Assignment of the multifunctional NS3 protein of bovine viral diarrhea virus during RNA replication: An in vivo and in vitro study

Journal of Virology

Volumn 73, Issue 11, 1999, Pages 9196-9205

  Grassmann, Claus W ^a   Isken, Olaf ^a   Behrens, Sven Erik ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; DIARRHEA; NONHUMAN; PESTIVIRUS; PRIORITY JOURNAL; RNA REPLICATION; VIRUS GENOME;

EID: 0032853360     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.73.11.9196-9205.1999     Document Type: Article

References (60)

1. Barton, D. J., and J. B. Flanegan. 1993. Coupled translation and replication of poliovirus RNA in vitro: synthesis of functional 3D polymerase and infectious virus. J. Virol. 67:822-831.
2. Behrens, S.-E., L. Tomei, and R. De Francesco. 1996. Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J. 15:12-22.
3. Behrens, S.-E., C. W. Grassmann, H.-J. Thiel, G. Meyers, and N. Tautz. 1998. Characterization of an autonomous subgenomic RNA replicon of a pestivirus. J. Virol. 72:2364-2372.
4. Bernstein, H. D., P. Sarnow, and D. Baltimore. 1986. Genetic complementation among poliovirus mutants derived from an infectious cDNA clone. J. Virol. 60:1040-1049.
5. Black, M. E., and D. E. Hruby. 1992. Site-directed mutagenesis of a conserved domain in vaccinia virus thymidine kinase. Evidence for a potential role in magnesium binding. J. Biol. Chem. 267:6801-6806.
6. Bredenbeek, P., and C. M. Rice. 1992. Animal RNA virus expression systems. Semin. Virol. 3:297-310.
7. Brosh, R. M., Jr., and S. W. Matson. 1995. Mutations in motif II of Escherichia coli DNA helicase II render the enzyme nonfunctional in both mismatch repair and excision repair with differential effects on the unwinding reaction. J. Bacteriol. 177:5612-5621.
8. Charini, W. A., C. C. Burns, E. Ehrenfeld, and B. L. Semler. 1991. trans rescue of a mutant poliovirus RNA polymerase function. J. Virol. 65:2655-2665.
9. Cho, H.-S., N.-C. Ha, L.-W. Kang, K. M. Chung, S. H. Back, S. K. Jang, and B.-H. Oh. 1998. Crystal structure of the RNA helicase from genotype IB hepatitis C virus. A feasible mechanism of unwinding duplex RNA. J. Biol. Chem. 273:15045-15052.
10. Corapi, W. V., R. O. Donis, and E. J. Dubovi. 1990. Characterization of a panel of monoclonal antibodies and their use in the study of the antigenic diversity of bovine viral diarrhea virus. Am. J. Vet. Res. 51:1388-1394.
11. Francki, R. I., D. L. Fauquet, D. L. Knudson, and F. Brown. 1991. Classification and nomenclature of viruses. Arch. Virol. Suppl. 2:223-233.
12. George, J. W., R. M. Brosh, Jr., and S. W. Matson. 1994. A dominant negative allele of the Escherichia coli uvrD gene encoding DNA helicase II. A biochemical and genetic characterization. J. Mol. Biol. 235:424-435.
13. Gorbalenya, A. E., A. P. Donchenko, V. Koonin, and V. M. Blinov. 1988. A conserved NTP-motif in putative helicases. Nature (London) 333:22.
14. Gorbalenya, A. E., A. P. Donchenko, V. Koonin, and V. M. Blinov. 1989. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res. 17:4713-4729.
15. Gorbalenya, A. E., and E. V. Koonin. 1993. Helicases: amino acid sequence comparisons and structure-function relationships. Curr. Opin. Struct. Biol. 3:419-429.
16. Grassmann, C. W. Unpublished results.
17. Gross, C. H., and S. Shuman. 1995. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase. J. Virol. 69:4727-4736.
18. Gwack, Y., D. W. Kim, J. H. Han, and J. Choe. 1996. Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein. Biochem. Biophys. Res. Commun. 225:654-659.
19. Heilek, G. M., and M. G. Peterson. 1997. A point mutation abolishes the helicase but not the nucleoside triphosphatase activity of hepatitis C virus NS3 protein. J. Virol. 71:6264-6266.
