The role of nitric oxide in systemic and hepatic haemodynamics in the rat in vivo

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 368, Issue 2, 2003, Pages 142-149

  Li, Xiangnong ^a,b   Benjamin, Irving S ^a   Alexander, Barry ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

3 Morpholinosydnonimine; Hepatic arterial flow; L arginine; NG nitro L arginine methyl ester; Nitric oxide; Portal venous flow; Portal venous pressure; Rat liver

Indexed keywords

ARGININE; FENTANYL DERIVATIVE; FLUANISONE; HEPARIN DERIVATIVE; LINSIDOMINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOSE RESPONSE; HEMODYNAMICS; HEPARINIZATION; IN VIVO STUDY; LAPAROTOMY; LIVER BLOOD FLOW; LIVER CIRCULATION; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PORTAL VEIN BLOOD; PORTAL VEIN BLOOD FLOW; RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; ARGININE; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HEART RATE; HEPATIC ARTERY; LIVER CIRCULATION; MALE; MOLSIDOMINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PORTAL VEIN; RATS; RATS, WISTAR;

EID: 0042377610     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-003-0774-8     Document Type: Article

References (45)

1. Aisaka K, Gross SS, Griffith OW, Levi R (1989) NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun 160:881-886
2. Alemany CA, Oh W, Stonestreet BS (1997) Effects of nitric oxide synthesis inhibition on mesenteric perfusion in young pigs. Am J Physiol 272:G612-G616
3. Alexander B (1998) The role of nitric oxide in hepatic metabolism. Nutrition 14:376-390
4. Alexander B, Cottam H, Naftalin R (2001) Hepatic arterial perfusion regulates portal venous flow between hepatic sinusoids and intrahepatic shunts in the normal rat liver in vitro. Pflugers Arch 443:257-264
5. Alexander B, Rogers C, Naftalin R (2002) Hepatic arterial perfusion decreases intrahepatic shunting and maintains glucose uptake in the rat liver. Pflugers Arch 444:291-298
6. Ayuse T, Brienza N, Revelly JP, Boitnott JK, Robotham JL (1995) Role of nitric oxide in porcine liver circulation under normal and endotoxemic conditions. J Appl Physiol 78:1319-1329
7. Bahn E, Nolte W, Kurth C, Ramadori G, Ruther E, Wiltfang J (2002) Quantification of the electroencephalographic theta/alpha ratio for the assessment of portal-systemic encephalopathy following implantation of transjugular intrahepatic portosystemic stent shunt (TIPSS). Metab Brain Dis 17:19-28
8. Bauer C, Walcher F, Kalweit U, Larsen R, Marzi I (1997) Role of nitric oxide in the regulation of the hepatic microcirculation in vivo. J Hepatol 27:1089-1095
9. Browse DJ, Mathie RT, Benjamin IS, Alexander B (1994) The transhepatic action of ATP on the hepatic arterial and portal venous vascular beds of the rabbit: the role of nitric oxide. Br J Pharmacol 113:987-993
10. Cahill PA, Foster C, Redmond EM, Gingalewski C, Wu Y, Sitzmann JV (1995) Enhanced nitric oxide synthase activity in portal hypertensive rabbits. Hepatology 22:598-606
11. Corso CO, Gundersen Y, Dorger M, Lilleaasen P, Aasen AO, Messmer K (1998) Effects of the nitric oxide synthase inhibitors N(G)-nitro-L-arginine methyl ester and aminoethyl-isothiourea on the liver microcirculation in rat endotoxemia. J Hepatol 28:61-69
12. Feletou M, Hoeffner U, Vanhoutte PM (1989) Endothelium-dependent relaxing factors do not affect the smooth muscle of portal-mesenteric veins. Blood Vessels 26:21-32
13. Fernandez M, Garcia-Pagan JC, Casadevall M, Bernadich C, Piera C, Whittle BJ, Pique JM, Bosch J, Rodes J (1995) Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats. Gastroenterology 108:1487-1495
14. Fleming I, Julou-Schaeffer G, Gray GA, Parratt JR, Stoclet JC (1991) Evidence that an L-arginine/nitric oxide dependent elevation of tissue cyclic GMP content is involved in depression of vascular reactivity by endotoxin. Br J Pharmacol 103:1047-1052
15. Gardiner SM, March JE, Kemp PA, Bennett T (1998) The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen-2)27) rats. Br J Pharmacol 124:299-306
16. Iwata F, Joh T, Kawai T, Itoh M (1992) Role of EDRF in splanchnic blood flow of normal and chronic portal hypertensive rats. Am J Physiol 263:G149-G154
17. Joly GA, Kilbourn RG (1997) Tetrahydrobiopterin synthesis inhibitors induce nitric oxide synthesis in rat aorta. Gen Pharmacol 28:475-480
18. Kakumitsu S, Shijo H, Yokoyama M, Kim T, Akiyoshi N, Ota K, Kubara K, Okumura M, Inoue K (1998) Effects of L-arginine on the systemic, mesenteric, and hepatic circulation in patients with cirrhosis. Hepatology 27:377-382
19. Kashiwagi S, Suematsu M, Wakabayashi Y, Kawada N, Tachibana M, Koizumi A, Inoue M, Ishimura Y, Kaneko A (1997) Electrophysiological characterization of cultured hepatic stellate cells in rats. Am J Physiol 272:G742-G750
20. Kinoshita H, Tsutsui M, Milstien S, Katusic ZS (1997) Tetrahydrobiopterin, nitric oxide and regulation of cerebral arterial tone. Prog Neurobiol 52:295-302
