Synthesis of linear, β-cyclodextrin-based polymers and their camptothecin conjugates

Bioconjugate Chemistry

Volumn 14, Issue 5, 2003, Pages 1007-1017

  Cheng, Jianjun ^a   Khin, Kay T ^a   Jensen, Gregory S ^a   Liu, Aijie ^a   Davis, Mark E ^b  

^a Insert Therapeutics Inc ^*  (United States)

^b California Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; CARBOXYLATION; CONJUGATED POLYMERS; CYCLODEXTRINS; HYDROLYSIS; MOLECULAR WEIGHT; SOLUTIONS;

ACID DERIVATIVE; CAMPTOTHECINS; COMONOMERS; DIAMINO ACIDS; HIGH MOLECULAR WEIGHT; HIGH-MOLECULAR WEIGHT POLYMERS; MICE PLASMA; PRODRUGS; SYNTHESISED; THREE ORDERS OF MAGNITUDE;

CELL CULTURE;

20 O TRIFLUOROGLYCINYLCAMPTOTHECIN; 20 O TRIFLUOROGLYCINYLGLYCINYLGLYCINYLCAMPTOTHECIN; 6A,6D BIS(2 AMINO 2 CARBOXYLETHYLTHIO) 6A,6D DIDEOXY BETA CYCLODEXTRIN; BETA CYCLODEXTRIN DERIVATIVE; CAMPTOTHECIN DERIVATIVE; CARBOXYLIC ACID; DIAMINO ACID; MACROGOL DERIVATIVE; MONOMER; POLYMER; PRODRUG; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CELL ASSAY; CELL CULTURE; CELL LINE; CONTROLLED STUDY; COVALENT BOND; CYTOPATHOGENIC EFFECT; DRUG CONJUGATION; DRUG HYDROLYSIS; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; IC 50; IN VITRO STUDY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PH; POLYMERIZATION; RING OPENING; SUBSTITUTION REACTION;

EID: 0141458033     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc0340924     Document Type: Article

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