Susceptibility to ovalbumin-induced airway inflammation and fibrosis in inducible nitric oxide synthetase-deficient mice: Mechanisms and consequences

Toxicology and Applied Pharmacology

Volumn 191, Issue 1, 2003, Pages 2-11

  Kenyon, Nicholas J ^a   Gohil, Kishorchandra ^a   Last, Jerold A ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Airway fibrosis; Airway inflammation; Airway reactivity; Asthma; Collagen; iNOS; Lung disease; Nitric oxide

Indexed keywords

ALLERGEN; COLLAGEN; METHACHOLINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OVALBUMIN; TRANSFORMING GROWTH FACTOR BETA1;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CYTOKINE RELEASE; DISEASE PREDISPOSITION; EFFECTOR CELL; ENZYME DEFICIENCY; EOSINOPHIL; KNOCKOUT GENE; KNOCKOUT MOUSE; LUNG; MOUSE; NONHUMAN; PROVOCATION TEST; RAT STRAIN; RESPIRATORY TRACT INFLAMMATION; SIGNAL TRANSDUCTION; TH1 CELL;

ANIMALIA;

EID: 0043065288     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00227-8     Document Type: Article

References (29)

1. Blyth D.I., Wharton T.F., Pedrick M.S., Savage T.J., Sanjar S. Airway subepithelial fibrosis in a murine model of atopic asthma. Am. J. Respir. Cell Mol. Biol. 23:2000;214-246.
2. Costa D.L., Lehmann J.R., Harold W.M., Drew R.T. Transoral tracheal intubation of rodents using a fiberoptic laryngoscope. Lab. Anim. Sci. 36:1986;256-261.
3. De Sanctis G.T., MacLean J.A., Hamada K., Mehta S., Scott J.A., Jiao A., Yandava C.N., Kobzik L., Wolyniec W.W., Fabian A.J. Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J. Exp. Med. 189:1999;1621-1629.
4. Glare E.M., Divjak M., Bailey M.J., Walters E.H. The usefulness of competitive PCR airway gene expression of IL-5, IL-4, IL-4δ2, IL-2, and IFNγ in asthma . Thorax. 56:2001;541-548.
5. Gohil K., Moy R.K., Farzin S., Maguire J.J., Packer L. mRNA expression profile of a human cancer cell line in response to Ginkgo biloba extract induction of antioxidant response and the Golgi system . Free Radical Res. 33:2000;831-849.
6. Hamada K., Goldsmith C., Goldman A., Kobzik L. Resistance of very young mice to inhaled allergen sensitization is overcome by coexposure to an air pollutant aerosol. Am. J. Respir. Crit. Care Med. 161:2000;1285-1293.
7. Hamelmann E., Schwarze J., Takeda K., Oshiba A., Larsen G.L., Irvin C.G., Gelfand E.W. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156:1997;766-775.
8. Hamid Q., Springall D.R., Riveros-Moreno V., Chanez P., Howarth P., Redington A., Bousquet J., Godard P., Holgate S., Polak J.M. Induction of nitric oxide synthase in asthma. Lancet. 342:1993;1510-1513.
9. Hantos Z., Brusasco V. Assessment of respiratory mechanics in small animals the simpler the better? J. Appl. Physiol. 93:2002;1196-1197.
10. 2-terminal kinase-dependent pathway. Am. J. Respir. Crit. Care Med. 163:2001;152-157.
11. Huang F.-P., Niedbala W., Wei X.-Q., Xu D., Feng G., Robinson J.H., Lam C., Liew F.Y. Nitric oxide regulates Th1 development through the inhibition of IL-12 synthesis by macrophages. Eur. J. Immunol. 28:1998;4062-4070.
12. Iijima H., Duguet A., Eum S.-Y., Hamid Q., Eidelman D.H. Nitric oxide and protein nitration are eosinophil dependent in allergen-challenged mice. Am. J. Respir. Crit. Care Med. 163:2001;1233-1240.
13. Kenyon N.J., van der Vliet A., Schock B.C., Okamoto T., McGrew G.M., Last J.A. Susceptibility to ozone-induced acute lung injury in iNOS-deficient mice. Am. J. Physiol. Lung Cell Mol. Physiol. 282:2002;L540-L545.
14. Kenyon N.J., Ward R.W., Last J.A. Airway fibrosis in a mouse model of airway inflammation. Toxicol. Appl. Pharmacol. 186:2003;90-100.
15. Lennart K., Lundblad A., Irvin C.G., Adler A., Bates J.H.T. A reevaluation of the validity of unrestrained plethysmography in mice. J. Appl. Physiol. 93:2002;1198-1207.
16. Lin C.-C. Noninvasive method to measure airway obstruction in nonanesthetized allergen-sensitized and challenged mice. Respiration. 68:2001;178-185.
17. MacMicking J.D., Nathan C., Hom G., Chartrain N., Fletcher D.S., Trumbauer M., Stevens K., Xie Q.W., Sokol K., Hutchinson N., Chen H., Mudgett J.S. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell. 81:1995;641-650.
18. Neuhaus-Steinmetz U., Uffhausen F., Herz U., Renz H. Priming of allergic immune responses by repeated ozone exposure in mice. Am. J. Respir. Cell Mol. Biol. 23:2000;228-233.
19. Ohno I., Nitta Y., Yamauchi K., Hoshi H., Honma M., Woolley K., O'Byrne P., Tamura G., Jordana M., Shirato K. Transforming growth factor beta 1 (TGF beta 1) gene expression by eosinophils in asthmatic airway inflammation. Am. J. Respir. Cell Mol. Biol. 15:1996;404-409.
20. Renauld J.-C. New insights into the role of cytokines in asthma. J. Clin. Pathol. 54:2001;577-589.
21. Sime P.J., O'Reilly K.M.A. Fibrosis of the lung and other tissues new concepts in pathogenesis and treatment . Clin. Immunol. 99:2001;308-319.
22. Srikiatkhachorn A., Chang W., Braciale T.J. Induction of Th-1 and Th-2 responses by respiratory syncytial virus attachment glycoprotein is epitope and major histocompatibility complex independent. J. Virol. 73:1999;6590-6597.
23. Tanaka H., Masuda T., Tokuoka S., Komai M., Nagao K., Takahashi Y., Nagai H. The effect of allergen-induced airway inflammation on airway remodeling in a murine model of allergic asthma. Inflamm. Res. 50:2001;616-624.
24. Temelkovski J., Hogan S.P., Sheppard D., Foster D.P., Kumar R.K. An improved murine model of asthma selective airway inflammation, epithelial lesions, and increased methacholine responsiveness following chronic exposure to aerosolized antigen . Thorax. 53:1998;849-856.
25. Watanabe C.M., Wolffram S., Ader P., Rimbach G., Packer L., Maguire J.J., Schultz P.G., Gohil K. The in vivo neuromodulatory effects of the herbal medicine ginkgo biloba. Proc. Natl. Acad. Sci. USA. 98:2001;6577-6580.
26. Woessner J.F. Jr. The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid. Arch. Biochem. Biophys. 93:1961;440-447.
27. Xiong Y., Karupiah G., Hogan S.P., Foster P.S., Ramsay A.J. Inhibition of allergic airway inflammation in mice lacking nitric oxide synthase 2. J. Immunol. 162:1999;445-452.
28. Zhang H.-Y., Gharaee-Kermani M., Zhang K., Karmiol S., Phan S.H. Lung fibroblast alpha-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 148:1996;527-537.
29. 1. Am. J. Respir. Cell Mol. Biol. 21:1999;658-665.