Potential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injury

Journal of Neuroscience Research

Volumn 73, Issue 4, 2003, Pages 557-564

  Xie, Yuanyun ^a,b   Yao, Zhibin ^b   Chai, Hong ^a   Wong, Wai Man ^a   Wu, Wutian ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

amyloid; Alzheimer precursor protein A4; Avulsion; Axotomy; Spinal motor neuron

Indexed keywords

ALZHEIMER PRECURSOR PROTEIN A4; AMYLOID PRECURSOR PROTEIN; CHOLINE ACETYLTRANSFERASE; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AVULSION INJURY; AXONAL INJURY; CELL ACTIVITY; CELL COUNT; CELL FUNCTION; CELL LOSS; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOWN REGULATION; IMMUNOREACTIVITY; MALE; NERVE DEGENERATION; NERVE FIBER TRANSECTION; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINAL CORD MOTONEURON; SPINAL CORD VENTRAL HORN; STAINING;

AGING; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXOTOMY; CELL SURVIVAL; CHOLINE O-ACETYLTRANSFERASE; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; MOTOR NEURONS; RADICULOPATHY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SPINAL INJURIES; TIME FACTORS;

EID: 0042172835     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.10667     Document Type: Article

References (60)

1. Andorn AC, Kalaria RN. 2000. Factors affecting pro- and antioxidant properties of fragments of the b-protein precursor (bpp): implication for Alzheimer's disease. J Alzheimer Dis 2:69-78.
2. Araki W, Kitaguchi N, Tokushima Y, Ishii K, Aratake H, Shimohama S, Nakamura S, Kimura J. 1991. Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture. Biochem Biophys Res Commun 181:265-271.
3. Atwood CS, Huang X, Khatri A, Scarpa RC, Kim YS, Moir RD, Tanzi RE, Roher AE, Bush AI. 1998. Copper catalyzed oxidation of Alzheimer Aβ. J Biol Chem 273:12817-12826.
4. Auld DS, Kar S, Quirion R. 1998. β-Amyloid peptides as direct cholinergic neuromodulators: a missing link? Trends Neurosci 21:43-49.
5. Barber RP, Phelps PE, Houser CR, Crawford GD, Salvaterra PM, Vaughn JE. 1984. The morphology and distribution of neurons containing choline acetyltransferase in the adult rat spinal cord: an immunocytochemical study. J Comp Neurol 229:329-346.
6. Barger SW, Harmon AD. 1997. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 388:878-881.
7. Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan C. 1998. Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J Neurosci 18:5869-5880.
8. Bishop GM, Robinson SR. 2000. β-Amyloid helps to protect neurons from oxidative stress. Neurobiol Aging 21:226.
9. Breen KC, Bruce M, Anderton BH. 1991. Beta amyloid precursor protein mediates neuronal cell-cell and cell-surface adhesion. J Neurosci Res 28:90-100.
10. Cornish R, Blumbergs PC, Manavis J, Scott G, Jones NR, Reilly PL. 2000. Topography and severity of axonal injury in human spinal cord trauma using amyloid precursor protein as a marker of axonal injury. Spine 25:1227-1233.
11. Dornan WA, Kang DE, McCampbell A, Kang EE. 1993. Bilateral injections of βA(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat. Neuroreport 18:165-168.
12. Gentleman SM, Nash MJ, Sweeting CJ, Graham DI, Roberts GW. 1993. β-Amyloid precursor protein (βAPP) as a marker for axonal injury after head injury. Neurosci Lett 160:139-144.
13. Gu YM, Spasic Z, Wu WT. 1997. The effects of remaining axons on motoneuron survival and NOS expression following axotomy in the adult rat. Dev Neurosci 19:255-259.
14. Hu J, el-Fakahany EE. 1993. β-Amyloid 25-35 activates nitric oxide synthase in a neuronal clone. Neuroreport 4:760-762.
15. Islam A, Kalaria RN, Winblad B, Adem A. 1998. Enhanced localization of amyloid β precursor protein in the rat hippocampus following long-term adrenalectomy. Brain Res 806:108-112.
16. Joseph J, Shukitt-Hale B, Denisova NA, Martin A, Perry G, Smith MA. 2001. Copernicus revisited: amyloid β in Alzheimer's disease. Neurobiol Aging 22:131-146.
