Dermatoses from ticks

Journal of the American Academy of Dermatology

Volumn 49, Issue 3, 2003, Pages 363-392

  McGinley Smith, Daniel E ^b   Tsao, Sandy S ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; ANTIBIOTIC AGENT; ANTIHISTAMINIC AGENT; ATOVAQUONE; AZITHROMYCIN; BACTERIAL VACCINE; BORRELIA BURGDORFERI VACCINE; CEFTRIAXONE; CEFUROXIME; CHLORAMPHENICOL; CLINDAMYCIN; CORTICOSTEROID; DOXYCYCLINE; ERYTHROMYCIN; GENTAMICIN; PENICILLIN DERIVATIVE; QUININE; QUINOLONE DERIVATIVE; STREPTOMYCIN; TETRACYCLINE; TOBRAMYCIN; UNCLASSIFIED DRUG;

BABESIOSIS; BACTERIAL INFECTION; BORRELIA INFECTION; CHILL; CLINICAL FEATURE; COLORADO TICK FEVER; DISEASE TRANSMISSION; DRUG FEVER; ECTOPARASITE; EHRLICHIOSIS; GEOGRAPHIC DISTRIBUTION; HERXHEIMER REACTION; HUMAN; HYPOTENSION; INFECTION CONTROL; LYME DISEASE; NORTH AMERICA; PATHOGENESIS; PRIORITY JOURNAL; PROTOZOAL INFECTION; REVIEW; RICKETTSIOSIS; ROCKY MOUNTAIN SPOTTED FEVER; SKIN INFECTION; TACHYCARDIA; TICK; TULAREMIA; VIRUS INFECTION;

EID: 0042858319     PISSN: 01909622     EISSN: None     Source Type: Journal    
DOI: 10.1067/S0190-9622(03)01868-1     Document Type: Review

References (383)

1. Sonenshine DE. Biology of Ticks, Vol 1. New York: Oxford University Press, 1991.
2. Failing RM, Lyone CB, McKittrick JE. The pajaroella tick bite: The frightening folklore and the mild disease. Calif Med 1972;116: 16-9.
3. Marshall J. Ticks and the human skin. Dermatologica 1967;135: 60-5.
4. Cupp EW. Biology ofticks. Vet Clin North Am Small Anim Pract 1991;21:1-26.
5. Hoogstraal H. Argasid and nuttalliellid ticks as parasites and vectors. Adv Parasitol 1985;24:135-238.
6. Walker DH. Tick-transmitted infectious diseases in the United States. Annu Rev Public Health 1998;19:237-69.
7. Mathieu ME, Wilson BB. Ticks (including tick paralysis). In: Mandell GL, editor. Principles and Practice of Infectious Diseases. 5th ed. Philadelphia: Churchill Livingstone; 2000. pp. 2980-3.
8. Gayle A, Ringdahl E, Tick-borne diseases. Am Fam Physician 2001;64:461-6.
9. Taege AJ. Tick trouble: overview of tick-borne diseases. Cleve Clin J Med 2000;67:241, 245-9.
10. Edlow JA. Lyme disease and related tick-borne illnesses. Ann Emerg Med 1999;33:680-93.
11. Parola P, Raoult D. Ticks and tickborne bacterial diseases in humans: an emerging infectious threat. Clin Infect Dis 2001;32: 897-928.
12. Spach DH, Liles WC, Campbell GL, Quick RE, Anderson DE, Fritsche TR. Tick-borne diseases in the United States. N Engl J Med 1993;329:936-47.
13. Doan-Wiggins L. Tick-borne diseases. Emerg Med Clin North Am 1991;9:303-25.
14. Sonenshine DE. Biology of Ticks, Vol 2. New York: Oxford University Press, 1993.
15. Anonymous. Tularemia - United States, 1990-2000. MMWR Morb Mortal Wkly Rep 2002;51:181-4.
16. Dennis DT, Inglesby TV, Henderson DA, Bartlett JG, Ascher MS, Eitzen E, et al. Tularemia as a biological weapon: medical and public health management. JAMA 2001;285:2763-73.
17. Franz DR, Jahrling PB, Friedlander AM, McClain DJ, Hoover DL, Bryne WR, et al. Clinical recognition and management of patients exposed to biological warfare agents. JAMA 1997;278: 399-411.
18. Evans ME, Gregory DW, Schaffner W, McGee ZA. Tularemia: a 30-year experience with 88 cases. Medicine (Baltimore) 1985; 64:251-69.
19. McGovern TW, Christopher GW, Eitzen EM. Cutaneous manifestations of biological warfare and related threat agents. Arch Dermatol 1999;135:311-22.
20. Myers SA, Sexton DJ. Dermatologic manifestations of arthropod-borne diseases. Infect Dis Clin North Am 1994;8:689-712.
21. Krinsky WL. Dermatoses associated with the bites of mites and ticks (Arthropoda: Acari). Int J Dermatol 1983;22:75-91.
22. Modly CE, Burnett JW. Tick-borne dermatologic diseases. Cutis 1988;41:244-6.
23. Weinberg GA. Laboratory diagnosis of ehrlichiosis and babesiosis. Pediatr Infect Dis J 2001;20:435-7.
24. Schwartz BS, Goldstein MD, Childs JE. Antibodies to Borrelia burgdorferi and tick salivary gland proteins in New Jersey outdoor workers. Am J Public Health 1993;83:1746-8.
25. Kain KC. Skin lesions in returned travelers. Travel Medicine 1999;83:1077-102.
26. Poland GA. Prevention of Lyme disease: a review of the evidence. Mayo Clin Proc 2001;76:713-24.
27. Midoneck SR, Richard J, Murray HW. Colorado tick fever in a resident of New York City. Arch Fam Med 1994;3:731-2.
28. Felz MW, Durden LA. Attachment sites of four tick species (Acari: Ixodidae) parasitizing human in Georgia and South Carolina. J Med Entomol 1999;36:361-4.
29. Winer LH, Strakosch EA. Tick bites - Dermacenter variabilis (say). J Invest Dermatol 1941;4:249-58.
30. Berger BW. Dermatologic manifestations of Lyme disease. Rev Infect Dis 1989;11:S1475-81.
31. Anonymous. Rocky Mountain spotted fever - United States, 1990. MMWR Morb Mortal Wkly Rep 1991;40:451-3, 459.
32. Hattwick MAW, Retailliau H,O'Brein RJ, Slutzker M, Fontaine RE, Hanson B. Fatal Rocky Mountain spotted fever. JAMA 1978; 240:1499-1503.
33. Dalton MJ, Clarke MJ, Holman RC, Krebs JW, Fishbein DB, Olson JG, et al. National surveillance for Rocky Mountain spotted fever, 1981-1992: Epidemiologic summary and evaluation of risk factors for fatal outcome. Am J Trop Med Hyg 1995;52:405-13.
34. McDade JE. Ehrlichiosis - a disease of animals and humans. J Infect Dis 1990;161:609-17.
35. Aoki K, Kamata H, Iida T, Suzuki H. Tick bite: two cases studied by scanning electron microscopy. Br J Dermatol 1984;110:233-40.
36. Aljamali M, Bowman AS, Dillwith JW, Tucker JS, Yates GW, Essenberg RC, et al. Identity and synthesis of prostaglandins in the lone star tick, Amblyomma americanum (L.), as assessed by radio-immunoassay and gas chromatography/mass spectrometry. Insect Biochem Mol Biol 2002;32:331-41.
37. Leboulle G, Crippa M, Decrem Y, Mejri N, Brossard M, Bollen A, et al. Characterization of a novel salivary immunosuppressive protein from Ixodes ricinus ticks. J Biol Chem 2002;277:10083-9.
38. Weston-Davies W, Nuttall P. Parasite saliva as a source of anti-allergic agents. Lancet 2002;359:1067.
39. Poucher KL, Hutcheson HJ, Keirans JE, Durden LA, Black WC IV. Molecular genetic key for the identification of 17 Ixodes species of the United States (Acari: Ixodidae): a methods model. J Parasitol 1999;85:623-9.
40. Hoskins JD. Ixodid and argasid ticks. Keys to their identification. Vet Clin North Am Small Anim Pract 1991;21:185-97.
41. Frazier CA. Cutaneous manifestation of insect allergy. Cutis 1974;13:1038-47.
42. Berenberug JL, Ward PA, Sonenshine DE. Tick-bite injury: Mediation by a complement-derived chemotictic chemotactic factor. J Immunol 1972;109:451-6.
43. Harves AD, Millikan LE. Current concepts of therapy and pathophysiology in arthropod bites and stings. Part 1. Arthropods. Int J Dermatol 1975;14:543-62.
