Chronic treatment with imipramine inhibits cell growth and enhances serotonin 2C receptor mRNA expression in NG 108-15 cells

Journal of Pharmacological Sciences

Volumn 92, Issue 4, 2003, Pages 433-436

  Sukma, Monrudee ^a   Tohda, Michihisa ^a   Watanabe, Hiroshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Antidepressant; Cell viability; Serotonin 2C receptor

Indexed keywords

ANTIDEPRESSANT AGENT; IMIPRAMINE; MESSENGER RNA; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG EXPOSURE; GROWTH INHIBITION; MOUSE; NERVE CELL GROWTH; NONHUMAN; PROTEIN EXPRESSION; RAT;

EID: 0043196955     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.92.433     Document Type: Article

References (15)

1. Tohda M, Watanabe H. Enhancement of serotonin 2C receptor mRNA expression by antidepressants possessing the receptor-blocking activity in the rat brain. Jpn J Pharmacol. 1998;78:515-517.
2. Gurevich I, Tamir H, Arango V, Dwork AJ, Mann JJ, Schmauss C. Altered editing of serotonin 2C receptor pre-mRNA in the prefrontal cortex of depressed suicide victims. Neuron. 2002;34:349-356.
3. Tohda M, Sukma M, Nomura Y, Watanabe H. The mRNA expression of serotonin 2C subtype receptors uncoupled with inositol hydrolysis in NG108-15 cells. Jpn J Pharmacol. 2002;90:138-144.
4. Gavrilova-Ruch O, Schonherr K, Gessner G, et al. Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol. 2002;188:137-149.
5. Xia Z, Bergstrand A, DePierre JW, Nassberger L. The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13:338-347.
6. Xia Z, Lundgren B, Bergstrand A, DePierre JW, Nassberger L. Changes in the generation of reactive oxygen species and in mitochondrial membrane potential during apoptosis induced by the antidepressants imipramine, clomipramine, and citalopram and the effects on these changes by Bcl-2 and Bcl-X(L). Biochem Pharmacol. 1999;57:1199-1208.
7. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
8. Tohda M, Takasu T, Nomura Y. Effects of antidepressants on serotonin-evoked current in Xenopus oocytes injected with rat brain mRNA. Eur J Pharmacol. 1989;166:57-63.
9. Xie E, Zhu L, Zhao L, Chang LS. The human serotonin 5-HT2C receptor: Complete cDNA, genomic structure, and alternatively spliced variant. Genomics. 1996;35:551-561.
10. Seuwen K, Pouyssegur J. Serotonin as a growth factor. Biochem Pharmacol. 1990;39:985-990.
11. 2B receptor in the development of enteric neurons. J Neurosci. 2000;20:294-305.
12. Julius D, Livelli TJ, Jessell TM, Axel R. Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science. 1989;244:1057-1062.
13. Duman RS, Malberg J, Nakagawa S, D'Sa C. Neuronal plasticity and survival in mood disorders. Biol Psychiatry. 2000;48:732-739.
14. Tohda M, Nomura Y, Watanabe H. Effect of imipramine on 5-HT2C mRNA and a novel depression related gene (DRF24) expression. Soc Neurosci Abstr. 1996;22:943.
15. Kitayama I, Yaga T, Kayahara T, et al. Long-term stress degenerates, but imipramine regenerates, noradrenergic axons in the rat cerebral cortex. Biol Psychiatry. 1997;42:687-696.