Synthesis and characterization of pseudopeptide bradykinin B2 receptor antagonists containing the 1,3,8-triazaspiro[4.5]decan-4-one ring system

Journal of Medicinal Chemistry

Volumn 39, Issue 16, 1996, Pages 3169-3173

  Mavunkel, Babu J ^a   Lu, Zhijian ^a   Goehring, R Richard ^a   Lu, Songfeng ^a   Chakravarty, Sarvajit ^a   Perumattam, John ^a   Novotny, Elizabeth A ^a   Connolly, Maureen ^a   Valentine, Heather ^a   Kyle, Donald J ^a  

^a Scios Nova Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ B2 RECEPTOR ANTAGONIST; NPC 18521; NPC 18688; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHO CELL; DRUG CONFORMATION; DRUG POTENCY; DRUG RECEPTOR BINDING; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RABBIT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING, COMPETITIVE; BLOOD PRESSURE; BRADYKININ; CELL MEMBRANE; CHO CELLS; CRICETINAE; IMIDAZOLES; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; OLIGOPEPTIDES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B2; RECEPTORS, BRADYKININ; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9344249013     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm950676i     Document Type: Article

References (19)

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