44. Yesudian P, Thambiah AS. Persistent papules after tick-bites. Dermatologica 1973;147:214-8.
45. Riek RF, Lavoipierre MMJ. Reaction of the skin of laboratory animals to the bites of argasid ticks. Trans R Soc Trop Med Hyg 1954;48:8-9.
46. Goldman L, Rockwell E, Richfield DF III. Histopathologic studies on cutaneous reactionsto the bites of various arthropods. Am J Trop Med Hyg vol 1:514-25.
47. Goldman L. Tick bite granuloma: Failure of prevention of lesion by excision of tick bite area. Am J Trop Med Hyg vol 12:246-8.
48. Halpern SM, Munro DD. Tick-borne melanoma? BMJ 1994;309: 1693.
49. Berger BW, Johnson RC, Kodner C, Coleman L. Cultivation of Borrelia burgdorferi from human tick bite sites: a guide to the risk of infection. J Am Acad Dermatol 1995;32:184-7.
50. Patterson JW, Fitzwater JE, Connell J. Localized tick bite reaction. Cutis 1979;24:168-9, 172.
51. Pearce RL, Grove DI. Tick infestation in soldiers who were bivouacked in the Perth region. Med J Aust 1987;146:238-40.
52. Cho BK, Kang H, Bang D, Kim SN, Hwang S, Song ES.Tick bites in Korea. Int J Dermatol 1994;33:552-5.
53. Allen AC. Persistent "insect bites" (dermal eosinophilic granulomas) simulating lymphoblastomas, histiocytoses, and squamous cell carcinomas. Am J Pathol 1948;24:367-75.
54. Hoogstraal H, Gallagher MD. Blisters, pruritus, and fever after bites by the Arabian tick Ornithodoros (Alectorobius) muesebecki. Lancet 1982;2:288-9.
55. Ronnen M, Kahana M, Schewach-Millet M. Ornithodoriasis preceding Borrelia infection. Arch Dermatol 1984;120:1520-1.
56. Nakamura-Uchiyama F, Komuro Y, Yoshii A, Nawa Y. Amblyomma testudinarium tick bite: one case of engorged adult and a case of extraordinary number of larval tick infestation. J Dermatol 2000;27:774-7.
57. Condy JB, Norval RAI, Blackburn NK, Clemence P. The effects of the bites of Argas brumpti (Acarina: Argasidae) on humans. Cent Afr J Med 1980;26:212-3.
58. Veraldi S, Scarabelli G, Grimalt R. Acute urticaria caused by pigeon ticks (Argas reflexus). Int J Dermatol 1996;35:34-5.
59. Veraldi S, Barbareschi M, Zerboni R, Scarabelli G. Skin manifestations caused by pigeon ticks (Argas reflexus). Cutis 1998;61: 38-40.
60. Van Mierlo P, Jacob W, Dockx P. Erythema chronicum migrans: an electron-microscopic study. Dermatology 1993;186:306-10.
61. Trager W. Acquired immunity to ticks. J Parasitol 1939;25:57-81.
62. Goldman L, Johnson P, Ramsay J. The insect bite reaction:I. The mechanism. J Invest Dermatol 1952;18:403-17,
63. Russell FE. Dermatitis due to imbedded tick parts. JAMA 1974; 228:1581.
64. Heyl T. Tick bite alopecia, Clin Exp Dermatol 1982;7:537-42,
65. Sauper L. Alopecie peladoide consecutive a une piqure de tique. Bull Soc Franc Derm Syph 1921;28:443.
66. Marshall J. Alopecia after tick bite. S Afr Med J 1966;40:555-6.
67. Ross MS, Friede H. Alopecia due to tick bite. Arch Dermatol 1955;71:524,
68. Spach DH, Shimada JK, Paauw DS. Localized alopecia at the site of erythema migrans. J Am Acad Dermatol 1992;27:1023-4.
69. Wilmer A, Kaatz M, Mentzel T, Wollina U. Lymphangioendothelioma after a tick bite. J Am Acad Dermatol 1998;39:126-8.
70. McCleary JE. Tick bite granuloma with autoeczematization. Arch Dermatol 1972;106:916.
71. Miadonna A, Tedeschi A, Leggieri E, Falagiani P, Nazzari M, Manzoni M, et al. Anaphylactic shock caused by allergy to the venom of Argos reflexus. Ann Allergy 1982;49:293-4.
72. Brown AF, Hamilton DL. Tick bite anaphylaxis in Australia. Emerg Med J 1998;15:111-3.
73. Benoit-Bazille H. L'Argas reflexus (Fabr) et son parasitisme chez I'homme. Mem Soc Zool Fr 1910;22:261.
74. Dworkin MS, Shoemaker PC, Anderson DE. Tick paralysis: 33 human cases in Washington State, 1946-1996. Clin Infect Dis 1999;29:1435-9.
75. Kincaid JC. Tick bite paralysis. Semin Neurol 1990;10:32-4.
76. Greenstein P. Tick paralysis. Med Clin North Am 2002;86:441-6.
77. Azad AF, Beard CB. Rickettsial pathogens and their arthropod vectors. Emerg Infect Dis 1998;4:179-86.
78. Hopla CE. The transmission of tularemia organisms by ticks in the southern states. South Med J 1960;53:92-7.
79. Katavolos P, Armstrong PM, Dawson JE, Telford SR III. Duration of tick attachment required for transmission of granulocytic ehrlichiosis. J Infect Dis 1998;177:1422-5.
80. Orloski KA, Hayes EB, Campbell GL, Dennis DT. Surveillance for Lyme disease - United States, 1992-1998. MMWR Surveill Summ 2000;49:1-11.
81. Steere AC. Lyme disease. N Engl J Med 2001;345:115-25.
82. Baranton G, Postic D, Saint Girons I, Boerlin P, Piffaretti JC, Assous M, et al. Delineation of Borrelia burgdorferi sensu stricto, Borrelio garinii sp. nov., and group VS461 associated with Lyme borreliosis. Int J Syst Bacteriol 1992;42:378-83.
83. Picken RN, Strle F, Ruzic-Sabljic E, Maraspin V, Lotric-Furlan S, Cimperman J, et al. Molecular subtyping of Borrelia burgdorferi sensu lato isolates from five patients with solitary lymphocytoma. J Invest Dermatol 1997;108:92-7.
84. Spielman A. The emergence of Lyme disease and human babesiosis in a changing environment. Ann N Y Acad Sci 1994;740: 146-56.
85. Shapiro ED, Gerber MA, Holabird NB, Berg AT, Feder HM Jr, Bell GL, et al. A controlled trial of antimicrobial prophylaxis for Lyme disease after deer-tick bites. N Engl J Med 1992;327:1769-73.
86. Steere AC. Lyme disease. N Engl J Med 1989;321:586-96.
87. Steere AC, Malawista SE, Bartenhagen NH, Spieler PN, Newman JH, Rahn DW, et al. The clinical spectrum and treatment of Lyme disease. Yale J Biol Med 1984;57:453-64.
88. Asbrink E, Hovmark A. Early and late cutaneous manifestations in Ixodes-borne borreliosis (erythema migrans borreliosis, Lyme borreliosis). Ann N Y Acad Sci 1988;539:4-15.
89. Strle F, Nelson JA, Ruzic-Sabljic E, Cimperman J, Maraspin V, Lotric-Furlan S, et al. European Lyme borreliosis: 231 culture-confirmed cases involving patients with erythema migrans. Clin Infect Dis 1996;23:61-5.
90. Asbrink E, Hovmark A. Cutaneous manifestations in Ixodes-borne Borrelia spirochetosis. Int J Dermatol 1987;26:215-23.
91. Abele DC, Anders KH. The many faces and phases of borreliosis II. J Am Acad Dermatol 1990;23:401-10.
92. Abele DC, Anders KH. The many faces and phases of borreliosis. I. Lyme disease. J Am Acad Dermatol 1990;23:167-86.
93. Malane MS, Grant-Kels JM, Feder HM, Luger SW. Diagnosis of Lyme disease based on dermatologic manifestations. Ann Intern Med 1991;114:490-8.
94. Melski JW. Lyme borreliosis. Semin Cutan Med Surg 2000;19: 10-8.
95. Granter SR, Barnhill RL, Duray PH. Borrelial fasciitis: Diffuse fasciitis and peripheral eosiniphilia associated with Borrelia infection. Am J Dermatopathol 1996;18:465-73.
96. Melski JW. Language, logic, and Lyme disease. Arch Dermatol 1999;135:1398-400.
97. Felz MW, Chandler FW Jr, Oliver JH Jr, Rahn DW, Schriefer ME. Solitary erythema migrans in Georgia and South Carolina. Arch Dermatol 1999;135:1317-26.
98. Kirkland KB. Erythema migrans-like rash illness at a camp in North Carolina: a new tick-borne disease? Arch Intern Med 1997;158:2162-5.
