Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: A randomized controlled trial

Cancer Epidemiology Biomarkers and Prevention

Volumn 12, Issue 8, 2003, Pages 721-727

  Fairey, Adrian S ^a   Courneya, Kerry S ^a   Field, Catherine J ^a   Bell, Gordon J ^a   Jones, Lee W ^a   Mackey, John R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANASTROZOLE; ANTHRACYCLINE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; ANTIINFLAMMATORY AGENT; ATORVASTATIN; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BISPHOSPHONIC ACID DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; GLUCOSE; HORMONE; INSULIN; LEUKOTRIENE RECEPTOR BLOCKING AGENT; PARACETAMOL; PROTON PUMP INHIBITOR; SEDATIVE AGENT; SEROTONIN UPTAKE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; STEROID; TAMOXIFEN; UNINDEXED DRUG;

ADULT; ARTICLE; BICYCLE ERGOMETER; BREAST CANCER; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EXERCISE; FEMALE; HORMONE BLOOD LEVEL; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MULTIMODALITY CANCER THERAPY; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN ANALYSIS; RANDOMIZED CONTROLLED TRIAL;

AGED; BREAST NEOPLASMS; EXERCISE; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; MIDDLE AGED; POSTMENOPAUSE; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 0042527257     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Yu, H., and Rohan, T. Role of the insulin-like growth factor family in cancer development and progression. J. Natl. Cancer Inst., 92: 1472-1489, 2000.
2. Belfiore, A., Frittitta, L., Costantino, A., Frasca, F., Pandini, G., Sciacca, L., Goldfine, I. D., and Vigneri, R. Insulin receptors in breast cancer. Ann. N. Y. Acad. Sci., 784: 173-188, 1996.
3. Papa, V., and Belfiore, A. Insulin receptors in breast cancer: biological and clinical role. J. Endocrinol. Investig., 19: 324-333, 1999.
4. Goodwin, P. J., Ennis, M., Pritchard, K., Trudeau, M. E., Koo, J., Madarnas, Y., Hartwick, W., Hoffman, B., and Hood, N. Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J. Clin. Oncol., 20: 42-51, 2002.
5. Le Roith, D. Insulin-like growth factors. N. Engl. J. Med., 336: 633-640, 1997.
6. Lee A. V., and Lee D. Role of the IGF system in breast cancer proliferation and progression. In: A. Manni (ed.), Endocrinology of Breast Cancer, pp. 187-203. Totowa, NJ: Humana Press, 1999.
7. Peyrat, J. P., Bonneterre, J., Hecquet, B., Vennin, P., Louchez, M. M., Fournier, C., Lefebvre, J., and Demaille, A. Plasma insulin-like growth factor-1 (IGF-1) concentrations in human breast cancer. Eur. J. Cancer, 29A: 492-497, 1993.
8. Bruning, P. F., Van Doom, J., Bonfrer, J. M. G., Van Noord, P. A., Korse, C. M., Linders, T. C., and Hart, A. A. Insulin-like growth-factor-binding protein 3 is decreased in early-stage operable pre-menopausal breast cancer. Int. J. Cancer, 62: 266-270, 1995.
9. Hankinson, S. E., Willett, W. C., Colditz, G. A., Hunter, D. J., Michaud, D. S., Deroo, B., Rosner, B., Speizer, F. E., and Pollak, M. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet. 351: 1393-1396, 1998.
10. Bohlke, K., Cramer, D. W., Trichopoulos, D., and Mantzoros, C. S. Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast. Epidemiology, 9: 570-573, 1998.
11. Goodwin, P. J., Ennis, M., Pritchard, K. I., Trudeau, M. E., Koo, J., Hartwick, W., Hoffma, B., and Hood, N. Insulin-like growth factor binding proteins 1 and 3 and breast cancer outcomes. Breast Cancer Res. Treat., 74: 65-76, 2002.
12. Vadgama, J. V., Yanyuan, W., Geetanjali, D., Khan, H., and Chillar, R. Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in african-american and hispanic women. Oncology, 57: 330-340, 1999.
13. Ross, R., Dagnone, D., Jones, P. J., Smith, I., Paddags, A., Hudson, R., and Janssen, I. Reduction in obesity and related comorbid conditions after diet-induced weight loss or exercise-induced weight loss in men. A randomized, controlled trial. Ann. Intern. Med., 133: 92-103, 2000.
14. Evans, E. M., Van Pelt., R. E., Binder, E. F., Williams, D. B., Ehsami, A. A., and Kohrt, W. M. Effects of HRT and exercise training on insulin action, glucose tolerance, and body composition in older women. J. Appl. Physiol., 90: 2033-2040, 2001.
15. Duncan, G. E., Perri, M. G., Theriaque, D. W., Hutson, A. D., Eckel, R. H., and Stacpoole, P. W. Exercise training, without weight loss, increases insulin sensitivity and postherapin plasma lipase activity in previously sedentary adults. Diabetes Care, 26: 557-562, 2003.
16. Schmitz, K. H., Ahmed, R. L., and Yee, D. Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF binding protein (IGFBP)-1, and IGFBP-3 in 30-50-year-old women. Cancer Epidemiol. Biomark. Prev., 11: 1597-604, 2002.
17. Courneya, K. S., Mackey, J. R., Bell, G. J., Jones, L. W., Field, C. J., and Fairey, A. S. Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J. Clin. Oncol., 21: 1660-1668, 2003.
18. Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., and Turner, R. C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28: 412-419, 1985.
19. Godin, G., and Shephard, R. J. A simple method to assess exercise behavior in the community. Can. J. Appl. Sport Sci., 10: 141-146, 1985.
20. Boule, N. G., Haddad, E., Kenny, G. P., Wells, G. A., and Sigal, R. J. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trails. JAMA, 286: 1218-1227, 2001.
21. Goodpaster, B. H., Kelley, D. E., Wing, R. R., Meier, A., and Thaete, F. L. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes, 48: 839-847, 1999.
22. Niskanen, L., Uusitupa, M., Sarlund, H., Siitonen, O., Paljarvi, L., and Laakso, M. The effects of weight loss on insulin sensitivity, skeletal muscle composition and capillary density in obese non-diabetic subjects. Int. J. Obes. Relat. Metab. Disord., 20: 154-160, 1996.
23. Perseghin, G., Price, T. B., Petersen, K. F., Roden, M., Cline, G. W., Gerow, K., Rothman, D. L., and Shulman, G. I. Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects. N. Engl. J. Med., 225: 1357-1362, 1996.
24. Goodyear, L. J., and Kahn, B. B. Exercise, glucose transport, and insulin sensitivity. Ann. Rev. Med., 49: 235-261, 1998.
25. Kohrt, W. M., Snead, D. B., Slatopolsky, E., and Birge, S. J., Jr. Additive effects of weight-bearing exercise and estrogen on bone mineral density in older women. J. Bone Miner. Res., 10: 1303-1311, 1995.
26. Parkhouse, W. S., Coupland, D. C., Li, C., and Vanderhoek K. J. IGF-1 bioavailability is increased by resistance training in older women with low bone mineral density. Mech. Ageing Dev., 113: 75-83, 2000.
27. Hakkinen, K., Pakarinen, A., Kraemer, W. J., Hakkinen, A., Valkeinen, H., and Alen, M. Selective muscle hypertrophy, changes in EMG and force, and serum hormones during strength training in older women. J. Appl. Physiol., 91: 569-580, 2001.
28. Poehlman, E. T., Rosen, C. J., and Copeland, K. C. The influence of endurance training on insulin-like growth factor-1 in older individuals. Metabolism, 43: 1401-1405, 1994.
29. Vitiello, M. V., Wilkinson, C. W., Merriam, G. R., Moe, K. E., Prinz, P. N., Ralph, D. D., Colasurdo E. A., and Schwartz R. S. Successful 6-month endurance training does not alter insulin-like growth factor-I in healthy older men and women. J. Gerontol. A Biol. Sci. Med. Sci., 52: M149-M154, 1997.
30. Maddalozzo, G. F., and Snow, C. M. High intensity resistance training: effects on bone in older men and women. Calcify Tissue Int., 66: 399-404, 2000.
31. Lange, K. H., Lorentsen, J., Isaksson, F., Juul, A., Rasmussen, M. H., Christensen, N. J., Bulow, J., and Kjaer, M. Endurance training and GH administration in elderly women: effects on abdominal adipose tissue lipolysis. Am. J. Physiol. Endocrinol. Metab., 280: E886-E897, 2001.
32. Borst, S. E., Vincent, K. R., Lowenthal, D. T., and Braith, R. W. Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85. J. Am. Geriatr. Soc., 50: 884-888, 2002.
33. Torrisl, R., Baglietto, L., Johansson, H., et al. Effect of raloxifene on IGF-1 and IGFBP-3 in postmenopausal women with breast cancer. Br. J. Cancer, 85: 1838-1841, 2001.
34. Ho, H. G., Ji, C. Y., Phang, B. H., Lee, K. C., and Ng, E. H. Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: a prospective paired cohort study. Ann. Surg. Oncol., 5: 361-367, 1988.
35. Lonning, P. E., Hall, K., Aakvaag, A., and Kien, E. A. Influence of tamoxifen on plasma levels of insulin-like growth factor-I and insulin-like growth factor binding protein-1 in breast cancer patients. Cancer Res., 52: 4719-4723, 1992.
36. Pollak, M., Constantino, J., Polychronakos, C., Blauer, S. A., Guyda, H., Redmond, C., Fisher, B., and Margolese, R. Effect of tamoxifen on serum insulin-like growth factor I levels in stage I breast cancer patients. J. Natl. Cancer Inst., 82: 1693-1697, 1990.
37. Lien, E. A., Johannessen, D. C., Aakvaag, A., and Lonning, P. E. Influence of tamoxifen, aminoglutethimide and goserelin on human plasma IGF-I levels in breast cancer patients. J. Steroid Biochem. Mol. Biol., 41: 541-543, 1992.
38. Helle, S. I., Anker, G. B., Tally, M., Hall, K., and Lonning, P. E. Influence of droloxifene on plasma levels of insulin-like growth factor (IGF)-I, pro-IGF-IIE, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-3 in breast cancer patients. J. Steroid Biochem. Mol. Biol., 57: 167-171, 1996.
39. Ivy, J. L., Zderic, T. W., and Fogt, D. L. Prevention and treatment on non-insulin-dependent diabetes mellitus. Exerc. Sport Sci. Rev., 27: 1-35, 1999.
40. Chlebowski, R. T., Aiello, E., and McTiernan, A. Weight loss in breast cancer management. J. Clin. Oncol., 20: 1128-1143, 2002.
41. Scheett, T. P., Milles, P. J., Ziegler, M. G., Stoppani, J., and Cooper, D. M. Effect of exercise on cytokines and growth mediators in prepubertal children. Pediatr. Res., 46: 429-434, 1999.