Insulin receptors in breast cancer: Biological and clinical role

Journal of Endocrinological Investigation

Volumn 19, Issue 5, 1996, Pages 324-333

  Papa, V ^a   Belfiore, A ^a  

^a UNIVERSITY OF CATANIA   (Italy)

Author keywords

Breast cancer; Growth factors; Insulin receptor; Tyrosine kinase

Indexed keywords

GROWTH PROMOTOR; INSULIN; INSULIN RECEPTOR;

ANIMAL; BREAST TUMOR; CELL TRANSFORMATION; FEMALE; HUMAN; PHYSIOLOGY; REVIEW;

ANIMALS; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GROWTH SUBSTANCES; HUMANS; INSULIN; RECEPTOR, INSULIN;

EID: 0030134585     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03347871     Document Type: Review

References (54)

1. Henderson I.C., Harris J.R., Kinne D.W., Hellmann S. In: De Vita V.T. Jr., Hellmann S., Rosenberg S.A. Cancer, principle and practice in oncology. (Eds.) Lippincott Co., Philadelphia, 1989.
2. Collins F.S. BRCA1-Lots of mutations, lots of dilemmas. N. Engl. J. Med. 334: 186, 1996.
3. Vogelstein B., Kinzler K.W. Has the breast cancer gene been found ? Cell. 7: 1, 1994.
4. Ames B.N., Gold L.S., Willst W.C. The causes and prevention of cancer. Proc. Natl. Aca Sci USA 92: 5258, 1995.
5. Wong W.W., Vijayakumor S., Weichsalbum R.R. Prognostic indicators in node negative early stage breast cancer. Am. J. Med. 92: 539, 1992.
6. Dickson R.B., Lippman M. Growth factors in breast cancer. Endocr. Rev. 16: 559, 1995.
7. Ames B.N. Mutagenesis and carcinogenesis: endogenous and exogenous factors. Environ. Mol. Mutagen. 13: 1, 1989.
8. Manni A. Hormone receptor and breast cancer. N. Engl. J. Med. 309: 1383, 1983.
9. McGuire W.L., Clark G.M. Prognostic factors and treatment decision in axillary node negative breast cancer. N. Engl. J. Med. 326: 1756, 1992.
10. Crysongelos S.A., Dickson R.B. EGF receptors expression, regulation and function in breast cancer. Breast Cancer Res. Treat. 29: 29, 1994.
11. Daughday W.H., Rotwein P. Insulin-like growth factor I and II, peptide messanger ribonucleic acid and gene structures. Endocr. Rev. 10: 68, 1989.
12. Le Roith D., Werner H., Beitner-Johnson D., Roberts C.T. Molecular and cellular aspect of the Insulin-like growth factor-I receptor. Endocr. Rev. 16: 143, 1995.
13. Cheatam B., Kahn C.R. Insulin action and the insulin signaling network. Endocr. Rev. 16: 117, 1995.
14. Heuson J.C., Legros N., Heimann R. Influence of insulin administration on growth of the 7,12 dimethylbenzanthracene-induced mammary carcinoma in intact, oophorectomized and hypophysectomized rats. Cancer Res. 32: 233, 1972.
15. Cohen N.D., Hilf R. Influence of insulin on growth and metabolism of 7,12 dimethylbenzanthracene-induced mammary tumors. Cancer Res. 34: 3245, 1974.
16. Heuson J.C., Legros N. Study of growth -promoting effect of insulin in relation to carbohydrate metabolism in organ culture of rat mammary carcinoma. Eur. J. Cancer 4: 1, 1968.
17. Drejer K. The bioactivity of insulin analogues from in vitro receptor binding to in vivo glucose uptake. Diab. Metab. Rev. 8: 259, 1992.
18. Fernandes G., Chandrasekar B., Troyer D.A., Venkatraman J.T., Good R.A. Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice. Proc. Natl. Acad. Sci USA 92: 6494, 1995.
