Genomic approach to identification of Mycobacterium bovis diagnostic antigens in cattle

Journal of Clinical Microbiology

Volumn 41, Issue 8, 2003, Pages 3719-3728

  Aagaard, Claus ^a   Govaerts, Marc ^b   Okkels, Limei Meng ^a   Andersen, Peter ^a   Pollock, John M ^c  

^a STATENS SERUM INSTITUT   (Denmark)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c AGRI FOOD AND BIOSCIENCES INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; MYCOBACTERIUM ANTIGEN; REAGENT; TUBERCULIN;

ARTICLE; BACTERIUM IDENTIFICATION; BIOINFORMATICS; CATTLE DISEASE; COMPUTER MODEL; CORRELATION ANALYSIS; DELAYED HYPERSENSITIVITY; DIAGNOSTIC TEST; ESCHERICHIA COLI; MOLECULAR BIOLOGY; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; NONHUMAN; PRIORITY JOURNAL; SKIN TEST;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CATTLE; DISEASE MODELS, ANIMAL; DNA PRIMERS; MYCOBACTERIUM BOVIS; POLYMERASE CHAIN REACTION; RECOMBINANT PROTEINS; TUBERCULOSIS, BOVINE;

ACTINOBACTERIA (CLASS); ANIMALIA; BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE; ESCHERICHIA COLI; MYCOBACTERIUM; MYCOBACTERIUM AVIUM; MYCOBACTERIUM BOVIS; UNCULTURED ACTINOMYCETE;

EID: 0042524266     PISSN: 00951137     EISSN: None     Source Type: Journal    
DOI: 10.1128/JCM.41.8.3719-3728.2003     Document Type: Article

References (46)

