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Volumn 91, Issue 6, 1997, Pages 291-300

Effects of Ginkgo biloba extract (EGb 761) on learning and possible actions on aging

Author keywords

Aging; EGb761; Genetics; Ginkgo biloba; Hippocampus; Inbred strains; Learning; Memory; Swiss mice; Transgenic mice

Indexed keywords

GINKGO BILOBA EXTRACT;

EID: 0031469681     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(97)82409-6     Document Type: Article
Times cited : (59)

References (53)
  • 1
    • 0025283076 scopus 로고
    • Effects of long term hydergine treatment on the age-dependent loss of mossy fibers and of granule cells in the rat hippocampus
    • Amenta F, Jaton A-L, Ricci A (1990) Effects of long term hydergine treatment on the age-dependent loss of mossy fibers and of granule cells in the rat hippocampus. Arch Gerontol Geriatr 12, 287-296
    • (1990) Arch Gerontol Geriatr , vol.12 , pp. 287-296
    • Amenta, F.1    Jaton, A.-L.2    Ricci, A.3
  • 2
    • 0027164515 scopus 로고
    • Learning in inbred mice: Strain-specific abilities across three radial maze problems
    • Ammassari-Teule M, Hoffmann HJ, Rossi-Arnaud C (1993) Learning in inbred mice: strain-specific abilities across three radial maze problems. Behav Genet 23, 405-412
    • (1993) Behav Genet , vol.23 , pp. 405-412
    • Ammassari-Teule, M.1    Hoffmann, H.J.2    Rossi-Arnaud, C.3
  • 3
    • 0026700217 scopus 로고
    • Genotype-dependant involvement of limbic areas in spatial learning and postlesion recovery
    • Ammassari-Teule M, Fagioli S, Rossi-Arnaud C (1992) Genotype-dependant involvement of limbic areas in spatial learning and postlesion recovery. Physiol Behav 52, 505-510
    • (1992) Physiol Behav , vol.52 , pp. 505-510
    • Ammassari-Teule, M.1    Fagioli, S.2    Rossi-Arnaud, C.3
  • 6
    • 0028795616 scopus 로고
    • Effects of longterm treatment with Egb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains
    • Barkats M, Venault P, Christen Y, Cohen-Salmon C (1995) Effects of longterm treatment with Egb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci 56, 213-222
    • (1995) Life Sci , vol.56 , pp. 213-222
    • Barkats, M.1    Venault, P.2    Christen, Y.3    Cohen-Salmon, C.4
  • 7
    • 0030011824 scopus 로고    scopus 로고
    • Age-related changes in the hippocampus of two mouse strains
    • Barkats M, Bertholet J-Y, Cohen-Salmon C (1996) Age-related changes in the hippocampus of two mouse strains. Mech Aging Dev 87, 155-164
    • (1996) Mech Aging Dev , vol.87 , pp. 155-164
    • Barkats, M.1    Bertholet, J.-Y.2    Cohen-Salmon, C.3
  • 8
    • 0014431103 scopus 로고
    • Memory and consolidation mechanism in avoidance learning of inbred mice
    • Bovet D, Bovet-Nitti F, Oliverio A (1968) Memory and consolidation mechanism in avoidance learning of inbred mice. Brain Res 10, 168-182
    • (1968) Brain Res , vol.10 , pp. 168-182
    • Bovet, D.1    Bovet-Nitti, F.2    Oliverio, A.3
  • 9
    • 0014669251 scopus 로고
    • Genetic aspect of learning and memory in mice
    • Bovet D, Bovet-Nitti F, Oliverio A (1969) Genetic aspect of learning and memory in mice. Science 163, 139-149
    • (1969) Science , vol.163 , pp. 139-149
    • Bovet, D.1    Bovet-Nitti, F.2    Oliverio, A.3
  • 10
    • 0003751690 scopus 로고