19. Shafie S.M., Gibson S.L., Hilf R. Effect of insulin and estrogen on hormone binding in R3230AC mammary adenocarcinoma. Cancer Res. 37: 4641, 1977.
20. Nandi S., Guzman R.C., Yang J. Hormones and mammary carcinogenesis in mice, rat and humans: a unifying hypothesis. Proc. Natl. Acad. Sci USA 92: 3650, 1995.
21. Sherman B., Wallace R., Bean J., Schlabaugh L. Relationship of body weight to menarcheal and menopausal age: implication for breast cancer risk. J. Clin. Endocrinol. Metab. 52: 488, 1982.
22. Greenberg E.R., Vessey M.P., Mc Pherson K., Doll R., Yeates D. Body size and survival in premenopausal breast cancer. Br. J. Cancer 51: 691, 1985.
23. Dao T.L., Hilf R. Dietary fat and breast cancer: a search for mechanisms. Adv. Exp. Med. Biol. 322: 223, 1992.
24. Folsom A.R., Kaye S.A., Prineas R.J., Potter J.D., Gapstur S.M., Wallace R.B. Increased incidence of carcinoma of the breast associated with abdominal adiposity in postmenopausal women. Am. J. Epidem. 131: 794, 1990.
25. Key T.J.A., Pike M.C. The role of oestrogens and progesterone in the epidemiology and prevention of breast cancer. Eur. J. Cancer Clin. Oncol. 24: 29, 1988.
26. Kirschner M.A., Samojlik E., Drejka M., Szmal E., Schneider G., Ertel N. Androgen-estrogen metabolism in women with upper body vs. lower body obesity. J. Clin. Endocrinol. Metab. 70: 473, 1990.
27. Kissebah A.H., Vydelingum N., Murray Y. Relationship of body fat distribution to metabolic complication of obesity. J. Clin. Endocrinol. Metab. 54: 254, 1982.
28. Hartz A.J., Rupley D.C., Rimm A.A. The association of girth measurement with disease in 32,856 women. Am. J. Epidemiol. 119: 71, 1984
29. Barnes-Josiah D., Potter J.D., Sellers T.A., Himes J.H. Early body size and subsequent weight gain as predictors of breast cancer incidence (Iowa, USA). Cancer Causes Control 6: 112, 1995.
30. Bruning P.F., Bonfrer J.M.G., van Noord P.A.H., Hart A.A.M., de-Jong Dakker M. Insulin resistance and breast cancer risk. Int. J. Cancer 52: 511, 1992.
31. Olefsky J.M. The insulin receptor: a multifunctional protein. Diabetes 39: 1009, 1990.
32. Pezzino V., Papa V., Trischitta V., Brunetti A., Goodman P.A., Treutelaar M.K., Williams J.A., Maddux B.A., Vigneri R., Goldfine I.D. Human insulin receptor radioimmunoassay: applicability to insulin-resistant states. Am. J. Physiol. 257: E451, 1989.
33. Papa V., Pezzino V., Costantino A., Belfiore A., Giuffrida D., Frittitta L., Vannelli G.B., Brand R., Goldfine I.D., Vigneri R. Elevated insulin receptor content in human breast cancer. J. Clin. Invest. 86: 1503, 1990.
34. Osborne C.K., Bolan G., Monaco M.E., Lippman M.E. Hormone responsive human breast cancer in long term tissue culture: effect of insulin. Proc. Natl. Acad. Sci USA 73: 4536, 1976.
35. Soule H.D., Maloney T.M., Wolman S.R., Peterson W.D., Brenz R., Mc Grath C.M., Russo J., Pauley R.J., Jones R.F., Brooks S.C. Isolation and characterization of a spontaneousy immortalized human breast epithelial cell line (MCF-10). Cancer Res. 50: 6075, 1990.
36. Milazzo G., Giorgino F., Damante G., Sung C., Stampfer M.R., Vigneri R., Goldfine I.D., Belfiore A. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res. 52: 3924, 1992.
