The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer

Journal of Immunology

Volumn 171, Issue 4, 2003, Pages 1825-1834

  Bros, Matthias ^a   Ross, Xiao Lan ^a   Pautz, Andrea ^a   Reske Kunz, Angelika B ^a   Ross, Ralf ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYTOSINE; CYTOSKELETON PROTEIN; DNA; FASCIN; GUANINE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANTIGEN PRESENTING CELL; ARTICLE; BINDING SITE; CELL CYCLE; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DNA FLANKING REGION; DNA SEQUENCE; ENHANCER REGION; EXON; FLOW CYTOMETRY; GENE ACTIVITY; GENE CONTROL; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; GENE ISOLATION; GENE LOCUS; GENE STRUCTURE; GENOME ANALYSIS; HUMAN; HUMAN CELL; IMMUNOTHERAPY; INTRON; MOLECULAR CLONING; NERVE CELL CULTURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SILENCER GENE; T LYMPHOCYTE ACTIVATION; TARGET CELL; TATA BOX; TRANSCRIPTION REGULATION; VACCINATION;

EID: 0042591370     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.4.1825     Document Type: Article

References (50)

1. Bancherau, J., and R. M. Steinman. 1998. Dendritic cells and the control of immunity. Nature 392:245.
2. Ross, R., J. Schwing, K. Kumpf, A. Endlich, and A. B. Reske-Kunz. 1997. Isolation of differentially expressed genes in epidermal Langerhans cells. Adv. Exp. Med. Biol. 417:481.
3. Ross, R., X.-L. Ross, T. Längin, and A. B. Reske-Kunz. 1999. Maturation of epidermal Langerhans cells: increased expression of β- and γ-actin isoforms as a basis of specialized cell functions. Exp. Dermatol. 8:487.
4. Ross, R., A. Endlich, K. Kumpf, J. Schwing, and A. B. Reske-Kunz. 1998. Maturation of epidermal Langerhans cells in vitro is accompanied by downregulation of 4F2 (CD98) as determined by differential display. J. Invest. Dermatol. 110:57.
5. Ross, R., X.-L. Ross, H. Ghadially, T. Lahr, J. Schwing, J. Knop, and A. B. Reske-Kunz. 1999. Mouse Langerhans cells differentially express an activated T cell-attracting CC chemokine. J. Invest. Dermatol. 113:991.
6. Schaniel, C., E. Pardali, F. Sallusto, M. Speletas, C. Ruedl, T. Shimizu, T. Seidl, J. Andersson, F. Melchers, A. G. Rolink, and P. Sideras. 1998. Activated murine B lymphocytes and dendritic cells produce a novel CC chemokine which acts selectively on activated T cells. J. Exp. Med. 188:451.
7. Ross, R., X.-L. Ross, J. Schwing, T. Längin, and A. B. Reske-Kunz. 1998. The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells. J. Immunol. 160:3776.
8. Edwards, R. A., and J. Bryan. 1995. Fascins, a family of actin bundling proteins. Cell Motil. Cytoskeleton 32:1.
9. Mosialos, G., M. Birkenbach, S. Ayehunie, F. Matsumura, G. S. Pinkus, E. Kieff, and E. Langhoff. 1996. Circulating human dendritic cells differentially express high levels of a 55-kD actin-bundling protein. Am. J. Pathol. 148:593.
10. Mosialos, G., S. Yamashiro, R. W. Baughman, P. Matsudaira, L. Vara, F. Matsumura, E. Kieff, and M. Birkenbach. 1994. Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein. J. Virol. 68:7320.
11. Pinkus, G. S., J. L. Pinkus, E. Langhoff, F. Matsumura, S. Yamashiro, G. Mosialos, and J. W. Said. 1997. Fascin, a sensitive new marker for Reed-Sternberg cells of Hodgkin's disease: evidence for a dendritic or B cell derivation? Am J. Pathol. 150:543.
12. Adams, J. C., and M. A. Schwartz. 2000. Stimulation of fascin spikes by thrombospondin-1 is mediated by the GTPases Rac and Cdc42. J. Cell Biol. 150:807.
13. Yamashiro, S., Y. Yamakita, S. Ono, and F. Matsumura. 1998. Fascin, an actin-bundling protein, induces membrane protrusions and increases cell motility of epithelial cells. Mol. Biol. Cell 9:993.
