Catalytic mechanism of the inverting N-acetylglucosaminyltransferase I: DFT quantum mechanical model of the reaction pathway and determination of the transition state structure

Glycobiology

Volumn 13, Issue 8, 2003, Pages 559-566

  Tvaroška, Igor ^a,b   André, Isabelle ^a   Carver, Jeremy P ^a  

^a Inflazyme Pharmaceuticals Ltd   (Canada)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

Author keywords

Catalytic mechanism N acetylglucosaminyltransferase I; Quantum chemical calculations; Reaction pathway; Transition state

Indexed keywords

GLYCAN; GLYCOPROTEIN; MANNOSE; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINYLTRANSFERASE;

ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL ADHESION; CHEMICAL MODEL; CHEMICAL REACTION; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DENSITY; ENZYME BINDING; ENZYME SUBSTRATE; METAZOON; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; QUANTUM MECHANICS; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BIOMECHANICS; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; N-ACETYLGLUCOSAMINYLTRANSFERASES; PROTEIN CONFORMATION; QUANTUM THEORY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

METAZOA;

EID: 0042697182     PISSN: 09596658     EISSN: None     Source Type: Journal    
DOI: 10.1093/glycob/cwg067     Document Type: Article

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