    • Brain protein synthesis after unilateral labyrinthectomy: Natural one-month evolution and EGb 761 treatment effect
    • (Christen Y, Costentin J, Lacour M, eds) Paris, Elsevier
    • Bustany P, Denise P, Pottier M, Moulin M (1992) Brain protein synthesis after unilateral labyrinthectomy: natural one-month evolution and EGb 761 treatment effect. In: Effects of Ginkgo biloba Extract (EGb 761) on the Central Nervous System (Christen Y, Costentin J, Lacour M, eds) Paris, Elsevier, 57-74
    • (1992) Effects of Ginkgo Biloba Extract (EGb 761) on the Central Nervous System , pp. 57-74
    • Bustany, P.1    Denise, P.2    Pottier, M.3    Moulin, M.4
  • 12
    • 0022549550 scopus 로고
    • De l'organisme aux membranes cellulaires: Les différents niveaux d'actions pharmacologiques de l'extrait de Ginkgo biloba
    • Clostre F (1986) De l'organisme aux membranes cellulaires: les différents niveaux d'actions pharmacologiques de l'extrait de Ginkgo biloba. Presse Méd 15, 1529-1545
    • (1986) Presse Méd , vol.15 , pp. 1529-1545
    • Clostre, F.1
  • 14
    • 0025668488 scopus 로고
    • No correlations between spatial and non-spatial reference memory in a T-maze task and hippocampal mossy fibre distribution in the mouse
    • Crusio WE, Bertholet JY, Schwegler H (1990) No correlations between spatial and non-spatial reference memory in a T-maze task and hippocampal mossy fibre distribution in the mouse. Behav Brain Res 41, 251-259
    • (1990) Behav Brain Res , vol.41 , pp. 251-259
    • Crusio, W.E.1    Bertholet, J.Y.2    Schwegler, H.3
  • 15
    • 0027056618 scopus 로고
    • Naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (Acomys cahirinus) during maturation, adulthood and aging
    • Dawirs RR, Teuchert-Noodt G, Kacza J (1992) Naturally occurring degrading events in axon terminals of the dentate gyrus and stratum lucidum in the spiny mouse (Acomys cahirinus) during maturation, adulthood and aging. Dev Neurosci 14, 210-220
    • (1992) Dev Neurosci , vol.14 , pp. 210-220
    • Dawirs, R.R.1    Teuchert-Noodt, G.2    Kacza, J.3
  • 16
    • 0004961289 scopus 로고
    • Efficiency of Ginkgo biloba extract (EGb 761) in neutralizing ferryl ioninduced peroxidations: Therapeutic implications
    • (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier
    • Deby C, Deby-Dupont G, Dister M, Pincemail J (1993) Efficiency of Ginkgo biloba extract (EGb 761) in neutralizing ferryl ioninduced peroxidations: therapeutic implications. In: Advances in Ginkgo biloba Extract (EGb 761) Research (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier, 13-26
    • (1993) Advances in Ginkgo Biloba Extract (EGb 761) Research , pp. 13-26
    • Deby, C.1    Deby-Dupont, G.2    Dister, M.3    Pincemail, J.4
  • 17
    • 0025030556 scopus 로고
    • The effects of EGb 761 on vestibular compensation in the rat
    • Abstr
    • Denise P, Bustany P, Moulin M, Pettier M (1990) The effects of EGb 761 on vestibular compensation in the rat. Eur J Pharmacol 183, 1459 (Abstr)
    • (1990) Eur J Pharmacol , vol.183 , pp. 1459
    • Denise, P.1    Bustany, P.2    Moulin, M.3    Pettier, M.4
  • 20
    • 0027283588 scopus 로고
    • Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice
    • Fordyce DE, Wehner JM (1993) Physical activity enhances spatial learning performance with an associated alteration in hippocampal protein kinase C activity in C57BL/6 and DBA/2 mice. Brain Res 619, 111-119
    • (1993) Brain Res , vol.619 , pp. 111-119
    • Fordyce, D.E.1    Wehner, J.M.2
  • 23
    • 0025046709 scopus 로고
    • Psychopharmacological effects of Ginkgo biloba extract (EGb 761) in healthy volunteers
    • abstr
    • Lacomblez L, Warot D, Tarrade T, Puech AJ (1990) Psychopharmacological effects of Ginkgo biloba extract (EGb 761) in healthy volunteers. Eur J Pharmacol 183, 1460 (abstr)
    • (1990) Eur J Pharmacol , vol.183 , pp. 1460
    • Lacomblez, L.1    Warot, D.2    Tarrade, T.3    Puech, A.J.4
  • 24
    • 0003373736 scopus 로고
    • Sensorimotor activity and metabolic factors in vestibular compensation
    • (Flohr YH, ed) Heidelberg, Springer-Verlag
    • Lacour M, El-Zaher L, Xerri C (1988) Sensorimotor activity and metabolic factors in vestibular compensation. In: Post-Lesion neural plasticity (Flohr YH, ed) Heidelberg, Springer-Verlag, 675-685
    • (1988) Post-lesion Neural Plasticity , pp. 675-685
    • Lacour, M.1    El-Zaher, L.2    Xerri, C.3
  • 25
    • 0010436625 scopus 로고
    • Restoration of nerve function
    • (Lacour M, Toupet M, Denise P, Christen Y, eds) Paris, Elsevier
    • Lacour M (1989) Restoration of nerve function. In: Vestibular compensation: facts, theories and clinical Perpectives (Lacour M, Toupet M, Denise P, Christen Y, eds) Paris, Elsevier, 11-34
    • (1989) Vestibular Compensation: Facts, Theories and Clinical Perpectives , pp. 11-34
    • Lacour, M.1
  • 26
    • 0003751690 scopus 로고
    • Neurotrophic (and/or neuritogenic) properties of the extract of Ginkgo biloba (EGb 761) as evidenced in vestibular compensation
    • (Christen Y, Costentin J, Lacour M, eds) Elsevier, Paris
    • Lacour M, Ez-Zaher L, Raymond J, Tighilet B (1992) Neurotrophic (and/or neuritogenic) properties of the extract of Ginkgo biloba (EGb 761) as evidenced in vestibular compensation. In: Effects of Ginkgo biloba Extract (EGb 761) on the Central Nervous System (Christen Y, Costentin J, Lacour M, eds) Elsevier, Paris, 37-56
    • (1992) Effects of Ginkgo Biloba Extract (EGb 761) on the Central Nervous System , pp. 37-56
    • Lacour, M.1    Ez-Zaher, L.2    Raymond, J.3    Tighilet, B.4
  • 27
    • 0027189950 scopus 로고
    • Locomotor and exploratory activity in three inbred strains of mice from young adulthood to senescence
    • Lhotellier L, Perez-Diaz F, Cohen-Salmon C (1993) Locomotor and exploratory activity in three inbred strains of mice from young adulthood to senescence. Exp Aging Res 19, 177-187
    • (1993) Exp Aging Res , vol.19 , pp. 177-187
    • Lhotellier, L.1    Perez-Diaz, F.2    Cohen-Salmon, C.3
  • 28
    • 0018706860 scopus 로고
    • Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats: A quantitative study
    • Lindsey JD, Landfield PW, Lynch G (1979) Early onset and topographical distribution of hypertrophied astrocytes in hippocampus of aging rats: a quantitative study. J Gerontol 34, 661-671
    • (1979) J Gerontol , vol.34 , pp. 661-671
    • Lindsey, J.D.1    Landfield, P.W.2    Lynch, G.3
  • 29
    • 0141577117 scopus 로고
    • Changes in the levels of catecholamines, indoleamines and their metabolites in the brains of mice and rats following acute and chronic administration of a Ginkgo biloba leave extract