20. Hodgman, T. 1988, A new superfamily of replicative proteins. Nature (London) 333:22-23.
21. Hong, Z., E. Ferrari, J. Wright-Minogue, R. Chase, C. Risano, G. Seelig, C. G. Lee, and A. D. Kwong. 1996. Enzymatic characterization of hepatitis C virus NS3/4A complexes expressed in mammalian cells by using the herpes simplex virus amplicon system. J. Virol. 70:4261-4268.
22. Jin, L., and D. L. Petterson. 1995. Expression, isolation, and characterization of the hepatitis C virus ATPase/RNA helicase. Arch. Biochem. Biophys. 323:47-53.
23. Johnson, K. L., and P. Sarnow. 1991. Three poliovirus 2B mutants exhibit noncomplementable defects in viral RNA amplification and display dosage-dependent dominance over wild-type poliovirus. J. Virol. 65:4341-4349.
24. Kadare, G., and A. Haenni. 1997. Virus-encoded helicases. J. Virol. 71:2583-2590.
25. Kamer, G., and P. Argos. 1984. Primary structural comparison of RNA-dependent polymerases from plant, animal, and bacterial viruses. Nucleic Acids Res. 12:7269-7282.
26. Kim, D. W., J. Kim, Y. Gwack, J. H. Han, and J. Choe. 1997. Mutational analysis of the hepatitis C virus RNA helicase. J. Virol. 71:9400-9409.
27. Kim, J. L., K. A. Morgenstern, J. P. Griffith, M. D. Dwyer, J. A. Thomson, M. A. Murcko, C. Lin, and P. R. Caron. 1998. Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding. Structure 6:89-100.
28. Laín, S., J. L. Riechmann, and J. A. García. 1989. RNA helicase: a novel activity associated with a protein encoded by a positive-strand RNA virus. Nucleic Acids Res. 18:7003-7006.
29. Mendez, E., N. Ruggli, M. S. Collett, and C. M. Rice. 1998. Infectious bovine viral diarrhea virus (strain NADL) RNA from stable cDNA clones: a cellular insert determines NS3 production and viral cytopathogenicity. J. Virol. 72: 4737-1745.
30. Meyers, G., N. Tautz, P. Becher, H.-J. Thiel, and B. M. Kümmerer. 1996. Recovery of cytopathogenic and noncytopathogenic bovine viral diarrhea viruses from cDNA constructs. J. Virol. 70:8606-8613.
31. Miller, R. H., and R. H. Purcell. 1990. Hepatitis C virus shares amino acid sequence similarity with pestivirus and flavivirus as well as members of two plant virus supergroups. Proc. Natl. Acad. Sci. USA 87:2057-2061.
32. Molla, A, A. V. Paul, and E. Wimmer. 1991. Cell-free, de novo synthesis of poliovirus. Science 254:1647-1651.
33. Morgenstern, K. A., J. A. Landro, K. Hsiao, C. Lin, Y. Gu, M. S. Su, and J. A. Thomson. 1997. Polynucleotide modulation of the protease, nucleoside triphosphatase, and helicase activities of a hepatitis C virus NS3-NS4A complex isolated from transfected COS cells. J. Virol. 71:3767-3775.
34. Novak, J. E., and K. Kirkegaard. 1994. Coupling between genome translation and replication in an RNA-virus. Genes Dev. 8:1726-1737.
35. Pause, A., and N. Sonenberg. 1992. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. EMBO J. 11:2643-2654.
36. Preugschat, F., D. R. Averett, B. E. Clarke, and D. J. T. Porter. 1996. A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain. J. Biol. Chem. 271:24449-24457.
37. Rice, C. M. 1996. Flaviviridae: the viruses and their replication, p. 931-959. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology. Raven Press, Philadelphia, Pa.
38. Sauerborn, M. Personal communication.
39. Steffens, S., H.-J. Thiel, and S.-E. Behrens. The RNA-dependent RNA polymerases of different members of the Flaviviridae family exhibit similar properties under in vitro conditions. J. Gen. Virol., in press.
