메뉴 건너뛰기




Volumn 47, Issue 3, 2003, Pages 261-271

Targeted therapies: Focus on a new strategy for gastrointestinal tumors

Author keywords

Angiogenesis inhibitors; COX 2 inhibitors; EGFR inhibitors; Gastrointestinal tumors; Targeted therapies

Indexed keywords

2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 3 BENZYL 7 CYANO 2,3,4,5 TETRAHYDRO 1 (1H IMIDAZOL 4 YLMETHYL) 4 (2 THIENYLSULFONYL) 1H 1,4 BENZODIAZEPINE; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CELECOXIB; CETUXIMAB; CGP 69846A; CYCLOOXYGENASE 2 INHIBITOR; EDRECOLOMAB; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; FLUOROURACIL; GEFITINIB; GEMCITABINE; IMATINIB; IRINOTECAN; ISIS 2503; LONAFARNIB; MARIMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; THALIDOMIDE; TIPIFARNIB; TRASTUZUMAB; VANDETANIB; VASCULOTROPIN ANTIBODY;

EID: 0042787020     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1040-8428(03)00057-X     Document Type: Review
Times cited : (8)

References (70)
  • 2
    • 0030240920 scopus 로고    scopus 로고
    • New molecular targets for cancer therapy
    • Oliff A., Gibbs J.B., McCormick F. New molecular targets for cancer therapy. Sci. Am. 275:1996;144-149.
    • (1996) Sci. Am. , vol.275 , pp. 144-149
    • Oliff, A.1    Gibbs, J.B.2    McCormick, F.3
  • 3
    • 0031671891 scopus 로고    scopus 로고
    • Clinical evaluation of biological targeted drugs: Obstacles and opportunities (review)
    • Boral A.L., Dessain S., Chabner B.A. Clinical evaluation of biological targeted drugs: obstacles and opportunities (review). Cancer Chemother. Pharmacol. 42:(Suppl):1998;S3-S21.
    • (1998) Cancer Chemother. Pharmacol. , vol.42 , Issue.SUPPL.
    • Boral, A.L.1    Dessain, S.2    Chabner, B.A.3
  • 4
    • 0033523233 scopus 로고    scopus 로고
    • Anticancer agents targeting signalling molecules and cancer cell environment: Challenges for drug development?
    • Gelmon K.A., Eisenhauer E.A., Harris A.L., Ratain M.J., Workman P. Anticancer agents targeting signalling molecules and cancer cell environment: challenges for drug development? J. Natl. Cancer Inst. 91:1999;1281-1287.
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1281-1287
    • Gelmon, K.A.1    Eisenhauer, E.A.2    Harris, A.L.3    Ratain, M.J.4    Workman, P.5
  • 5
    • 0035218360 scopus 로고    scopus 로고
    • Novel pharmacological agents in clinical developments for solid tumors
    • Dy G.K., Haluska P., Adjei A.A. Novel pharmacological agents in clinical developments for solid tumors. Expert Opin. Invest. Drugs. 10:(12):2001; 2059-2088.
    • (2001) Expert Opin. Invest. Drugs , vol.10 , Issue.12 , pp. 2059-2088
    • Dy, G.K.1    Haluska, P.2    Adjei, A.A.3
  • 6
    • 0033623988 scopus 로고    scopus 로고
    • Changes in 18F-FDG uptake measured by PET as a pharmacodynamic end-point in anticancer therapy. How far we got?
    • Price P. Changes in 18F-FDG uptake measured by PET as a pharmacodynamic end-point in anticancer therapy. How far we got? Br. J. Cancer. 83:2000;281-283.
    • (2000) Br. J. Cancer , vol.83 , pp. 281-283
    • Price, P.1
  • 7
    • 0033992633 scopus 로고    scopus 로고
    • Biochemical and clinical implications of the ErbB/HER signalling network of growth factor receptors
    • Klapper L.N., Kirschbaum M.H., Sela M., Yarden Y. Biochemical and clinical implications of the ErbB/HER signalling network of growth factor receptors. Adv. Cancer Res. 77:2000;25-79.
