Biology of aromatase inhibitors: Pharmacology/endocrinology within the breast

Endocrine-Related Cancer

Volumn 6, Issue 2, 1999, Pages 187-195

  Miller, W R ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLUTETHIMIDE; ANASTROZOLE; ANDROSTENEDIONE; AROMATASE; AROMATASE INHIBITOR; CARBON 14; ESTRADIOL; ESTROGEN; ESTRONE; EXEMESTANE; FORMESTANE; LETROZOLE; TRITIUM;

ADIPOSE TISSUE; AROMATIZATION; ARTICLE; BREAST BIOPSY; BREAST CANCER; CANCER ADJUVANT THERAPY; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STABILITY; ESTROGEN SYNTHESIS; FEMALE; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; MASTECTOMY; POSTMENOPAUSE;

ANTINEOPLASTIC AGENTS; AROMATASE; AROMATASE INHIBITORS; BREAST; BREAST NEOPLASMS; CELLS, CULTURED; ENZYME INHIBITORS; ESTROGENS; FEMALE; FIBROBLASTS; HUMANS; NEOPLASMS, HORMONE-DEPENDENT; NITRILES; POSTMENOPAUSE; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 0032974458     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0060187     Document Type: Article

References (26)

1. Bhatnagar A & Miller WR 1998 Pharmacology of inhibitors of estrogen biosynthesis. In Handbook of Experimental Pharmacology: Estrogens and Antiestrogens. Eds M Oertel & E Schillinger. Berlin, New York: Springer-Verlag (In Press).
2. Bhatnagar AS, Hausler A, Schieweck K, Lang M & Bowman R 1998 Highly selective inhibition of estrogen biosynthesis by CGS20267. A new non-steroidal aromatase inhibitor. Journal of Steroid Biochemistry and Molecular Biology 37 1021-1027.
3. Brodie AMH, Garnett WM, Hendrickson JR, Tsai-Morris CH, Marcotte PA & Robinson CH 1981 Inactivation of aromatase in vitro by 4-hydroxy-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo. Steroids 38 693-702.
4. Buzdar A 1999 Role of aromatase inhibitors in advanced breast cancer. Endocrine-Related Cancer 6 219-225.
5. Chen S, Zhou D, Okubo T, Kao Y-C & Yang C 1999 Breast tumor aromatase: functional role and transcriptional regulation. Endocrine-Related Cancer 6 149-156.
6. Coombes RC, Goss P, Dowsett M, Gazet J-C & Brodie A 1984 4-Hydroxyandrostenedione in treatment of postmenopausal patients with advanced breast cancer. Lancet ii 1237-1239.
7. Dixon JM, Love CDB, Renshaw L, Bellamy C, Cameron DA, Miller WR et al. 1999 Lessons from the use of aromatase inhibitors in the neoadjuvant setting. Endocrine-Related Cancer 6 227-230.
8. Dowsett M, Harris AL, Smith IE & Jeffcoate SL 1984 Endocrine changes associated with relapse in advanced breast cancer patients on aminoglutethimide therapy. Journal of Clinical Endocrinology and Metabolism 58 99-104.
9. Geisler J, King N, Dowsett M, Ottestad L, Lundgren S, Walton P, Kormeset PO & Lonning PC 1996 Influence of anastrozole (Arimidex) a selective non-steroidal aromatase inhibitor on in vivo aromatization and plasma estrogen levels in postmenopausal women with breast cancer. British Journal of Cancer 74 1286-1291.
10. Harada N, Honda S-I & Hatano O 1999 Aromatase inhibitors and enzyme stability. Endocrine-Related Cancer 6 211-218.
11. James VHT, McNeill JM, Lai LC, Newton CJ, Ghilchik MW & Reed MJ 1987 Aromatase activity in normal breast and breast tumor tissues: in vivo and in vitro studies. Steroids 50 269-279.
12. Jordan VC, Parker CJ & Morrow M 1993 Update: breast cancer treatment and prevention with antioestrogens in the 1990s. Endocrine Reviews 1 82-85.
13. Lonning PE 1996 Pharmacology of new aromatase inhibitors. The Breast 5 202-208.
14. Miller WR 1986 Steroid metabolism in breast cancer. In Breast Cancer: Treatment and Progress, pp 156-172. Ed B A Stoll. Oxford: Blackwell Scientific Publications.
15. Miller WR 1996a Estrogens and endocrine therapy for breast cancer. In Estrogen and Breast Cancer, pp 125-150. Ed WR Miller. Austin, Texas: RG Landes & Co.
16. Miller WR 1996b Aromatase inhibitors - where are we now? British Journal of Cancer 73 415-417.
17. Miller WR 1997a Aromatase inhibitors and breast cancer. Cancer Treatment Reviews 23 171-187.
18. Miller WR 1997b Uptake and synthesis of steroid hormones by the breast. Endocrine Related Cancer 4 307-311.
19. Miller WR & O'Neill J 1987 The importance of local synthesis of estrogen within the breast. Steroids 50 537-540.
20. Miller WR, Mullen P, Sourdaine P, Watson C, Dixon JM & Telford J 1997 Regulation of aromatase activity within the breast. Journal of Steroid Biochemistry 61 193-202.
21. Perel E & Killinger DW 1979 The interconversion and aromatization of androgens by human adipose tissue. Journal of Steroid Biochemistry 10 623-627.
22. Plourde PV, Dyroff M & Dukes M 1994 Arimidex: a potent and selective fourth-generation aromatase inhibitor. Breast Cancer Research and Treatment 30 103-111.
23. Reed MJ, Beranek PA, Ghilchik MW & James VHT 1986 Oestrogen production and metabolism in normal postmenopausal women and postmenopausal women with breast or endometrial cancer. European Journal of Cancer and Clinical Oncology 22 1395-1400.
24. Reed MJ, Owen AM, Lai C, Coloham NG, Ghilchik M W, Shaikh NA et al. 1989 In situ oestrone synthesis in normal breast and breast tumour tissues: effect of treatment with 4-hydroxy-androstenedione. International Journal of Cancer 44 233-237.
25. Salle E, Ornati G, Giudici D, Lassus M, Evans TRJ & Coombes RC 1992 Exemestane (FCE 24304), a new steroidal aromatase inhibitor. Journal of Steroid Biochemistry and Molecular Biology 43 137-143.
26. Thijssen JHH, Blankenstein MA, Donker GH, Daroszewski J 1991 Endogenous steroid hormones and local aromatase activity in the breast. Journal of Steroid Biochemistry 39 799-804.