The mRNA expression of serotonin 2C subtype receptors uncoupled with inositol hydrolysis in NG108-15 cells

Japanese Journal of Pharmacology

Volumn 90, Issue 2, 2002, Pages 138-144

  Tohda, Michihisa ^a   Sukma, Monrudee ^a   Nomura, Yasuyuki ^a   Watanabe, Hiroshi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Inositolphosphate formation; Modification of RNA; NG108 15; RNA editing; Serotonin 2C subtype receptor

Indexed keywords

INOSITOL PHOSPHATE; MESSENGER RNA; NUCLEOTIDE; POLYACRYLAMIDE GEL; SEROTONIN; SEROTONIN 2C RECEPTOR;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL FUNCTION; ELECTROPHORESIS; HYDROLYSIS; MOLECULAR SIZE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EDITING; RNA SEQUENCE; RNA SPLICING; SEQUENCE ANALYSIS;

EID: 0036806247     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.90.138     Document Type: Article

References (33)

1. Boess F and Martin IL: Molecular biology of 5-HT receptors. Neuropharmacology 33, 275 - 317 (1994)
2. Julius D, MacDermott AB, Axel R and Jessell TM: Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science 241, 558 - 564 (1988)
3. Molineaux SM, Jessell TM, Axel R and Julius D: 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci USA 86, 6793 - 6797 (1989)
4. Tecott LH, Sun LM, Akana SF, Strack AM, Lowenstein DH, Dallman MF and Julius D: Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature 374, 542 - 546 (1995)
5. 2C receptor. J Pharmacol Exp Ther 299, 83 - 89 (2001)
6. Newton RA, Phipps SL, Flanigan TP, Newberry NR, Carey JE, Kumar C, McDonald B, Chen C and Elliott JM: Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs. J Neurochem 67, 2521 - 2531 (1996)
7. Palvimaki EP, Roth BL, Majasuo H, Laakso A, Kuoppamaki M, Syvalahti E and Hietala J: Interactions of selective serotonin reuptake inhibitors with the serotonin 5-HT2c receptor. Psychopharmacology (Berl) 126, 234 - 240 (1996)
8. Tohda M, Takasu T and Nomura Y: Effects of antidepressants on serotonin-evoked current in Xenopus oocytes injected with rat brain mRNA. Eur J Pharmacol 166, 57 - 63 (1989)
9. Tohda M and Watanabe H: Imipramine-induced increase in 5-HT2C receptor mRNA level in the rat brain. Neurosci Res 24, 189 - 193 (1996)
10. Tohda M, Abdel-Fattah AM, Nakamura S and Watanabe H: Effects of Hochu-ekki-to (Bu-Zhong-Yi-Qi-Tang), a Kampo medicine, on serotonin 2C subtype receptor-evoked current response and the receptor mRNA expression. J Trad Med 17, 34 - 40 (2000)
11. Saucier C, Morris SJ and Albert PR: Endogenous serotonin-2A and -2C receptors in Balb/c-3T3 cells revealed in serotonin-free medium: desensitization and down-regulation by serotonin. Biochem Pharmacol 56, 1347 - 1357 (1998)
12. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162, 156 - 159 (1987)
13. Canton H, Emeson RB, Barker EL, Backstrom JR, Lu JT, Chang MS and Sanders-Bush E: Identification, molecular cloning, and distribution of a short variant of the 5-hydroxytryptamine2C receptor produced by alternative splicing. Mol Pharmacol 50, 799 - 807 (1996)
14. Yano K, Higashida H, Inoue R and Nozawa Y: Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma × glioma hybrid NG108-15 cells. J Biol Chem 259, 10201 - 10207 (1984)
15. Tohda M and Nomura Y: Effects of histamine on polyphosphoinositide metabolism in NG108-15 cells. Neurochem Int 14, 73 - 78 (1989)
16. Lin TA, Lustig KD, Sportiello MG, Weisman GA and Sun GY: Signal transduction pathways coupled to a P2U receptor in neuroblastoma × glioma (NG108-15) cells. J Neurochem 60, 1115 - 1125 (1993)
17. 2+ increase by bradykinin or ATP in NG108-15 cells. J Biol Chem 270, 16630-16637 (1995)
18. Yue TL, Nambi P, Wu HL and Feuerstein G: Endothelin receptor binding and cellular signal transduction in neurohybrid NG108-15 cells. Neuroscience 44, 215-222 (1991)
19. Speth RC, Mei L and Yamamura HI: Angiotensin II receptor binding and actions in NG108-15 cells. Pept Res 2, 232-239 (1989)
20. Higashida H, Yokoyama S, Hoshi N, Myojo Y, Kawamura T, Ito Y, Hashii M, Sagara J and Furuya K: Phosphoinositides and synaptic function in NG108-15 neuroblastoma × glioma hybrid cells. Comp Biochem Physiol C 98, 129-137 (1991)
21. Higashida H, Hashii M, Yokoyama S, Hoshi N, Chen XL, Egorova A, Noda M and Zhang JS: Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase. Pharmacol Ther 90, 283-296 (2001)
22. + currents of muscarinic acetylcholine receptor subtypes in NG108-15 cells. Nature 335, 355-358 (1988)
23. Tohda M, Tohda C, Sakuma S, Higashida H and Nomura Y: Distinct induction of c-fos mRNA in NG108-15 cells transfected with muscarinic m1 and m3 receptors. Eur J Pharmacol 268, 169-176 (1994)
24. Ronde P and Nichols RA: Postsynaptic target regulates functional responses induced by 5-HT3 serotonin receptors on axonal varicosities of NG108-15 hybrid neuroblastoma cells. Neuroscience 102, 979-987 (2001)
25. Tohda M, Imaizumi R, Sekiya A, Itoh N and Nomura Y: Studies on the activation mechanisms of guanylyl cyclase by serotonin, probably through a novel subtype of serotonin receptor (5-HTGC). Biol Pharm Bull 18, 1072-1075 (1995)
26. Tohda M, Sakuma I and Nomura Y: The slow cyclic GMP increase caused by serotonin in NG108-15 cells is not inhibited by antagonists of known serotonin receptors: possible existence of a new receptor subtype coupled with membrane-bound guanylate cyclase. J Neurochem 57, 714-717 (1991)
27. Simpson L and Emeson RB: RNA editing. Annu Rev Neurosci 19, 27-52 (1996)
28. Sommer B, Kohler M, Sprengel R and Seeburg PH: RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19 (1991)
29. Seeburg PH: The role of RNA editing in controlling glutamate receptor channel properties. J Neurochem 66, 1-5 (1996)
30. Fitzgerald LW, Iyer G, Conklin DS, Krause CM, Marshall A, Patterson JP, Tran DP, Jonak GJ and Hartig PG: Messenger RNA editing of the human serotonin 5-HT2C receptor. Neuropsychopharmacology 21, Suppl, 82S-90S (1999)
31. Niswender CM, Copeland SC, Herrick-Davis K, Emeson RB and Sanders-Bush E: RNA editing of the human serotonin 5-hydroxytryptamine 2C receptor silences constitutive activity. J Biol Chem 274, 9472-9478 (1999)
32. Price RD, Weiner DM, Chang MS and Sanders-Bush E: RNA editing of the human serotonin 5-HT2C receptor alters receptor-mediated activation of G13 protein. J Biol Chem 276, 44663-44668 (2001)
33. Julius D, Livelli TJ, Jessell TM and Axel R: Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science 244, 1057-1062 (1989)