Structural basis for topoisomerase I inhibition by nucleoside analogs

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 653-658

  Gmeiner, William H ^a   Yu, Shuyuan ^b   Pon, Richard T ^b   Pourquier, Philippe ^c   Pommier, Yves ^d  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALGARY   (Canada)

^c INSTITUT BERGONIÉ   (France)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antimetabolite; Ara C; Cancer chemotherapy; DNA; Gemcitabine; Topoisomerase 1

Indexed keywords

1 BETA DEXTRO ARABINOFURANOSYLCYTIDINE; DNA POLYMERASE; DNA TOPOISOMERASE; DNA TOPOISOMERASE INHIBITOR; DOUBLE STRANDED DNA; GEMCITABINE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; COMPLEX FORMATION; CONFERENCE PAPER; CYTOTOXICITY; DNA REPLICATION; DRUG CONFORMATION; DRUG STRUCTURE; ENZYME INHIBITION; INHIBITION KINETICS; NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

ANTIMETABOLITES, ANTINEOPLASTIC; CYTARABINE; DEOXYCYTIDINE; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; NUCLEOSIDES;

ARA;

EID: 0141425710     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022604     Document Type: Conference Paper

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