamandis EP et al. Immunofluorometric assay of human kallikrein 6 (zyme/protease M/neurosin) and preliminary clinical applications. Clin Biochem 2000; 33: 369-375.
8. Luo LY et al. Immunofluorometric assay of human kallikrein 10 and its identification in biological fluids and tissues. Clin Chem 2001; 47: 237-246.
9. Kapadia C et al. Human kallikrein 13: production and purification of recombinant protein, monoclonal and polyclonal antibodies, and development of a sensitive and specific immunofluorometric assay. Clin Chem 2003; 49: 77-86.
10. Oesterling JE. Prostate-specific antigen. The best prostatic tumor marker. Urol Clin N Am 1997; 24: 247-458.
11. Rittenhouse HG et al. Human kallikrein 2 (hK2) and prostate-specific antigen (PSA): two closely related, but distinct, kallikreins in the prostate. Crit Rev Clin Lab Sci 1998; 35: 275-368.
12. Becker C et al. The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extraprostatic disease. Crit Rev Clin Lab Sci 2001; 38: 357-399.
13. Stephan C et al. Prostate-specific antigen, its molecular forms, and other kallikrein markers for detection of prostate cancer. Urology 2002; 59: 2-8.
14. Recker F et al. Human glandular kallikrein as a tool to improve discrimination of poorly differentiated and non-organ-confined prostate cancer compared with prostate-specific antigen. Urology 2000; 55: 481-485.
15. Nam RK et al. Serum human glandular kallikrein-2 protease levels predict the presence of prostate cancer among men with elevated prostate-specific antigen. J Clin Oncol 2000; 18: 1036-1042.
16. Obiezu CV et al. Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry. Clin Chem 2002; 48: 1232-1240.
17. Yousef GM et al. Molecular cloning of the human kallikrein 15 gene (KLK15): upregulation in prostate cancer. J Biol Chem 2001; 276: 53-61.
18. Diamandis EP et al. Human kallikrein 11: a new biomarker of prostate and ovarian carcinoma. Cancer Res 2002; 62: 295-300.
19. Darson MF et al. Human glandular kallikrein 2 (hK2) expression in prostate intraepithelial neoplasia and adenocarcinoma: a novel prostate cancer marker. Urology 1997; 49: 857-862.
20. Darson MF et al. Human glandular kallikrein 2 expression in prostate adenocarcinoma and lymph node metastases. Urology 1999; 53: 939-944.
21. Maglara A et al. Decreased concentration of prostate-specific antigen and human glandular kallikrein 2 in malignant versus nonmalignant prostatic tissue. Urology 2000; 56: 527-532.
22. Pretlow TG et al. Tissue concentrations of prostate-specific antigen in prostatic carcinoma and benign prostatic hyperplasia. Int J Cancer 1991; 49: 645-649.
23. Diamandis EP et al. Human kallikrein 6 (zyme/protease M/neurosin): a new serum biomarker of ovarian carcinoma. Clin Biochem 2000; 33: 579-583.
24. Luo L-Y et al. Human kallikrein 10: a novel tumor marker for ovarian carcinoma? Clin Chim Acta 2001; 306: 111-118.