14. Ross, R., H. Jonuleit, M. Bros, X.-L. Ross, S. Yamashiro, F. Matsumura, A. H. Enk, J. Knop, and A. B. Reske-Kunz. 2000. Expression of the actin-bundling protein fascin in cultured human dendritic cells correlates with dendritic morphology and cell differentiation. J. Invest. Dermatol. 115:658.
15. Al-Alwan, M. M., G. Rowden, T. D. Lee, and K. A. West. 2001. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166:1452.
16. Al-Alwan, M. M., G. Rowden, T. D. Lee, and K. A. West. 2001. Fascin is involved in the antigen presentation activity of mature dendritic cells. J. Immunol. 166:338.
17. Ross, R., S. Sudowe, J. Beisner, X.-L. Ross, I. Ludwig-Portugall, J. Steitz, T. Tüting, J. Knop, and A. B. Reske-Kunz. 2003. Transcriptional targeting of dendritic cells for gene therapy using the promoter of the cytoskeletal protein fascin. Gene Therapy. In press.
18. + T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:1213.
19. Yamashiro-Matsumura, S., and F. Matsumura. 1986. Intracellular localization of the 55-kD actin-bundling protein in cultured cells: spatial relationships with actin, α-actinin, tropomyosin, and fimbrin. J. Biol. Chem. 103:631.
20. Ross, R., R. Kleinz, and A. B. Reske-Kunz. 1995. A method for rapid generation of competitive standard molecules for RT-PCR avoiding the problem of competitor/probe cross-reactions. PCR Methods Appl. 4:371.
21. Waiyawuth, W., L. Zhang, C. Rittner, and P. M. Schneider. 1998. Genetic analysis of the short tandem repeat system D12S391 in the German and three Asian populations. Forensic Sci. Int. 94:25.
22. Schneider, P. M., K. Witzel-Schlömp, C. Steinhauer, B. Stradmann-Bellinghausen, and C. Rittner. 2001. Rapid detection of the ERV-K(C4) retroviral insertion reveals further structural polymorphism of the complement C4 genes in old world primates. Exp. Clin. Immunogenet. 18:130.
23. Ioannou, P. A., C. T. Amemiya, J, Garnes, P. M. Kroisel, H. Shizuya, C. Chen, M. A. Batzer, and P. J. de Jong. 1994. A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nat. Genet. 6:84.
24. Ross, R., X.-L. Ross, B. Rueger, T. Längin, and A. B. Reske-Kunz. 1999. Non-radioactive detection of differentially expressed genes using complex RNA or DNA hybridization probes. BioTechniques 26:150.
25. 2 and cytokines. Exp. Lung Res. 24:3.
26. Kim, D. W., T. Uetsuki, Y. Kaziro, N. Yamaguchi, and S. Sugano, 1990. Use of the human elongation factor 1α promoter as a versatile and efficient expression system. Gene 91:217.
27. Mizushima, S., and S. Nagata. 1990. pEF-BOS, a powerful mammalian expression vector. Nucleic Acids Res. 18:5322.
28. Kalkbrenner, F., E. Dippel, B. Wittig, and G. Schultz. 1996. Specificity of interaction between receptor and G protein: use of antisense techniques to relate G-protein subunits to function. Biochim. Biophys. Acta 1314:125.
29. Arthur, J. F., L. H. Butterfield, M. D. Roth, L. A. Bui, S. M. Kiertscher, R. Lau, S. Dubinett, J. Glaspy, W. H. McBride, and J. S. Economou. 1997. A comparison of gene transfer methods in human dendritic cells. Cancer Gene Ther. 4:17.
30. Granelli-Piperno, A., M. Pope, K. Inaba, and R. M. Steinman. 1995. Coexpression of NF-κB/Rel and Sp1 transcription factors in human immunodeficiency virus 1-induced, dendritic cell-T-cell syncytia. Proc. Natl. Acad. Sci. USA 92:10944.
31. Bakri, Y., C. Schiffer, V. Zennou, P. Charneau, E. Kahn, A. Benjouad, J. C. Gluckman, and B. Canque. 2001. The maturation of dendritic cells results in postintegration inhibition of HIV-1 replication. J. Immunol. 166:3780.
