Factors affecting pro- and anti-oxidant properties of fragments of the β-protein precursor (βPP): Implication for Alzheimer's disease

Journal of Alzheimer's Disease

Volumn 2, Issue 2, 2000, Pages 69-78

  Andorn, A C ^a   Kalaria, R N ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASCORBIC ACID; BOVINE SERUM ALBUMIN; HUMAN SERUM ALBUMIN; INSULIN; PEPSTATIN;

ADULT; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROCESSING;

EID: 0033794471     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2000-2201     Document Type: Article

References (36)

1. Immunohistochemical evaluation of oxidative stress in Alzheimer's disease
2. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type
3. Advanced Maillard reaction end products are associated with Alzheimer disease pathology
4. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation
5. Evidence of an oxidative challenge in the Alzheimer's brain
6. Oxidative stress hypothesis in Alzheimer's disease
7. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
8. Actions of neurotoxic β-amyloid on calcium homeostasis and viability of PC12 cells are blocked by antioxidants but not by calcium channel antagonists
9. Selective increase in lipid peroxidation in the inferior temporal cortex in Alzheimer's disease
10. Brain membrane fluidity and lipid peroxidation in Alzheimer's disease
11. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro
12. Ascorbate-stimulated lipid peroxidation and nonheme iron concentrations in Alzheimer's disease
13. Amyloid peptides are toxic via a common oxidative mechanism
14. Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
15. Hydrogen peroxide mediates amyloid β protein toxicity
16. 2 generation
17. Inhibitors of free radical formation fail to attenuate direct β-amyloid(25-35) peptide-mediated neurotoxicity in rat hippocampal cultures
18. Amyloidogenicity of βA4 and βA4-bearing amyloid protein precursor fragments by metal-catalyzed oxidation
19. Oxidative stress increases production of β-amyloid precursor protein and β-amyloid (Aβ) in mammalian lenses and Aβ has toxic effects on lens epithelial cells
20. Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide
21. The antioxidant role of vitamin C
22. Ascorbate-stimulated lipid peroxidation in human brain is dependent on iron but not on hydroxyl radical
23. Protein measurements with the Folin phenol reagent
24. Alzheimer's disease amyloid β peptide 25-35 inhibits lipid peroxidation as a result of its membrane interations
25. Nanomolar amyloid β protein-induced inhibition of cellular redox activity in cultured astrocytes
26. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
27. β-Amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals
28. Secreted forms of β-amyloid precursor protein protect against ischemic brain injury
29. β-Amyloid toxicity in organotypic hippocampal cultures: Protection by EUK-8, a synthetic catalytic free radical scavenger
30. Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death
31. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors
32. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
33. Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
34. 1-Trypsin immunoreactivity in Alzheimer disease
35. Heat shock alters Alzheimer's β amyloid precursor protein expression in human endothelial cells
36. Heat shock factor-1 mediates the transcriptional activation of Alzheimer's β-amyloid precursor protein gene in response to stress