-
1
-
-
0025022272
-
Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals
-
Ikeda H, Taketomi S, Sugiyama Y, et al. Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals. Arzneim-Forsh/Drug Res 1990; 40: 156-162.
-
(1990)
Arzneim-Forsh/Drug Res.
, vol.40
, pp. 156-162
-
-
Ikeda, H.1
Taketomi, S.2
Sugiyama, Y.3
-
2
-
-
0026664271
-
New oral thiazolidinedione antidiabetic agents act as insulin sensitizers
-
Hofmann CA, Colca JR. New oral thiazolidinedione antidiabetic agents act as insulin sensitizers. Diabetes Care 1992; 15: 1075-1078.
-
(1992)
Diabetes Care
, vol.15
, pp. 1075-1078
-
-
Hofmann, C.A.1
Colca, J.R.2
-
3
-
-
0034920087
-
Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes
-
Koshiyama H, Shimono D, Kuwamura N, Minamikawa, J, Nakamura Y. Inhibitory effect of pioglitazone on carotid arterial wall thickness in type 2 diabetes. J Clin Endocrinol Metab 2001; 86: 3452-3456.
-
(2001)
J. Clin. Endocrinol. Metab.
, vol.86
, pp. 3452-3456
-
-
Koshiyama, H.1
Shimono, D.2
Kuwamura, N.3
Minamikawa, J.4
Nakamura, Y.5
-
4
-
-
0027443636
-
Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats
-
Dubey RK, Zhang HY, Reddy SR, Boegehold MA, Kotchen TA. Pioglitazone attenuates hypertension and inhibits growth of renal arteriolar smooth muscle in rats. Am J Physiol 1993; 265: R726-R732.
-
(1993)
Am. J. Physiol.
, vol.265
-
-
Dubey, R.K.1
Zhang, H.Y.2
Reddy, S.R.3
Boegehold, M.A.4
Kotchen, T.A.5
-
5
-
-
0029871969
-
Differential inhibitory effects of antidiabetic drugs on arterial smooth muscle cell proliferation
-
Peuler JD, Phare MP, Iannucci AR, Hodorek MJ. Differential inhibitory effects of antidiabetic drugs on arterial smooth muscle cell proliferation. Am J Hypertens 1996; 9: 188-192.
-
(1996)
Am. J. Hypertens.
, vol.9
, pp. 188-192
-
-
Peuler, J.D.1
Phare, M.P.2
Iannucci, A.R.3
Hodorek, M.J.4
-
6
-
-
0032794799
-
Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy
-
Yoshimoto T, Naruse M, Shizumi H, et al. Vasculo-protective effects of insulin sensitizing agent pioglitazone in neointimal thickening and hypertensive vascular hypertrophy. Atherosclerosis 1999; 145: 333-340.
-
(1999)
Atherosclerosis
, vol.145
, pp. 333-340
-
-
Yoshimoto, T.1
Naruse, M.2
Shizumi, H.3
-
7
-
-
0034864919
-
Characterization of an inhibitory effect of pioglitazone on balloon-injured vascular smooth muscle cell growth
-
Igarashi M, Hirata A, Yamaguchi H, et al. Characterization of an inhibitory effect of pioglitazone on balloon-injured vascular smooth muscle cell growth. Metabolism 2001; 50: 955-962.
-
(2001)
Metabolism
, vol.50
, pp. 955-962
-
-
Igarashi, M.1
Hirata, A.2
Yamaguchi, H.3
-
8
-
-
0034898803
-
Thiazolidinediones, peroxisome proliferator-activated receptor γ agonists, regulate endothelial cell growth and secretion of vasoactive peptides
-
Fukunaga Y, Itoh H, Doi K, et al. Thiazolidinediones, peroxisome proliferator-activated receptor γ agonists, regulate endothelial cell growth and secretion of vasoactive peptides. Atherosclerosis 2001; 158: 13-119.
-
(2001)
Atherosclerosis
, vol.158
, pp. 13-119
-
-
Fukunaga, Y.1
Itoh, H.2
Doi, K.3
-
10
-
-
0030763565
-
Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat
-
Kotchen TA, Reddy S, Zhang HY. Increasing insulin sensitivity lowers blood pressure in the fructose-fed rat. Am J Hypertens 1997; 10: 1020-1026.
