Glucose-induced TGF-β1 and TGF-β receptor-1 expression in vascular smooth muscle cells is mediated by protein kinase C-α

Hypertension

Volumn 42, Issue 3, 2003, Pages 335-341

  Lindschau, Carsten ^a   Quass, Petra ^a   Menne, Jan ^a   Güler, Faikah ^a   Fiebeler, Anette ^a   Leitges, Michael ^b   Luft, Friedrich C ^c   Haller, Hermann ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^c HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Atherosclerosis; Diabetes; Glucose; Growth substances; Muscle, vascular, smooth; Protein kinases

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GLUCOSE; ISOENZYME; PROTEIN KINASE C ALPHA; PROTEIN KINASE C INHIBITOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HYPERGLYCEMIA; IMMUNOCYTOCHEMISTRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

ACTIVIN RECEPTORS, TYPE I; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GLUCOSE; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICROSCOPY, CONFOCAL; MUSCLE, SMOOTH, VASCULAR; NAPHTHALENES; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAUROSPORINE; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 0042834368     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000087839.72582.DD     Document Type: Article

References (47)

1. Eddy AE. Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol. 1996;7:2495-2508.
2. Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease: the case for transforming growth factor-β as a key mediator. Diabetes. 1995;44:1139-1146.
3. Sharma K, Ziyadeh FN. Renal hypertrophy is associated with upregulation of TGF-β1 gene expression in diabetic BB rat and NOD mouse. Am J Physiol. 1994;267:FI094-FI098.
4. Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-β by anti-TGF-β antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes. 1996;45:522-530.
5. Cosio FG. Effects of high glucose concentrations on human mesangial cell proliferation. J Am Soc Nephrol. 1995;5:1600-1609.
6. Kolm V, Sauer U, Olgemooller B, Schleicher ED. High glucose-induced TGF-β1 regulates mesangial production of heparan sulfate proteoglycan. Am J Physiol. 1996;270:F812-F821.
7. Kreisberg JI, Garoni JA, Radnik R, Ayo SH. High glucose and TGF-β1 stimulate fibronectin gene expression through a cAMP response element. Kidney Int. 1994;46:1019-1024.
8. Phillips AO, Topley N, Steadman R, Morrisey K, Williams JD. Induction of TGF-β1 synthesis in D-glucose primed human proximal tubular cells by IL-1β and TNF-α. Kidney Int. 1996;50:1546-1554.
9. Reinhold D, Ansorge S, Schleicher ED. Elevated glucose levels stimulate transforming growth factor-β1 (TGF-β1), suppress interleukin IL-2, IL-6 and IL-10 production and DNA synthesis in peripheral blood mononuclear cells. Horm Metab Res. 1996;28:267-270.
10. Rocco MV, Chen Y, Goldfarb S, Ziyadeh FN. Elevated glucose stimulates TGF-β gene expression and bioactivity in proximal tubule. Kidney Int. 1992;41:107-114.
11. van Det NF, Verhagen NA, Tamsma JT, Berden JH, Bruijn JA, Daha MR, van der Woude FJ. Regulation of glomerular epithelial cell production of fibronectin and transforming growth factor-β by high glucose, not by angiotensin II. Diabetes. 1997;46:834-840.
12. Wahab NA, Harper K, Mason RM. Expression of extracellular matrix molecules in human mesangial cells in response to prolonged hyperglycaemia. Biochem J. 1996;316:985-992.
13. Ziyadeh FN, Sharma K, Ericksen M, Wolf G. Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by autocrine activation of transforming growth factor-β. J Clin Invest. 1994;93:536-542.
14. Shankland SJ, Scholey JW, Ly H, Thai K. Expression of transforming growth factor-β1 during diabetic renal hypertrophy. Kidney Int. 1994;46:430-442.
15. Pfeiffer A, Middelberg-Bisping K, Drewes C, Schatz H. Elevated plasma levels of transforming growth factor-β1 in NIDDM. Diabetes Care. 1996;19:1113-1117.
16. Wells RG, Yankelev H, Lin HY, Lodish HF. Biosynthesis of the type I and type II TGF-β receptors: implications for complex formation. J Biol Chem. 1997;272:11444-11451.
17. Koli KM, Arteaga CL. Processing of the transforming growth factor-β type I and II receptors: biosynthesis and ligand-induced regulation. J Biol Chem. 1997;272:6423-6427.
18. Guh JY, Yang ML, Yang YL, Chang CC, Chuang LY. Captopril reverses high-glucose-induced growth effects on LLC-PK1 cells partly by decreasing transforming growth factor-β receptor protein expressions. J Am Soc Nephrol. 1996;7:1207-1215.
19. Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN. Stimulation of TGF-β type II receptor by high glucose in mouse mesangial cells and in diabetic kidney. Am J Physiol Renal Physiol. 2000;278:F830-F838.
20. Craven PA, Studer RK, Negrete H, DeRubertis FR. Protein kinase C in diabetic nephropathy. J Diabetes Complicat. 1995;9:241-245.
21. Derubertis FR, Craven PA. Activation of protein kinase C in glomerular cells in diabetes: mechanisms and potential links to the pathogenesis of diabetic glomerulopathy. Diabetes. 1994;43:1-8.