    • (2000) Adv. Cancer Res. , vol.77 , pp. 25-79
    • Klapper, L.N.1    Kirschbaum, M.H.2    Sela, M.3    Yarden, Y.4
  • 8
    • 0021238735 scopus 로고
    • Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells
    • Kawamoto T., Mendelsohn J., Le A., Sato G.H., Lazar C.S., Gill G.N. Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells. J. Biol. Chem. 259:1984;7761-7766.
    • (1984) J. Biol. Chem. , vol.259 , pp. 7761-7766
    • Kawamoto, T.1    Mendelsohn, J.2    Le, A.3    Sato, G.H.4    Lazar, C.S.5    Gill, G.N.6
  • 9
    • 0029441596 scopus 로고
    • Association of epidermal growth factor-related peptides and type I receptors with prognosis of human colorectal carcinomas
    • Saeki T., Salomon D.S., Johnson G.R., et al. Association of epidermal growth factor-related peptides and type I receptors with prognosis of human colorectal carcinomas. Jpn J. Clin. Oncol. 25:(6):1995;240-249.
    • (1995) Jpn J. Clin. Oncol. , vol.25 , Issue.6 , pp. 240-249
    • Saeki, T.1    Salomon, D.S.2    Johnson, G.R.3
  • 10
    • 0034779291 scopus 로고    scopus 로고
    • The EGFR as a target for anticancer therapy-focus on cetuximab
    • Baselga J. The EGFR as a target for anticancer therapy-focus on cetuximab. Eur. J. Cancer. 37:(Suppl 4):2001;16-22.
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 4 , pp. 16-22
    • Baselga, J.1
  • 11
    • 0001407135 scopus 로고    scopus 로고
    • Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
    • Saltz L., Meropol N.J., Loehrer P.J., Waskal H., Needle M.N., et al. Single agent IMC-C225 (Erbitux) has activity in CPT-11 refractory colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc. Am. Soc. Clin. Oncol. 21:2002;504.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 504
    • Saltz, L.1    Meropol, N.J.2    Loehrer, P.J.3    Waskal, H.4    Needle, M.N.5
  • 12
    • 0041745094 scopus 로고    scopus 로고
    • Cetuximab in combination with irinotecan, infusional 5FU and folinic acid is a safe and active regimen in metastatic colorectal cancer expressing epidermal growth factor receptor (EGFR)
    • Folprecht G., Haag C., Beutel G., et al. Cetuximab in combination with irinotecan, infusional 5FU and folinic acid is a safe and active regimen in metastatic colorectal cancer expressing epidermal growth factor receptor (EGFR). Tumori. 1:(2):2002;S82.
    • (2002) Tumori , vol.1 , Issue.2 , pp. 82
    • Folprecht, G.1    Haag, C.2    Beutel, G.3
  • 13
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer that expresses epidermal growth factor receptor (EGFR)
    • Saltz L., Rubin M., Hochster H., et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11 refractory colorectal cancer that expresses epidermal growth factor receptor (EGFR). Proc. Am. Soc. Clin. Oncol. 20:2001;7.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 7
    • Saltz, L.1    Rubin, M.2    Hochster, H.3
  • 14
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer that expresses the epidermal growth factor receptor
    • Rosenberg A.H., Loehrer P.J., Needle M.N., et al. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer that expresses the epidermal growth factor receptor. Proc. Am. Soc. Clin. Oncol. 21:2002;536.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 536
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3
  • 15
    • 0012722459 scopus 로고    scopus 로고
    • Cetuximab (C225) plus irinotecan (CPT-11) plus infusional 5FU-folinic acid (FA) is safe and active in metastatic colorectal cancer, that expresses epidermal growth factor receptor (EGFR)
    • Schoffski P., Lutz M.P., Folprecht G., et al. Cetuximab (C225) plus irinotecan (CPT-11) plus infusional 5FU-folinic acid (FA) is safe and active in metastatic colorectal cancer, that expresses epidermal growth factor receptor (EGFR). Proc. Am. Soc. Clin. Oncol. 21:2002;633.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 633
