Determination of the GABA(B) receptor agonist CGP 44532 (3-amino-2-hydroxypropylmethylphosphinic acid) in rat plasma after pre-column derivatization by micro-high-performance liquid chromatography combined with negative electrospray tandem mass spectrometry

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 748, Issue 2, 2000, Pages 349-359

  Blum, W ^a   Aichholz, R ^a   Ramstein, P ^a   Kuhnol J ^a   Froestl, W ^a   Desrayaud, S ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

3 Amino 2 hydroxypropylmethylphosphininc acid; Nitrobenzylcarbamate isopropylidene derivative

Indexed keywords

3 AMINO 2 HYDROXYPROPYLMETHYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; CARBAMIC ACID DERIVATIVE; CGP 44532; NITROBENZENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DERIVATIZATION; DRUG BLOOD LEVEL; DRUG DETERMINATION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL NOISE RATIO; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GABA AGONISTS; RATS; RECEPTORS, GABA-B; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0034633806     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(00)00352-2     Document Type: Article

References (20)