    • Morier-Tessier E, L'Helgonach A, Drieu K, Rips R (1987) Changes in the levels of catecholamines, indoleamines and their metabolites in the brains of mice and rats following acute and chronic administration of a Ginkgo biloba leave extract. Biogenic Amines 4, 351-358
    • (1987) Biogenic Amines , vol.4 , pp. 351-358
    • Morier-Tessier, E.1    L'Helgonach, A.2    Drieu, K.3    Rips, R.4
  • 30
    • 0025981361 scopus 로고
    • Protein, lipid and DNA repair systems in oxidatives stress: The free radical theory of aging revisited
    • Pacifici RE, Davies KJA (1991) Protein, lipid and DNA repair systems in oxidatives stress: the free radical theory of aging revisited. Gerontology 37, 166-180
    • (1991) Gerontology , vol.37 , pp. 166-180
    • Pacifici, R.E.1    Davies, K.J.A.2
  • 31
    • 0027403446 scopus 로고
    • Behavioral dissociations between C57BL/6 and DBA/2mice on learning and memory tasks: A hippocampal-dysfunction hypothesis
    • Paylor R, Baskall L, Wehner JM (1993) Behavioral dissociations between C57BL/6 and DBA/2mice on learning and memory tasks: a hippocampal-dysfunction hypothesis. Psychobiology 21, 11-26
    • (1993) Psychobiology , vol.21 , pp. 11-26
    • Paylor, R.1    Baskall, L.2    Wehner, J.M.3
  • 34
    • 0025008599 scopus 로고
    • Methyl β-carboline-3-carboxylate enhances performance in a multiple-trial learning task in mice
    • Raffalli-Sébille M-J, Chapouthier G, Venault P, Dodd RH (1990) Methyl β-carboline-3-carboxylate enhances performance in a multiple-trial learning task in mice. Pharmacol Biochem Behav 35, 281-284
    • (1990) Pharmacol Biochem Behav , vol.35 , pp. 281-284
    • Raffalli-Sébille, M.-J.1    Chapouthier, G.2    Venault, P.3    Dodd, R.H.4
  • 35
    • 0345082766 scopus 로고
    • Ginkgo biloba extract (EGb 761) prevents free-radical modifications of synaptosomal membrane fluidity and ability to take up serotonin
    • (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier
    • Ramassamy C, Christen Y, Clostre F, Costentin J (1993) Ginkgo biloba extract (EGb 761) prevents free-radical modifications of synaptosomal membrane fluidity and ability to take up serotonin. In: Advances in Ginkgo biloba Extract (EGb 761) Research (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier, 39-50
    • (1993) Advances in Ginkgo Biloba Extract (EGb 761) Research , pp. 39-50
    • Ramassamy, C.1    Christen, Y.2    Clostre, F.3    Costentin, J.4
  • 36
    • 0022551740 scopus 로고
    • Consommation cérébrale de glucose: Effet de l'extrait de Ginkgo biloba
    • Rapin JR, Le Poncin Lafitte M (1986) Consommation cérébrale de glucose: effet de l'extrait de Ginkgo biloba. Presse Méd 15, 1494-1497
    • (1986) Presse Méd , vol.15 , pp. 1494-1497
    • Rapin, J.R.1    Le Poncin Lafitte, M.2
  • 37
    • 0024495743 scopus 로고
    • Age-related changes of the mossy fibre system in rat hippocampus: Effect of long term actyl-L carnitine treatment
    • Ricci A, RamacciA MT, Ghirardi O, Amenta F (1989) Age-related changes of the mossy fibre system in rat hippocampus: effect of long term actyl-L carnitine treatment. Arch Gerontol Geriatr 8, 63-71
    • (1989) Arch Gerontol Geriatr , vol.8 , pp. 63-71
    • Ricci, A.1    Ramaccia, M.T.2    Ghirardi, O.3    Amenta, F.4