    • Schoffski, P.1    Lutz, M.P.2    Folprecht, G.3
  • 16
    • 0032850677 scopus 로고    scopus 로고
    • Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2 overexpression metastatic breast cancer that as progressed after chemotherapy for metastatic disease
    • Cobleigh M.A., Vogel C.L., Tripathy D., et al. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2 overexpression metastatic breast cancer that as progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 17:1999;2639-2648.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 2639-2648
    • Cobleigh, M.A.1    Vogel, C.L.2    Tripathy, D.3
  • 17
    • 0011042221 scopus 로고    scopus 로고
    • A phase II trial of irinotecan and trastuzumab (Herceptin) in patients overexpressing HER-2/neu in metastatic colorectal cancer
    • Hwang J.J., Sinicrope F., Safran H., et al. A phase II trial of irinotecan and trastuzumab (Herceptin) in patients overexpressing HER-2/neu in metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;565.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 565
    • Hwang, J.J.1    Sinicrope, F.2    Safran, H.3
  • 18
    • 0035746630 scopus 로고    scopus 로고
    • Trop molecules as targets for anti-tumor immunotherapy in man
    • Alberti S. Trop molecules as targets for anti-tumor immunotherapy in man. Tumori. 87:(6):2001;S4-S7.
    • (2001) Tumori , vol.87 , Issue.6
    • Alberti, S.1
  • 19
    • 0343965762 scopus 로고    scopus 로고
    • Monoclonal antibody therapy for resected Dukes C colorectal cancer: Seven year outcome of a multicenter randomised trial
    • Riethmuller G., Holz E., Schlimok G., et al. Monoclonal antibody therapy for resected Dukes C colorectal cancer: seven year outcome of a multicenter randomised trial. J. Clin. Oncol. 16:1998;1788-1794.
    • (1998) J. Clin. Oncol. , vol.16 , pp. 1788-1794
    • Riethmuller, G.1    Holz, E.2    Schlimok, G.3
  • 20
    • 0001648039 scopus 로고    scopus 로고
    • Edrecolomab (17-1A antibody) alone or in combination with 5 fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: Results of a phase III study
    • Punt C.J.A., Nagy A., Douillard J.Y., et al. Edrecolomab (17-1A antibody) alone or in combination with 5 fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a phase III study. Proc. Am. Soc. Clin. Oncol. 20:2001;487.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 487
    • Punt, C.J.A.1    Nagy, A.2    Douillard, J.Y.3
  • 21
    • 0001430827 scopus 로고    scopus 로고
    • Edrecolomab (17-1A antibody) (EDR) in combination with 5-fluorouracil (FU) based chemotherapy in the adjuvant treatment of stage III colon cancer: Results of a randomised north American phase III study
    • Fields A.L., Keller A.M., Schwartzberg, et al. Edrecolomab (17-1A antibody) (EDR) in combination with 5-fluorouracil (FU) based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised north American phase III study. Proc. Am. Soc. Clin. Oncol. 21:2002;508.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 508
    • Fields, A.L.1    Keller, A.M.2    Schwartzberg3
  • 22
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • Ciardiello F., Caputo R., Bianco R., et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin. Cancer Res. 7:(5):2001;1459-1465.
    • (2001) Clin. Cancer Res. , vol.7 , Issue.5 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 23
    • 0001174063 scopus 로고    scopus 로고
    • ZD1839 (IRESSA) activity and safety in non small cell lung cancer patients validate preclinical data
    • Abstract
    • Kris M.G. ZD1839 (IRESSA) activity and safety in non small cell lung cancer patients validate preclinical data. Lung Cancer. 29:(140):2000;233. Abstract.