-
(1997)
Am. J. Hypertens.
, vol.10
, pp. 1020-1026
-
-
Kotchen, T.A.1
Reddy, S.2
Zhang, H.Y.3
-
11
-
-
0035943010
-
Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia
-
Aizawa Y, Kawabe J, Hasebe N, Takehara N, Kikuchi K. Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Circulation 2001; 104: 455-460.
-
(2001)
Circulation
, vol.104
, pp. 455-460
-
-
Aizawa, Y.1
Kawabe, J.2
Hasebe, N.3
Takehara, N.4
Kikuchi, K.5
-
12
-
-
0029746269
-
Attenuation of hypertension by insulin-sensitizing agents
-
Kotchen TA. Attenuation of hypertension by insulin-sensitizing agents. Hypertension 1996; 28: 219-223.
-
(1996)
Hypertension
, vol.28
, pp. 219-223
-
-
Kotchen, T.A.1
-
13
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
-
United Kingdom Prospective Diabetes Study (UKPDS) Group
-
United Kingdom Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-865.
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
14
-
-
0037034257
-
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
-
Diabetes Prevention Program Research Group
-
Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403.
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 393-403
-
-
-
15
-
-
0030175581
-
Vascular effects of metformin: Possible mechanisms for its antihypertensive action in the spontaneously hypertensive rat
-
Bhalla RC, Toth KF, Tan E, Bhatty RA, Mathias BE, Sharma RV. Vascular effects of metformin: possible mechanisms for its antihypertensive action in the spontaneously hypertensive rat. Am J Hypertens 1996; 9: 570-576.
-
(1996)
Am. J. Hypertens.
, vol.9
, pp. 570-576
-
-
Bhalla, R.C.1
Toth, K.F.2
Tan, E.3
Bhatty, R.A.4
Mathias, B.E.5
Sharma, R.V.6
-
16
-
-
0029778182
-
Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients
-
Marfella R, Acampora R, Verrazzo G, et al. Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients. Diabetes Care 1996; 19: 934-939.
-
(1996)
Diabetes Care
, vol.19
, pp. 934-939
-
-
Marfella, R.1
Acampora, R.2
Verrazzo, G.3
-
18
-
-
0037275650
-
Cardioprotection with metformin is abolished by nitric oxide synthase inhibitor in ischemic rabbit hearts
-
Kawabata H, Ishikawa K. Cardioprotection with metformin is abolished by nitric oxide synthase inhibitor in ischemic rabbit hearts. Hypertens Res 2003; 26: 107-110.
-
(2003)
Hypertens. Res.
, vol.26
, pp. 107-110
-
-
Kawabata, H.1
Ishikawa, K.2
-
19
-
-
0001282033
-
Study of AD-4833 in clinical practice by phase I
-
(in Japanese)
-
Hiraga K. Study of AD-4833 in clinical practice by phase I (in Japanese). Jan J Clin Exp Med 1997; 74: 1184-1201.
-
(1997)
Jan. J. Clin. Exp. Med.
, vol.74
, pp. 1184-1201
-
-
Hiraga, K.1
-
20
-
-
0029933886
-
Clinical pharmacokinetics of metformin
-
Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 1996; 30: 359-371.
-
(1996)
Clin. Pharmacokinet.
, vol.30
, pp. 359-371
-
-
Scheen, A.J.1
-
22
-
-
0022272914
-
31P nuclear magnetic resonance analysis of metabolite concentrations in Langendorff-perfused rabbit hearts
-
31P nuclear magnetic resonance analysis of metabolite concentrations in Langendorff-perfused rabbit hearts. Biophys J 1985; 48: 803-813.
-
(1985)
Biophys. J.
, vol.48
, pp. 803-813
-
-
Gard, J.K.1
Kichura, G.M.2
Ackerman, J.J.H.3
-
23
-
-
0024369941
-
Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication
-
Moncada S, Palmer RMJ, Higgs EA. Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol 1989; 38: 1709-1715.
-
(1989)
Biochem. Pharmacol.
, vol.38
, pp. 1709-1715
-
-
Moncada, S.1
Palmer, R.M.J.2
Higgs, E.A.3
-
24
-
-
0025194144
-
G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro
-
G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol 1990; 99: 408-412.