  • 38
    • 0026489646 scopus 로고
    • Oral choline alfoscerate counteracts age-dependent loss of mossy fibres in the rat hippocampus
    • Ricci A, Bronzetti E, Vega JA, Amenta F (1990) Oral choline alfoscerate counteracts age-dependent loss of mossy fibres in the rat hippocampus. Mech Age Dev 66, 81-91
    • (1990) Mech Age Dev , vol.66 , pp. 81-91
    • Ricci, A.1    Bronzetti, E.2    Vega, J.A.3    Amenta, F.4
  • 39
    • 0023864255 scopus 로고
    • Flavonoids are scavengers of Superoxide anions
    • Robak J, Gryglrwski RJ (1988) Flavonoids are scavengers of Superoxide anions. Biochem Pharmacol 37, 837-841
    • (1988) Biochem Pharmacol , vol.37 , pp. 837-841
    • Robak, J.1    Gryglrwski, R.J.2
  • 40
    • 0026040084 scopus 로고
    • Spatial learning in two inbred strains of mice: Genotype-dependent effects of amygdaloid and hippocampal lesions
    • Rossi-Arnaud C, Fagioli S, Ammassari-Teule M (1991) Spatial learning in two inbred strains of mice: genotype-dependent effects of amygdaloid and hippocampal lesions. Behav Brain Res 45, 9-16
    • (1991) Behav Brain Res , vol.45 , pp. 9-16
    • Rossi-Arnaud, C.1    Fagioli, S.2    Ammassari-Teule, M.3
  • 41
    • 0344220471 scopus 로고
    • Plasticity of visual pathways of the rat during postnatal development: Effect of the Ginkgo biloba extract EGb 761
    • (Christen Y, Costentin J. Lacour M, eds) Paris, Elsevier
    • Ruiz G, Droy-Lefaix MT (1992) Plasticity of visual pathways of the rat during postnatal development: effect of the Ginkgo biloba extract EGb 761. In: Effects of Ginkgo biloba Extract (EGb 761 ) on the Central Nervous System (Christen Y, Costentin J. Lacour M, eds) Paris, Elsevier, 89-103
    • (1992) Effects of Ginkgo Biloba Extract (EGb 761 ) on the Central Nervous System , pp. 89-103
    • Ruiz, G.1    Droy-Lefaix, M.T.2
  • 42
    • 0025268240 scopus 로고
    • Hippocampal mossy fibers and radial-maze learning in the mouse: Correlations with spatial working memory but not with non-spatial reference memory
    • Schwegler H, Crusio WE, Brust I (1990) Hippocampal mossy fibers and radial-maze learning in the mouse: correlations with spatial working memory but not with non-spatial reference memory. Neuroscience 34, 293-298
    • (1990) Neuroscience , vol.34 , pp. 293-298
    • Schwegler, H.1    Crusio, W.E.2    Brust, I.3
  • 43
    • 0020331749 scopus 로고
    • Metabolism of oxygen derivatives in Down's syndrome
    • Sinet P-M (1982) Metabolism of oxygen derivatives in Down's syndrome. Ann NY Acad Sci USA 396, 83-94
    • (1982) Ann NY Acad Sci USA , vol.396 , pp. 83-94
    • Sinet, P.-M.1
  • 44
    • 0002491318 scopus 로고
    • Ginkgo biloba extract (EGb 761) protects against delayed neuronal death in gerbil
    • (Christen Y, Costentin J. Lacour M. eds) Paris, Elsevier
    • Spinnewyn B (1992) Ginkgo biloba Extract (EGb 761) protects against delayed neuronal death in gerbil. In: Effects of Ginkgo biloba Extract (EGb 761) on the Central Nervous System (Christen Y, Costentin J. Lacour M. eds) Paris, Elsevier, 113-118
    • (1992) Effects of Ginkgo Biloba Extract (EGb 761) on the Central Nervous System , pp. 113-118
    • Spinnewyn, B.1
  • 45
    • 0016731105 scopus 로고
    • Behavioral characteristics of C57BL/6J, DBA/3J and B6D2FI mice which are potentially useful for gerontological research