    • (2000) Lung Cancer , vol.29 , Issue.140 , pp. 233
    • Kris, M.G.1
  • 24
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxics agents against human tumor xenografts is markedly enhanced by co-administration of ZD1839 (Iressa), an inhibitor of tyrosine kinase
    • Sirotnak F.M., Zakowski M.F., Miller V.A., Scher H.I., Kris M.G. Efficacy of cytotoxics agents against human tumor xenografts is markedly enhanced by co-administration of ZD1839 (Iressa), an inhibitor of tyrosine kinase. Clin. Cancer Res. 6:2000;4885-4892.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 25
    • 0042245646 scopus 로고    scopus 로고
    • Combination therapy with the epidermal growth factor receptor inhibitor ZD1839 (Iressa) and irinotecan in human colon cancer cells. A preclinical evaluation
    • Braun A., Schleucher N., Dirsch O., et al. Combination therapy with the epidermal growth factor receptor inhibitor ZD1839 (Iressa) and irinotecan in human colon cancer cells. A preclinical evaluation. Tumori. 1:(2):2002;S93.
    • (2002) Tumori , vol.1 , Issue.2 , pp. 93
    • Braun, A.1    Schleucher, N.2    Dirsch, O.3
  • 26
    • 0003300507 scopus 로고    scopus 로고
    • Feasibility and pharmacokinetic trial of ZD1839 (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in combination with 5-fluorouracil and leucovorin in patients with advanced colorectal cancer
    • Hammond L.A., Figueroa J., Scwartzberg L. Feasibility and pharmacokinetic trial of ZD1839 (Iressa), an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in combination with 5-fluorouracil and leucovorin in patients with advanced colorectal cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;544.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 544
    • Hammond, L.A.1    Figueroa, J.2    Scwartzberg, L.3
  • 27
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker B.J., Talpaz M., Resta D.J., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344:2001;1038-1042.
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 28
    • 0035211136 scopus 로고    scopus 로고
    • Targeting c-kit mutations in solid tumors: Scientific rationale and novel therapeutic options
    • Demetri G.D. Targeting c-kit mutations in solid tumors: scientific rationale and novel therapeutic options. Semin. Oncol. 28:(5 Suppl 17):2001;19-26.
    • (2001) Semin. Oncol. , vol.28 , Issue.5 SUPPL. 17 , pp. 19-26
    • Demetri, G.D.1
  • 29
    • 0005828537 scopus 로고    scopus 로고
    • Imatinib (Glivec) 400 vs in patients with gastrointestinal stromal tumors (GIST): A randomised phase III trial from the EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG) and the Australasian Gastro-Intestinal Trials Group (AGITG)
    • Casali P, Verweij J, Zalcberg J, et al. Imatinib (Glivec) 400 vs in patients with gastrointestinal stromal tumors (GIST): a randomised phase III trial from the EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group (ISG) and the Australasian Gastro-Intestinal Trials Group (AGITG). A toxicity report. Proc. Am. Soc. Clin. Oncol. 2002; 21: 1650.
    • (2002) A toxicity report. Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 1650
    • Casali, P.1    Verweij, J.2    Zalcberg, J.3
  • 30
    • 0032704708 scopus 로고    scopus 로고
    • Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development
    • Rowinsky E.K., Windle J.J., Von Hoff D. Ras protein farnesyltransferase: a strategic target for anticancer therapeutic development. J. Clin. Oncol. 17:1999;3631-3652.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 3631-3652
    • Rowinsky, E.K.1    Windle, J.J.2    Von Hoff, D.3
  • 31
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos J.L. Ras oncogenes in human cancer: a review. Cancer Res. 49:1989;4682-4689.
    • (1989) Cancer Res. , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 32
    • 0034071688 scopus 로고    scopus 로고
    • A phase I trial of the farnesyl transferase inhibitor SCH 66336: Evidence for biological and clinical activity
    • Adjej A.A., Erlichmman C., Davis J.N., et al. A phase I trial of the farnesyl transferase inhibitor SCH 66336: evidence for biological and clinical activity. Cancer Res. 60:2000;1871-1877.
