The cyclic AMP/protein kinase A signal transduction pathway modulates tolerance to sedative and hypothermic effects of ethanol

Alcoholism: Clinical and Experimental Research

Volumn 27, Issue 8, 2003, Pages 1220-1225

  Yang, Xioaju ^b   Oswald, Lynn ^b   Wand, Gary ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

Adenylyl cyclase; Alcohol; Alcoholism; cAMP PKA; Cyclic AMP; Gs ; Protein Kinase A; Sedation; Tolerance

Indexed keywords

ALCOHOL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ALCOHOL TOLERANCE; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CEREBELLUM; CONTROLLED STUDY; EMBRYO; ENZYME ANALYSIS; FEMALE; FRONTAL CORTEX; GENE DISRUPTION; GENE INACTIVATION; GNAS GENE; HETEROZYGOSITY; HIPPOCAMPUS; HYPOTHERMIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEDATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; WILD TYPE;

ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG TOLERANCE; ETHANOL; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HYPNOTICS AND SEDATIVES; HYPOTHERMIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0042664098     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000081626.02910.19     Document Type: Article

References (29)

1. Asher O, Cunningham TD, Yao L, Gordon AS, Diamond I (2002) Ethanol stimulates cAMP-responsive element (CRE)-mediated transcription via CRE-binding protein and cAMP-dependent protein kinase. J Pharmacol Exp Ther 301:66-70.
2. Freund RK, Palmer MR (1997a) Beta adrenergic sensitization of gamma-aminobutyric acid receptors to ethanol involves a cyclic AMP/protein kinase A second-messenger mechanism. J Pharmacol Exp Ther 280: 1192-2000.
3. Freund RK, Palmer MR (1997b) Ethanol depression of cerebellar Purkinje neuron firing involves nicotinic acetylcholine receptors. Exp Neurol 143:319-322.
4. Froehlich JC, Wand GS (1997) Adenylyl cyclase signal transduction and alcohol-induced sedation. Pharmacol Biochem Behav 58:1021-1030.
5. Hoffman PL, Tabakoff B (1990) Ethanol and guanine nucleotide binding proteins: A selective interaction. FASEB J 4:2612-2622.
6. Kalant H (1998) Research on tolerance: What can we learn from history? Alcohol Clin Exp Res 22:67-76.
7. Kirstein SL, Davidson KL, Ehringer MA, Sikela JM, Erwin VG, Tabakoff B (2002) Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice. J Pharmacol Exp Ther 302:1238-1245.
8. Kirstein SL, Tabakoff B (2001) Genetic correlations between initial sensitivity to ethanol and brain cAMP signaling in inbred and selectively bred mice. Alcohol Clin Exp Res 25:791-799.
9. Lane ME, Kalderon D (1993) Genetic investigation of cAMP-dependent protein kinase function in Drosophila development. Genes Dev 7:1229-1243.
10. Leidenheimer NJ, Machu TK, Endo S, Olsen RW, Harris RA, Browning MD (1991) Cyclic AMP-dependent protein kinase decreases gamma-aminobutyric acidA receptor-mediated 36Cl-uptake by brain microsacs. J Neurochem 57:722-725.
11. Lin FT, Krueger KM, Kendall HE, Daaka Y, Fredericks ZL, Pitcher JA, Lefkowtiz RJ (1997) Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1. J Biol Chem 272:31051-31057.
12. Livingstone MS (1985) Genetic dissection of Drosophila adenylate cyclase. Proc Natl Acad Sci USA 82:5992-5996.
13. Martin CS, Moss HB (1993) Measurement of acute tolerance to alcohol in human subjects. Alcohol Clin Exp Res 17:211-216.
14. Menard L, Ferguson SS, Zhang J, Lin FT, Lefkowitz RJ, Caron MG, Barak LS (1997) Synergistic regulation of beta2-adrenergic receptor sequestration: Intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization. Mol Pharmacol 51:800-808.
15. Moore MS, DeZazzo J, Luk AY, Tully T, Singh CM, Heberlein U (1998) Ethanol intoxication in Drosophila; Genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell 93:909-912.
16. Nestler EJ (2001) Molecular neurobiology of addiction. Am J Addict 10:201-217.
17. Pandey SC, Saito T, Yoshimura M, Sohma H, Gotz ME (2001) cAMP signaling cascade: A promising role in ethanol tolerance and dependence. Alcohol Clin Exp Res 25:46S-48S.
18. Radlow R (1994) A quantitative theory of acute tolerance to alcohol. Psychopharmacology 114:1-8.
19. Schuckit MA (1994) The Isaacson Award Lecture: A prospective study of sons of alcoholics. Alcohol Alcohol Suppl 2:1-6.
20. Schuckit MA, Smith TL (2000) The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders. J Stud Alcohol 61:827-835.
21. Schwindinger WF, Reese KJ, Lawler AM, Gearhart JD, Levine MA (1997) Targeted disruption of Gnas in embryonic stem cells. Endocrinology 138:4058-4063.
22. Self DW, Genova LM, Hope BT, Barnhart WJ, Spencer JJ, Nestler EJ (1998) Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J Neurosci 18:1848-1859.
23. Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: Past and current status. Trends Neurosci 22:521-527.
24. Spuhler K, Hoffer B, Weiner N, Palmer M (1982) Evidence for genetic correlation of hypnotic effects and cerebellar Purkinje neuron depression in response to ethanol in mice. Pharmacol Biochem Behav 17:569-578.
25. Tabakoff B, Cornell N, Hoffman PL (1986) Alcohol tolerance. Ann Emerg Med 15:1005-1012.
26. Wand GS, Froehlich JC (1997) Adenylyl cyclase signal transduction and alcohol-induced sedation. Pharmacol Biochem Behav 58:1021-1030.
27. Wand GS, Levine M, Zweifel L, Schwindinger W, Ted Abel (2001) The cAMP-protein kinase A signal transduction pathway modulates ethanol consumption and sedative effects of ethanol. J Neurosci 21:5297-5303.
28. Yang X, Diehl AM, Wand GS (1996) Ethanol exposure alters the phosphorylation of cyclic AMP responsive element binding protein and cyclic AMP responsive element binding activity in rat cerebellum. J Pharmacol Exp Ther 278:338-346.
29. Yang X, Horn K, Wand GS (1998) Chronic ethanol administration impairs phosphorylation of CREB and CRE binding activity in rat striatum. Alcohol Clin Exp Res 22:382-390.