1. Amadori, M., S. Tagliabue, S. Lauzi, G. Finazzi, G. Lombardi, P. Telò, L. Pacciarini, and L. Bonizzi. 2002. Diagnosis of Mycobacterium bovis infection in calves sensitized by mycobacteria of the avium/ intracellulare group. J. Vet. Med. B Infect. Dis. Vet. Public Health 49:89-96.
2. Andersen, P., M. E. Munk, J. M. Pollock, and T. M. Doherty. 2000. Specific immune-based diagnosis of tuberculosis. Lancet 356:1099-1104.
3. Arend, S. M., A. C. Engelhard, G. Groot, K. de Boer, P. Andersen, T. H. Ottenhoff, and J. T. van Dissel. 2001. Tuberculin skin testing compared with T-cell responses to Mycobacterium tuberculosis-specific and nonspecific antigens for detection of latent infection in persons with recent tuberculosis contact. Clin. Diagn. Lab. Immunol. 8:1089-1096.
4. Behr, M. A., M. A. Wilson, W. P. Gill, H. Salamon, G. K. Schoolnik, S. Rane, and P. M. Small. 1999. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 284:1520-1523.
5. Berthet, F.-X., P. B. Rasmussen, I. Rosenkrands, P. Andersen, and B. Gicquel. 1998. A Mycobacterium tuberculosis operon encoding ESAT-6 and a novel low-molecular-mass culture filtrate protein (CFP-10). Microbiology 144:3195-3203.
6. Boon, C., R. Li, R. Qi, and T. Dick. 2001. Proteins of Mycobacterium bovis BCG induced in the Wayne dormancy model. J. Bacteriol. 183:2672-2676.
7. Brodin, P., K. Eiglmeier, M. Marmiesse, A. Billault, T. Garnier, S. Niemann, S. T. Cole, and R. Brosch. 2002. Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant. Infect. Immun. 70:5568-5578.
8. Brosch, R., S. V. Gordon, M. Marmiesse, P. Brodin, C. Buchrieser, K. Eiglmeier, T. Garnier, C. Gutierrez, G. Hewinson, K. Kremer, L. M. Parsons, A. S. Pym, S. Sanger, D. van Soolingen, and S. T. Cole. 2002. A new evolutionary scenario for the Mycobacterium tuberculosis complex. Proc. Natl. Acad. Sci. USA 99:3684-3689.
9. Brusasca, P. N., R. Colangeli, K. P. Lyashchenko, X. Zhao, M. Vogelstein, J. S. Spencer, D. N. McMurray, and M. L. Gennaro. 2001. Immunological characterization of antigens encoded by the RD1 region of the Mycobacterium tuberculosis genome. Scand. J. Immunol. 54:448-452.
10. Cockle, P. J., S. V. Gordon, A. Lalvani, B. M. Buddle, R. G. Hewinson, and H. M Vordermeier. 2002. Identification of novel Mycobacterium tuberculosis antigens with potential as diagnostic reagents or subunit vaccine candidates by comparative genomics. Infect. Immun. 70:6996-7003.
11. Cole, S. T., R. Brosch, J. Parkhill, T. Garnier, C. Churcher, D. Harris, S. V. Gordon, K. Eiglmeier, S. Gas, C. E. Barry, 3rd, F. Tekaia, K. Badcock, D. Basham, D. Brown, T. Chillingworth, R. Connor, R. Davies, K. Devlin, T. Feltwell, S. Gentles, N. Hamlin, S. Holroyd, T. Hornsby, K. Jagels, A. Krogh, J. Mclean, S. Moule, L. Murphy, K. Oliver, J. Osborne, M. A. Quail, M.-A. Rajandream, J. Rogers, S. Rutter, K. Seeger, J. Skelton, R. Squares, S. Squares, J. E. Sulston, K. Taylor, S. Whitehead, and B. G. Barrell. 1998. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393:537-544.
12. Daborn, C. J., and J. M. Grange. 1993. HIV/AIDS and its implications for the control of animal tuberculosis. Br. Vet. J. 149:405-417.
13. Dillon, D. C., M. R. Alderson, C. H. Day, T. Bement, A. Campos-Neto, Y. A. Skeiky, T. Vedvick, R. Badaro, S. G. Reed, and R. Houghton. 2000. Molecular and immunological characterization of Mycobacterium tuberculosis CFP-10, an immunodiagnostic antigen missing in Mycobacterium bovis BCG. J. Clin. Microbiol. 38:3285-3290.
14. Dolin, P. J., M. C. Raviglione, and A. Kochi. 1994. Global tuberculosis incidence and mortality during 1990-2000. Bull. W.H.O. 72:213-220.
15. Gomez, M., S. Johnson, and M. L. Gennaro. 2000. Identification of secreted proteins of Mycobacterium tuberculosis by a bioinformatic approach. Infect. Immun. 68:2323-2327.
16. Gordon, S. V., R. Brosch, A. Billault, T. Garnier, K. Eiglmeier, and S. T. Cole. 1999. Identification of variable regions in the genomes of tubercle bacilli with bacterial artificial chromosome arrays. Mol. Microbiol. 32:643-655.
17. Grosse, W. M., S. M. Kappes, W. W. Laegreid, J. W. Keele, C. G. Chitko-McKown, and M. P. Heaton. 1999. Single nucleotide polymorphism (SNP) discovery and linkage mapping of bovine cytokine genes. Mamm. Genome 10:1062-1069.
18. Harboe, M., A. S. Malin, H. S. Dockrell, H. G. Wiker, G. Ulvund, A. Holm, M. C. Jorgensen, and P. Andersen. 1998. B-cell epitopes and quantification of the ESAT-6 protein of Mycobacterium tuberculosis. Infect. Immun. 66: 717-723.
19. Harboe, M., T. Oettinger, H. G. Wiker, I. Rosenkrands, and P. Andersen. 1996. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect. Immun. 64:16-22.
20. Harth, G., B. Y. Lee, and M. A. Horwitz. 1997. High-level heterologous expression and secretion in rapidly growing nonpathogenic mycobacteria of four major Mycobacterium tuberculosis extracellular proteins considered to be leading vaccine candidates and drug targets. Infect. Immun. 65:2321-2328.
21. Jungblut, P. R., U. E. Schaible, H. J. Mollenkopf, U. Zimny-Arndt, B. Raupach, J. Mattow, P. Halada, S. Lamer, K. Hagens, and S. H. Kaufmann. 1999. Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens. Mol. Microbiol. 33:1103-1117.