37. Papa V., Gliozzo, B., Clark, G.M., McGuire W.L., Moore D., Fujita-Yamaguchi Y., Vigneri R., Goldfine I.D., Pezzino V. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res. 53: 3736-, 1993.
38. Tewari D.S., Cook D.M., Taub R. Characterization of the promoter region and 3'end of the human insulin receptor gene. J. Biol. Chem. 264: 16238, 1989.
39. Frittitta L, Vigneri R., Papa V., Goldfine I.D., Grasso G., Trischitta V. Structural and functional studies of insulin receptors in human breast cancer. Breast Cancer Res Treat 25: 73, 1993.
40. Costantino A., Milazzo G., Giorgino F., Russo P., Goldfine I.D., Vigneri R., Belfiore A. Insulin resistant MDA-MB231 human breast cancer cells contain a tyrosine kinase inhibiting activity. Mol. Endocrinol. 7: 1667, 1993.
41. Maddux B.A., Sbraccia P., Kumakura S., Sasson S., Youngren J., Fisher A., Spencer S., Grupe A., Henzel W., Stewart T.A., Reaven G.M., Goldfine I.D. Membrane glycoprotein PC-1 and non insulin dependent diabetes mellitus. Nature 373: 448, 1995.
42. Whittaker J., Soos M.A., Siddle K. Hybrid insulin receptors. Diabetes Care 13: 576, 1990.
43. Soos M.A., Field C.E., Siddle K. Purified hybrid insulin/IGF-I receptors bind IGF-I but not insulin with high affinity. Biochem. J. 290: 419, 1993.
44. Milazzo G., Yip C.C., Maddux B.A., Vigneri R., Goldfine I.D. High-affinity insulin binding to an atypical insulin-like growth factor-I receptor in human breast cancer cells. J. Clin. Invest. 89: 899, 1992.
45. Kaleko M., Butter W.J., Miller A.D. Overexpression of the human insulin-like growth factor-I receptor promotes ligand-dependent neoplastic transformation. Mol. Cell Biol. 10: 464, 1990.
46. Di Fiore P.P., Pierce J.H., Fleming T.P., Hazan R., Ullrich A., King C.R., Schlessinger J., Aaronson S.A. Overexpression of the human EGF receptors confers an EGF dependent transformed phenotype to NIH 3T3 cells. Cell 51: 1063, 1987.
47. Giordano S., Zhen Z., Medico E., Gaudino G., Galimi F., Comoglio P.M. Transfer of mitogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of human met protooncogene. Proc. Natl. Acd Sci USA 90: 649, 1993.
48. Giorgino F., Belfiore A., Milazzo G., Costantino A., Maddux B., Whittaker J., Goldfine I.D., Vigneri R. Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype. Mol. Endocrinol. 5: 452, 1991.
49. Frittitta L., Vigneri R., Stampfer M., Goldfine I.D. Insulin receptor overexpression in 184 B5 human mammary epithelial cells induces a ligand dependent transformed phenotype. J. Cell. Biochem. 57: 666, 1995.
50. Baserga R. The insulin-like growth factor-I receptor: a key to tumor growth. Cancer Res. 55: 249, 1995.
51. Valentinis B., Porcu P.L., Quinn K., Baserga R. The role of the insulin-like growth factor-I receptor in the transformation by simian virus 40 T antigen. Oncogene 9: 825, 1994.
52. Resnicoff M., Sell C., Rubini M., Coppola D., Ambrose D., Baserga R. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor -I receptor are non tumorigenic and induce regression of wilde type tumor. Cancer Res. 54: 2218, 1994.
53. Giovannucci E. Insulin and colon cancer. Cancer Causes Control 6: 164, 1995.
54. Pillemer G., Lugasi-Evgi H., Scharovsky G., Naor D. Insulin dependance of murine lymphoid T-cell leukemia. Int. J. Cancer 50: 80, 1992.