Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas

Cancer Research

Volumn 63, Issue 15, 2003, Pages 4656-4661

  Leslie, Amy ^a   Pratt, Norman R ^a   Gillespie, Karen ^a   Sales, Mark ^a   Kernohan, Neil M ^a   Smith, Gillian ^a   Wolf, C Roland ^b   Carey, Francis A ^a   Steele, Robert J C ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

APC; PROTEIN P53;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CHROMOSOME 12P; CHROMOSOME 13Q; CHROMOSOME 18Q; CHROMOSOME 20Q; CHROMOSOME 7P; CHROMOSOME 8Q; CHROMOSOME ABERRATION; COLON ADENOCARCINOMA; COMPARATIVE GENOMIC HYBRIDIZATION; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC DISORDER; HUMAN; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PRIORITY JOURNAL; RECTUM CARCINOMA;

ADENOCARCINOMA; AGED; AGED, 80 AND OVER; CARRIER PROTEINS; CHROMOSOME ABERRATIONS; COLORECTAL NEOPLASMS; DNA-BINDING PROTEINS; FEMALE; GENES, APC; GENES, P53; GENES, RAS; GENOTYPE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; MUTS HOMOLOG 2 PROTEIN; NEOPLASM PROTEINS; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS;

EID: 0042635802     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Fearon, E. R., and Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell, 61: 759-767, 1990.
2. Groden, J., Thliveris, A., Samowitz, W., Carlson, M., Gelbert, L., Albertsen, H., Joslyn, G., Stevens, J., Spirio, L., Robertson, M., et al. Identification and characterization of the familial adenomatous polyposis coli gene. Cell, 66: 589-600, 1991.
3. Arends, J. W. Molecular interactions in the Vogelstein model of colorectal carcinoma. J. Pathol., 190: 412-416, 2000.
4. Smith, G., Carey, F. A., Beattie, J., Wilkie, M. J., Lightfoot, T. J., Coxhead, J., Garner, R. C., Steele, R. J., and Wolf, C. R. Mutations in APC, Kirsten-ras, and p53: alternative genetic pathways to colorectal cancer. Proc. Natl. Acad. Sci. USA, 99: 9433-9438, 2002.
5. Ionov, Y., Peinado, M. A., Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (Lond.), 363: 558-561, 1993.
6. Olschwang, S., Hamelin, R., Laurent-Puig, P., Thuille, B., De Rycke, Y., Li, Y. J., Muzeau, F., Girodet, J., Salmon, R. J., and Thomas, G. Alternative genetic pathways in colorectal carcinogenesis. Proc. Natl. Acad. Sci. USA, 94: 12122-12127, 1997.
7. Schreiber, S., Hampe, J., Eickhoff, H., and Lehrach, H. Functional genomics in gastroenterology. Gut, 47: 601-607, 2000.
8. Bardi, G., Pandis, N., Mitelman, F., and Heim, S. Karyotypic characteristics of colorectal tumors. In: S. R. Wolman and S. Sell (eds.). Human Cytogenetic Cancer Markers, 1st ed., pp. 151-168. Totowa, NJ: Humana Press Inc., 1997.
9. Kallioniemi, A., Kallioniemi, O. P., Sudar, D., Rutovitz, D., Gray, J. W., Waldman, F., and Pinkel, D. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science (Wash. DC), 258: 818-821, 1992.
10. Ried, T., Knutzen, R., Steinbeck, R., Blegen, H., Schrock, E., Heselmeyer, K., du Manoir, S., and Auer, G. Comparative genomic hybridization reveals a specific pattern of chromosomal gains and losses during the genesis of colorectal tumors. Genes Chromosomes Cancer, 15: 234-245, 1996.
11. De Angelis, P. M., Clausen, O. P., Schjolberg, A., and Stokke, T. Chromosomal gains and losses in primary colorectal carcinomas detected by CGH and their associations with tumour DNA ploidy, genotypes and phenotypes. Br. J. Cancer, 80: 526-535, 1999.
12. Curtis, L. J., Georgiades, I. B., White, S., Bird, C. C., Harrison, D. J., and Wyllie, A. H. Specific patterns of chromosomal abnormalities are associated with RER status in sporadic colorectal cancer. J. Pathol., 192: 440-445, 2000.