    • (2000) Cancer Res. , vol.60 , pp. 1871-1877
    • Adjej, A.A.1    Erlichmman, C.2    Davis, J.N.3
  • 33
    • 0002989445 scopus 로고    scopus 로고
    • Randomized phase II study of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas
    • Lersch C., van Cutsem E., Amado R., et al. Randomized phase II study of SCH 66336 and gemcitabine in the treatment of metastatic adenocarcinoma of the pancreas. Proc. Am. Soc. Clin. Oncol. 20:2001;608.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 608
    • Lersch, C.1    Van Cutsem, E.2    Amado, R.3
  • 34
    • 0035132538 scopus 로고    scopus 로고
    • Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro
    • End D.W., Smets G., Todd A.V., et al. Characterization of the antitumor effects of the selective farnesyl protein transferase inhibitor R115777 in vivo and in vitro. Cancer Res. 61:(1):2001;131.
    • (2001) Cancer Res. , vol.61 , Issue.1 , pp. 131
    • End, D.W.1    Smets, G.2    Todd, A.V.3
  • 35
    • 18544412314 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer
    • Zujewsky J., Horak I.D., Bol C.J., et al. Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J. Clin. Oncol. 18:2000;927-941.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 927-941
    • Zujewsky, J.1    Horak, I.D.2    Bol, C.J.3
  • 36
    • 0000658075 scopus 로고    scopus 로고
    • Phase II and pharmacodynamic trial of the farnesyl transferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic carcinoma
    • Cohen S.J., Ho L., Ranganathan S., et al. Phase II and pharmacodynamic trial of the farnesyl transferase inhibitor R115777 as initial therapy in patients with metastatic pancreatic carcinoma. Proc. Am. Soc. Clin. Oncol. 21:2001;545.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 545
    • Cohen, S.J.1    Ho, L.2    Ranganathan, S.3
  • 37
    • 0001120709 scopus 로고    scopus 로고
    • A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer. A Southwest Oncology Group (SWOG) Study
    • Macdonald J.S., Chansky K., Whitehead R., et al. A phase II study of farnesyl transferase inhibitor R115777 in pancreatic cancer. A Southwest Oncology Group (SWOG) Study. Proc. Am. Soc. Clin. Oncol. 21:2002;548.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 548
    • Macdonald, J.S.1    Chansky, K.2    Whitehead, R.3
  • 38
    • 0000324578 scopus 로고    scopus 로고
    • Phase III trial comparing gemcitabine+R115777 (Zarnestra) versus gemcitabine+placebo in advanced pancreatic cancer
    • Van Cutsem E., Karasek P., Oettle H., et al. Phase III trial comparing gemcitabine+R115777 (Zarnestra) versus gemcitabine+placebo in advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;517.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 517
    • Van Cutsem, E.1    Karasek, P.2    Oettle, H.3
  • 39
    • 0001674319 scopus 로고    scopus 로고
    • Randomized double-blind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colorectal cancer
    • Cunningham D., De Gramont A., Scheithauer W., et al. Randomized double-blind placebo-controlled trial of the farnesyltransferase inhibitor R115777 (Zarnestra) in advanced refractory colorectal cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;502.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 502
    • Cunningham, D.1    De Gramont, A.2    Scheithauer, W.3
  • 40
    • 0035352721 scopus 로고    scopus 로고
    • Angiogenesis: Pathological, prognostic and growth factor pathways and their link to trial design and anticancer drugs
    • Fox S.B., Gasparini G., Harris A.L. Angiogenesis: pathological, prognostic and growth factor pathways and their link to trial design and anticancer drugs. Lancet Oncol. 2:2001;278-289.
    • (2001) Lancet Oncol. , vol.2 , pp. 278-289
    • Fox, S.B.1    Gasparini, G.2    Harris, A.L.3
  • 41
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J. Natl. Cancer Inst. 82:1990;4-6.
    • (1990) J. Natl. Cancer Inst. , vol.82 , pp. 4-6
    • Folkman, J.1
  • 42
    • 16144362509 scopus 로고    scopus 로고
    • Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A
    • Ciardiello F., Damiano V., Bianco R., et al. Antitumor activity of combined blockade of epidermal growth factor receptor and protein kinase A. J. Natl. Cancer Inst. 88:1996;1770-1776.