17. Kalaria RN, Bhatti SU, Palatinsky EA, Pennington DH, Shelton ER, Chan H W, Perry G, Lust WD. 1993. Accumulation of the β-amyloid precursor protein at sites of ischemic injury in rat brain. Neuroreport 4:211-214.
18. Kar S, Issa AM, Seto D, Auld DS, Collier B, Quirion R. 1998. Amyloid β-peptide inhibits high-affinity choline uptake and acetylcholine release in rat hippocampal slices. J Neurochem 70:2179-2187.
19. Kelly JF, Furukawa K, Barger SW, Rengen MR, Mark RJ, Blanc EM, Roth GS, Mattson MP. 1996. Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons. Proc Natl Acad Sci USA 93:6753-6758.
20. Koo EH, Sisodia SS, Archer DR, Martin LJ, Weidemann A, Beyreuther K, Fischer P, Masters CL, Price DL. 1990. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc Natl Acad Sci USA 87:1561-1565.
21. LaFerla FM, Hall CK, Ngo L, Jay G. 1996. Extracellular deposition of β-amyloid upon p53-dependent neuronal cell death in transgenic mice. J Clin Invest 98:1626-1632.
22. LeBlanc AC, Kovacs DM, Chen HY, Villare F, Tykocinski M, Autilio-Gambetti L, Gambetti P. 1992. Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J Neurosci Res 31:635-645.
23. Lewen A, Li GL, Nilsson P, Olsson Y, Hillered L. 1995. Traumatic brain injury in rat produces changes of β-amyloid precursor protein immunoreactivity. Neuroreport 6:357-360.
24. Li Y, Liu L, Kang J, Sheng JG, Barger SW, Mrak RE, Griffin WS. 2000. Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J Neurosci 20:149-155.
25. Mark RJ, Pang Z, Geddes JW, Uchida K, Mattson MP. 1997. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation. J Neurosci 17:1046-1054.
26. Marquez-Sterling NR, Lo ACY, Sisodia SS, Koo EH. 1997. Trafficking of cell-surface β-amyloid precursor protein: evidence that a sorting intermediate participates in synaptic vesicle recycling. J Neurosci 17:140-151.
27. Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. 1991. Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci USA 88:1461-1465.
28. Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Muckle L. 1997. Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78:135-146.
29. Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10:243-254.
30. McKenzie KJ, McLellan DR, Gentleman SM, Maxwell WL, Gennarelli TA, Graham DL. 1996. Is β-APP a marker of axonal damage in short surviving head injury? Acta Neuropathol (Berl) 92:608-613.
31. McMillian M, Kong LY, Sawin SM, Wilson B, Das K, Hudson P, Hong JS, Bing G. 1995. Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures. Biochem Biophys Res Commun 215:572-577.
32. Nakamura Y, Takeda M, Niigawa H, Hariguchi S, Nishimura T. 1992. Amyloid β-protein precursor deposition in rat hippocampus lesioned by ibotenic acid injection. Neurosci Lett 136:95-98.
33. Naves FJ, Calzada B, Cabal A, Alonso-Cortina V, Del Valle ME, Fernandez-Sanchez MT, Vega JA. 1994. Expression of β-Alzheimer precursor protein (APP) in human dorsal root ganglia. Neurosci Lett 181:73-77.
34. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA. 2001. Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60:759-767.
35. Nunomura A, Perry G, Pappolla MA, Friedland RP, Hirai K, Chiba S, Smith MA. 2000. Neuronal oxidative stress precedes amyloid-β deposition in Down syndrome. J Neuropathol Exp Neurol 59:1011-1017.
36. Oltersdorf T, Fritz LC, Schenk DB, Lieberburg I, Johnson-Wood KL, Beattie EC, Ward PJ, Blacher RW, Dovey HF, Sinha S. 1989. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature 341:144-147.
37. Otsuka N, Tomonaga M, Ikeda K. 1991. Rapid appearance of β-Alzheimer precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury. Brain Res 568:335-338.
38. Panegyres PK, Zafiris-Toufexis K, Kakulas BA. 2000. Amyloid precursor protein gene isoforms in Alzheimer's disease and other neurodegenerative disorders. J Neurol Sci 173:81-92.
39. Perez RG, Zheng H, Van der Ploeg LHT, Koo EH. 1997. The β-Alzheimer precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J Neurosci 17:9407-9414.
