Animal and in vitro models for the study of hair follicles

Journal of Investigative Dermatology Symposium Proceedings

Volumn 8, Issue 1, 2003, Pages 39-45

  Randall, Valerie A ^a   Sundberg, John P ^b   Philpott, Michael P ^c  

^a UNIVERSITY OF BRADFORD   (United Kingdom)

^b JACKSON LABORATORY   (United States)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Dermal papilla cells; Genetically engineered mice; Human; Mouse; Organ culture

Indexed keywords

BIOCHEMISTRY; CELL TYPE; CONFERENCE PAPER; CYTOLOGY; DNA MODIFICATION; GENETIC MANIPULATION; HAIR FOLLICLE; HAIR GROWTH; HUMAN; MESENCHYME; NONHUMAN; ORGAN CULTURE;

EID: 0042870164     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12170.x     Document Type: Conference Paper

References (83)

1. Adachi K, Kano M: The role of receptor proteins in controlling androgen action in the sebaceous glands of hamsters. Steroids 19:567-574, 1972
2. Buhl AE, Waldon DJ, Kawabe TT, Holland JM: Minoxidil stimulates mouse vibrissae follicles in organ culture. J Invest Dermatol 92:315-320, 1989
3. Camacho FM, Randall VA, Price VH: Hair and its Disorders: Biology, Pathology and Management. London: Martin Dunitz, 2000
4. Chase HB, Rauch H, Smith VW: Critical stages of hair development and pigmentation in the mouse. Physiol Zoöl 24:1-8, 1951
5. Dry FW: Coat of the mouse (Mus muscularus). J Genet 16:287-340, 1926
6. Ebling FJG, Hale P, Randall VA: Hormones and hair growth. In: Goldsmith L (ed). Biochemistry and Physiology of the Skin, (2nd edn). New York: Oxford University Press, 1991
7. Gaskoin JS: On a peculiar variety of Mus musculus. Proc Zool Soc Lond 24:38-40, 1856
8. Gilhar A, Shalaginov R, Assay B, Serafimovich S, Kalish RS: Alopecia areata is a T-lymphocyte mediated autoimmune disease: Lesional human T-lymphocytes transfer alopecia areata to human skin grafts on SCID mice. J Invest Dermatol Symp Proc 4:207-210, 1999
9. Hamada K, Thornton MJ, Laing I, Messenger AG, Randall VA: The metabolism of testosterone by dermal papilla cells cultured from human pubic and axillary hair follicles concurs with hair growth in 5α-reductase deficiency. J Invest Dermatol 106:1017-1022, 1996
10. Hamilton JB: Age, sex and genetic factors in the regulation of hair growth in man: A comparison of Caucasian and Japanese populations. In: Montagna W, Ellis RA (eds). The Biology of Hair Growth. New York: Academic Press, 1958; p 399-433
11. Hamilton JB: Patterned loss of hair in man; Types and incidence. Ann N Y Acad Sci 53:708-728, 1951
12. Hibberts NA, Howell AE, Randall VA: Dermal papilla cells from human balding scalp hair follicles contain higher levels of androgen receptors than those from non-balding scalp. J Endocrinol 156:59-65, 1998
13. Hibberts NA, Randall VA: Testosterone inhibits the capacity of cultured cells from human balding scalp dermal papilla cells to produce keratinocyte mitogenic factors. In: Van Neste DV, Randall VA (eds). Hair Research for the Next Millenium. Amsterdam: Elsevier, 1996; p 303-306
14. Hibberts NA, Messenger AG, Randall VA: Dermal papille cells derived from beard hair follicles secrete more stem cell factor (SCF) in culture than scalp cells or dermal fibroblasts. Biochem Biophys Res Commun 222:401-405, 1996
15. Hoffman RM, Li LN: The feasibility of targeted selective gene therapy of the hair follicle. Nat Med 1:705-706, 1995
16. Ibraheem M, Galbraith H, Scaife J, et al: Growth and viability of secondary hair follicles in the angora goat cultured in vitro. J Anat 182:231-238, 1993
17. Itami S, Kurata S, Sonada T, Takayasu S: Interaction between dermal papilla cells and follicular epithelial cells in vitro: Effect of androgen. Br J Dermatol 132:527-532, 1995