    • (1996) J. Natl. Cancer Inst. , vol.88 , pp. 1770-1776
    • Ciardiello, F.1    Damiano, V.2    Bianco, R.3
  • 43
    • 0032482939 scopus 로고    scopus 로고
    • Antiangiogenic gene therapy
    • Folkman J. Antiangiogenic gene therapy. Proc. Natl. Acad. Sci. USA. 95:1998;9064-9066.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9064-9066
    • Folkman, J.1
  • 44
    • 0033370229 scopus 로고    scopus 로고
    • Angiogenesis at the interface between basic and clinical research
    • Albini A., Noonan D., Santi L. Angiogenesis at the interface between basic and clinical research. Int. J. Biol. Markers. 14:1999;202-206.
    • (1999) Int. J. Biol. Markers , vol.14 , pp. 202-206
    • Albini, A.1    Noonan, D.2    Santi, L.3
  • 45
    • 0033941120 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer
    • Cascinu S., Staccioli M.P., Gasparini G., et al. Expression of vascular endothelial growth factor can predict event-free survival in stage II colon cancer. Clin. Cancer Res. 6:(7):2000;2803-2807.
    • (2000) Clin. Cancer Res. , vol.6 , Issue.7 , pp. 2803-2807
    • Cascinu, S.1    Staccioli, M.P.2    Gasparini, G.3
  • 46
    • 0041745092 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF), p53 and BAX expression in node positive rectal cancer. Relationships with tumor recurrence after adjuvant chemoradiation
    • Cascinu S., Graziano F., Catalano V., et al. Vascular endothelial growth factor (VEGF), p53 and BAX expression in node positive rectal cancer. Relationships with tumor recurrence after adjuvant chemoradiation. Proc. Am. Soc. Clin. Oncol. 20:2001;595.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 595
    • Cascinu, S.1    Graziano, F.2    Catalano, V.3
  • 47
    • 0003305378 scopus 로고    scopus 로고
    • Successful long-term therapy with bevacizumab (Avastin) in solid tumors
    • Langmuir V.K., Cobleigh M.A., Herbst R.S., et al. Successful long-term therapy with bevacizumab (Avastin) in solid tumors. Proc. Am. Soc. Clin. Oncol. 21:2002;32.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 32
    • Langmuir, V.K.1    Cobleigh, M.A.2    Herbst, R.S.3
  • 48
    • 0001496152 scopus 로고    scopus 로고
    • Bevacizumab (BV)+chemotherapy (CT) may improve survival in metastatic colorectal cancer subjects with unfavourable prognostic indicators
    • Bergsland E.K., Fehrenbacher L., Novotny W., et al. Bevacizumab (BV)+chemotherapy (CT) may improve survival in metastatic colorectal cancer subjects with unfavourable prognostic indicators. Proc. Am. Soc. Clin. Oncol. 20:2001;2247.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2247
    • Bergsland, E.K.1    Fehrenbacher, L.2    Novotny, W.3
  • 49
    • 0001922504 scopus 로고    scopus 로고
    • A phase I trial of an anti-KDR (VEGFR) chimeric antibody in patient with liver metastases in colorectal cancer (CRC)
    • Posey J., Ng T., Yang B., et al. A phase I trial of an anti-KDR (VEGFR) chimeric antibody in patient with liver metastases in colorectal cancer (CRC). Proc. Am. Soc. Clin. Oncol. 21:2002;63.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 63
    • Posey, J.1    Ng, T.2    Yang, B.3
  • 50
    • 0034508512 scopus 로고    scopus 로고
    • Current role of thalidomide in cancer treatment
    • Thomas D.A., Kantarjian H.M. Current role of thalidomide in cancer treatment. Curr. Opin. Oncol. 12:(6):2000;564-573.
