A maurotoxin with constrained standard disulfide bridging. Innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels

Journal of Biological Chemistry

Volumn 278, Issue 33, 2003, Pages 31095-31104

  M'Barek, Sarrah ^a   Lopez Gonzalez, Ignacio ^b   Andreotti, Nicolas ^a   Di Luccio, Eric ^a   Visan, Violeta ^c   Grissmer, Stephan ^c   Judge, Susan ^d   El Ayeb, Mohamed ^e   Darbon, Hervé ^f   Rochat, Hervé ^a   Sampieri, François ^a   Béraud, Evelyne ^g   Fajloun, Ziad ^a   De Waard, Michel ^b   Sabatier, Jean Marc ^a  

^a CNRS   (France)

^b INSERM   (France)

^c UNIVERSITY OF ULM   (Germany)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^e PASTEUR INSTITUTE OF TUNIS   (Tunisia)

^f Centre National de la Recherche Scientifique   (France)

^g AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; CONFORMATIONS; DRUG PRODUCTS; MOLECULAR STRUCTURE; POTASSIUM; SYNTHESIS (CHEMICAL); TOXIC MATERIALS;

TOXINS;

BIOLOGICAL MATERIALS;

CALCIUM ION; CYSTINE; MAUROTOXIN; POTASSIUM CHANNEL; SCORPION VENOM; TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CALCIUM CONDUCTANCE; CALCULATION; CHANNEL GATING; CONTROLLED STUDY; DISULFIDE BOND; ELECTRIC POTENTIAL; MOLECULAR MODEL; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; SCORPION; TOXIN STRUCTURE; TOXIN SYNTHESIS;

AMINO ACID SEQUENCE; ANIMALS; APAMIN; BINDING SITES; BINDING, COMPETITIVE; DISULFIDES; IODINE RADIOISOTOPES; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; OOCYTES; POTASSIUM CHANNELS; PROTEIN STRUCTURE, TERTIARY; RATS; SCORPION VENOMS; SCORPIONS; SEQUENCE ANALYSIS, PROTEIN; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SYNAPTOSOMES; XENOPUS;

ANIMALIA; SCORPIO; SCORPIO MAURUS PALMATUS; SCORPIONES;

EID: 0042733129     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304271200     Document Type: Article

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