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Volumn 18, Issue 9, 2003, Pages 1689-1692

Ciliary function of polycystins: A new model for cystogenesis

Author keywords

Autosomal dominant polycystic kidney disease; Polycystins cation channels; Primary cilia

Indexed keywords

BETA CATENIN; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; POLYCYSTIN; PROTEIN P21; RYANODINE RECEPTOR; STAT1 PROTEIN; TAXANE DERIVATIVE; WNT PROTEIN;

EID: 0042385071     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg256     Document Type: Editorial
Times cited : (23)

References (35)
  • 1
    • 0035079832 scopus 로고    scopus 로고
    • Polycystin: New aspects of structure, function, and regulation
    • Wilson PD. Polycystin: new aspects of structure, function, and regulation. J Am Soc Nephrol 2001; 12: 834-845
    • (2001) J. Am. Soc. Nephrol. , vol.12 , pp. 834-845
    • Wilson, P.D.1
  • 2
    • 0034700483 scopus 로고    scopus 로고
    • Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents
    • Hanaoka K, Qian F, Boletta A et al. Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents. Nature 2000; 408: 990-994
    • (2000) Nature , vol.408 , pp. 990-994
    • Hanaoka, K.1    Qian, F.2    Boletta, A.3
  • 3
    • 0036151534 scopus 로고    scopus 로고
    • Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells
    • Scheffers MS, Le H, van der Bent P et al. Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells. Hum Mol Genet 2002; 11: 59-67
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 59-67
    • Scheffers, M.S.1    Le, H.2    van der Bent, P.3
  • 4
    • 0037317302 scopus 로고    scopus 로고
    • Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
    • Nauli SM, Alenghat FJ, Luo Y et al. Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells. Nat Genet 2003; 33: 123-135
    • (2003) Nat. Genet. , vol.33 , pp. 123-135
    • Nauli, S.M.1    Alenghat, F.J.2    Luo, Y.3
  • 5
    • 0029586470 scopus 로고
    • Primary cilia in normal and pathological tissues
    • Wheatley DN. Primary cilia in normal and pathological tissues. Pathobiology 1995; 63: 222-238
    • (1995) Pathobiology , vol.63 , pp. 222-238
    • Wheatley, D.N.1
  • 6
    • 18144444613 scopus 로고
    • Flexible-substratum technique for viewing cells from the side: Some in vivo properties of primary (9+0) cilia in cultured kidney epithelia
    • Roth KE, Rieder CL, Bowser SS. Flexible-substratum technique for viewing cells from the side: some in vivo properties of primary (9+0) cilia in cultured kidney epithelia. J Cell Sci 1988; 89: 457-466
    • (1988) J. Cell Sci. , vol.89 , pp. 457-466
    • Roth, K.E.1    Rieder, C.L.2    Bowser, S.S.3
  • 7
    • 0033598394 scopus 로고    scopus 로고
    • A polycystic kidney-disease gene homologue required for male mating behaviour in C.elegans
    • Barr MM, Sternberg PW. A polycystic kidney-disease gene homologue required for male mating behaviour in C.elegans. Nature 1999; 401: 386-389
    • (1999) Nature , vol.401 , pp. 386-389
    • Barr, M.M.1    Sternberg, P.W.2
  • 8
    • 0035806961 scopus 로고    scopus 로고
    • The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway
    • Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW. The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol 2001; 11: 1341-1346
    • (2001) Curr. Biol. , vol.11 , pp. 1341-1346
    • Barr, M.M.1    DeModena, J.2    Braun, D.3    Nguyen, C.Q.4    Hall, D.H.5    Sternberg, P.W.6
  • 9
    • 0034987372 scopus 로고    scopus 로고
    • The C.elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms
    • Haycraft CJ, Swoboda P, Taulman PD, Thomas JH, Yoder BK. The C.elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 2001; 128: 1493-1505
    • (2001) Development , vol.128 , pp. 1493-1505
    • Haycraft, C.J.1    Swoboda, P.2    Taulman, P.D.3    Thomas, J.H.4    Yoder, B.K.5
  • 10
    • 0034042763 scopus 로고    scopus 로고
    • The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination
    • Murcia NS, Richards WG, Yoder BK, Mucenski ML, Dunlap JR, Woychik RP. The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development 2000; 127: 2347-2355