    • (2000) Curr. Opin. Oncol. , vol.12 , Issue.6 , pp. 564-573
    • Thomas, D.A.1    Kantarjian, H.M.2
  • 51
    • 0036605759 scopus 로고    scopus 로고
    • Thalidomide in solid malignancies
    • Eisen T. Thalidomide in solid malignancies. J. Clin. Oncol. 20:(11):2002;2607-2609.
    • (2002) J. Clin. Oncol. , vol.20 , Issue.11 , pp. 2607-2609
    • Eisen, T.1
  • 52
    • 0012206623 scopus 로고    scopus 로고
    • The efficacy of thalidomide and irinotecan in metastatic colorectal carcinoma (phase II study)
    • Govindarajan R., Maddox A.M., Safar A.M., et al. The efficacy of thalidomide and irinotecan in metastatic colorectal carcinoma (phase II study). Proc. Am. Soc. Clin. Oncol. 21:2002;2222.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 2222
    • Govindarajan, R.1    Maddox, A.M.2    Safar, A.M.3
  • 53
    • 0043247931 scopus 로고    scopus 로고
    • Palliative benefit for salvage treatment with capecitabine and thalidomide for gastric and/or esophageal adenocarcinoma: A retrospective case series
    • Merin J.M., Lee F.C. Palliative benefit for salvage treatment with capecitabine and thalidomide for gastric and/or esophageal adenocarcinoma: a retrospective case series. Proc. Am. Soc. Clin. Oncol. 21:2002;2391.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 2391
    • Merin, J.M.1    Lee, F.C.2
  • 54
    • 0003207832 scopus 로고    scopus 로고
    • Thalidomide for unresectable hepatocellular cancer (HCC) with optional interferon-alpha upon disease progression
    • Schwartz J.D., Sung M.W., Lehrer D., et al. Thalidomide for unresectable hepatocellular cancer (HCC) with optional interferon-alpha upon disease progression. Proc. Am. Soc. Clin. Oncol. 21:2002;1847.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 1847
    • Schwartz, J.D.1    Sung, M.W.2    Lehrer, D.3
  • 55
    • 23544478499 scopus 로고    scopus 로고
    • A phase II study of thalidomide in metastatic neuroendocrin tumors
    • Xu Y., Ellison C., Martin E., et al. A phase II study of thalidomide in metastatic neuroendocrin tumors. Proc. Am. Soc. Clin. Oncol. 21:2002;1931.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 1931
    • Xu, Y.1    Ellison, C.2    Martin, E.3
  • 59
    • 0035556141 scopus 로고    scopus 로고
    • A phase II trial of marimastat in advanced pancreatic cancer
    • Evans J.D., Stark A., Johnson C.D., et al. A phase II trial of marimastat in advanced pancreatic cancer. Br. J. Cancer. 85:(12):2001;1865-1870.
    • (2001) Br. J. Cancer , vol.85 , Issue.12 , pp. 1865-1870
    • Evans, J.D.1    Stark, A.2    Johnson, C.D.3
  • 60
    • 0038252922 scopus 로고    scopus 로고
    • Marimastat following chemoradiation for locally advanced pancreatic cancer
    • Iannitti D., McKenna M., Pacha C.M., et al. Marimastat following chemoradiation for locally advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;2285.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 2285
    • Iannitti, D.1    McKenna, M.2    Pacha, C.M.3
  • 61
    • 0037100983 scopus 로고    scopus 로고
    • A double blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
    • Bramhall S.R., Schulz J., Nemunaitis J., Brown P.D., Baillet M., Buckels J.A. A double blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br. J. Cancer. 87:(2):2002;161-167.
