Cognitive and other behavioral effects of EGb 761® in animal models

Pharmacopsychiatry

Volumn 36, Issue SUPPL. 1, 2003, Pages

  Müller, Walter E ^b   Chatterjee, S S ^a  

^a DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^b GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILOBALIDE; GINKGO BILOBA EXTRACT; GINKGOLIDE; MEMBRANE PROTEIN; SCOPOLAMINE;

AFFECT; AGING; ALZHEIMER DISEASE; ANIMAL MODEL; BEHAVIOR; BRAIN FUNCTION; CELL ACTIVITY; CHANNEL GATING; CHLORIDE CONDUCTANCE; COGNITION; COGNITIVE DEFECT; CONFERENCE PAPER; DEPRESSION; DISEASE SEVERITY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; EMOTION; MITOCHONDRION; NERVE CELL; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; STRESS;

ANIMALS; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM; COGNITION; GINKGO BILOBA; LEARNING; MODELS, ANIMAL; PLANT EXTRACTS;

EID: 0042326265     PISSN: 01763679     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (58)

1. Attela MJ, Hoffman SW, Stasio MJ, Stein DJ. Ginkgo biloba extract facilitates recovery from penetrating brain injury in adult male rats. Exp Neurol 1989; 105: 62-71.
2. Bastianetto S, Zheng W-H, Quirion R. The Ginkgo biloba extract (EGb 761®) protects and rescues hippocampal cells against nitric Oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase c. J Neurochem 2000; 74: 2268-2277
3. Bhattacharya SK, Chakrabarti A, Chatterjee SS. Behavioral effects of bilobalide isolated from Ginkgo biloba leaves: Some experimental observations. Naunyn-Schmiedeberg's Arch. Pharmacol, 1998; 358 (Suppl. 2), R 489; Abst. P5121
4. Blavet N. Effects of Ginkgo biloba extract (EGb 761®) on learning in the aged rat. In: Effects of Ginkgo biloba extract (EGb 761®) on central nervous system Eds. Y. Christen, J. Costentin and M. Lacour. Elsevier. Paris: 1992: 119-127
5. Brochet D, Chermat R, DeFeudis FV, Drieu K. Effects of single intraperitoneal injections of an extract of Ginkgo biloba (EGb 761®) and its terpene trilactone constituents on barbital-induced narcosis in the mouse. Gen Pharmacol 1999; 33: 249-256
6. Chandrasekaran K, Mehrabin Z, Spinnewyn B, Drieu K, Fiskum G. Neuroprotective effect of bilobalide, a component of the Ginkgo biloba extract (EGb 761®), in gerbil global ischemia. Brain Res 2001; 922: 282-292
7. Chatterjee 1984 SS, Gabard B. Effect of an extract of Ginkgo biloba on experimental neurotoxicity. Naunyn-Schmiedeberg's Arch Pharmacol 1984; 325 (Suppl.): Abs. 327
8. Chatterjee SS, Gabard BL, Jaggy HEW. Pharmaceutical composition containing bilobalide for the treatment of neuropathies. US patent no. 4,571,407. 1986
9. Chatterjee SS, Klessing K, Jaggy H, Saederup E, Squires RF. Bilobalide and its structural analogs as novel chloride channel ligands without convulsant activity. Naunyn-Schmiedeberg's Arch Pharmacol 2002a; (Suppl. 1) R79: Abst. 304
10. Chatterjee SS, Nöldner M. Behavioral observations demonstrating influences of the extract of Ginkgo biloba (EGb 761®) on some specific central cholinergic systems. Naunyn-Schmiedeberg's Arch Pharmacol 1989; 339 (Suppl.): Abs. 425
11. Chatterjee SS. Species specific behavioral activity profile of bilobalide in mice. Pharmacologist 2002c; 44 (Suppl. 1) A 129: Abst. 77.6
12. - and inhibitory transmitters. Mol Pharmacol 1998; 53: 564-572
13. Chermat R, Brochet D, DeFeudis FV, Drieu K. Interactions of Ginkgo biloba extract (EGb 761®), diazepam and ethyl β -carboline-3-carboxylate on social behaviour of the rat. Pharmacol Biochem Behav 1997; 56: 333-339
14. Chopin P, Briley M. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacol 1992; 106: 26-30
15. Christen Y, Maixent JM. Molecular and cellular studies of Ginkgo biloba extract EGb 761® - From mechanism of action to therapy. Cell Mol Biol 2002b; 48 (6): 591 731
16. Christen 2002a Y, Maixent JM. What is Ginkgo biloba extract EGb 761®? An overview - From molecular biology to clinical medicine. Cell Mol Biol 2002a; 48 (6): 601-611