    • (2000) Development , vol.127 , pp. 2347-2355
    • Murcia, N.S.1    Richards, W.G.2    Yoder, B.K.3    Mucenski, M.L.4    Dunlap, J.R.5    Woychik, R.P.6
  • 11
    • 0034735526 scopus 로고    scopus 로고
    • Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    • Pazour GJ, Dickert BL, Vucica Y et al. Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 2000; 151: 709-718
    • (2000) J. Cell Biol. , vol.151 , pp. 709-718
    • Pazour, G.J.1    Dickert, B.L.2    Vucica, Y.3
  • 12
    • 0035159015 scopus 로고    scopus 로고
    • Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia
    • Taulman PD, Haycraft CJ, Balkovetz; DF, Yoder BK. Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia. Mol Biol Cell 2001; 12: 589-599
    • (2001) Mol. Biol. Cell , vol.12 , pp. 589-599
    • Taulman, P.D.1    Haycraft, C.J.2    Balkovetz, D.F.3    Yoder, B.K.4
  • 13
    • 0032504963 scopus 로고    scopus 로고
    • Cloning of inv, a gene that controls left/right asymmetry and kidney development
    • Mochizuki T, Saijoh Y, Tsuchiya K et al. Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature 1998; 395: 177-181
    • (1998) Nature , vol.395 , pp. 177-181
    • Mochizuki, T.1    Saijoh, Y.2    Tsuchiya, K.3
  • 14
    • 0037115494 scopus 로고    scopus 로고
    • Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle
    • Morgan D, Eley L, Sayer J et al. Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle. Hum Mol Genet 2002; 11: 3345-3350
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 3345-3350
    • Morgan, D.1    Eley, L.2    Sayer, J.3
  • 15
    • 0036177603 scopus 로고    scopus 로고
    • Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease
    • Hou X, Mrug M, Yoder BK et al. Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest 2002; 109: 533-540
    • (2002) J. Clin. Invest. , vol.109 , pp. 533-540
    • Hou, X.1    Mrug, M.2    Yoder, B.K.3
  • 16
    • 0037018850 scopus 로고    scopus 로고
    • The ion channel polycystin-2 is required for left-right axis determination in mice
    • Pennekamp P, Karcher C, Fischer A et al. The ion channel polycystin-2 is required for left-right axis determination in mice. Curr Biol 2002; 12: 938-943
    • (2002) Curr. Biol. , vol.12 , pp. 938-943
    • Pennekamp, P.1    Karcher, C.2    Fischer, A.3
  • 17
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease
    • Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB. Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol 2002; 12: R378-R380
    • (2002) Curr. Biol. , vol.12
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3    Rosenbaum, J.L.4    Witman, G.B.5
  • 18
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • Yoder BK, Hou X, Guay-Woodford LM. The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 2002; 13: 2508-2516
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3
  • 19
    • 0030845225 scopus 로고    scopus 로고
    • Analysis and modeling of the primary cilium bending response to fluid shear
    • Schwartz EA, Leonard ML, Bizios R, Bowser SS. Analysis and modeling of the primary cilium bending response to fluid shear. Am J Physiol 1997; 272: F132-F138
    • (1997) Am. J. Physiol. , vol.272
    • Schwartz, E.A.1    Leonard, M.L.2    Bizios, R.3    Bowser, S.S.4
  • 20
    • 0035498717 scopus 로고    scopus 로고
    • Bending the MDCK cell primary cilium increases intracellular calcium
    • Praetorius HA, Spring KR. Bending the MDCK cell primary cilium increases intracellular calcium. J Membr Biol 2001; 184: 71-79
    • (2001) J. Membr. Biol. , vol.184 , pp. 71-79
    • Praetorius, H.A.1    Spring, K.R.2
  • 21
    • 0034214837 scopus 로고    scopus 로고
    • Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1
    • Ibraghimov-Beskrovnaya O, Bukanov NO, Donohue LC, Dackowski WR, Klinger KW, Landes GM. Strong homophilic interactions of the Ig-like domains of polycystin-1, the protein product of an autosomal dominant polycystic kidney disease gene, PKD1. Hum Mol Genet 2000; 9: 1641-1649
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 1641-1649