    • (2002) Br. J. Cancer , vol.87 , Issue.2 , pp. 161-167
    • Bramhall, S.R.1    Schulz, J.2    Nemunaitis, J.3    Brown, P.D.4    Baillet, M.5    Buckels, J.A.6
  • 62
    • 0012749733 scopus 로고    scopus 로고
    • Placebo control double-blind randomised clinical trial of the matrix metalloproteinase inhibitor marimastat in patients with inoperable colorectal cancer liver metastases: Significant survival advantage in patients with musculo skeletal symptoms
    • King J., Clingan P., Morris D.L. Placebo control double-blind randomised clinical trial of the matrix metalloproteinase inhibitor marimastat in patients with inoperable colorectal cancer liver metastases: significant survival advantage in patients with musculo skeletal symptoms. Proc. Am. Soc. Clin. Oncol. 21:2002;537.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 537
    • King, J.1    Clingan, P.2    Morris, D.L.3
  • 63
    • 3042802135 scopus 로고    scopus 로고
    • Marimastat as maintenance therapy for patients with advanced gastric cancer: A randomised trial
    • Bramhall S.R., Hallissey M.T., Whiting J., et al. Marimastat as maintenance therapy for patients with advanced gastric cancer: a randomised trial. Br. J. Cancer. 86:(12):2002;1864-1870.
    • (2002) Br. J. Cancer , vol.86 , Issue.12 , pp. 1864-1870
    • Bramhall, S.R.1    Hallissey, M.T.2    Whiting, J.3
  • 65
    • 0043247932 scopus 로고    scopus 로고
    • Cycloxygenase-2 (COX-2) expression and human colon cancer
    • Robles C., Ying D., Xu R., et al. Cycloxygenase-2 (COX-2) expression and human colon cancer. Proc. Am. Soc. Clin. Oncol. 20:2001;2164.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2164
    • Robles, C.1    Ying, D.2    Xu, R.3
  • 66
    • 0000539777 scopus 로고    scopus 로고
    • A phase II trial of celecoxib, irinotecan, 5-fluorouracil and leucovorin in patients with unresectable or metastatic colorectal cancer
    • Blanke C.D., Benson A.B. III, Dragovich T., et al. A phase II trial of celecoxib, irinotecan, 5-fluorouracil and leucovorin in patients with unresectable or metastatic colorectal cancer. Proc. Am. Soc. Clin. Oncol. 21:2002;505.
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21 , pp. 505
    • Blanke, C.D.1    Benson A.B. III2    Dragovich, T.3
  • 67
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instability in human cancers
    • Lengauer C., Kinzler K.W., Vogelstein B. Genetic instability in human cancers. Nature. 396:(6712):1998;643-649.
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 68
    • 0032898651 scopus 로고    scopus 로고
    • Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumors
    • Ghimenti C., Tannegard P., Walburg S., et al. Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumors. Br. J. Cancer. 80:(1-2):1999;11-16.
    • (1999) Br. J. Cancer , vol.80 , Issue.1-2 , pp. 11-16
    • Ghimenti, C.1    Tannegard, P.2    Walburg, S.3
  • 69
    • 0003354373 scopus 로고    scopus 로고
    • Firstline irinotecan (C), fluorouracil (F), leucovorin (L) especially improves survival (OS) in metastatic coilorectal cancer (MCRC) patients (PT) with favourable prognostic indicators
    • Knight R.D., Miller R.R., Pirotta N., et al. Firstline irinotecan (C), fluorouracil (F), leucovorin (L) especially improves survival (OS) in metastatic coilorectal cancer (MCRC) patients (PT) with favourable prognostic indicators. Proc. Am. Soc. Clin. Oncol. 19:2000;991.
    • (2000) Proc. Am. Soc. Clin. Oncol. , vol.19 , pp. 991
    • Knight, R.D.1    Miller, R.R.2    Pirotta, N.3
  • 70
    • 0041745091 scopus 로고    scopus 로고
    • Thymidylate synthase expression as a predictor of clinical response to fluoro pyrimidinebased chemotherapy
    • Aschele C., Lonardi S., Monfardini S. Thymidylate synthase expression as a predictor of clinical response to fluoro pyrimidinebased chemotherapy. Cancer Treat. Rev. 28:2002;2747.
    • (2002) Cancer Treat. Rev. , vol.28 , pp. 2747
    • Aschele, C.1    Lonardi, S.2    Monfardini, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.