99. James AM, Liveris D, Wormser GP, Schwartz I, Montecalvo MA, Johnson BJ. Borrelia Ionestari infection after a bite by an Amblyomma americanum tick. J Infect Dis 2001;183:1810-4.
100. Krause PJ, Telford SR III, Spielman A, Sikand V, Ryan R, Christianson D, et al. Concurrent Lyme disease and babesiosis: Evidence for increased severity and duration of illness. JAMA 1996;275: 1657-60.
101. Fix AD, Pena CA, Strickland GT. Racial differences in reported Lyme disease incidence. Am J Epidemiol 2000;152:756-9.
102. Melski JW, Reed KD, Mitchell PD, Barth GD. Primary and secondary erythema migrans in central Wisconsin. Arch Dermatol 1993;129:709-16.
103. Berger BW. Erythema chronicum migrans of Lyme disease. Arch Dermatol 1984,120:1017-21.
104. Kimsey RB, Spielman A. Motility of Lyme disease spirochetes in fluids as viscous as the extracellular matrix. J Infect Dis 1990;162:1205-8.
105. Wu YS, Zhang WF, Feng FP, Wang BZ, Zhang YJ. Atypical cutaneous lesions of Lyme disease. Clin Exp Dermatol 1993;18:434-6.
106. Kuiper H, van Dam AP, Spanjaard L, de Jongh BM, Widjojokusumo A, Ramselaar TC, et al. Isolation of Borrelia burgdorferi from biopsy specimens taken from healthy-looking skin of patients with Lyme borreliosis. J Clin Microbiol 1994;32:715-20.
107. Goldberg NS, Forseter G, Nadelman RB, Schwartz I, Jorde U, McKenna D, et al. Vesicular erythema migrans. Arch Dermatol 1992;128:1495-8.
108. Nadelman RB, Wormser GP. Lyme borreliosis. Lancet 1998;352:557-65.
109. Hulshof MM, Vandenbroucke JP, Nohimans LM, Spanjaard L, Bavinck JN, Dijkmans BA. Long-term prognosis in patients treated for erythema chronicum migrans and acrodermatitis chronica atrophicans. Arch Dermatol 1997;133:33-7.
110. Mullegger RR, McHugh G, Ruthazer R, Binder B, Kerl H, Steere AC. Differential expression of cytokine mRNA in skin specimens from patients with erythema migrans or acrodermatitis chronica atrophicans. J Invest Dermatol 2000;115:1115-23.
111. Kramer N, Rickert RR, Brodkin RH, Rosenstein ED. Septal panniculitis as a manifestation of Lyme disease. Am J Med 1986;81:149-52.
112. Pohl-Koppe A, Wilske B, Weiss M, Schmidt H. Borrelia lymphocytoma in childhood. Pediatr Infect Dis J 1998;17:423-6.
113. Chodynicka B, Flisiak I, Okrasinska K, Andrzejewska A, Schwartz RA. Lymphocytoma cutis: cases linked with Lyme disease. Cutis 2000;66:243-6.
114. Hovmark A, Asbrink E, Olsson I. The spirochetal etiology of lymphadenosis benigna cutis solitaria. Acta Derm Venereol 1986;66:479-84.
115. Albrecht S, Hofstadter S, Artsob H, Chaban O, From L. Lymphadenosis benigna cutis resulting from Borrelia infection (Borrelia lymphocytoma). J Am Acad Dermatol 1991;24:621-5.
116. Finkel MF, Johnson RC. Borrelia lymphocytoma: a possible North American case. WMJ 1990;89:683-6.
117. Smullen MJ. Lyme disease article questioned. WMJ 1991;90:105-6,108.
118. Strle F, Pleterski-Rigler D, Stanek G, Pejovnik-Pustinek A, Ruzic E, Cimperman J. Solitary borrelial lymphocytoma: report of 36 cases. Infection 1992;20:201-6.
119. Asbrink E, Hovmark A. Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans. Acta Pathol Microbiol Immunol Scand [B] 1985;93:161-3.
120. Menni S, Pistritto G, Piccinno R, Trevisan G. Acrodermatitis chronica atrophicans in an Italian child. Acta Derm Venereol 1996;76:243.
121. Muellegger RR, Schluepen EM, Millner MM, Soyer HP, Volkenandt M, Kerl H. Acrodermatitis chronica atrophicans in an 11-year-old girl. Br J Dermatol 1996;135:609-12.
122. Picken RN, Strle F, Picken MM, Ruzic-Sabljic E, Maraspin V, Lotric-Furlan S, et al. Identification of three species of Borrelia burgdorferi sensu lato (B burgdorferi sensu stricto, B garinii, and B afzelii) among isolates from acrodermatitis chronica atrophicans lesions. J Invest Dermatol 1998;110:211-4.
123. Patmas MA. Lyme disease: the evolution of erythema chronicum migrans into acrodermatitis chronica atrophicans. Cutis 1993;52:169-70.
124. DiCaudo DJ, Su WP, Marshall WF, Malawista SE, Barthold S, Persing DH. Acrodermatitis chronica atrophicans in the United States: clinical and histopathologic features of six cases. Cutis 1994;54:81-4.
125. Buechner SA, Rufli T, Erb P. Acrodermatitis chronic atrophicans: a chronic T-cell-mediated immune reaction against Borrelia burgdorferi? Clinical, histologic, and immunohistochemical study of five cases. J Am Acad Dermatol 1993;28:399-405.
126. Silberer M, Koszik F, Stingl G, Aberer E. Downregulation of class II molecules on epidermal Langerhans cells in Lyme borreliosis. Br J Dermatol 2000;143:786-94.
127. Marshall J. Acrodermatitis chronica atrophicans (pick-herxheimer). S Afr Med J 1958;32:753-8.
128. Muller DE, Itin PH, Buchner SA, Rufli T. Acrodermatitis chronica atrophicans involving the face. Evidence for Borrelia burgdorferi infection confirmed by DNA amplification. Dermatology 1994;189:430-1.
129. Marsch WC, Mayet A, Wolter M. Cutaneous fibroses induced by Borrelia burgdorferi. Br J Dermatol 1993;128:674-8.
130. Asbrink E, Brehmer-Andersson E, Hovmark A. Acrodermatitis chronica atrophicans - a spirochetosis. Clinical and histopathological picture based on 32 patients; course and relationship to erythema chronicum migrans Afzelius. Am J Dermatopathol 1986;8:209-19.
131. Breier P, Klade H, Stanek G, Poitschek C, Kirnbauer R, Dorda W, et al. Lymphoproliferative responses to Borrelia burgdorferi in circumscribed scleroderma. Br J Dermatol 1996;134:285-91.
132. Buechner SA, Winkelmann RK, Lautenschlager S, Gilli L, Rufli T. Localized scleroderma associated with Borrelia burgdorferi infection. Clinical, histologic, and immunohistochemical observations. J Am Acad Dermatot 1993;29:190-6.
133. Schempp C, Bocklage H, Lange R, Kolmel HW, Orfanos CE, Gollnick H. Further evidence for Borrelia burgdorferi infection in morphea and lichen scierosus et atrophicus confirmed by DNA amplification. J Invest Dermatol 1993;100:717-20.
134. Aberer E, Klade H, Stanek G, Gebhart W. Borrelia burgdorferi and different types of morphea. Dermatologica 1991;182:145-54.
135. Wienecke R, Schlupen EM, Zochling N, Neubert U, Meurer M, Volkenandt M. No evidence for Borrelia burgdorferi-specific DNA in lesions of localized scleroderma. J Invest Dermatol 1995;104:23-6.
136. Weide B, Schittek B, Klyscz T, Schuz K, Stark M, Rassner G, et al. Morphoea is neither associated with features of Borrelia burgdorferi infection, nor is this agent detectable in lesional skin by polymerase chain reaction. Br J Dermatol 2000;143:780-5.
137. Raguin G, Boisnic S, Souteyrand P, Baranton G, Piette JC, Godeau P, et al. No evidence for spirochaetal origin of localized scleroderma. Br J Dermatol 1992;127:218-20.
138. Alonso-Llamazares J, Persing DH, Anda P, Gibson LE, Rutledge BJ, Iglesias L. No evidence for Borrelia burgdorferi infection in lesions of morphea and lichen sclerosis et atrophicus in Spain. A prospective study and literature review. Acta Derm Venereol 1997;77:299-304.
139. Abele DC, Bedingfield RB, Chandler FW, Given KS. Progressive facial hemiatrophy (Parry-Romberg syndrome) and borreliosis. J Am Acad Dermatol 1990;22:531-3.
140. Hoesly JM, Mertz LE, Winkelmann RK. Localized scleroderma (morphea) and antibody to Borrelia burgdorferi. J Am Acad Dermatol 1987;17:455-8.