40. Phelps PE, Barber RP, Houser CR, Crawford GD, Salvaterra PM, Vaughn JE. 1984. Postnatal development of neurons containing choline acetyltransferase in rat spinal cord: an immunocytochemical study. J Comp Neurol 229:347-361.
41. Pierce JES, Trojanowski JQ, Graham DI, Smith DH, McIntosh TK. 1996. Immunohistochemical characterization of alterations in the distribution of Amyloid precursor proteins and β-amyloid peptide after experimental brain injury in the rat. J Neurosci 16:1083-1090.
42. Qiu WQ, Ferreira A, Miller C, Koo EH, Selkoe DJ. 1995. Cell-surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner. J Neurosci 15:2157-2167.
43. Rottkamp CA, Atwood CS, Joseph JA, Nunomura A, Perry G, Smith MA. 2002. The state versus amyloid-β: the trial of the most wanted criminal in Alzheimer disease. Peptides 23:1333-1341.
44. Schubert D, Jin LW, Saitoh T, Cole G. 1989. The regulation amyloid β protein precursor secretion and its modulatory role in cell adhesion. Neuron 3:689-694.
45. Shigematsu K, McGeer PL. 1992. Accumulation of amyloid precursor protein in neurons after intraventricular injection of colchicine. Am J Pathol 140:787-794.
46. Shivers BD, Hilbich C, Multhaup G, Salbaum M, Beyreuther K, Seeburg PH. 1988. Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact. EMBO J 7:1365-1370.
47. Sigurdsson EM, Hejna MJ, Lee JM, Lorens SA. 1995. β-Amyloid 25-35 and/or quinolinic acid injections into the basal forebrain of young male Fischer-344 rats: behavioral, neurochemical and histological effects. Behav Brain Res 72:141-156.
48. Sigurdsson EM, Lee JM, Dong XW, Hejna MJ, Lorens SA. 1997. Bilateral injections of amyloid-β 25-35 into the amygdala of young Fischer rats: behavioral, neurochemical, and time dependent histopathological effects. Neurobiol Aging 18:591-608.
49. Siman R, Card JP, Nelson RB, Davis LG. 1989. Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage. Neuron 3:275-285.
50. Storey E, Spurck T, Pickett-Heaps J, Beyreuther K, Masters CL. 1996. The amyloid precursor protein of Alzheimer's disease is found on the surface of static but not actively motile portions of neurites. Brain Res 735:59-66.
51. Wakita H, Tomimoto H, Akiguchi I, Ohnishi K, Nakamura S, Kimura J. 1992. Regional accumulation of amyloid β/A4 protein precursor in the gerbil brain following transient cerebral ischemia. Neurosci Lett 146:135-138.
52. Wallace WC, Bragin V, Robakis NK, Sambamurti K, VanderPutten D, Merril CR, Davis KL, Santucci AC, Haroutunian V. 1991. Increased biosynthesis of Alzheimer amyloid precursor protein in the cerebral cortex of rats with lesions of the nucleus basalis of Meynert. Brain Res Mol Brain Res 10:173-178.
53. Weidemann A, Konig G, Bunke D, Fischer P, Salbaum JM, Masters CL, Beyreuther K. 1989. Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57:115-126.
54. Whitson JS, Selkoe DJ, Cotman CW. 1989. Amyloid β precursor protein enhances the survival of hippocampal neurons in vitro. Science 243:1488-1490.
55. Wu WT. 1996. Potential roles of gene expression change in adult rat spinal motoneurons following axonal injury: a comparison among c-jun, low-affinity nerve growth factor receptor (LNGFR), and nitric oxide synthase (NOS). Exp Neurol 141:190-200.
56. Wu WT, Han K, Li LX, Schinco FP. 1994. Implantation of PNS graft inhibits the induction of neuronal nitric oxide synthase and enhance the survival of spinal motoneurons following root avulsion. Exp Neurol 129:335-339.
57. Wu WT, Li LX. 1993. Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion. Neurosci Lett 153:121-124.
58. Wu YG, Li YF, Liu HL, Wu WT. 1995. Induction of nitric oxide synthase and motoneuron death in newborn and early postnatal rats following spinal root avulsion. Neurosci Lett 194:109-112.
59. Xie YY, Yao ZB, Wu WT. 2000. Survival of motor neurons and expression of β-amyloid protein in the aged spinal cord. Neuroreport 11:697-700.
60. Yamazaki T, Selkoe DJ, Koo EH. 1995. Trafficking of cell surface β-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons. J Cell Biol 129:432-442.