22. Krebs, J., R. Anderson, T. Clutton-Brock, I. Morrison, D. Young, and C. Donnely. 1997. Bovine tuberculosis in cattle and badgers: report to the Rt. Hon. Dr. Jack Cunningham MP. MAFF Publications, London, UK.
23. Lewin, H. A., G. C. Russell, and E. J. Glass. 1999. Comparative organization and function of the major histocompatibility complex of domesticated cattle. Immunol. Rev. 167:145-158.
24. Mahairas, G. G., P. J. Sabo, M. J. Hickey, D. C. Singh, and C. K. Stover. 1996. Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M. bovis. J. Bacteriol. 178:1274-1282.
25. Monaghan, M. L., M. L. Doherty, J. D. Collins, J. F. Kazda, and P. J. Quinn. 1994. The tuberculin test. Vet. Microbiol. 40:111-124.
26. Monahan, I. M., J. Betts, D. K. Banerjee, and P. D. Butcher. 2001. Differential expression of mycobacterial proteins following phagocytosis by macrophages. Microbiology 147:459-471.
27. Neill, S. D., J. Hanna, J. J. O'Brien, and R. M. McCracken. 1988. Excretion of Mycobacterium bovis by experimentally infected cattle. Vet. Rec. 123:340-343.
28. O'Reilly, L. M., and C. J. Daborn. 1995. The epidemiology of Mycobacterium bovis infections in animals and man: a review. Tuberc. Lung Dis. 76(Suppl. 1):1-46.
29. Pallen, M. J. 2002. The ESAT-6/WXG100 superfamily-and a new Gram-positive secretion system? Trends Microbiol. 10:209-212.
30. Pollock, J. M., and P. Andersen. 1997. The potential of the ESAT-6 antigen secreted by virulent mycobacteria for specific diagnosis of tuberculosis. J. Infect. Dis. 175:1251-1254.
31. Pollock, J. M., and P. Andersen. 1997. Predominant recognition of the ESAT-6 protein in the first phase of interferon with Mycobacterium bovis in cattle. Infect. Immun. 65:2587-2592.
32. Pollock, J. M., A. J. Douglas, D. P. Mackie, and S. D. Neill. 1994. Identification of bovine T-cell epitopes for three Mycobacterium bovis antigens: MPB70, 19, 000 MW and MPB57. Immunology 82:9-15.
33. Pollock, J. M., A. J. Douglas, D. P. Mackie, and S. D. Neill. 1995. Peptide mapping of bovine T-cell epitopes for the 38 kDa tuberculosis antigen. Scand. J. Immunol. 41:85-93.
34. Renshaw, P. S., P. Panagiotidou, A. Whelan, S. V. Gordon, R. G. Hewinson, R. A. Williamson, and M. D. Carr. 2002. Conclusive evidence that the major T-cell antigens of the Mycobacterium tuberculosis complex ESAT-6 and CFP-10 form a tight, 1:1 complex and characterization of the structural properties of ESAT-6, CFP-10, and the ESAT-6*CFP-10 complex. Implications for pathogenesis and virulence. J. Biol. Chem. 277:21598-21603.
35. Romain, F., C. Horn, P. Pescher, A. Namane, M. Riviere, G. Puzo, O. Barzu, and G. Marchal. 1999. Deglycosylation of the 45/47-kilodalton antigen complex of Mycobacterium tuberculosis decreases its capacity to elicit in vivo or in vitro cellular immune responses. Infect. Immun. 67:5567-5572.
36. Rosenkrands, I., A. King, K. Weldingh, M. Moniatte, E. Moertz, and P. Andersen. 2000. Towards the proteome of Mycobacterium tuberculosis. Electrophoresis 21:3740-3756.
37. Rosenkrands, I., R. A. Slayden, J. Crawford, C. Aagaard, C. E. Barry, 3rd, and P. Andersen. 2002. Hypoxic response of Mycobacterium tuberculosis studied by metabolic labeling and proteome analysis of cellular and extracellular proteins. J. Bacteriol. 184:3485-3491.
38. Sherman, D. R., M. Voskuil, D. Schnappinger, R. Liao, M. I. Harrell, and G. K. Schoolnik. 2001. Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin. Proc. Natl. Acad. Sci. USA 98: 7534-7539.
39. Skjøt, L. R. M., E. M. Agger, and P. Andersen. 2001. Antigen discovery and tuberculosis vaccine development in the post-genomic era. Scand. J. Infect. Dis. 33:643-647.
40. Skjot, R. L., T. Oettinger, I. Rosenkrands, P. Ravn, I. Brock, S. Jacobsen, and P. Andersen. 2000. Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens. Infect. Immun. 68:214-220.
41. Sorensen A. L., S. Nagai, G. Houen, P. Andersen, and Å. B. Andersen. 1995. Purification and characterization of a low-molecular-mass T-cell antigen secreted by Mycobacterium tuberculosis.Infect. Immun. 63:1710-1717.
42. van Pinxteren, L. A., P. Ravn, E. M. Agger, J. Pollock, and P. Andersen. 2000. Diagnosis of tuberculosis based on the two specific antigens ESAT-6 and CFP10. Clin. Diagn. Lab. Immunol. 7:155-160.
43. Vordermeier, H. M., D. P. Harris, R. Lathigra, E. Roman, C. Moreno, and J. Ivanyi. 1993. Recognition of peptide epitopes of the 16, 000 MW antigen of Mycobacterium tuberculosis by murine T cells. Immunology 80:6-12.
44. Weynants, V., J. Godfroid, B. Limbourg, C. Saegerman, and J. J. Letesson. 1995. Specific bovine brucellosis diagnosis based on in vitro antigen-specific gamma interferon production. J. Clin. Microbiol. 3:706-712.
45. Wilkinson, R. J., K. A. Wilkinson, K. A. De Smet, K. Haslov, G. Pasvol, M. Singh, I. Svarcova, and J. Ivanyi. 1998. Human T- and B-cell reactivity to the 16kDa alpha-crystallin protein of Mycobacterium tuberculosis. Scand. J. Immunol. 48:403-409.
46. Wood P.R., L.A. Corner, and P. Plackett. 1990. Development of a simple, rapid in vitro cellular assay for bovine tuberculosis based on the production of gamma interferon. Res. Vet. Sci. 49:46-49.