141. Dillon WI, Saed GM, Fivenson DP. Borrelia burgdorferi DNA is undetectable by polymerase chain reaction in skin lesions of morphea, scleroderma, or lichen sclerosus et atrophicus of patients from North America. J Am Acad Dermatol 1995;33:617-20.
142. De Vito JR, Merogi AJ, Vo T, Boh EE, Fung HK, Freeman SM, et al. Role of Borrelia burgdorferi in the pathogenesis of morphea/ scleroderma and lichen sclerosis et atrophicus: A PCR study of thirty-five cases. J Cutan Pathol 1996;23:350-8.
143. Tuffanelli DL, Tuffanelli LR, Hoke A. False-positive Lyme antibody test in morphea. J Am Acad Dermatol 1993;28:112-3.
144. Klempner MS, Noring R, Rogers RA. Invasion of human skin fibroblasts by the Lyme disease spirochete, Borrelia burgdorferi. J Infect Dis 1993;167:1074-81.
145. Garbe C, Stein H, Gollnick H, Taud W, Orfanos CE. Cutaneous B cell lymphoma in chronic Borrelia burgdorferi infection. Report of 2 cases and a review of the literature (in German). Hautarzt 1988;39:717-26.
146. Garbe C, Stein H, Dienemann D, Orfanos CE. Borrelia burgdorferi associated cutaneous B cell lymphoma: clinical and immunohistologic characterization of four cases. J Am Acad Dermatol 1991;24:584-90.
147. Jelic S, Filipovic-Ljeskovic I. Positive serology for Lyme disease borrelias in primary cutaneous B-cell lymphoma: a study in 22 patients; is it a fortuitous finding? Hematol Oncol 1999;17:107-16.
148. Goodlad JR, Davidson MM, Hollowood K, Batstone P, Ho-Yen DO. Borrelia burgdorferi-associated cutaneous marginal zone lymphoma: a clinicopathological study of two cases illustrating the temporal progression of B burgdorferi-associated B-cell proliferation in the skin. Histopathology 2000;37:501-8.
149. Kutting B, Bonsmann G, Metze D, Luger TA, Cerroni L. Borrelia burgdorferi-associated primary cutaneous B cell lymphoma: complete clearing of skin lesions after antibiotic pulse therapy or intralesional injection of interferon alfa-2a. J Am Acad Dermatol 1997;36:311-4.
150. Munksgaard L, Frisch M, Melbye M, Hjalgrim H. Incidence patterns of lyme disease and cutaneous B-cell non-Hodgkin's lymphoma in the United States. Dermatology 2000;201:351-2.
151. Slater DN. Borrelia burgdorferi-associated primary cutaneous B-cell lymphoma. Histopathology 2001;38:73-7.
152. Roggero E, Zucca E, Mainetti C, Bertoni F, Valsangiacomo C, Pedrinis E, et al. Eradication of Borrelia burgdorferi infection in primary marginal zone B-cell lymphoma of the skin. Hum Pathol 2000;31:263-8.
153. Hashimoto Y, Takahashi H, Matsuo S, Hirai K, Takemori N, Nakao M, et al. Polymerase chain reaction of Borrelia burgdorferi flagellin gene in Shulman syndrome. Dermatology 1996;192:136-9.
154. Abele DC, Anders KH, Chandler FW. Benign lymphocytic infiltration (Jessner-Kanof): Another manifestation of borreliosis? J Am Acad Dermatol 1989;21:795-7.
155. Aberer E, Schmidt BL. Amplification of DNA of Borrelia burgdorferi in urine samples of patients with granuloma annulare and lichen sclerosis et atrophicus. Arch Dermatol 1999;135:210-1.
156. Schuttelaar ML, Laeijendecker R, Heinhuis RJ, Van Joost T. Erythema multiforme and persistent erythema as early cutaneous manifestations of Lyme disease. J Am Acad Dermatol 1997;37:873-5.
157. Lesire V, Machet L, Toledano C, de Muret A, Maillard H, Lorette G, et al. Atypical erythema multiforme occurring at the early phase of Lyme disease? Acta Derm Venereol 2000;80:222.
158. Olson JC, Esterly NB. Urticarial vasculitis and Lyme disease. J Am Acad Dermatol 1990;22:1114-6.
159. McFadden JP, Greaves MW. Urticarial lesions and Lyme disease. J Am Acad Dermatol 1991;25:131-2.
160. Kawagishi N, Takahashi H, Hashimoto Y, Miyamoto K, lizuka H. A case of Lyme disease with parotitis. Dermatology 1998;197:386-7.
161. Baldari U, Cattonar P, Nobile C, Celli B, Righini MG, Trevisan G. Infantile acrodermatitis of Gianotti-Crosti and Lyme borreliosis. Acta Derm Venereol 1996;76:242-3.
162. Berger BW. Erythema migrans. Clin Dermatol 1993;11:359-62.
163. van Dam AP. Recent advances in the diagnosis of Lyme disease. Expert Rev Mol Diagn 2001;1:413-27.
164. Jurca T, Ruzic-Sabljic E, Lotric-Furlan S, Maraspin V, Cimperman J, Picken RN, et al. Comparison of peripheral and central biopsy sites for the isolation of Borrelia burgdorferi sensu lato from erythema migrans skin lesions. Clin Infect Dis 1998;27:636-8.
165. Lebech AM. Polymerase chain reaction in diagnosis of Borrelia burgdorferi infections and studies on taxonomic classification. APMIS Suppl 2002,(suppl 105):1-40.
166. Wormser GP, Nadelman RB, Dattwyler RJ, Dennis DT, Shapiro ED, Steere AC, et al. Practice guidelines for the treatment of Lyme disease. The Infectious Diseases Society of America. Clin Infect Dis 2000;31:1-14.
167. Poland GA, Jacobson RM. The prevention of Lyme disease with vaccine. Vaccine 2001;19:2303-8.
168. Wallich R, Jahraus O, Stehle T, Tran TT, Brenner C, Hofmann H, et al. Artificial-infection protocols allow immunodetection of novel Borrelia burgdorferi antigens suitable as vaccine candidates against Lyme disease. Eur J Immunol 2003;33:708-19.
169. Spach DH, Liles WC, Campbell GL, Quick RE, Anderson DE Jr, Fritsche TR. Tick-borne diseases in the United States. N Engl J Med 1993;329:936-47.
170. Thompson RS, Burgdorger W, Russel R, Francis BJ. Outbreak of tick-borne relapsing fever in Spokane County, Washington. JAMA 1969;210:1045-50.
171. Meader CN. Five cases of relapsing fever originating in Colorado, with positive blood findings in two. Colo Med 1915;12.
172. Malison MD. Relapsing fever. JAMA 1979;241:2819-20.
173. Southern PM, Sanford JP. Relapsing fever. A clinical and microbiological review. Medicine 1969;48:129-49.
174. Kemp HA, Moursund WH, Wright HE. Relapsing fever in Texas: A survey of the epidemiology and clinical manifestations of the disease as it occurs in Texas. Am J Trop Med 1935;15:495-506.
175. Fihn S, Larson EB. Tick-borne relapsing fever in the Pacific Northwest: an underdiagnosed illness? West J Med 1980;133:203-9.
176. Dworkin MS, Anderson DE Jr, Schwan TG, Shoemaker PC, Banerjee SN, Kassen BO, et al. Tick-borne relapsing fever in the northwestern United States and southwestern Canada. Clin Infect Dis 1998;26:122-31.
177. Rawlings JA. An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. Tex Med 1995;91:56-9.
178. Dupont HT, La Scola B, Williams RC, Raoult D. A focus of tickborne relapsing fever in southern Zaire. Clin Infect Dis 1997;25:139-44.
179. Edell TA, Emerson JK, Maupin GO, Barnes AM, Vernon TM. Tickborne relapsing fever in Colorado. JAMA 1979;241:2279-82.
180. Boyer KM, Munford RS, Maupin GO, Pattison CP, Fox MD, Barnes AM, et al. Tick-borne relapsing fever: an interstate outbreak originating at Grand Canyon National Park. Am J Epidemiol 1977;105:469-79.
181. Flanigan TP, Schwan TG, Armstrong C, Van Voris LP, Salata RA. Relapsing fever in the US Virgin Islands: A previously unrecognized focus of infection. J Infect Dis 1991;163:1391-2.
182. Dworkin MS, Schwan TG, Anderson DE Jr. Tick-borne relapsing fever in North America. Med Clin North Am 2002;86:417-33.
183. Le CT. Tick-borne relapsing fever in children. Pediatrics 1980;66:963-6.
184. Taft W, Pike J. Relapsing fever. Report of a sporadic outbreak, including treatment with penicillin. JAMA 1945;129:1002.
185. Goubau PF. Relapsing fevers. A review. Ann Soc Beige Med Trop 1984;64:335-64.
186. Francis E. Tularemia: A new disease of man. JAMA 1922;78:1015-8.
187. Ayres JC, Feemster RF. Epidemiology of tularemia in Massachusetts with a review of the literature. N Engl J Med 1948;238:187-94.