18. Itami S, Kurata S, Sonoda T, Takayasu S: Characterization of 5α-reductase in cultured human dermal papilla cells from beard and occipital scalp hair. J Invest Dermatol 96:57-60, 1991
19. Itami S, Kurata S, Takayasu S: Androgen induction of follicular epithelial cell growth is mediated via insulin-like growth factor 1 from dermal papilla cells. Biochem Biophys Res Commun 212:988-994, 1995
20. Jahoda CAB, Horne KA, Oliver RF: Induction of hair growth by implantation of cultured dermal papilla cells. Nature 311:560-562, 1984
21. Jahoda CAB, Reynolds AJ: Dermal-epidermal interactions. Adult-derived follicle populations and hair growth. In: Whiting DA (ed). Philadelphia: W.B. Saunders Press, 1996; p 573-583
22. Kishimoto J, Burgeson RE, Morgan BA: Wnt signalling maintains the hair inducing activity of the dermal papilla. Genes Dev 14:1181-1185, 2000
23. Kligman AG: The human hair cycle. J Invest Dermatol 33:307-316, 1959
24. Kondo S, Hozumi Y, Aso K: Organ culture of human scalp hair follicles: Effect of testosterone and oestrogen on hair growth. Arch Dermatol Res 282:442-445, 1990
25. Li YC, Pirro AE, Amling M, Delling G, Baron R, Bronson R, Demay MB: Targeted ablation of the vitamin D receptor: An animal model of vitamin-D-dependent rickets type II with alopecia. Proc Natl Acad Sci USA 94:9831-9835, 1997
26. Lichti U, Weinberg WC, Goodman L, et al: In vivo regulation of mouse hair growth: Insights from grafting defined cell populations onto nude mice. J Invest Dermatol 101:124S-129S, 1993
27. Limat A, Hunziker T, Waelti E, Inaebrit S, Wiesmann U, Braethen LR: Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells. Arch Dermatol Res 285:205-210, 1993
28. Ludwig E: Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. Br J Dermatol 97:247-254, 1977
29. Luetteke NC, Phillips HK, Qiu TH, Copeland NG, Earp HS, Jenkins NA, Lee DC: The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase. Genes Dev 8:399-413, 1994
30. Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC: TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-278, 1993
31. Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR: Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249-261, 1993
32. Matheson HB, Westgate GE, Parmar PP, Riches C, Blount MA, Ellory JC: Nutrition and metabolism in isolated human hair follicles. Exp Dermatol 8:319-320, 1999
33. Matias JR, Malloy V, Orentreich N: Animal models of androgen-dependent disorders of the pilosebaceons apparatus. Arch Dermatol Res 281:247-253, 1989
34. Matsuzaki T, Yoshizato K: Role of hair papilla cells on induction and regeneration processes of hair follicles. Wound Repair Regen 6:524-530, 1998
35. McElwee K: (This volume, on alopecia areata). J Investig Dermatol Symp. Proc 2002
36. Messenger AG: The culture of dermal papilla cells from human hair follicles. Br J Dermatol 110:685-689, 1984
37. Messenger AG, Elliott K, Temple A, Randall VA: Expression of basement membrane proteins and interstitial collagens in dermal papillae of human hair follicles. J Invest Dermatol 96:93-97, 1991
38. Nakamura M, Sundberg JP, Paus R: Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: Annotated tables. Exp Dermatol 10:369-390, 2001
39. Obana N, Chang C, Uno H: Inhibition of hair growth by testosterone in the presence of dermal papilla cells from the frontal bald scalp of the post-pubertal stumptailed macaque. Endocrinology 138:356-361, 1997
40. Orentreich N: Biology of Skin. In: Montagna W, Dobson RL (eds). Hair Growth, Vol. IX. Oxford: Pergamon, 1969:p 99-108
41. Panteleyev AA, Christiano AM, O'Brien TG, Sundberg JP: Ornithine decarboxylase transgenic mice as a model for human atrichia with papular lesions. Exp Dermatol 9:146-151, 2000
42. Paus R, Stenn KS, Link RE: The induction of anagen hair growth in telogen mouse skin by cyclosporine A administration. Lab Invest 60:365-369, 1989