40. Suzich, J. A., J. K. Tamura, F. Palmer-Hill, P. Warrener, A. Grakoui, C. M. Rice, S. M. Feinstone, and M. S. Collett. 1993. Hepatitis C virus NS3 protein: polynucleotide-stimulated NTPase and comparison with the related pestivirus and flavivirus enzymes. J. Virol. 67:6152-6158.
41. Tai, C. L., W. K. Chi, D. S. Chen, and L. H. Hwang. 1996. The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J. Virol. 70:8477-8484.
42. Tamura, J. K., P. Warrener, and M. S. Collett. 1993. RNA-stimulated NTPase activity associated with the p80 protein of the pestivirus bovine viral diarrhea virus. Virology 193:1-10.
43. Tan, B.-H., J. Fu, R. J. Sugrue, E.-H. Yap, Y.-C. Chan, and Y. H. Tan. 1996. Recombinant Dengue type 1 virus NS5 protein expressed in E. coli exhibits RNA-dependent RNA polymerase activity. Virology 216:317-315.
44. Tautz, N. Unpublished results.
45. Tautz, N., H.-J. Thiel, E. J. Dubovi, and G. Meyers. 1994. Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion. J. Virol. 68:3289-3297.
46. Tautz, N., G. Meyers, R. Stark, E. J. Dubovi, and H.-J. Thiel. 1996. Cytopathogenicity of a pestivirus correlates with a 27-nudeotide insertion. J. Virol. 70:7851-7858.
47. Tautz, N., K. Elbers, D. Stoll, G. Meyers, and H.-J. Thiel. 1997. Serine protease of pestiviruses: determination of cleavage sites. J. Virol. 71:5415-5422.
48. Thiel, H.-J., P. G. W. Plagemann, and V. Moennig. 1996. Pestiviruses, p. 1059-1074. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields virology. Raven Press, Philadelphia, Pa.
49. Vassilev, V. B., M. S. Collett, and R. O. Donis. 1997. Authentic and chimeric full-length genomic cDNA clones of bovine viral diarrhea virus that yield infectious transcripts. J. Virol. 71:451-457.
50. Walker, J. E., M. Saraste, M. J. Runswick, and N. J. Gay. 1982. Distantly related sequences in the alpha and beta subunits of ATP synthase, myosin kinases and other ATP-requiring enzymes and a common nucleotide binding fold. EMBO J. 1:945-951.
51. Warrarer, P., and M. S. Collett. 1995. Pestivirus NS3 (p80) protein possesses RNA helicase activity. J. Virol. 69:1720-1726.
52. Wengler, G., and G. Wengler. 1991. The carboxy-terminal part of the NS3 protein of the West Nile flavivirus can be located as soluble protein after proteolytic cleavage and represents an RNA-stimulated NTPase. Virology 184:309-319.
53. Wimmer, E., C. U. T. Hellen, and X. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27:453-436.
54. Wiskerchen, M., S. K. Belzer, and M. S. Collett. 1991. Pestivirus gene expression: the first protein product of the bovine viral diarrhea virus large open reading frame, p20, possesses proteolytic activity. J. Virol. 65:4508-4514.
55. Wiskerchen, M., and M. S. Collett. 1991. Pestivirus gene expression: protein p80 of bovine viral diarrhea virus is a proteinase involved in polyprotein processing. Virology 184:341-350.
56. Xu, J., E. Mendez, P. R. Caron, C. Lin, M. A. Murcko, M. S. Collett, and C. M. Rice. 1997. Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication. J. Virol. 71:5312-5322.
57. 2+ by site-directed mutagenesis and proton, phosphorus-31, and magnesium-25 NMR. Biochemistry 30:5539-5546.
58. Yao, N., T. Hesson, M. Cable, Z. Hong, A. D. Kwong, H. V. Le, and P. C. Weber. 1997. Structure of the hepatitis C virus RNA helicase domain. Nat. Struct. Biol. 4:463-467.
59. Yu, H., C. W. Grassmann, and S.-E. Behrens. 1999. Sequence and structural elements at the 3' terminus of bovine viral diarrhea virus genomic RNA: functional role during RNA replication. J. Virol. 73:3638-3648.
60. Zhong, W., L. L. Gutshall, and A. M. Del Vecchio. 1998. Identification and characterization of an RNA-dependent RNA polymerase activity within the nonstructural protein 5B region of bovine viral diarrhea virus. J. Virol. 72:9365-9369.