188. Cox SK, Everett ED. Tularemia: An analysis of 25 cases. Mo Med 1981;78:70-4.
189. Langley R, Campbell R. Tularemia in North Carolina, 1965-1990. N C Med J 1995;56:314-7.
190. Levin SL. Tularemia due to tick bite. South Med J 1941;34:116-972.
191. Lopez CE, Kornblatt AN, Sikes RK, Hanes OE. Tularemia: review of eight cases of tick-borne infection and the epidemiology of the disease in Georgia. South Med J 1982;75:405-7.
192. Uhari M, Syrjala H, Salminen A. Tularemia in children caused by Francisella tularensis biovar palaearctica. Pediatr Infect Dis J 1990;9:80-3.
193. Markowitz LE, Hynes NA, de la Cruz P, Campos E, Barbaree JM, Plikaytis BD, et al. Tick-borne tularemia. JAMA 1985;254:2922-5.
194. Anonymous, Outbreak of tick-borne tularemia - South Dakota. MMWR Morb Mortal Wkly Rep 1984;33:601-2.
195. Saliba GS, Harmston FC, Diamond BE, Zymet CL, Goldenberg MI, Chin TDY. An outbreak of human tularemia associated with the American dog tick, Dermacenter variabilis. Am J Trop Med Hyg 1966;15:531-8.
196. Schmid GP, Kornblatt AN, Conners CA, Patton C, Carney J, Hobbs J, et al. Clinically mild tularemia associated with tickborne Francisella tularensis. J Infect Dis 1983;148:63-7.
197. Jacobs RF. Tularemia. Adv Pediatr Infect Dis 1996;12:55-69.
198. Cerny Z. Skin manifestations of tularemia. Int J Dermatol 1994;33:468-70.
199. Jacobs RF, Condrey YM, Yamauchi T. Tularemia in adults and children: a changing presentation. Pediatrics 1985;76:818-22.
200. Kostman JR, DiNubile MJ. Nodular lymphangitis: a distinctive but often unrecognized syndrome. Ann Intern Med 1993;118:883-8.
201. Jacobs RF, Narain JP. Tularemia in children. Pediatr Infect Dis 1983;2:487-91.
202. Guerrant RL, Humphries MK, Butler JE, Jackson RS. Tick-borne oculoglandular tularemia. Arch Intern Med 1976;136:811-3.
203. Young LS, Bickness DS, Archer BG, Clinton JM, Leavens LJ, Feeley JC, et al. Tularemia epidemic: Vermont, 1968. Forty-seven cases linked to contact with muskrats. N Engl J Med 1969;280:1253-60.
204. Foshay L. Tularemia: a summary of certain aspects of the disease including methods for early diagnosis and the results of serum treatment in 600 patients. Medicine 1940;19:1-83.
205. Kavanaugh CN. Tularemia: a consideration of one hundred and twenty-three cases, with observations at autopsy in one. Arch Intern Med 1945;55:61-85.
206. Sanders CV, Hahn R. Analysis of 106 cases of tularemia. J La State Med Soc 1968;120:391-3.
207. Pullen RL, Stuart BM. Tularemia: Analysis of 225 cases. JAMA 1945;129:495-500.
208. Syrjala H, Karvonen J, Salminen A. Skin manifestations of tularemia: a study of 88 cases in northern Finland during 16 years (1967-1983). Acta Derm Venereol 1984;64:513-6.
209. Lewis JE. Suppurative inflammatory eruption occurring in septicemia tularemia. Cutis 1982;30:92, 96-7, 100.
210. Martin T, Holmes IH, Wobeser GA, Anthony RF, Greefkes I. Tularemia in Canada with a focus on Saskatchewan. CMAJ 1982;127:279-82.
211. Akdis AC, Kilicturgay K, Helvaci S, Mistik R, Oral B. Immunological evaluation of erythema nodosum in tularaemia. Br J Dermatol 1993;129:275-9.
212. Peter R, Banyai T. Erythema nodosum revealing oculoglandular tularemia. Dermatology 2001;202:79-80.
213. Kodama BF, Fitzpatrick JE, Gentry RH. Tularemia. Cutis 1994;54:279-80.
214. Speert DP, Britt WJ, Kaplan EL. Tick-borne tularemia presenting as ulcerative lymphadenitis. Clin Pediatr 1979;18:239-41.
215. Centers for Disease Control and Prevention. Level A laboratory procedures for identification of Francicella tularensis. Available at: http://www.bt.cdc.gov/Agent/Tularemia/ftu_la_cp_121301.pdf. Accessed April 27, 2003.
216. Enderlin G, Morales L, Jacobs RF, Cross JT. Streptomycin and alternative agents for the treatment of tularemia: review of the literature. Clin Infect Dis 1994;19:42-7.
217. Smith T, Kilbourne FL. Investigation into the nature, causation, and prevention of Texas or south cattle fever. USDA Bur Anim Ind Bull 1893;1:1-301.
218. Ruebush TKI, Cassaday PB, Marsh HJ, Lisker SA, Voorhees DB, Mahoney EB, et al. Human babesiosis on Nantucket Island. Ann Intern Med 1977;86:6-9.
219. Gorenflot A, Moubri K. Precigout E, Carcy B, Schetters TP. Human babesiosis. Ann Trop Med Parasitol 1998;92:489-501.
220. Homer MJ, Aguilar-Delfin I, Telford SR III, Krause PJ, Persing DH. Babesiosis. Clin Microbiol Rev 2000;13:451-69.
221. Krause PJ, McKay K, Thompson CA, Sikand VK, Lentz R, Lepore T, et al. Disease-specific diagnosis of coinfecting tick-borne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme disease. Clin Infect Dis 2002;34:1184-91.
222. Boustani MR, Gelfand JA. Babesiosis. Clin Infect Dis 1996;22:611-5.
223. Kain KC, Jassoum SB, Fong IW, Hannach B. Transfusion-transmitted babesiosis in Ontario: first reported case in Canada. CMAJ 2001;164:1721-3.
224. Krause PJ, Telford SR III, Ryan R, Hurta AB, Kwasnik I, Luger S, et al. Geographical and temporal distribution of babesial infection in Connecticut. J Clin Microbiol 1991;29:1-4.
225. Meldrum SC, Birkhead GS, White DJ, Benach JL, Morse DL. Human babesiosis in New York State: an epidemiological description of 136 cases. Clin Infect Dis 1992;15:1019-23.
226. Krause PJ, Telford SR III, Pollack RJ, Ryan R, Brassard P, Zemel L, et al. Babesiosis: An underdiagnosed disease in children. Pediatrics 1992;89:1045-8.
227. White DJ, Talarico J, Chang HG, Birkhead GS, Heimberger T, Morse DL. Human babesiosis in New York State: Review of 139 hospitalized cases and analysis of prognostic factors. Arch Intern Med 1998;158:2149-54.
228. Benach JL, Habicht GS. Clinical characteristics of human babesiosis. J Infect Dis 1981;144:481.
229. Mylonakis E. When to suspect and how to monitor babesiosis. Am Fam Physician 2001;63:1969-74.
230. Hatcher JC, Greenberg PD, Antique J, Jimenez-Lucho VE. Severe babesiosis in Long Island: review of 34 cases and their complications. Clin Infect Dis 2001;32:1117-25.
231. Pruthi RK, Marshall WF, Wiltsie JC, Persing DH. Human babesiosis. Mayo Clinic Proc 1995;70:853-62.
232. Thompson C, Spielman A, Krause PJ. Coinfecting deer-associated zoonoses: Lyme disease, babesiosis, and ehrlichiosis. Clin Infect Dis 2001;33:676-85.
233. Rosner F,Zarrabi MH, Benach JL, Habicht GS. Babesiosis in splenectomized adults. Review of 22 reported cases. Am J Med 1984;76:696-701.
234. Dorman SE, Cannon ME, Telford SR III, Frank KM, Churchill WH. Fulminant babesiosis treated with clindamycin, quinine, and whole-blood exchange transfusion. Transfusion 2000;40:375-80.
235. Ryan R, Krause PJ, Radolf J, Freeman K, Spielman A, Lenz R, et al. Diagnosis of babesiosis using an immunoblot serologic test. Clin Diagn Lab Immunol 2001;8:1177-80.
236. Janbon F, Raoult D, Reynes J, Dyer RE. Concomitant human infection due to Rickettsia conorii and Coxiella burnetii. J Infect Dis 1989;160:354-5.