43. Philpott MP: The roles of growth factors in hair follicles: Investigations using cultured hair follicles. In: Camacho FM, Randall VA, Price VH (eds). Hair and its Disorders: Biology, Pathology, and Management. London, Martin Dunitz, 2000:p 103-113
44. Philpott MP, Kealey T: Cyclical changes in rat vibrissae follicles maintained in vitro. J Invest Dermatol 115:1152-1155, 2000
45. Philpott MP, Sanders DA, Bowen J, Kealey T: Effects of interleukins, colony stimulating factor and tumour necrosis factor on human hair follicle growth in vitro: a possible role for interleukin-1 and tumour necrosis factor-α in alopecia areata. Br J Derm 135:942-948, 1996
46. Philpott MP, Sanders DA, Kealey T: Effects of insulin and insulin-like growth factors on human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J Invest Dermatol 102:857-861, 1994
47. Philpott MP, Sanders DA, Kealey T: Whole human hair follicle culture. In: Whiting DA (ed). Dermatologic Clinics Philadelphia: W.B. Saunders Press, 1996:p 595-607
48. Philpott MP, Green MR, Kealey T: Human hair growth in vitro. J Cell Sci 97:463-471, 1990
49. 1-acetyltransferase. J Invest Dermatol 116:801-805, 2001
50. Randall VA: Androgens and human hair growth. Clin Endocrinol 40:439-457, 1994
51. Randall VA: Androgens are the main regulator of human hair growth. In: Camacho F, Randall VA, Price V (eds). Hair and its Disorders: Biology, Pathology, and Management. London: Martin Dunitz, 2000:p 121-136
52. Randall VA: Physiology and pathophysiology of androgenetic alopecia. In: De Groot LJ, Jameson JL (eds). Endocrinology, (4th edn). Philadelphia: W.B. Saunders, 2001:p 2257-2268
53. Randall VA: The use of dermal papilla cells in studies of normal and abnormal hair follicle biology. Dermatol Clin 14:573-594, 1996
54. Randall VA, Hibberts NA, Hamada K: A comparison of the culture and growth of dermal papilla cells from hair follicles from non-balding and balding (andro-genetic alopecia) scalp. Br J Dermatol 134:437-444, 1996
55. Randall VA, Ebling FJG: Seasonal changes in human hair growth. Br J Dermatol 124:146-151, 1991
56. Randall VA, Hibberts NA, Thornton MJ, et al: Do androgens influence hair growth by altering the paracrine factors secreted by dermal papilla cells? Eur J Dermatol. 11:315-320, 2001
57. Randall VA, Thornton MJ, Hamada K, Redfern CPF, Nutbrown M, Ebling FJG, Messenger AG: Androgens and the hair follicle: Cultured dermal papilla cells as a model system. Ann N Y Acad Sci 642:355-375, 1991
58. Randall VA, Thornton MJ, Messenger AG: Cultured dermal papilla cells from androgen-dependent human hair follicles (e.g. beard) contain more androgen receptors than those from non-balding areas of scalp. J Endocrinol 133:141-147, 1992
59. Reynolds AJ, Lawrence C, Cserhalmi-Friedman PB, Christiano AM, Jahoda CAB: Trans-gender induction of hair follicles. Nature 402:33-34, 1999
60. Robinson M, Reynolds AJ, Jahoda CAB: Hair cycle stage of the mouse vibrissa follicle determines subsequent fibre growth and follicle behaviour in vitro. J Invest Dermatol 108:495-500, 1997
61. Rudman SR, Philpott MP, Kealey T: The role of IGF-1 in human skin and it's appendages: morphogen as well as nitrogen. J Invest Dermatol 109:770-777, 1997
62. Russell ES: A quantitative histologic study of the pigment found in the coat-color mutants of the house mouse. I. Variable attributes of the pigment granules Genetics 31:327-346, 1946
63. Russell ES: A quantitative histological study of the pigment found in the coat-color mutants of the house mouse. III. Interdependence among the variable granule attributes. IV. The nature of the effects of genic substitution in five major allelic series. Genetics 34:133-166, 1949a
64. Russell ES: A quantitative of genetic effects on guinea pig coat colors. Genetics 24:322-355, 1939