17. Clostre F, Millerin M, Betin C, Bazan N, Braquet P. Effects of two platelet-activating factor antagonists, BN 52 063 and alprazolam on forced swimming-induced behavioral despair in mice. In: Ginkgolides: Chemistry, biology, pharmacology and clinical perspective, Vol. 1. Ed. P. Braquet. J.R. Prous science publishers, Barcelona: 1988: 649-664
18. Cohen-Salmon Ch., Venault P, Martin B, Raffalli-Sébille MJ, Barkats M, Clostre F, Pardon MC, Christen Y, Chapouthier G. Effects of Ginkgo biloba extract (EGb 761®) on learning and possible actions on aging. J Physiol 1997; 91: 291-300
19. Continella G, Drago F. Behavioral effects of Ginkgo-biloba extract. In: Effects of Ginkgo biloba extract on organic cerebral impairment Eds. A. Angoli, J. R. Rapain, V. Scapagnini and W. V. Weitbrecht. John Libbey, London - Paris: 1985: 35-42
20. DeFeudis FV, Drieu K. Ginkgo biloba extract (EGb 761®) and CNS functions: Basic studies and clinical applications. Curr Drug Targets 2000; 1: 25-58
21. Galeffi F, Sinnar S, Schwartz-Bloom RD. Diazepam promotes ATP recovery and prevents cytochrome c release in hippocampal slices after in vitro ischemia. J Neurochem 2000; 75: 1242-1249
22. Hoyer S, Lannert H, Nöldner M, Chatterjee SS. Damaged neuronal energy metabolism and behavior are improved by Ginkgo biloba extract (EGb 761). J Neural Transm 1999; 106: 1171-1188
23. - and cell volume. J Neurochem 1998b; 71: 1396-1404
24. Inglefield JR, Schwartz-Bloom RD. Optical imaging of hippocampal neurones with a chloride sensitive dye: Early effects of in vitro ischemia. J Neurochem 1998a ; 70: 2500-2509
25. Janssens D, Michiels C, Delaive E, Eliaers F, Drieu K, Remacle J. Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem Pharmacol 1995; 50: 991-999
26. Janssens D, Remacle J, Drieu K, Michiels C. Protection of mitochondrial respiration activity by bilobalide. Biochem Pharmacol 1999; 58: 109-119
27. Klusa V, Germane S, Nöldner M, Chatterjee SS. Effects of bilobalide in two rodent learning models. Naunyn-Schmiedeberg's Arch Pharmacol, 1998; 358 (Suppl. 2); R 494: Abst. P5143
28. Krieglstein J, Ausmeier F, El-Abhar H, Lippert K, Welsch M, Rupalla K, Henrich-Noack P. Neuroprotective effects of Ginkgo biloba constituents. Eur J Phar Sci 1995; 3: 39-48
29. Lambert N, Grover L. The mechanism of biphasic GABA responses. Science 1995; 269: 928-929
30. Lamproglou I, Boisserie G, Vranckx R, Baillet F, Bok B, Drieu K. Cognitive dysfunction induced by cranial irradiation: effect of Ginkgo biloba extract (EGb 761®) in 4-month-old male rats. Adv Ginkgo biloba Extract Res 1997; 6: 73-87
31. Maclennan KM, Darlington CL, Smith PF. The CNS effects of Ginkgo biloba extracts and ginkgolide. B Progr Neurobiol 2002; 67: 235-257
32. Nöldner M, Chatterjee SS. Anxiolytic-like activity of bilobalide. Naunyn-Schmiedeberg's Arch Pharmacol, 1994; 349 (Suppl.): Abst. 388
33. Nöldner M, Chatterjee SS. Pharmaceutical preparations containing bilobalide for the treatment of nervous tension and anxiety. International Patent A61K31/365,35/78, WO 93/12784. 1993
34. Otani M, Chatterjee SS, Gabard B, Kreutzberg GW. Effect of an extract of Ginkgo biloba on triethyltin-induced cerebral edema. Acta Neuropathol, 1886: 54-65
35. Pardon MC, Hanoun N, Perez-Diaz F, Launay JM. Christen Y, Hamon M, Cohen-Salmon C. Age-related changes in the effects of a chronic ultra-mild stress procedure on decision-making, open-field behaviour and some indices of serotoninergic neurotransmission in B6D2F1 mice. Influence of a long-term treatment with EGb 761® (Tanakan®). In: Advances in Ginkgo biloba extract research, Vol. 8. Ginkgo biloba extract (EGb 761®) as a neuroprotective agent: from basic studies to clinical trials Ed. Y. Christen. Solal éditeur, Marseille: 2001: 187-204
36. Porsolt RD, Martin P, Lenégre A, Fromge S, Drieu K. Effects of an extract of Ginkgo biloba (EGb 761®) on "learned helplessness" and other models of stress in rodents. Pharmacol Biochem Behav 1990; 36: 963-971
37. Raffali-Sébille MJ, Chapouthier G, Clostre F, Christen Y. Learning improvement in adult and aged mice induced by Ginkgo biloba extract. In: Effects of Ginkgo biloba extract (EGb 761) on central nervous system Eds. Y. Christen, J. Costentin and M. Lacour. Elsevier, Paris: 1992: 129-134
