An in vitro Flaviviridae replicase system capable of authentic RNA replication

Virology

Volumn 313, Issue 1, 2003, Pages 274-285

  Tomassini, J E ^a   Boots, E ^a   Gan, L ^b   Graham, P ^a   Munshi, V ^a   Wolanski, B ^a   Fay, J F ^a   Getty, K ^a   LaFemina, R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Bovine viral diarrhea virus (BVDV); Flaviviridae; Replication complexes

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; HEPARIN; PROTEIN; PROTEIN INHIBITOR; PROTEIN NS5B; RNA DIRECTED RNA POLYMERASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CATTLE DISEASE; ENZYME ACTIVITY; FLAVIVIRUS; HEPATITIS C VIRUS; IN VITRO STUDY; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RECYCLING; REGULATORY MECHANISM; RNA REPLICATION; VIRUS REPLICATION;

BOVINAE; BOVINE VIRAL DIARRHEA VIRUS 1; FLAVIVIRIDAE; HEPATITIS C VIRUS;

EID: 0042388766     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0042-6822(03)00314-3     Document Type: Article

References (30)

1. Arnold J.J., Cameron C.E. Poliovirus RNA-dependent RNA polymerase (3Dpol) is sufficient for template switching in vitro. J. Biol. Chem. 274:1999;2706-2716.
2. Baginski S.G., Pevear D.C., Seipel M., Sun S.C.C., Benetatos C.A., Chunduru S.K., Rice C.M., Collett M.S. Mechanism of action of a pestivirus antiviral compound. Proc. Natl. Acad. Sci. USA. 97:2000;7981-7986.
3. Behrens S.-E., Tomei L., DeFrancesco R. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15:1996;12-22.
4. Bienz K., Egger D., Pfister T., Troxler M. Structural and functional characterization of the poliovirus replication complex. J. Virol. 66:1992;2740-2747.
5. Carroll S.J., Sardana V., Yang Z., Jacobs A.R., Mizenko C., Hall D., Hill L., Zugay-Murphy J., Kuo L.C. Only a small fraction of purified hepatitis C RNA-dependent RNA polymerase is catalytically competent implications for viral replication and in vitro assays . Biochemistry. 39:2000;8243-8249.
6. Chu P.W.G., Westaway E.G. Replication strategy of Kunjin virus evidence for recycling role of replicative form RNA as template in semiconservative and asymmetric replication . Virology. 140:1985;68-79.
7. Chu P.W.G., Westaway E.G. Characterization of Kunjin virus RNA-dependent RNA polymerase reinitiation of synthesis in vitro . Virology. 157:1987;330-337.
8. Chu P.W.G., Westaway E.G. Molecular and ultrastructural analysis of heavy membrane fractions associated with the replication of Kunjin virus and RNA. Arch. Virol. 125:1992;177-191.
9. Egger D., Pasamontes L., Bolten R., Boyko V., Bienz K. Reversible dissociation of the poliovirus replication complex functions and interactions of its components in viral RNA synthesis . J. Virol. 70:1996;8675-8683.
10. Frolov I., McBride M.S., Rice C.M. Cis-acting RNA elements required for replication of bovine viral diarrhea virus-hepatitis C virus 5′ non-translated region chimeras. RNA. 4:1998;1418-1435.
11. Gladych J.M.Z., Hornby R., Hunt J.H., Jack D., Boyle J.J., Ferlauto R.F., Kormendy C.G., Stanfield F.J., Stewart R.C. Antiviral agents. 5H-as-triazino [5,6-b] indoles. J. Med. Chem. 15:1972;277-279.
12. Gong Y., Trowbridge R., Macnaughton T.B., Westaway E.G., Shannon A.D., Gowans E.J. Characterization of RNA synthesis during a one-step growth curve and of the replication mechanism of bovine viral diarrhoea virus. J. Gen. Virol. 77:1996;2729-2736.