13. Paredes-Zaglul, A., Kang, J. J., Essig, Y. P., Mao, W., Irby, R., Wloch, M., and Yeatman, T. J. Analysis of colorectal cancer by comparative genomic hybridization: evidence for induction of the metastatic phenotype by loss of tumor suppressor genes. Clin. Cancer Res., 4: 879-886, 1998.
14. Hermsen, M., Postma, C., Baak, J., Weiss, M., Rapallo, A., Sciutto, A., Roemen, G., Arends, J. W., Williams, R., Giaretti, W., De Goeij, A., and Meijer, G. Colorectal adenoma to carcinoma progression follows multiple pathways of chromosomal instability. Gastroenterology, 123: 1109-1119, 2002.
15. Leslie, A., Carey, F. A., Pratt, N. R., and Steele, R. J. The colorectal adenomacarcinoma sequence. Br. J. Surg., 89: 845-860, 2002.
16. Hidaka, S., Yasutake, T., Takeshita, H., Kondo, M., Tsuji, T., Nanashima, A., Sawai, T., Yamaguchi, H., Nakagoe, T., Ayabe, H., and Tagawa, Y. Differences in 20q13.2 copy number between colorectal cancers with and without liver metastasis. Clin. Cancer Res., 6: 2712-2717, 2000.
17. Kaplan, K. B., Burds, A. A., Swedlow, J. R., Bekir, S. S., Sorger, P. K., and Nathke, I. S. A role for the adenomatous polyposis coli protein in chromosome segregation. Nat. Cell Biol., 3: 429-432, 2001.
18. Fodde, R., Kuipers, J., Rosenberg, C., Smits, R., Kielman, M., Gaspar, C., van Es, J. H., Breukel, C., Wiegant, J., Giles, R. H., and Clevers, H. Mutations in the APC tumour suppressor gene cause chromosomal instability. Nat. Cell Biol., 3: 433-438, 2001.
19. Höglund, M., Gisselsson, D., Hansen, G. B., Sall, T., Mitelman, F., and Nilbert, M. Dissecting karyotypic patterns in colorectal tumors: two distinct but overlapping pathways in the adenoma-carcinoma transition. Cancer Res., 62: 5939-5946, 2002.
20. Smith, A. J., Stern, H. S., Penner, M., Hay, K., Mitri, A., Bapat, B. V., and Gallinger, S. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res., 54: 5527-5530, 1994.
21. Talamonti, M. S., Roh, M. S., Curley, S. A., and Gallick, G. E. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J. Clin. Investig., 91: 53-60, 1993.
22. Le Beau, M. M., Westbrook, C. A., Diaz, M. O., and Rowley, J. D. Evidence for two distinct c-src loci on human chromosomes 1 and 20. Nature (Lond.), 312: 70-71, 1984.
23. Taub, R., Kirsch, I., Morton, C., Lenoir, G., Swan, D., Tronick, S., Aaronson, S., and Leder, P. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc. Natl. Acad. Sci. USA, 79: 7837-7841, 1982.
24. Masramon, L., Arribas, R., Tortola, S., Perucho, M., and Peinado, M. A. Moderate amplifications of the c-myc gene correlate with molecular and clinicopathological parameters in colorectal cancer. Br. J. Cancer, 77: 2349-2356, 1998.
25. Carlin, C. R., and Knowles, B. B. Identity of human epidermal growth factor (EGF) receptor with glycoprotein SA-7: evidence for differential phosphorylation of the two components of the EGF receptor from A431 cells. Proc. Natl. Acad. Sci. USA, 79: 5026-5030, 1982.
26. Porebska, I., Harlozinska, A., and Bojarowski, T. Expression of the tyrosine kinase activity growth factor receptors (EGFR, ERB B2, ERB B3) in colorectal adenocarcinomas and adenomas. Tumour Biol, 21: 105-115, 2000.
27. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kem, S. E. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (Wash. DC), 271: 350-353, 1996.
28. Eppert, K., Scherer, S. W., Ozcelik, H., Pirone, R., Hoodless, P., Kim, H., Tsui, L. C., Bapat, B., Gallinger, S., Andrulis, I. L., Thomsen, G. H., Wrana, J. L., and Attisano, L. MADR2 maps to 18q21 and encodes a TGFβ-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. Cell, 86: 543-552, 1996.
29. Roberts, R. B., Min, L., Washington, M. K., Olsen, S. J., Settle, S. H., Coffey, R. J., and Threadgill, D. W. Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc. Natl. Acad. Sci. USA, 99: 1521-1526, 2002.