65. Russell ES: A quantitative study of the pigment found in the coat-color mutants of the house mouse. II. Estimates of the total volume of pigment. Genetics 33:228-236, 1948
66. Russell ES: Analysis of pleiomorphism of the W-locus in the mouse: Relationship between the W and Wv substitution on hair pigmentation and on erythrocytes. Genetics 34:708-723, 1949b
67. Soma T, Ogo M, Suzuki J, Takahasi T, Hibino T: Analysis of apoptotic cell death in human hair follicles. J Invest Dermatol 112:518-526, 1998
68. Sundberg JP, King LE Jr, Bascom C: Animal models for male pattern (androgenetic) alopecia. Eur J Dermatol 11:321-325, 2001
69. Sundberg JP, Beamer WG, Uno H, Van Neste D, King LE Jr: Androgenetic alopecia: in vivo models. Exp Mol Pathol 67:118-130, 1999
70. Sundberg JP, Bult CJ: Professional use of mutant laboratory mice in hair research. In: Paus R (ed). Biology of the Hair Follicle. Austin, TX: RG Landes, in press
71. Sundberg JP, King LE Jr: Morphology of hair in normal and mutant laboratory mice. Eur J Dermatol 11:357-361, 2001
72. Sundberg JP, Price VH, King LE Jr: The 'hairless' gene in mouse and man. Arch Dermatol 133:718-720, 1999
73. Tarlow JK, Clay FE, Cork MJ, Blakemore AIF, McDonagh AJG, Messenger AG, Duff GW: Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J Invest Dermatol 96:673-681, 1994
74. Thomas DG, Brinklow BR, Loudon ASI, Randall VA: Seasonal effects of prolactin and triidothyronine on hair follicle growth in red deer (Cervus elaphus). In: Milne JA (ed). Recent Developments in Deer Biology. Macaulay Land Use Research Insitute, 1994
75. Thornton MJ, Hamada K, Messenger AG, Randall VA: Androgen-dependent beard dermal papilla cells secrete autocrine growth factor (s) in response to testosterone unlike scalp cells. J Invest Dermatol 111:727-732, 1998
76. Thornton MJ, Hibberts NA, Street T, Brinklow BR, Louden ASI, Randall VA: Androgen receptors are only present in mesenchyme-derived dermal papilla cells of red deer (Cervus elaphus) neck follicles when raised androgens induce a mane in the breeding season. J Endocrinol 168:401-408, 2001
77. Thornton MJ, Kato S, Hibberts NA, Brinklow BR, Loudon ASI, Randall VA: Ability to culture dermal papilla cells from red deer (Cervus elaphus) hair follicles with differing hormonal responses in vivo offers a new model for studying the control of hair follicle biology. J Exp Zool 275:452-458, 1996b
78. Thornton MJ, Laing I, Hamada K, Messenger AG, Randall VA: Differences in testosterone metabolism by beard and scalp dermal papilla. Clin Endocrinol 39:633-639, 1993
79. Thornton MJ, Thomas DJ, Brinklow BR, Loudon ASI, Randall VA: Testosterone or IGF-1 stimulates hair growth in whole organ culture only in androgen-dependent red deer follicles. In: Van Neste D, Randall VA (eds.) Hair Research for the Next Millenium. Amsterdam: Elsevier Science BV, 1996a:p 311-314
80. Uno H, Imamura K, Pan H: Androgenetic alopecia in the stump-tailed macaque. An important model for investigating the pathology and antiandrogenetic therapy of male pattern baldness. In: Camacho F, Randall VA, Price V (eds). Hair and its Disorders: Biology Pathology and Management. London: Martin Dunitz, 2000:p 137-151
81. Van Neste D, B de Brouwer: Human hair follicle grafts in nude mice. An important in vivo model for investigating the control of hair growth. In: Camacho F, Randall VA, Price V (eds). Hair and its Disorders: Biology, Pathology and Management. London: Martin Dunitz, 2000; p 115-119
82. Williams R, Philpott MP, Kealey T: The metabolism of the growing human hair follicle. A glutaminolytic aerobic glycelytic tissue. J Invest Dermatol 100:834-840, 1993
83. Wilson JD, Griffin JE, Russell DW: Steroid 5α-reductase 2 deficiency: Endocr Rev 14:577-593, 1993