32. Prieschl, E. E., V. Novotny, R. Csonga, D. Jaksche, A. Elbe-Burger, W. Thumb, M. Auer, G. Stingl, and T. Baumruker. 1998. A novel splice variant of the transcription factor Nrf1 interacts with the TNFα promoter and stimulates transcription. Nucleic Acids Res. 26:2291.
33. Rowlands, J. C., and J. A. Gustafsson. 1997. Aryl hydrocarbon receptor-mediated signal transduction. Crit. Rev. Toxicol. 27:109.
34. Häcker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G. B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 17:6230.
35. Ardeshna, K. M., A. R. Pizzey, S. Devereux, and A. Khwaja. 2000. The PI3 kinase, p38 SAP kinase, and NF-κB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimulated human monocyte-derived dendritic cells. Blood 96:1039.
36. Mann, J., F. Oakley, P. W. Johnson, and D. A. Mann. 2002. CD40 induces interleukin-6 gene transcription in dendritic cells: regulation by TRAF2, AP-1, NF-κB, and CBF1. J. Biol. Chem. 277:17125.
37. Venugopal, R., and A. K. Jaiswal. 1996. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc. Natl. Acad. Sci. USA 93:14960.
38. Wang, L., X. Liu, and R. H. Lenox. 2002. Transcriptional regulation of mouse MARCKS promoter in immortalized hippocampal cells. Biochem. Biophys. Res. Commun. 292:969.
39. Salmon, P., V. Kindler, O. Ducrey, B. Chapuis, R. H. Zubler, and D. Trono. 2000. High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors. Blood 96:3392.
40. Ng, S. Y., P. Gunning, S. H. Liu, J. Leavitt, and L. Kedes. 1989. Regulation of the human β-actin promoter by upstream and intron domains. Nucleic Acids Res. 17:601.
41. Nakano, Y., T. Nishihara, S. Sasayama, T. Miwa, S. Kamada, and T. Kakunaga. 1991. Transcriptional regulatory elements in the 5′ upstream and first intron regions of the human smooth muscle (aortic type) α-actin-encoding gene. Gene 99:285.
42. DePonti-Zilli, L., A. Seiler-Tuyns, and B. M. Paterson. 1988. A 40-base pair sequence in the 3′ end of the β-actin gene regulates β-actin mRNA transcription during myogenesis. Proc. Natl. Acad. Sci. USA 85:1389.
43. Valladeau, J., V. Clair-Moninot, C. Dezutter-Dambuyant, J. J. Pin, A. Kissenpfennig, M. G. Mattei, S. Ait-Yahia, E. E. Bates, B. Malissen, F. Koch, et al. 2002. Identification of mouse langerin/CD207 in Langerhans cells and some dendritic cells of lymphoid tissues. J. Immunol. 168:782.
44. Kalinski, P., C. M. Hilkens, E. A. Wierenga, and M. L. Kapsenberg. 1999. T-cell priming by type-1 and type-2 polarized dendritic cells: the concept of a third signal. Immunol. Today 20:561.
45. Riedinger, M., K. Karjalainen, and T. Brocker. 1997. Targeted expression of MHC class II genes to dendritic cells in vivo. Immunol. Lett. 57:155.
46. Robinson, S. P., S. Patterson, N. English, D. Davies, S. C. Knight, and C. D. Reid. 1999. Human peripheral blood contains two distinct lineages of dendritic cells. Eur. J. Immunol. 29:2769.
47. + T cells in vivo. J. Immunol. 154:5684.
48. + eosinophils in the murine thymus: developmental regulation and recruitment upon MHC class I-restricted thymocyte deletion. J. Immunol. 165:1965.
49. Bonkobara, M., P. K. Zukas, S. Shikano, S. Nakamura, P. D. Cruz, and K. Ariizumi. 2001. Epidermal Langerhans cell-targeted gene expression by a dectin-2 promoter. J. Immunol. 167:6893.
50. Morita, A., K. Ariizumi, R. Ritter, J. V. Jester, T. Kumamoto, S. A. Johnston, and A. Takashima. 2001. Development of a Langerhans cell-targeted gene therapy format using a dendritic cell-specific promoter. Gene Ther. 8:1729.