22. Williams B, Tsai P, Schrier RW. Glucose-induced downregulation of angiotensin II and arginine vasopressin receptors in cultured rat aortic vascular smooth muscle cells: role of protein kinase C. J Clin Invest. 1992;90:1992-1999.
23. Haller H, Drab M, Luft FC. The role of hyperglycemia and hyperinsulinemia in the pathogenesis of diabetic angiopathy. Clin Nephrol. 1996;46:246-255.
24. Williams B, Schrier RW. Characterization of glucose-induced in situ protein kinase C activity in cultured vascular smooth muscle cells. Diabetes. 1992;41:1464-1472.
25. Haller H, Lindschau C, Luft FC. Role of protein kinase C in intracellular signaling. Ann N Y Acad Sci. 1994;733:313-324.
26. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform βII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci U S A. 1992;89:11059-11063.
27. Ishii H, Koya D, King GL. Protein kinase C activation and its role in the development of vascular complications in diabetes mellitus. J Mol Med. 1998;76:21-31.
28. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. Amelioration of vascular dysfunction in diabetic rats by an oral PKC-β inhibitor. Science. 1996;272:699-700.
29. Haller H, Ziegler W, Lindschau C, Luft FC. Endothelial cell tyrosine kinase receptor and G-protein coupled receptor activation involves distinct protein kinase C isoforms. Arterioscler Thromb Vasc Biol. 1996;16:678-686.
30. Hempel A, Maasch C, Heintze U, Lindschau C, Dietz R, Luft FC, Haller H. High glucose concentrations increase endothelial cell permeability via activation of protein kinase C-α. Circ Res. 1997;81:363-371.
31. Haller H, Baur E, Quass P, Behrend M, Lindschau C, Distler A, Luft FC. High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells. Kidney Int. 1995;47:1057-1067.
32. Haller H, Lindschau C, Maasch C, Olthoff H, Kurscheid D, Luft FC. Integrin-induced protein kinase Cα and Cε translocation to focal adhesions mediates vascular smooth muscle cell spreading. Circ Res. 1998;82:157-165.
33. Maasch C, Wagner S, Lindschau C, Alexander G, Buchner K, Gollasch M, Luft FC, Haller H. Receptor-dependent protein kinase Cα targeting with GFP technology in vascular smooth muscle cells. FASEB J. 2000;14:1653-1663.
34. Leitges M, Plohmann M, Standaert ML, Bandyopadhyay G, Sajan MP, Kanoh Y, Farese RV. Knockout of PKC-α enhances insulin signaling through PI3K. Mol Endocrinol. 2002;16:847-858.
35. Ganesan S, Calle R, Zawalich K, Smallwood JI, Zawalich WS, Rasmussen H. Glucose-induced translocation of protein kinase C in rat pancreatic islets. Proc Natl Acad Sci U S A. 1990;87:9893-9897.
36. Kunisaki M, Fumio U, Nawata H, King GL. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. 1996;45(suppl 3):S117-S119.
37. Koya D, Jirousek MR, Lin YW, Ishii H, Kuboki K, King GL. Characterization of protein kinase C-β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats. J Clin Invest. 1997;100:115-126.
38. Avignon A, Yamada K, Zhou X, Spencer B, Cardona O, Saba-Siddique S, Galloway L, Standaert ML, Farese RV. Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats: a mechanism for inhibiting glycogen synthesis. Diabetes. 1996;45:1396-1404.
39. Donnelly R, Reed MJ, Azhar S, Reaven GM. Expression of the major isoenzyme of protein kinase-C in skeletal muscle, nPKC-θ, varies with muscle type and in response to fructose-induced insulin resistance. Endocrinology. 1994;135:2369-2374.
40. Giles TD, Ouyang J, Kerut EK, Given MB, Allen GE, Mcllwain EF, Greenberg SS. Changes in protein kinase C in early cardiomyopathy and in gracilis muscle in the BB/Wor diabetic rat. Am J Physiol. 1998;274:H295-H307.
41. Fumo P, Kuncio GS, Ziyadeh FN. PKC and high glucose stimulate collagen α1 (IV) transcriptional activity in a reporter mesangial cell line. Am J Physiol. 1994;267:F632-F638.
42. Haneda M, Kikkawa R, Sugimoto T, Koya D, Araki S, Togawa M, Shigeta Y. Abnormalities in protein kinase C and MAP kinase cascade in mesangial cells cultured under high glucose conditions. J Diabetes Complicat. 1995;9:246-248.
43. Studer RK, Craven PA, DeRubertis FR. Role for protein kinase C in the mediation of increased fibronectin accumulation by mesangial cells grown in high-glucose medium. Diabetes. 1993;42:118-126.
44. Iwano M, Kubo A, Nishino T, Sato H, Nishioka H, Akai Y, Kurioka H, Fujii Y, Kanauchi M, Shiiki H, Dohi K. Quantification of glomerular TGF-β1 mRNA in patients with diabetes mellitus. Kidney Int. 1996;49:1120-1126.
45. MacKay K, Striker LJ, Stauffer JW, Doi T, Agodoa LY, Striker GE. Transforming growth factor-β: murine glomerular receptors and responses of isolated glomerular cells. J Clin Invest. 1989;83:1160-1167.
46. Ahuja SS, Shrivastav S, Danielpour D, Balow JE, Boumpas DT. Regulation of transforming growth factor-β1 and its receptor by cyclosporine in human T lymphocytes. Transplantation. 1995;60:718-723.
47. Yamamoto T, Nakamura T, Noble NA, Ruoslahti E, Border WA. Expression of transforming growth factor-β is elevated in human and experimental diabetic nephropathy. Proc Natl Acad Sci U S A. 1993;90:1814-1818.