38. Rapin JR, Lamproglou I, Drieu K, DeFeudis FV. Demonstration of the "anti-stress" activity of an extract of Ginkgo biloba (EGb 761®) using a discrimination learning task. Gen Pharmacol 1994; 25: 1009-1016
39. Rapin JR, Lamproglou I, Drieu K. Anti-stress activity of Ginkgo biloba extract (EGb 761®) on a learning test and neuroendocrine responses. In: Advances in Ginkgo biloba extract research, Vol. 4. Effects of Ginkgo biloba extract (EGb 761®) on aging and age related disorders Eds. Y. Christen, Y. Courtois and MT Droy-Lefaix. Elsevier, Paris: 1995: 99-106
40. Ravel N, Chabaud P, Mannino M, Vigouroux M, Gervais R, Droy-Lefaix MT. Ginkgo biloba extract and short-term olfactory memory. In: Advances in Ginkgo biloba extract research, Vol. 5. Effects of Ginkgo biloba extract (EGb 761®) on neuronal plasticity Eds. Y. Christen, M: T: Droy-Lefaix and J. F. Macais-Nunez. Elsevier, Paris: 1996: 35-44
41. Rickard NS, Kowadlo N, Gibbs ME. Effects of the Ginkgo biloba extract, EGb 761®; on memory formation in day-old chicks. Pharmacol Biochem Behav 2001; 69: 351-358
42. Sancesario G, Kreutzberg GW. Stimulation of astrocytes effects cytotoxic brain edema. Acta Neuropathol 1986; 72: 3-14
43. Scheuer K, Stoll S, Paschke U, Weigel R, Müller WE. NMDA receptor density and membrane fluidity as possible determinants of the decline of passive avoidance learning in aging. Pharmacol Biochem Behav 1995; 50: 65-70
44. Scheuer K, Rostock A, Bartsch R, Müller WE. Piracetam improves cognitive performance by restoring neurochemical deficits of the aged rat brain. Pharmacopsychiatry 1999; 32: 10-16
45. Schwartz-Bloom RD, Miller KA, Evenson DA, Crain BJ, Nadler JV. Benzodiazepines protect hippocampal neurons from degeneration after transient cerebral ischemia: an ultrastructural study. Neurosci 2000; 98: 471-484
46. A neurotransmission and cerebral ischemia. J Neurochem 2001; 77: 353-371
47. Stoll S, Scheuer K, Pohl O, Müller WE. Ginkgo biloba extract (EGb 761®) independently improves changes in passive avoidance learning and brain membrane fluidity in aging mouse. Pharmacopsychiat 1996; 29: 144-149
48. Tatton WG, Chalmers-Redman RM. Mitochondria in neurodegenerative apoptosis: an opportunity for therapy? Ann Neurol 1998; 44 (Suppl 1): 134-141
49. Teather LA, Magnusson JE, Wurtman RJ. Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats. Psychopharmacol 2002; 163: 430-433
50. Tendi EA, Bosetti F, DasGupta SF, Stella AMG, Drieu K, Rapoport SI. Ginkgo biloba Extracts EGb 761® and Bilobalide Increase NADH Dehydrogenase mRNA Level and Mitochondrial Respiratory Control Ratio in PC12 Cells. 2002; 27: 319-323
51. Venkatachalam MA, Weinberg JM, Patel Y, Seikumar P, Dong Z. Cytoprotection of kidney epithelial cells by compounds that target amino acid gated chloride channels. Kidney Int 1996; 49: 449-460
52. Weichel O, Hilgert M, Chatterjee SS, Lehr M, Klein J. Bilobalide, a constituent of Ginkgo biloba, inhibits NMDA-induced phospholipase A2 activation and phospholipid breakdown in rat hippocampus. Naunyn-Schmiedebergs Arch Pharmacol 1999; 360: 609-615
53. Winter JC, Timineri D. The discriminative stimulus properties of EGb 761®, an extract of Ginkgo biloba. Pharmacol Biochem Behav 1999; 62: 543-547
54. Winter JC. Effects of an extract of Ginkgo biloba, EGb 761, on cognitive behavior and longevity in the rat. Physiol Behav 1998; 63: 425-433
55. Winter E. Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol. Biochem. Behav. 1991; 38: 109-114
56. Wirth S, Stemmelin J, Will B, Christen Y, Scala GD. Facilitative effects of EGb 761® on olfactory recognition in young and aged rats. Pharmacol Biochem Behav 2000; 65: 321-326
57. Zhou LJ and Zhu XZ. Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. J Pharmacol Exp Ther 2000; 293: 982-988
58. Zimmermann M, Colciaghi F, Cattabeni F, DiLuca M. Ginkgo biloba extract: From molecular mechanisms to the treatment of Alzheimer's disease. Cell Mol Biol 2002; 48(6): 613-623