237. RehacekJ,Tarasevich IV. Ecological questions concerning rickettsiae. Eur J Epidemiol 1991;7:229-36.
238. McDade JE, Newhouse VF.Natural history of Rickettsia rickettsii. Ann Rev Microbiol 1986;40:287-309.
239. Niebylski ML, Schrumpf ME, Burgdorfer W, Fischer ER, Gage KL, Schwan TG. Rickettsia peacockii sp. nov., a new species infecting wood ticks, Dermacenter andersoni, in western Montana. Int J Syst Bacteriol 1997;47:446-52.
240. Kaplan LI. Other spotted fevers. Clin Dermatol 1996;14:259-67.
241. Burnett JW. Rickettsioses: a review for the dermatologist. J Am Acad Dermatol 1980;2:359-73.
242. Elghetany MT, Walker DH. Hemostatic changes in Rocky Mountain spotted fever and Mediterranean spotted fever. Am J Clin Pathol 1999;112:159-68.
243. Boele van Hensbroek M, de Vries E, Dolan G, Schneeberger P. Rash and petechiae as presenting signs of Q fever. Pediatr Infect Dis J 2000;19:358.
244. Ricketts HT. Some aspects of Rocky Mountain spotted fever as shown by recent investigations. Med Rec 1909;76:843-55.
245. Maxey EE. Some observations on the so-called spotted fever of Idaho. Medical Sentinel 1899;7:433.
246. Sexton DJ, Kaye KS. Rocky mountain spotted fever. Med Clin North Am 2002;86:351-60.
247. Treadwell TA, Holman RC, Clarke MJ, Krebs JW, Paddock CD, Childs JE. Rocky Mountain spotted fever in the United States, 1993-1996. Am J Trop Med Hyg 2000;63:21-6.
248. Hilton E, DeVoti J, Benach JL, Halluska ML, White DJ, Paxton H, et al. Seroprevalence and seroconversion for tick-borne diseases in a high-risk population in the northeast United States. Am J Med 1999;106:404-9.
249. Anonymous. Rocky Mountain spotted fever - United States, 1990. MMWR Morb Mortal Wkly Rep 1991;40:451-3,459.
250. Helmick CG, Bernard KW, D'Angelo LJ. Rocky Mountain spotted fever: Clinical, laboratory, and epidemiological features of 262 cases. J Infect Dis 1984;150:480-7.
251. Kirk JL, Fine DP, Sexton DJ, Muchmore HG. Rocky Mountain spotted fever: A clinical review based on 48 confirmed cases, 1943-1986. Medicine 1990;69:35-45.
252. Anonymous. From the MMWR. Rocky Mountain spotted fever - United States, 1987. Arch Dermatol 1988;124:1172.
253. Wilfert CM, MacCormack JN, Kleeman K, Philip RN, Austin E, Dickenson V, et al. Epidemiology of Rocky Mountain spotted fever as determined by active surveillance. J Infect Dis 1984;150:469-79.
254. Hattwick MAW, O'Brein RJ, Hanson BF. Rocky Mountain spotted fever: Epidemiology of an increasing problem. Ann Intern Med 1974;84:732-9.
255. Callahan EF, Adal KA, Tomecki KJ. Cutaneous (non-HIV) infections. Dermatol Clin 2000;18:497-508.
256. Parker RR. Symptomatology and certain other aspects of Rocky Mountain spotted fever. In: Moulton FR, editor. The Rickettsial Diseases of Man. Washington, DC: American Association of the Advancement of Science; 1948. pp. 139-46.
257. Sexton DJ, Banks PM, Weig S, Roe CR. Late appearance of skin rash and abnormal serum enzymes in Rocky Mountain spotted fever. A case report. J Pediatr 1975;87:580-2.
258. Cohen JI, Corson AP, Corey GR. Late appearance of skin rash in Rocky Mountain spotted fever. South Med J 1983;76:1457-8.
259. Sexton DJ, Corey GR. Rocky Mountain "spotless" and "almost spotless" fever: a wolf in sheep's clothing. Clin Infect Dis 1992;15:439-48.
260. Kirkland KB, Marcom PK, Sexton DJ, Dumler JS, Walker DH. Rocky Mountain spotted fever complicated by gangrene: report of six cases and review. Clin Infect Dis 1993;16:629-34.
261. Griffith GL, Luce EA. Massive skin necrosis in Rocky Mountain spotted fever. South Med J 1978;71:1337-40.
262. Stoenner HG, Lackman DB, Bell EJ. Factors affecting the growth of rickettsias of the spotted fever group in fertile hen's eggs. J Infect Dis 1962;110:121-8.
263. Walker DH, Gay RM, Valdes-Dapena M. The occurrence of eschars in Rocky Mountain spotted fever. J Am Acad Dermatol 1981;4:571-6.
264. Silber JL. Rocky Mountain spotted fever. Clin Dermatol 1996; 14:245-58.
265. Hughes C. Rocky Mountain "spotless" fever with an erythema migrans-like skin lesion. Clin Infect Dis 1995;21:1328-9.
266. Turner RC, Chaplinski TJ, Adams HG. Rocky Mountain spotted fever presenting as thrombotic thrombocytopenic purpura. Am J Med 1986;81:151-7.
267. Kao GF, Evancho CD, Ioffe O, Lowitt MH, Dumler JS. Cutaneous histopathology of Rocky Mountain spotted fever. J Cutan Pathol 1997;24:604-10.
268. Dumler JS, Gage WR, Pettis GL, Azad AF, Kuhadja FP. Rapid immunoperoxidase demonstration of Rickettsia rickettsii in fixed cutaneous specimens from patients with Rocky Mountain spotted fever. Am J Clin Pathol 1990;93:410-4.
269. Wolbach SB. The pathology of the rickettsial diseases of man. In: Moulton FR, editor. The Rickettsial Diseases of Man. Washington, DC: American Association of the Advancement of Science; 1948. pp. 118-25.
270. Cherry JD. Contemporary infectious exanthems. Clin Infect Dis 1993;16:199-207.
271. Horwitz MS, Grose C, Fisher M. Letter: Atypical measles rash mimicking Rocky Mountain spotted fever. N Engl J Med 1973;289:1203-4.
272. McKinnon HD Jr, Howard T. Evaluating the febrile patient with a rash. Am Fam Physician 2000;62:804-16.
273. Milunski MR, Gallis HA, Fulkerson WJ. Staphylococcus aureus septicemia mimicking fulminant Rocky Mountain spotted fever. Am J Med 1987;83:801-3.
274. Paddock CD, Greer PW, Ferebee TL, Singleton J Jr, McKechnie DB, Treadwell TA, et al. Hidden mortality attributable to Rocky Mountain spotted fever: immunohistochemical detection of fatal, serologically unconfirmed disease. J Infect Dis 1999;179:1469-76.
275. Walker DH, Cain BG, Olmstead PM. Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in cutaneous lesions. Am J Clin Path 1978;69:619-23.
276. Procop GW, Burchette JL, Howell DN, Sexton DJ. Immunoperoxidase and immunofluorescent staining of Rickettsia rickettsii in skin biopsies. A comparative study. Arch Pathol Lab Med 1997;121:894-9.
277. Holman RC, Paddock CD, Curns AT, Krebs JW, McQuiston JH, Childs JE. Analysis of risk factors for fatal Rocky Mountain spotted fever: evidence for superiority of tetracyclines for therapy. J Infect Dis 2001;184:1437-44.
278. American Academy of Pediatrics. Rocky mountain spotted fever. In: Pickering LK, editor. 2000 Red Book: Report of the Committee on Infectious Diseases. Elk Grove Village, IL: American Academy of Pediatrics; 2000. pp. 491-3.
279. Williams WJ, Radulovic S, Dasch GA, Lindstrom J, Kelly DJ, Oster CN, et al. Identification of Rickettsia conorii infection by polymerase chain reaction in a soldier returning from Somalia. Clin Infect Dis 1994;19:93-9.
280. Barrett-Conner E, Ginsberg MM. Imported South African tick typhus. West J Med 1983;138:264-6.
281. McDonald JC, MacLean JD, McDade JE. Imported rickettsial disease: Clinical and epidemiologic features. Am J Med 1988;85:799-805.
282. Harris RL, Kaplan SL, Bradshaw MW, Williams TW. Boutonneuse fever in American travelers. J Infect Dis 1986;153:126-8.
283. Otero R, Fenoll A, Casal J. Resurgence of mediterranean spotted fever. Lancet 1982;2:1107.
284. Vicente V, Alberca I, Ruiz R, Herrero I, Gonzalez R, Portugal J. Coagulation abnormalities in patients with Mediterranean spotted fever. J Infect Dis 1986;153:128-31.
285. Font-Creus B, Bella-Cueto F, Espejo-Arenas E, Vidal-Sanahuja R, Munoz-Espin T, Nolla-Salas M, et al. Mediterranean spotted fever: a cooperative study of 227 cases. Rev Infect Dis 1985;7:635-42.