    • Sprott, RL (1975) Behavioral characteristics of C57BL/6J, DBA/3J and B6D2FI mice which are potentially useful for gerontological research. Exp Aging Res 1, 313-323
    • (1975) Exp Aging Res , vol.1 , pp. 313-323
    • Sprott, R.L.1
  • 46
    • 0003104805 scopus 로고
    • Effect of EGb 761 on lipid peroxydation, DNA repair and antioxienzyme activity
    • (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier
    • Sram RJ, Binkova B, Stejskalova J, Topinka J (1993) Effect of EGb 761 on lipid peroxydation, DNA repair and antioxienzyme activity. In: Advances in Ginkgo biloba Extract (EGb 761 ) Research (Ferradini C, Droy-Lefaix MT, Christen Y, eds) Paris, Elsevier, 27-38
    • (1993) Advances in Ginkgo Biloba Extract (EGb 761 ) Research , pp. 27-38
    • Sram, R.J.1    Binkova, B.2    Stejskalova, J.3    Topinka, J.4
  • 47
    • 0021969431 scopus 로고
    • Standardized nomenclature for inbred strains of mice: Eighth listing
    • Staats J (1985) Standardized nomenclature for inbred strains of mice: Eighth listing. Cancer Res 45, 945-977
    • (1985) Cancer Res , vol.45 , pp. 945-977
    • Staats, J.1
  • 48
    • 0021139688 scopus 로고
    • The psychopharmacological effects of Ginkgo biloba extract in normal healthy volunteers
    • Subhan Z, Hindmarch I (1984) The psychopharmacological effects of Ginkgo biloba extract in normal healthy volunteers. Int J Clin Pharmacol Res 4, 89
    • (1984) Int J Clin Pharmacol Res , vol.4 , pp. 89
    • Subhan, Z.1    Hindmarch, I.2
  • 49
    • 0005534183 scopus 로고
    • The effects of chronic oral Ginkgo biloba extract administration on neurotransmitter receptor binding in young and aged Fisher 344 rats
    • Agnoli A, Rapin JR, Scapagnini V, Weitbrecht WV, eds, John Libbey/Eurotext
    • Taylor JE (1985) The effects of chronic oral Ginkgo biloba extract administration on neurotransmitter receptor binding in young and aged Fisher 344 rats. In: Effects of Ginkgo biloba Extract on organic cerebral impairment (Agnoli A, Rapin JR, Scapagnini V, Weitbrecht WV, eds), John Libbey/Eurotext, 31-34
    • (1985) Effects of Ginkgo Biloba Extract on Organic Cerebral Impairment , pp. 31-34
    • Taylor, J.E.1
  • 50
    • 0023866498 scopus 로고
    • Differences between inbred strains of mice in Morris water maze performance
    • Upchurch M, Wehner JM (1988) Differences between inbred strains of mice in Morris water maze performance. Behav Genet, 18, 55-68
    • (1988) Behav Genet , vol.18 , pp. 55-68
    • Upchurch, M.1    Wehner, J.M.2
  • 52
    • 0025351941 scopus 로고
    • Hippocampal protein kinase C activity is reduced in poor spatial learners
    • Wehner J M, Sleight S, Upchurch M (1990) Hippocampal protein kinase C activity is reduced in poor spatial learners. Brain Res 523, 181-187
    • (1990) Brain Res , vol.523 , pp. 181-187
    • Wehner, J.M.1    Sleight, S.2    Upchurch, M.3
  • 53
    • 0025962632 scopus 로고
    • Effects of an extract of Ginkgo biloba on learning and memory in mice
    • Winter E (1991) Effects of an extract of Ginkgo biloba on learning and memory in mice. Pharmacol Biochem Behav 38, 109-114
    • (1991) Pharmacol Biochem Behav , vol.38 , pp. 109-114
    • Winter, E.1


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