Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease

Brain Research Bulletin

Volumn 61, Issue 4, 2003, Pages 427-435

  Surendran, Sankar ^a   Rady, Peter L ^b   Michals Matalon, Kimberlee ^a   Quast, Michael J ^a   Rassin, David K ^a   Campbell, Gerald A ^b   Ezell, Ed L ^a   Wei, Jingna ^a   Tyring, Stephen K ^b   Szucs, Sylvia ^a   Matalon, Reuben ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Canavan disease; EAAT4; GABA; GABRA6; Glutamate; Spi2

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ASPARTOACYLASE; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; SERINE PROTEINASE INHIBITOR;

AMINO ACID ANALYSIS; ANIMAL TISSUE; ARTICLE; CANAVAN DISEASE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE;

EID: 0042165900     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(03)00158-8     Document Type: Article

References (57)

1. Arriza J.L., Eliasof S., Kavanaugh M.P., Amara S.G. Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4155-4160.
2. Balcom G.J., Lenox R.H., Meyerhoff J.L. Regional glutamate levels in rat brain determined after microwave fixation. J. Neurochem. 26:1976;423-425.
3. Bar-Peled O., Ben-Hur H., Biegon A., Groner Y., Dewhurst S., Furuta A., Rothstein J.D. Distribution of glutamate transporter subtypes during human brain development. J. Neurochem. 69:1997;2571-2580.
4. 1H -NMR spectroscopy - MRS studies in vivo Neuroreport. 7:1996;1397-1400.
5. Bhakoo K.K., Craig T.J., Styles P. Developmental and regional distribution of aspartocylase in rat brain tissue. J. Neurochem. 79:2001;211-220.
6. 1H -NMR spectroscopic studies of brain Neurosci. Behav. Rev. 13:1989;23-31.
7. Bordon L.A. GABA heterogeneity: pharmacology and cellular localization. Neurochem. Int. 29:1996;335-356.
8. Bustin S.A. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 25:2000;169-193.
9. Chakraborthy G., Mekala P., Yahya D., Wu G., Ledeen W. Intraneuronal N-acetylaspartate supplies acetyl groups for myelin lipid synthesis. Evidence for myelin-associated aspartoacylase. J. Neurochem. 78:2001;736-745.
10. Dandoy-Dron F., Benboudjema L., Guillo F., Jaegly A., Jasmin C., Dormont D., Tovey M.G., Dron M. Enhanced levels of scrapie responsive gene mRNA in BSE-infected mouse brain. Brain Res. Mol. Brain Res. 76:2000;173-179.
11. De Biasi S., Vitellaro-Zuccarello L., Brecha N.C. Immunoreactivity for the GABA transporter-1 and GABA transporter-3 is restricted to astrocytes in the rat thalamus. A light and electronic-microscopic immunolocalization. Neuroscience. 83:1998;815-828.
12. Dehnes Y., Chaudhry F.A., Ullensvang K., Lehre K.P., Storm-Mathisen J., Danbolt N.C. The glutamate reporter EAAT4 in rat cerebellar purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. J. Neurosci. 18:1998;3606-3619.
13. J. Dichgans, H.C. Diener, Clinical evidence for functional compartmentalization of the cerebellum, in: J.R. Bloedel, J. Dichgans, W. Precht (Eds.), Cerebellar Functions, Springer-Verlag, New York, 1985, pp. 126-147.
14. Erecinska M., Nelson D., Wilson D.F., Silver I.A. Neurotransmitter amino acids in the CNS. I. Regional changes in amino acid levels in rat brain during ischemia and reperfusion. Brain Res. 304:1984;9-22.
15. Fairman W.A., Vandenberg R.J., Arriza J.L., Kavanaugh M.P., Amara S.G. An excitatory amino acid transporter with properties of a ligand-gated chloride channel. Nature. 375:1995;599-603.