    • Ibraghimov-Beskrovnaya, O.1    Bukanov, N.O.2    Donohue, L.C.3    Dackowski, W.R.4    Klinger, K.W.5    Landes, G.M.6
  • 22
    • 0037168674 scopus 로고    scopus 로고
    • Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic: Kidney disease 1-associated mutations
    • Qian F, Boletta A, Bhunia AK et al. Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic: kidney disease 1-associated mutations. Proc Natl Acad Sci USA 2002; 99: 16981-16986
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16981-16986
    • Qian, F.1    Boletta, A.2    Bhunia, A.K.3
  • 23
    • 0037133954 scopus 로고    scopus 로고
    • PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2
    • Bhunia AK, Piontek K, Boletta A et al. PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2. Cell 2002; 109: 157-168
    • (2002) Cell , vol.109 , pp. 157-168
    • Bhunia, A.K.1    Piontek, K.2    Boletta, A.3
  • 24
    • 0032513031 scopus 로고    scopus 로고
    • The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1
    • Arnould T, Kim E, Tsiokas L et al. The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1. J Biol Chem 1998; 273: 6013-6018
    • (1998) J. Biol. Chem. , vol.273 , pp. 6013-6018
    • Arnould, T.1    Kim, E.2    Tsiokas, L.3
  • 25
    • 0033582438 scopus 로고    scopus 로고
    • The polycystic kidney disease 1 gene product modulates Wnt signaling
    • Kim E, Arnould T, Sellin LK et al. The polycystic kidney disease 1 gene product modulates Wnt signaling. J Biol Chem 1999; 274: 4947-4953
    • (1999) J. Biol. Chem. , vol.274 , pp. 4947-4953
    • Kim, E.1    Arnould, T.2    Sellin, L.K.3
  • 26
    • 0030582668 scopus 로고    scopus 로고
    • The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I
    • Qian F, Watnick TJ, Onuchic LF, Germino GG. The molecular basis of focal cyst formation in human autosomal dominant polycystic kidney disease type I. Cell 1996; 87: 979-987
    • (1996) Cell , vol.87 , pp. 979-987
    • Qian, F.1    Watnick, T.J.2    Onuchic, L.F.3    Germino, G.G.4
  • 27
    • 0036707893 scopus 로고    scopus 로고
    • Genetics and pathogenesis of polycystic kidney disease
    • Igarashi P, Somlo S. Genetics and pathogenesis of polycystic kidney disease. J Am Soc Nephrol 2002; 13: 2384-2398
    • (2002) J. Am. Soc. Nephrol. , vol.13 , pp. 2384-2398
    • Igarashi, P.1    Somlo, S.2
  • 29
    • 0028227826 scopus 로고
    • Taxol inhibits progression of congenital polycystic kidney disease
    • Woo DD, Miao SY, Pelayo JC, Woolf AS. Taxol inhibits progression of congenital polycystic kidney disease. Nature 1994; 368: 750-753
    • (1994) Nature , vol.368 , pp. 750-753
    • Woo, D.D.1    Miao, S.Y.2    Pelayo, J.C.3    Woolf, A.S.4
  • 30
    • 0028322016 scopus 로고
    • Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice
    • Moyer JH, Lee-Tischler MJ, Kwon HY et al. Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science 1994; 264: 1329-1333
    • (1994) Science , vol.264 , pp. 1329-1333
    • Moyer, J.H.1    Lee-Tischler, M.J.2    Kwon, H.Y.3
  • 31
    • 0031252295 scopus 로고    scopus 로고
    • Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
    • Lu W, Peissel B, Babakhanlou H et al. Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet 1997; 17: 179-181
    • (1997) Nat. Genet. , vol.17 , pp. 179-181
    • Lu, W.1    Peissel, B.2    Babakhanlou, H.3
  • 32
    • 0035504102 scopus 로고    scopus 로고
    • Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects
    • Lu W, Shen X, Pavlova A et al. Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects. Hum Mol Genet 2001; 10: 2385-2396
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 2385-2396
    • Lu, W.1    Shen, X.2    Pavlova, A.3
  • 35
    • 0033989173 scopus 로고    scopus 로고
    • Cardiac defects and renal failure in mice with targeted mutations in Pkd2
    • Wu G, Markowitz GS, Li L et al. Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet 2000; 24: 75-78
    • (2000) Nat. Genet. , vol.24 , pp. 75-78
    • Wu, G.1    Markowitz, G.S.2    Li, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.