286. Mansueto S, Tringali G, Di Leo R, Maniscalco M, Montenegro MR, Walker DH. Demonstration of spotted fever group rickettsiae in the tache noire of a healthy person in Sicily. Am J Trop Med Hyg 1984;33:479-82.
287. Raoult D, Weiller PJ, Chagnon A, Chaudet H, Gallais H, Casanova P. Mediterranean spotted fever: Clinical, laboratory and epidemiologic features of 199 cases. Am J Trop Med Hyg 1986;35:845-50.
288. La Scola B, Raoult D. Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases. J Clin Microbiol 1997;35:2715-27.
289. Jayaseelan E, Rajendran SC, Shariff S, Fishbein D, Keystone JS. Cutaneous eruptions in Indian tick typhus. Int J Dermatol 1991;30:790-4.
290. Kemper CA, Spivack AP, Deresinski SC. Atypical papulovesicular rash due to infection with Rickettsia conorii. Clin Infect Dis 1992;15:591-4.
291. Walker DH, Gear JHS. Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever. Am J Trop Med Hyg 1985;34:361-71.
292. Brouqui P, Dupont HT, Drancourt M, Bourgeade A, Raoult D. Spotless boutonneuse fever. Clin Infect Dis 1992;14:114-6.
293. Walker DH, Occhino C, Tringali GR, Di Rosa S, Mansueto S. Pathogenesis of rickettsial eschars: the tache noire of boutonneuse fever. Hum Pathol 1988;19:1449-54.
294. Montenegro MR, Mansueto S, Hegarty BC, Walker DH. The histology of "taches noires" of boutonneuse fever and demonstration of Rickettsia conorii in them by immunofluorescence. Virchows Arch 1983;400:309-17.
295. Dujella J, Morovic M, Dzelalija B, Gveric M, Novakovic S. Histopathology and immunopathology of skin biopsy specimens in Mediterranean spotted fever. Acta Virol 1991;35:566-72.
296. Maeda K, Markowitz N, Hawley RC, Ristic M, Cox D, McDade JE. Human infection with Ehrlichia canis, a leukocytic rickettsia. N Engl J Med 1987;316:853-6.
297. Chen SM, Dumler JS, Bakken JS, Walker DH. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. J Clin Microbiol 1994;32:589-95.
298. Bakken JS, Dumler JS, Chen SM, Eckman MR, Van Etta LL, Walker DH. Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging? JAMA 1994;272:212-8.
299. Telford SR III, Lepore TJ, Snow P, Warner CK, Dawson JE. Human granulocytic ehrlichiosis in Massachusetts. Ann Intern Med 1995;123:277-9.
300. McQuiston JH, Paddock CD, Holman RC, Childs JE. The human ehrlichioses in the United States. Emerg Infect Dis 1999;5:635-42.
301. Anderson BE, Sims KG, Olson JG, Childs JE, Piesman JF, Happ CM, et al. Amblyomma americanum: a potential vector of human ehrlichiosis. Am J Trop Med Hyg 1993;49:239-44.
302. Anonymous. Statewide surveillance for ehrlichiosis - MMWR Morb Mortal Wkly Rep 1998;47:476-80.
303. Richter PJ Jr, Kimsey RB, Madigan JE, Barlough JE, Dumler JS, Brooks DL. Ixodes pacificus (Acari: Ixodidae) as a vector of Ehrlichia equi (Rickettsiales: Ehrlichieae). J Med Entomol 1996;33:1-5.
304. Dumler JS, Bakken JS. Ehrlichial diseases of humans: emerging tick-borne infections. Clin Infect Dis 1995;20:1102-10.
305. Ravyn MD, Kodner CB, Carter SE, Jarnefeld JL, Johnson RC. Isolation of the etiologic agent of human granulocytic ehrlichiosis from the white-footed mouse (Peromyscus leucopus). J Clin Microbiol 2001;39:335-8.
306. Marshall GS, Jacobs RF, Schutze GE, Paxton H, Buckingham SC, DeVincenzo JP, et al. Ehrlichia chaffeensis seroprevalence among children in the southeast and south-central regions of the United States. Arch Pediatr Adolesc Med 2002;156:166-70.
307. Fritz CL, Glaser CA. Ehrlichlosis. Infect Dis Clin North Am 1998;12:123-36.
308. Ramsey AH, Belongia EA, Gale CM, Davis JP. Outcomes of treated human granulocytic ehrlichiosis cases. Emerg Infect Dis 2002;8:398-401.
309. Rohrbach BW, Harkess JR, Ewing SA, Kudlac J, McKee GL, Istre GR. Epidemiology and clinical characteristics of persons with serologic evidence of E canis infection. Am J Public Health 1990;80:442-5.
310. Fishbein DB, Dawson JE, Robinson LE. Human ehrlichiosis in the United States, 1985-1990. Ann Intern Med 1994;120:736-43.
311. Anonymous. Human ehrlichiosis - United States. Arch Dermatol 1988;124:993-4.
312. Everett ED, Evans KA, Henry B, McDonald G. Human ehrlichiosis in adults after tick exposure. Ann Intern Med 1994;120:730-5.
313. Eng TR, Harkess JR, Fishbein DB, Dawson JE, Greene CN, Redus MA, et al. Epidemiology, clinical, and laboratory findings of human ehrlichiosis in the United States, 1988. JAMA 1990;264:2251-8.
314. Heymann WR. Human ehrlichiosis. Int J Dermatol 1995;34:618-9.
315. Fichtenbaum CJ, Peterson LR, Weil GJ. Ehrlichiosis presenting as a life-threatening illness with features of the toxic shock syndrome. Am J Med 1993;95:351-7.
316. Bakken JS, Dumler JS. Human granulocytic ehrlichiosis. Clin Infect Dis 2000;31:554-60.
317. Bakken JS, Krueth J, Wilson-Nordskog C, Tilden RL, Asanovich K, Dumler JS. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 1996;275:199-205.
318. Bakken JS, Dumler JS, Chen S, Eckman MR, Van Etta LL, Walker DH. Human granulocytic ehrlichiosis in the upper Midwest United States. JAMA 1994;272:212-8.
319. Aguero-Rosenfeld ME, Horowitz HW, Wormser GP, McKenna DF, Nowakowski J, Munoz J, et al. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Ann Intern Med 1996;125:904-8.
320. Wallace BJ, Brady G, Ackman DM, Wong SJ, Jacquette G, Lloyd EE, et al. Human granulocytic ehrlichiosis in New York. Arch Intern Med 1998;158:769-73.
321. Barton LL, Foy TM. Ehrlichia canis infection in a child. Pediatrics 1989;4:580-2.
322. Dumler JS, Brouqui P, Aronson J, Taylor JP, Walker DH. Identification of ehrlichia in human tissue. N Engl J Med 1991;325:1109-10.
323. Edwards MS, Jones JE, Leass DL, Whitmore JW, Dawson JE, Fishbein DB. Childhood infection caused by Ehrlichia canis or a closely related organism. Pediatr Infect Dis J 1988;7:651-4.
324. Ende M, O'Donnal PM, Ende FI, Ende M. Ehrlichiosis in Virginia: case reports. Va Med 1990;117:160-1.
325. Harkess JR, Stucky D, Ewing SA. Neurologic abnormalities in a patient with human ehrlichiosis. South Med J 1990;83:1341-3.
326. Dimmitt DC, Fishbein DB, Dawson JE. Human ehrlichiosis associated with cerebrospinal fluid pleocytosis: a case report. Am J Med 1989;87:677-8.
327. Taylor JP, Betz TG, Fishbein DB, Roberts MA, Dawson J, Ristic M. Serologic evidence of possible human infection with Ehrlichia in Texas. J Infect Dis 1988;158:217-23.
328. Pick N, Potasman I, Strenger C, Keysary A, Schwartz I. Ehrlichiosis associated vasculitis. J Intern Med 2000;247:674-8.
329. Golden SE. Aseptic meningitis associated with ehrlichia canis. Pediatr Infect Dis 1989;8:335-7.
330. Harkess JR, Ewing SA, Brumit T, Mettry CR, Ehrlichiosis in children. Pediatrics 1991;87:199-203.
331. Barton LL, Rathore MH, Dawson JE. Infection with Ehrlichia in childhood. J Pediatr 1992;120:998-1001.
332. Marty AM, Dumler JS, Imes GI, Brusman HP, Smrkovski LL, Frisman DM. Ehrlichiosis mimicking thrombotic thrombocytopenic purpura. Case report and pathologic correlation. Hum Pathol 1995;26:920-5.
333. Dawson JE, Paddock CD, Warner CK, Greer PW, Bartlett JH, Ewing SA, et al. Tissue diagnosis of Ehrlichia chaffeensis in patients with fatal ehrlichiosis by use of immunohistochemistry, in situ hybridization, and polymerase chain reaction. Am J Trop Med Hyg 2001;65:603-9.