16. Goldstein F.B. The enzymatic synthesis of N-acetyl-L-aspartic acid by subcellular preparations of the rat brain. J. Biol. Chem. 244:1969;4257-4260.
17. Grodd W., Krageloh-Mann I., Peterson D., Trefz F.K., Harzer K. In vivo assessment of N-acetylaspartate in brain spongy degeneration (Canavan disease) by proton spectroscopy. Lancet. 336:1990;437-438.
18. Hong J.H., Chiang C.S., Campbell I.L., Sun J.R., Withers W.H., McBride W.H. Induction of acute phase gene expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33:1995;619-626.
19. Inglis J.D., Lee M., Davidson R.E., Hill R.E. Isolation of two cDNAs encoding novel alpha 1-antichymotrypsin like proteins in a murine chondrocytic cell line. Gene. 106:1991;213-220.
20. Jackson M., Song W., Liu M.Y., Jin L., Dykes-Hoberg M., Lin C.I., Bowers W.J., Federoff H.J., Sternweis P.C., Rothstein J.D. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410:2001;89-93.
21. Kanemaru K., Mecklein B., Marshall D.C., Sipe J.D., Abraham C.R. Synthesis and secretion of active alpha 1-antichymotrypsin by murine primary astrocytes. Neurobiol. Aging. 17:1996;767-771.
22. Kanzai Y., Hediger M.A. Primary structure and functional characterization of a high affinity glutamate transporter. Nature. 360:1992;467-471.
23. A receptor α subunit is expressed only in cerebellar granule cells. J. Mol. Biol. 214:1990;619-624.
24. Kaul R., Casanova J., Johnson A., Tang P., Matalon R. Purification, characterization and localization of aspartoacylase from bovine brain. J. Neurochem. 56:1991;129-135.
25. Kirmani B.F., Jacobowitz D.M., Kallarakal A.T., Namboodiri M.A. Aspartoacylase is restricted primarily to myelin synthesizing cells in the CNS: therapeutic implications for Canavan disease. Brain Res. Mol. Brain. Res. 107:2002;176-182.
26. Kocsis J.D., Mattson R.H. GABA levels in the brain: a target for new antiepileptic drugs. Neuroscientist. 3:1996;326-334.
27. Krnjevic K. Glutamate and γ-aminobutyric acid in brain. Nature. 228:1970;119-124.
28. Lieb K., Fiebich B.L., Schaller H., Berger M., Bauer J. Interleukin-1 beta and tumour necrosis factor-alpha induce expression of alpha 1-antichymotrypsin in human in human astrocytoma cells by activation of nuclear factor kappa B. J. Neurochem. 67:1996;2039-2044.
29. Lopez S.M., Rassin D.K. Brain large neutral amino acids and catecholamines in parentally nourished preterm rabbits. Int. J. Dev. Neurosci. 13:1995;619-626.
30. A receptor selective for a behavioural alcohol antagonist. Nature. 346:1990;648-651.
31. Massie A., Vandesande F., Arckens L. Expression of the high affinity glutamate EAAT4 in mammalian cerebral cortex. Neuroreport. 12:2001;393-397.
32. Matalon R., Kaul R., Casanova J., Michals K., Johnson A., Rapin I., Gashkoff P., Deanching M. Aspartoacylase deficiency: the enzyme defect in Canavan disease. J. Inherit. Metab. Dis. 12:1989;744-752.
33. Matalon R., Michals K., Sebasta D., Deanching M., Gashkoff P., Casanova J. Aspartoacylase deficiency and N-acetyl aspartic aciduria in patients with Canavan disease. Am. J. Med. Genet. 29:1988;463-471.
34. Matalon R., Michals-Matalon K. Biochemistry and molecular biology of Canavan disease. Neurochem. Res. 24:1999;507-513.
35. Matalon R., Michals-Matalon K. Canavan disease, prenatal diagnosis and genetic counseling. Obstet. Gynecol. Clin. North Am. 29:2002;297-304.
36. Matalon R., Rady P.L., Platt K.A., Skinner H.B., Quast M.J., Campbell G.A., Matalon K., Ceci J.D., Tyring S.K., Nehls M., Surendran S., Wei J., Ezell E.L., Szucs S. Knock-out mouse for Canavan disease: a model for gene transfer to the central nervous system. J. Gene Med. 2:2000;165-175.