13. Gong Y., Shannon A., Westaway E.G., Gowans E.J. The replicative intermediate molecule of bovine viral diarrhoea virus contains multiple nascent strands. Arch. Virol. 143:1998;399-404.
14. Grassmann C.W., Isken O., Behrens S.-E. Assignment of the multifunctional NS3 protein of bovine viral diarrhea virus during RNA replication an in vivo and in vitro study . J. Virol. 73:1999;9196-9205.
15. Grun J.B., Brinton M.A. Characterization of West Nile virus RNA-dependent RNA polymerase and cellular terminal adenylyl and uridylyl transferases in cell-free extracts. J. Virol. 60:1986;1113-1124.
16. Hong, Z., Cameron, C.E., Walker, M.P., M.P., Castro, C., Yao, N., Lau, J.Y.N., Zhong, W. (2001). A novel mechanism to ensure terminal initiation by hepatitis C virus NS5B polymerase. Virology, 285, 6-11.
17. Kao C.C., Del Vecchio A.M., Zhong W. De novo initiation of RNA synthesis by a recombinant flaviridae RNA-dependent RNA polymerase. Virology. 253:1999;1-7.
18. Lai V.C.H., Kao C.C., Ferrari E., Park J., Uss A.S., Wright-Minogue J., Hong Z., Lau J.Y.N. Mutational analysis of bovine viral diarrhea virus RNA-dependent RNA polymerase. J. Virol. 73:1999;10129-10136.
19. Lindenbach B.D., Rice C.M. Flaviviridae. Knipe D.M., Howley P. Fields Virology the viruses and their replication . 4th ed. 2001;991-1041 Lippincott, Williams &, Wilkins, Philadelphia.
20. Luo, G., Hamatake, R., K., Mathin, D.M., Racel, J., Rigat, K.L., Lemm, J., Colonno, R.J. (2000). De novo initiation of RNA synthesis by the RNA-dependent RNA polymerase (NS5b) of hepatitis C virus. J. Virol. 74, 851-863.
21. Neufeld K.L., Richards O.C., Ehrenfeld E. Purification, characterization and comparison of poliovirus RNA polymerase from native and recombinant sources. J. Biol. Chem. 266:1991;24212-24219.
22. Paul A.V., Reider E., Kim D.W., van Boom J.H., Wimmer E. Identification of an RNA hairpin in poliovirus RNA that serves as the primary template in the in vitro uridylylation of VPg. J. Virol. 74:2000;10359-10370.
23. Racaniello V.R. Picornaviridae. Knipe D., Howley P. Fields Virology the viruses and their replication . 4th ed. 2001;685-722 Lippincott, Williams & Wilkins, Philadelphia.
24. Ranjuith-Kumar C.T., Gutshall L., Kim Min-J.u, Sarisky R.T., Kao C.C. Requirements for de novo initiation of RNA synthesis by recombinant Flaviviral RNA-dependent RNA polymerases. J. Virol. 76:2002;12526-12536.
25. Reider E., Paul A.V., Kim D.W., van Boom J.H., Wimmer E. Genetic and biochemical studies of poliovirus cis-acting replication element cre in relation to VPg uridylylation. J. Virol. 74:2000;10371-10380.
26. Takeda N., Kuhn R.J., Yang C.-F., Takegami T., Wimmer E. Initiation of poliovirus plus-strand RNA synthesis in a membrane complex of infected HeLa cells. J. Virol. 60:1986;43-53.
27. Takegami T., Kuhn R.J., Anderson C.W., Wimmer E. Membrane-dependent uridylylation of the genome-linked protein VPg of poliovirus. Biochemistry. 80:1983;7447-7451.
28. Warrilow D., Lott W.B., Greive S., Gowans E.J. Properties of the bovine viral diarrhoea virus replicase in extracts of infected MDBK cells. Arch. Virol. 145:2000;2163-2171.
29. Westaway E.G., Khromykh A.A., Mackenzie J.M. Nascent flavivirus RNA colocalized in situ with double-stranded RNA in stable replication complexes. Virology. 258:1999;108-117.
30. Zhong W., Gutshall L.L., Del Vecchio A.M. Identification and characterization of an RNA-Dependent RNA polymerase activity within the nonstructural protein 5B region of bovine viral diarrhea virus. J. Virol. 72:1998;9365-9369.