21. Krige JE, Beckingham IJ (2001) ABC of diseases of liver, pancreas, and biliary system: portal hypertension-2. Ascites, encephalopathy, and other conditions. BMJ 322:416-418
22. Lautt WW, Legare DJ (1992) Passive autoregulation of portal venous pressure: distensible hepatic resistance. Am J Physiol 263:G702-G708
23. Macedo MP, Lautt WW (1997) Potentiation to vasodilators by nitric oxide synthase blockade in superior mesenteric but not hepatic artery. Am J Physiol 272:G507-G514
24. Malek AM, Greene AL, Izumo S (1993) Regulation of endothelin 1 gene by fluid shear stress is transcriptionally mediated and independent of protein kinase C and cAMP. Proc Natl Acad Sci USA 90:5999-6003
25. Mathie RT, Ralevic V, Burnstock G (1996) Portal vascular responsiveness to sympathetic stimulation and nitric oxide in cirrhotic rats. J Hepatol 25:90-97
26. Meininger CJ, Marinos RS, Hatakeyama K, Martinez-Zaguilan R, Rojas JD, Kelly KA, Wu G (2000) Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J 349:353-356
27. Ming Z, Han C, Lautt WW (2000) Nitric oxide inhibits norepinephrine-induced hepatic vascular responses but potentiates hepatic glucose output. Can J Physiol Pharmacol 78:36-44
28. Mittal MK, Gupta TK, Lee FY, Sieber CC, Groszmann RJ (1994) Nitric oxide modulates hepatic vascular tone in normal rat liver. Am J Physiol 267:G416-G422
29. Moncada S, Higgs EA (1995) Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 9:1319-1330
30. Niederberger M, Gines P, Tsai P, Martin PY, Morris K, Weigert A, McMurtry I, Schrier RW (1995) Increased aortic cyclic guanosine monophosphate concentration in experimental cirrhosis in rats: evidence for a role of nitric oxide in the pathogenesis of arterial vasodilation in cirrhosis. Hepatology 21:1625-1631
31. Nishida J, McCuskey RS, McDonnell D, Fox ES (1994) Protective role of NO in hepatic microcirculatory dysfunction during endotoxemia. Am J Physiol 267:G1135-G1141
32. Ohta M, Tanoue K, Tamawski AS, Pai R, Itani RM, Sander FC, Sugimachi K, Sarfeh IJ (1997) Overexpressed nitric oxide synthase in portal-hypertensive stomach of rat: a key to increased susceptibility to damage? Gastroenterology 112:1920-1930
33. Pannen BH, Bauer M, Zhang JX, Robotham JL, Clemens MG (1996) A time-dependent balance between endothelins and nitric oxide regulating portal resistance after endotoxin. Am J Physiol 271:H1953-H1961
34. Pizcueta MP, Pique JM, Bosch J, Whittle BJ, Moncada S (1992) Effects of inhibiting nitric oxide biosynthesis on the systemic and splanchnic circulation of rats with portal hypertension. Br J Pharmacol 105:184-190
35. Ramadori G (1991) The stellate cell (Ito-cell, fat-storing cell, lipocyte, perisinusoidal cell) of the liver. New insights into pathophysiology of an intriguing cell. Virchows Arch B Cell Pathol Incl Mol Pathol 61:147-158
36. Rockey D (1997) The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin, and nitric oxide. Hepatology 25:2-5
37. Shimizu S, Ishii M, Kawakami Y, Kiuchi Y, Momose K, Yamamoto T (1999) Presence of excess tetrahydrobiopterin during nitric oxide production from inducible nitric oxide synthase in LPS-treated rat aorta. Life Sci 65:2769-2779
38. Tajiri K, Miyakawa H, Izumi N, Marumo F, Sato C (1995) Systemic hypotension and diuresis by L-arginine in cirrhotic patients with ascites: role of nitric oxide. Hepatology 22:1430-1435
39. Van de Casteele CM, Omasta A, Janssens S, Roskams T, Desmet V, Nevens F, Fevery J (2002) In vivo gene transfer of endothelial nitric oxide synthase decreases portal pressure in anaesthetised carbon tetrachloride cirrhotic rats. Gut 51:440-445
40. Vodovotz Y, Kwon NS, Pospischil M, Manning J, Paik J, Nathan C (1994) Inactivation of nitric oxide synthase after prolonged incubation of mouse macrophages with IFN-gamma and bacterial lipopolysaccharide. J Immunol 152:4110-4118
41. Vos TA, Gouw AS, Klok PA, Havinga R, van Goor H, Huitema S, Roelofsen H, Kuipers F, Jansen PL, Moshage H (1997) Differential effects of nitric oxide synthase inhibitors on endotoxin-induced liver damage in rats. Gastroenterology 113:1323-1333
42. Yang W, Benjamin IS, Alexander B (1999) Localisation of hepatic vascular resistance sites in the isolated dual-perfused rat liver. Eur J Pharmacol 364:13-21
43. Yang W, Benjamin IS, Alexander B (2001) Nitric oxide modulates acetylcholine-induced vasodilatation in the hepatic arterial vasculature of the dual-perfused rat liver. Acta Physiol Scand 171:413-418
44. Yang W, Benjamin IS, Moore K, Portmann B, Alexander B (2003) The action of nitric oxide on hepatic haemodynamics during secondary biliary cirrhosis in the rat. Eur J Pharmacol 461:41-48
45. Zhang B, Borderie D, Sogni P, Soubrane O, Houssin D, Calmus Y (1997) NO-mediated vasodilation in the rat liver. Role of hepatocytes and liver endothelial cells. J Hepatol 26:1348-1355