37. Matalon R., Surendran S., Rady P.L., Quast M.J., Campbell G.A., Matalon K.M., Tyring S.K., Wei J., Peden C.S., Ezell E.L., Muzyczka N., Mandel R.J. Adeno-associated virus mediated aspartoacylase gene transfer to the brain of knock out mouse for Canavan Disease. Mol. Ther. 7(5):2003;580-587.
38. McCllumsmith R.E., Meador-Woodruff J.H. Striatal excitatory amino acid transporter transcript expression in schizophrenia. Neuropsychopharmacology. 26:2002;368-375.
39. McCormick D.A. GABA as inhibitory neurotransmitter in human cerebral cortex. J. Neurophysiol. 62:1989;1018-1027.
40. Minelli M., Brecha N.C., Karschin C., De Biasi S., Conti F. GAT-1, a high affinity GABA plasma membrane transporter is localized to neurons and astroglia in the cerebral cortex. J. Neurosci. 15:1995;7734-7746.
41. 13C ] glucose infusion J. Neurochem. 77:2001;347-350.
42. Nesic O., Svrakic N.M., Xu G.Y., McAdoo D., Westlund K.N., Hulsebosch C.E., Ye Z., Galante A., Soteropoulous P., Tolias P., Young W., Hart R.P., Perespolo J.R. DNA microarray analysis of the contused spinal cord: effect of NMDA receptor inhibition. J. Neurosci. Res. 68:2002;406-423.
43. Nicoletti F., Magri G., Ingrao F., Bruno V., Catania M.V., Dell'Albani P., Condorolli D.F., Avola R. Excitatory amino acids stimulate inositol phospholipid hydrolysis and reduce proliferation in cultured astrocytes. J. Neurochem. 54:1990;771-777.
44. Olsen R.W., DeLorey T.M., Gordey M., Kang M.H. GABA receptor function and epilepsy. Adv. Neurol. 79:1999;499-510.
45. Patel T.B., Clark J.B. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem. J. 184:1979;539-546.
46. Pearce I.A., Cambray-Deakin M.A., Burgoyne R.D. Glutamate acting on NMDA receptors stimulates neurite outgrowth from cerebellar granule cells. FEBS Lett. 223:1987;143-147.
47. Perry T.L., Berry K., Hanson S., Diamond S., Mok C. Regional distribution of amino acids in human brain obtained at autopsy. J. Neurochem. 18:1971;513-519.
48. Petroff O.A. Glutamate and GABA in the human brain. Neuroscientist. 8:2002;562-573.
49. Petroff O.A., Hyder F., Mattson R.H., Rothman D.L. Topiramate increases brain GABA, homocarnosin and pyrolidone in patients with epilepsy. Neurology. 52:1999;473-478.
50. Pines G., Danbolt N.C., Bijras M., Zhang Y., Bendaham A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E., Kanner B.I. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
51. Richerson G.B., Gaspery H.L. Carrier-mediated GABA release: is there a functional role? Neuroscientist. 3:1997;151-157.
52. A receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits. Neuroscience. 80:1997;987-1000.
53. + dependent glutamate/aspartate transporter from rat brain. Proc. Natl. Acad. Sci. U.S.A. 89:1992;10955-10959.
54. Tallan H.H. Studies on the distribution of N-acetyl-L-aspartic acid in brain. J. Biol. Chem. 224:1956;41-45.
55. Van Bogaert L., Bertrand I. Sur une idiotie familiale avec degerescence sponglieuse de neuraxe (note preliminaire). Acta Neurol. Belg. 49:1949;572-587.
56. Van den Berg C.J., Garfinkel D. A stimulation study of brain compartments: metabolism of glutamate and related substances in mouse brain. Biochem. J. 113:1971;281-290.
57. Yamada K., Watanabe M., Shibata T., Tanaka K., Wada K., Inoue Y. EAAT4 is a post-synaptic glutamate transporter at purkinje cell synapses. Neuroreport. 7:1996;2013-2017.