-
(1990)
Br. J. Pharmacol.
, vol.99
, pp. 408-412
-
-
Moore, P.K.1
al-Swayeh, O.A.2
Chong, N.W.S.3
Evans, R.A.4
Gibson, A.5
-
25
-
-
0029044895
-
Plasma nitric oxide end products are increased in the ischemic canine heart
-
Node K, Kitakaze M, Kosaka H, et al. Plasma nitric oxide end products are increased in the ischemic canine heart. Biochem Biophys Res Commun 1995; 211: 370-374.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.211
, pp. 370-374
-
-
Node, K.1
Kitakaze, M.2
Kosaka, H.3
-
27
-
-
0036233969
-
A novel cardioprotective agent, JTV-519, is abolished by nitric oxide synthase inhibitor on myocardial metabolism in ischemia-reperfused rabbit hearts
-
Kawabata H, Nakagawa K, Ishikawa K. A novel cardioprotective agent, JTV-519, is abolished by nitric oxide synthase inhibitor on myocardial metabolism in ischemia-reperfused rabbit hearts. Hypertens Res 2002; 25: 303-309.
-
(2002)
Hypertens. Res.
, vol.25
, pp. 303-309
-
-
Kawabata, H.1
Nakagawa, K.2
Ishikawa, K.3
-
28
-
-
0019814285
-
Lethal myocardial ischemic injury
-
Jennings RB, Reimer KA. Lethal myocardial ischemic injury. Am J Pathol 1981; 102: 241-255.
-
(1981)
Am. J. Pathol.
, vol.102
, pp. 241-255
-
-
Jennings, R.B.1
Reimer, K.A.2
-
29
-
-
0034102887
-
Effect of beta-blocker on metabolism and contraction of doxorubicin-induced cardiotoxicity in the isolated perfused rabbit heart
-
Kawabata H, Ryomoto T, Ishikawa K. Effect of beta-blocker on metabolism and contraction of doxorubicin-induced cardiotoxicity in the isolated perfused rabbit heart. Angiology 2000; 21: 405-413.
-
(2000)
Angiology
, vol.21
, pp. 405-413
-
-
Kawabata, H.1
Ryomoto, T.2
Ishikawa, K.3
-
30
-
-
0032544632
-
Effects of troglitazone and pioglitazone on the action potentials and membrane currents of rabbit ventricular myocytes
-
Ikeda S, Watanabe T. Effects of troglitazone and pioglitazone on the action potentials and membrane currents of rabbit ventricular myocytes. Eur J Pharmacol 1998; 357: 243-250.
-
(1998)
Eur. J. Pharmacol.
, vol.357
, pp. 243-250
-
-
Ikeda, S.1
Watanabe, T.2
-
31
-
-
0034033786
-
Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats
-
Isshiki K, Haneda M, Koya D, Maeda S, Sugimoto T, Kikkawa R. Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rats. Diabetes 2000; 49: 1022-1032.
-
(2000)
Diabetes
, vol.49
, pp. 1022-1032
-
-
Isshiki, K.1
Haneda, M.2
Koya, D.3
Maeda, S.4
Sugimoto, T.5
Kikkawa, R.6
-
32
-
-
0031600501
-
Growth factors and mitogen-activated protein kinases
-
Force T, Bonventre JV. Growth factors and mitogen-activated protein kinases. Hypertension 1998; 31: 152-161.
-
(1998)
Hypertension
, vol.31
, pp. 152-161
-
-
Force, T.1
Bonventre, J.V.2
-
33
-
-
0033917736
-
Neuroprotection mediated by changes in the endothelial action cytoskeleton
-
Laufs U, Endres M, Stagliano N, et al. Neuroprotection mediated by changes in the endothelial action cytoskeleton. J Clin Invest 2000; 106: 15-24.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 15-24
-
-
Laufs, U.1
Endres, M.2
Stagliano, N.3
-
34
-
-
0027055170
-
Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size
-
Nakanishi K, Vinten-Johansen J, Lefer DJ, et al. Intracoronary L-arginine during reperfusion improves endothelial function and reduces infarct size. Am J Physiol 1992; 263: H1650-H1658.
-
(1992)
Am. J. Physiol.
