The protective effects of physiological and pharmacological concentrations of melatonin on renal ischemia-reperfusion injury in rats

Urological Research

Volumn 31, Issue 3, 2003, Pages 188-193

  Sahna, Engin ^a   Parlakpinar, Hakan ^b   Ozturk, Feral ^b   Cigremis, Yilmaz ^b   Acet, Ahmet ^b  

^a FIRAT UNIVERSITY   (Turkey)

^b NONE

Author keywords

Melatonin; Pinealectomy; Renal ischemia reperfusion

Indexed keywords

CREATININE; MALONALDEHYDE; MELATONIN; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL OCCLUSION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE RESPONSE; DRUG EFFECT; KIDNEY BLOOD VESSEL; KIDNEY ISCHEMIA; MALE; NEPHRECTOMY; NONHUMAN; PINEALECTOMY; PRIORITY JOURNAL; PROTECTION; RAT; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD UREA NITROGEN; CREATINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FREE RADICAL SCAVENGERS; KIDNEY; MALE; MALONDIALDEHYDE; MELATONIN; OSMOLAR CONCENTRATION; RATS; RATS, WISTAR; RENAL CIRCULATION; REPERFUSION INJURY;

EID: 0042564554     PISSN: 03005623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00240-003-0314-5     Document Type: Article

References (30)

1. Akcetin Z, Erdemli G, Bromme HJ (2000) Experimental study showing a diminished cytosolic antioxidative capacity in kidneys of aged rats. Urol Int 64: 70
2. Carneiro RCG, Reiter RJ (1998) δ-Aminolevulinic acid-induced lipid peroxidation in rat kidney and liver is attenuated by melatonin: an in-vitro and in-vivo study. J Pineal Res 13: 287
3. Del Zar MM, Martinuzzo C, Falcon C, Cardinali DP, Carreras LO, Vacas MI (1990) Inhibition of human platelet aggregation and tromboxane-B2 production by melatonin: evidence for a diurnal variation. J Clin Endocrinol 70: 246
4. Dziegiel P, Suder E, Surowiak P, Jethon Z, Rabczynski J, Januszewska L, Sopel M, Zabel M (2002) Role of exogenous melatonin in reducing the nephrotoxic effect of daunorubicin and doxorubicin in the rat. J Pineal Res 33: 95
5. 1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores. Urol Res 28: 122
6. Giovannini L, Migliori M, Longoni BM, Das DK, Bertelli AA, Panichi V, Filippi C, Bertelli A (2001) Resveratrol, a polyphenol found in wine, reduces ischemia reperfusion injury in rat kidneys. J Cardiovasc Pharmacol 37: 262
7. Grace MS, Cahill GM, Besharse JC (1991) Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution. Brain Res 559: 56
8. Kilic E, Ozdemir YG, Bolay H, Kelestimur H, Dalkara T (1999) Pinealectomy aggravates and melatonin administration attenuates brain damage in focal ischemia. J Cereb Blood Flow Metab 19: 511
9. Kuszak J, Rodin M (1977) A new technique of pinealectomy for adult rats. Experientia 33: 283
10. K-Laflamme A, Wu L, Foucart S, de Champlain J (1998) Impaired basal sympathetic tone and alpha1-adrenergic responsiveness in association with the hypotensive effect of melatonin in spontaneously hypertensive rats. Am J Hypertens 11: 219
11. Lagneux C, Joyeux M, Demenge P, Ribuot C, Godin-Ribuot D (2000) Protective effects of melatonin against ischemia-reperfusion injury in the isolated rat heart. Life Sci 66: 503
12. Montilla P, Tunez I, Munoz MC, Lopez A, Soria JV (1997) Hyperlipidemic nephropathy induced by adriamycin: effect of melatonin administration. Nephron 76: 345
13. Nava M, Romero F, Quiroz Y, Parra G, Bonet L, Rodriguez-Iturbe B (2000) Melatonin attenuates acute renal failure and oxidative stress induced by mercuric chloride in rats. Am J Physiol Renal Physiol 279: 910
14. Ozbek E, Turkoz Y, Sahna E, Ozugurlu F, Mizrak B, Ozbek M (2000) Melatonin administration prevents the nephrotoxicity induced by gentamicin. BJU Int 85: 742
15. Paller MS (1998) Acute renal failure: controversies, clinical trials, and future. Semin Nephrol 18: 482
16. Paller MS, Hoidal J, Ferris TF (1984) Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest 74: 1156
17. Reiter RJ, Guerrero JM, Garcia JJ, Acuna-Castroviejo D (1998) Reactive oxygen intermediates, molecular damage and aging. Relation to melatonin. Ann N Y Acad Sci 854: 410
18. Reiter RJ (1991) Melatonin: that ubiquitously acting pineal hormone. News Physiol Sci 6: 223
19. Reiter RJ (1992) The aging pineal gland and its physiological consequences. BioEssays 14: 169
20. Reiter RJ, Tan DX, Qi W, Manchester LC, Karbownik M, Calvo JR (2000) Pharmacology and physiology of melatonin in the reduction of oxidative stress in vivo. Biol Signals Recept 9: 160
21. Reiter RJ, Tan DX, Manchester LC, Qi W (2001) Biochemical reactivity of melatonin with reactive oxygen and nitrogen species. Cell Biochem Biophysics 34: 237
22. Rhoden EL, Pereira-Lima L, Teloken C, Lucas ML, Bello-Klein A, Rhoden CR (2001) Beneficial effect of alpha-tocopherol in renal ischemia-reperfusion in rats. Jpn J Pharmacol 87: 164
23. Sahna E, Olmez E, Acet A (2002) Effects of physiological and pharmacological concentrations of melatonin on ischemia-reperfusion arrhythmias in rats: can the incidence of sudden cardiac death be reduced? J Pineal Res 32: 194
24. Sahna E, Acet A, M.K Ozer, Olmez E (2002) Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin. J Pin Res 30: 234
25. Seth P, Kumari R, Madhavan S, Singh AK, Mani H, Banaudha KK, Sharma SC, Kulshreshtha DK, Mahshwari RK (2000) Prevention of renal ischemia/reperfusion-induced injury in rats by picroliv. Biochem Pharmacol 59: 1315
26. Tan DX, Reiter RJ, Manchester LC, Yan MT, El-Sawi M, Sainz RM, Mayo JC, Kohen R, Allegra M, Hardeland R (2002) Chemical and physical proporties and potential mechanisms: melatonin: melatonin as a broad spectrum antioxidant and free radical scavenger. Curr Top Med Chem 2: 181
27. Vanecek J (1995) Melatonin inhibits increase of intracellular calcium and cyclic AMP in neonatal rat pituitary via independent pathways. Mol Cell Endocrinol 107: 1497
28. Vanecek J (1998) Cellular mechanisms of melatonin action. Physiol Rev 78: 68
29. Vermeulen NPE, Baldew GS (1992) The role of lipid peroxidation in the nephrotoxicity of cisplatin. Biochem Pharmacol 44: 1193
30. Zanoboni A, Forni A, Zanoboni-Muciaccia W, Zanussi CT (1978) Effect of pinealectomy on arterial blood pressure and food and water intake in the rat. J Endocrinol Invest 1: 125