Determination of a small, highly polar aminopropylphosphinic acid as racemate in plasma and urine and as separated enantiomers in plasma by liquid chromatography and tandem mass spectrometry

Analytica Chimica Acta

Volumn 492, Issue 1-2, 2003, Pages 261-269

  Fakt, Christina ^a   Jacobson, Britt Marie ^a   Leandersson, Sara ^a   Olsson, Britt Marie ^a   Persson, Bengt Arne ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Aminopropylphosphinic acid; Enantiomers; GABA receptor; LC MS MS; Plasma; Urine

Indexed keywords

ION EXCHANGERS; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION (CHEMICAL); PROTEINS; ULTRAFILTRATION;

CHIRAL METHODS;

BODY FLUIDS;

1 FLUORO 2,4 DINITROBENZENE; 3 AMINO 2 FLUOROPROPYLPHOSPHINIC ACID; 3 AMINO 2 OXOPROPYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; AMPHOLYTE; BENZENE DERIVATIVE; PHOSPHINIC ACID DERIVATIVE; PLASMA PROTEIN; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANION EXCHANGE; ARTICLE; BLOOD ANALYSIS; CHIRALITY; DERIVATIZATION; DILUTION; DRUG DETERMINATION; DRUG ISOLATION; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RACEMIC MIXTURE; REPRODUCIBILITY; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY; ULTRAFILTRATION; URINALYSIS;

EID: 0042326260     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-2670(03)00250-2     Document Type: Article

References (13)

1. Lehmann A., Hansson-Brändén L., Kärrberg L. Eur. J. Pharmacol. 403:2000;163-167.
2. Zhang Q., Lehmann A., Rigda R., Dent J., Holloway R.H. Gut. 50:2002;19-24.
3. Froestl W., Mickel S.J., Hall R.G., von Sprecher G., Strub D., Baumann P.A., Brugger F., Gentsch C., Jaekel J., Olpe H.-R., Rihs G., Vassout A., Waldmeier P.C., Bittiger H. J. Med. Chem. 38:1995;3297-3312.
4. Flärdh M., Jacobson B.-M. J. Chromatogr. A. 846:1999;169-173.
5. Steulet A.-F., Möbius H.-J., Mickel S.J., Stöcklin K., Waldmeier P.C. J. Biochem. Pharmacol. 51:1996;613-619.
6. Andrén P.E., Emmett M.R., Da Gue B.B., Steulet A.-F., Waldmeier P., Caprioli R.M. J. Mass Spectrom. 33:1998;281-287.
7. Blum W., Aichholz R., Ramstein P., Kühnöl J., Froestl W., Desrayaud S. J. Chromatogr. B. 748:2000;349-359.
8. Gleiter C.H., Farger G., Möbius H.-J. J. Clin. Pharmacol. 36:1996;428-438.
9. Zarbl E., Lämmerhofer M., Hammerschmidt F., Wuggenig F., Hanbauer M., Maier N.M., Sajovic L., Lindner W. Anal. Chim. Acta. 404:2000;169-177.
10. Kotrebai M., Tyson J.F., Block E., Uden P.C. J. Chromatogr. A. 866:2000;51-63.
11. Chaimbault P., Petritis K., Elfakir C., Dreux M. J. Chromatogr. A. 870:2000;245-254.
12. Alpert A.J. J. Chromatogr. A. 499:1990;177-196.
13. Maier N.M., Nicoletti L., Lämmerhofer M., Lindner W. Chirality. 11:1999;522-528.