Synthesis and binding selectivity of 7- and 15-decylbenzolactone-V8 for the C1 domains of protein kinase C isozymes

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 18, 2003, Pages 3015-3019

  Nakagawa, Yu ^a   Irie, Kazuhiro ^a   Yamanaka, Nobuhiro ^a   Ohigashi, Hajime ^a   Tsuda, Ken Ichiro ^b  

^a KYOTO UNIVERSITY   (Japan)

^b NEC CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 DECYLBENZOLACTONE V8; 7 DECYLBENZOLACTONE V8; 8 DECYLBENZOLACTONE V8; 9 DECYLBENZOLACTONE V8; ISOENZYME; LACTONE DERIVATIVE; PEPTIDE; PROTEIN KINASE C; PROTEIN KINASE C EPSILON; PROTEIN KINASE C ETA; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG EFFECT; DRUG EFFICACY; DRUG SELECTIVITY; DRUG SYNTHESIS; HYDROPHOBICITY; PROTEIN DOMAIN;

EID: 0042510624     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00637-1     Document Type: Article

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22. abstract
23. abstract
24. 3CN, 0.071 M, 27°C) δ 0.87 (3H, t, J=7.0 Hz), 0.98 (3H, d, J=6.6 Hz), 1.08 (3H, d, J=6.7 Hz), 1.15-1.30 (18H, m), 2.28 (1H, m), 2.65 (1H, dd, J=13.1, 2.7 Hz), 2.88 (1H, m), 2.96 (2H, m), 3.12 (1H, d, J=9.3 Hz), 3.40 (1H, br.d, J=5.2 Hz), 3.85 (1H, dd, J=11.1, 5.4 Hz), 4.06 (1H, m), 4.40 (1H, br.s), 7.12-7.24 (4H, m).
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