334. Maurin M, Raoult D. Q fever. Clin Microbiol Rev 1999;12:518-53.
335. Raoult D, Tissot-Dupont H, Foucault C, Gouvernet J, Fournier PE, Bernit E, et al. Q fever 1985-1998: Clinical and epidemiologic features of 1,383 infections. Medicine 2000;79:109-23.
336. Eklund CM. A case of Q fever probably contracted by exposure to ticks in nature. Pub Health Rep 1947;62:1413-6.
337. Levinson W, Jawetz E. Medical microbiology and immunology. Stamford (CT): Appleton and Lange; 1998.
338. Ruiz-Contreras J, Montero RG, Amador JTR, Corradi EG, Vera AS. Q fever in children. Am J Dis Child 1993;147:300-2.
339. Huebner RJ, Jellison WL, Beck MD. Q fever - a review of current knowledge. Ann Intern Med 1949;30:495-509.
340. Clark HF, Lennette EH, Railsback OC, Romer MS. Q fever in California. Arch Intern Med 1951;88:155-67.
341. Dupuis G, Peter O, Pedroni D, Petite J. Clinical aspects observed during an epidemic of 415 cases of Q fever (in French). Schweiz Med Wochenschr 1985;115:814-8.
342. Powell O. "Q" fever: clinical features in 72 cases. Aust Ann Med 1960;9:214-23.
343. Spicknall CG, Huebner RJ, Finger JA, Blocker WP. Report of an outbreak of Q fever at the National Institutes of Health. I. Clinical features. Ann Intern Med 1947;27:28-40.
344. Spelman DW. Q fever: a study of 111 consecutive cases. Med J Aust 1982;1:547-53.
345. Dupont HT, Raoult D, Brouqui P, Janbon F, Peyramond D, Weiller PJ, et al. Epidemiologic features and clinical presentation of acute Q fever in hospitalized patients:323 French cases. Am J Med 1992;93:427-34.
346. Brouqui P, Dupont HT, Drancourt M, Berland Y, Etienne J, Leport CL, et al. Chronic Q fever: ninety-two cases from France, including 27 cases without endocarditis. Arch Intern Med 1993;153:642-8.
347. Duval X, Debord T, Fournier B, Darie H, Lemoing V, Roue R. Q fever with cutaneous and encephalitic involvement. Lancet 1993;341:1094-5.
348. Raoult D, Marrie T. Q fever. Clin Infect Dis 1995;20:489-95.
349. Gluckman SJ. Q fever and trench fever. Clin Dermatol 1996;14:283-7.
350. Granel B, Genty I, Serratrice J, Rey J, Disdier P, Raoult D, et al, Livedo reticularis revealing a latent infective endocarditis due to Coxiella burnetti. J Am Acad Dermatol 1999;41:842-4.
351. Vazquez-Lopez F, Rippe ML, Soler T, Rodriguez A, Arribas JM, Perez-Oliva N. Erythema nodosum and acute Q fever: report of a case with granulomatous hepatitis and immunological abnormalities. Acta Derm Venereol 1997;77:73-4.
352. Conget I, Mallolas J, Mensa J, Rovira M. Erythema nodosum and Q fever. Arch Dermatol 1987;123:867.
353. Calisher CH. Medically important arboviruses of the United States and Canada. Clin Microbiol Rev 1994;7:89-116.
354. Nuttall PA, Jones LD, Labuda M, Kaufman WR. Adaptations of arboviruses to ticks. J Med Entomol 1994;31:1-9.
355. Jones LD, Kaufman WR, Nuttall PA. Modification of the skin feeding site by tick saliva mediates virus transmission. Experientia 1992;48:779-82.
356. Eklund CM, Kohls GM, Brennan JM. Distribution of Colorado tick fever and virus-carrying ticks. JAMA 1955;157:335-7.
357. Emmons RW. An overview of Colorado tick fever. Prog Clin Biol Res 1985;178:47-52.
358. Ater JL, Overall JC, Yeh TJ, O'Brien RT, Bailey A. Circulating interferon and clinical symptoms in Colorado tick fever. J Infect Dis 1985;151:966-8.
359. Burgdorfer W. Tick-borne diseases in the United States: Rocky Mountain spotted fever and Colorado tick fever. A review. Acta Trop 1977;34:103-26.
360. Spruance SL, Bailey A. Colorado Tick Fever. A review of 115 laboratory confirmed cases. Arch Intern Med 1973;131:288-93.
361. Goodpasture HC, Poland JD, Francy DB, Bowen GS, Horn KA. Colorado tick fever: clinical, epidemiologic, and laboratory aspects of 228 cases in Colorado in 1973-1974. Ann Intern Med 1978;88:303-10.
362. Silver HK, Meiklejohn G, Kempe CH. Colorado tick fever. Am J Dis Child 1961;101:56-61.
363. Earnest MP, Breckinridge JC, Barr RJ, Francy DB, Mollohan CS. Colorado tick fever. Clinical and epidemiologic features and evaluation of diagnostic methods. Rocky Mt Med J 1971;68:60-2.
364. Johnson AJ, Karabatsos N, Lanciotti RS. Detection of Colorado tick fever virus by using reverse transcriptase PCR and application of the technique in laboratory diagnosis. J Clin Microbiol 1997;35:1203-8.
365. Calisher CH, Poland JD, Calisher SB, Warmoth LA. Diagnosis of Colorado tick fever virus infection by enzyme immunoassays for immunoglobulin M and G antibodies. J Clin Microbiol 1985;22:84-8.
366. Attoui H, Billoir F, Bruey JM, de Micco P, de Lamballerie X. Serologic and molecular diagnosis of Colorado tick fever viral infections. Am J Trop Med Hyg 1998;59:763-8.
367. Anonymous. Arboviral disease - United States, 1994. MMWR Morb Mortal Wkly Rep 1995;44:641-4.
368. Anonymous. Outbreak of Powassan encephalitis - Maine and Vermont, 1999-2001. MMWR Morb Mortal Wkly Rep 2001;50:761-4.
369. Gholam BI, Puksa S, Provias JP. Powassan encephalitis: a case report with neuropathology and literature review. CMAJ 1999;161:1419-22.
370. Smith R, Woodall JP, Whitney E, Deibel R, Gross MA, Smith V, et al. Powassan virus infection: A report of three human cases of encephalitis. Am J Dis Child 1974;127:691-3.
371. Schulze TL, Bowen GS, Bosler EM, Lakat MF, Parkin WE, Altman R, et al. Amblyomma americanum: a potential vector of Lyme disease in New Jersey. Science 1984;224:601-3.
372. Masters E, Granter S, Duray P, Cordes P. Physician-diagnosed erythema migrans and erythema migrans-like rashes following Lone Star tick bites. Arch Dermatol 1998;134:955-60.
373. Rich SM, Armstrong PM, Smith CB, Telford SR III. Lone Star tick-infecting Borreliae are most closely related to the agent of bovine borreliosis. J Clin Microbiol 2001;39:494-7.
374. Barbour AG, Maupin GO, Teltow GJ, Carter CJ, Piesman J. Identification of an uncultivable Borrelia species in the hard tick Amblyomma americanum: Possible agent of a Lyme disease-like illness. J Infect Dis 1996;173:403-9.
375. Masters EJ. Erythema migrans in the South. Arch Intern Med 1998;158:2162-5.
376. Campbell GL, Paul WS, Schriefer ME, Craven RB, Robbins KE, Dennis DT. Epidemiologic and diagnostic studies of patients with suspected early Lyme disease, Missouri, 1990-1993. J Infect Dis 1995;172:470-80.
377. Armstrong PM, Rich SM, Smith RD, Hartl DL, Spielman A, Telford SR III. A new Borrelia infecting Lone Star ticks. Lancet 1996;347:67-8.
378. Wilson ME. Prevention of tick-borne diseases. Med Clin North Am 2002;86:219-38.
379. Needham GR. Evaluation of five popular methods for tick removal. Pediatrics 1985;75:997-1002.
380. Lee MD, Sonenshine DE, Counselman FL. Evaluation of subcutaneous injection of local anesthetic agents as a method of tick removal. Am J Emerg Med 1995;13:14-6.
381. Nadelman RB, Nowakowski J, Fish D, Falco RC, Freeman K, McKenna D, et al. Prophylaxis with single-dose doxycycline for the prevention of Lyme disease after an Ixodes scapularis tick bite. N Engl J Med 2001;345:79-84.
382. Shadick NA, Daltroy LH, Phillips CB, Liang US, Liang MH. Determinants of tick-avoidance behaviors in an endemic area for Lyme disease. Am J Prev Med 1997;13:265-70.
383. Walker DH, Barbour AG, Oliver JH, Lane RS, Dumler JS, Dennis DT, et al. Emerging bacterial zoonotic and vector-borne diseases. Ecological and epidemiological factors. JAMA 1996;275:463-9.