, vol.263
-
-
Nakanishi, K.1
Vinten-Johansen, J.2
Lefer, D.J.3
-
35
-
-
0032572603
-
Stress (heat shock) proteins: Molecular chaperones in cardiovascular biology and disease
-
Benjamin IJ, McMillan DR. Stress (heat shock) proteins: molecular chaperones in cardiovascular biology and disease. Circ Res 1998; 83: 117-132.
-
(1998)
Circ. Res.
, vol.83
, pp. 117-132
-
-
Benjamin, I.J.1
McMillan, D.R.2
-
36
-
-
0026801464
-
Preconditioning of the ischaemic myocardium: Involvement of the L-arginine nitric oxide pathway
-
Vegh A, Szekeres L, Parratt J. Preconditioning of the ischaemic myocardium: involvement of the L-arginine nitric oxide pathway. Br J Pharmacol 1992; 107: 648-652.
-
(1992)
Br. J. Pharmacol.
, vol.107
, pp. 648-652
-
-
Vegh, A.1
Szekeres, L.2
Parratt, J.3
-
38
-
-
0034141455
-
Activation of mitochondrial ATP-dependent potassium channels by nitric oxide
-
Sasaki N, Sato T, Ohler A, O'Rourke B, Marban E. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation 2000; 101: 439-445.
-
(2000)
Circulation
, vol.101
, pp. 439-445
-
-
Sasaki, N.1
Sato, T.2
Ohler, A.3
O'Rourke, B.4
Marban, E.5
-
39
-
-
0026547286
-
Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
-
Gross GJ, Auchanpach JA. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs. Circ Res 1992; 70: 223-233.
-
(1992)
Circ. Res.
, vol.70
, pp. 223-233
-
-
Gross, G.J.1
Auchanpach, J.A.2
-
41
-
-
0035168435
-
Role of cardiac ATP-sensitive K+ channels induced by HMG CoA reductase inhibitor in ischemic rabbit heart
-
Kawabata H, Ryomoto T, Ishikawa K. Role of cardiac ATP-sensitive K+ channels induced by HMG CoA reductase inhibitor in ischemic rabbit heart. Hypertens Res 2001; 24: 573-577.
-
(2001)
Hypertens. Res.
, vol.24
, pp. 573-577
-
-
Kawabata, H.1
Ryomoto, T.2
Ishikawa, K.3
-
42
-
-
0036238159
-
Effects of an HMG-CoA reductase inhibitor in combination with an ACE inhibitor or angiotensin II type 1 receptor antagonist on myocardial metabolism in ischemic rabbit hearts
-
Kawabata H, Nakagawa K, Ishikawa K. Effects of an HMG-CoA reductase inhibitor in combination with an ACE inhibitor or angiotensin II type 1 receptor antagonist on myocardial metabolism in ischemic rabbit hearts. Hypertens Res 2002; 25: 203-210.
-
(2002)
Hypertens. Res.
, vol.25
, pp. 203-210
-
-
Kawabata, H.1
Nakagawa, K.2
Ishikawa, K.3
-
44
-
-
0037058874
-
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction
-
Shiomi T, Tsutsui H, Hayashidani S, et al. Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction. Circulation 2002; 106: 3126-3132.
-
(2002)
Circulation
, vol.106
, pp. 3126-3132
-
-
Shiomi, T.1
Tsutsui, H.2
Hayashidani, S.3
-
45
-
-
0036959197
-
Pioglitazone: Cardiovascular effects in prediabetic patients
-
Mizushige K, Tsuji T, Noma T. Pioglitazone: cardiovascular effects in prediabetic patients. Cardiovasc Drug Rev 2002; 20: 329-340.
-
(2002)
Cardiovasc. Drug Rev.
, vol.20
, pp. 329-340
-
-
Mizushige, K.1
Tsuji, T.2
Noma, T.3
-
46
-
-
0013290685
-
Reduction of myocardial infarct size by metformin in rats submitted to permanent left coronary artery ligation
-
Charlon V, Boucher F, Mouhieddine S, Leiris JD. Reduction of myocardial infarct size by metformin in rats submitted to permanent left coronary artery ligation. Diabetes Metab 1988; 14: 591-595.
-
(1988)
Diabetes Metab.
, vol.14
, pp. 591-595
-
-
Charlon, V.1
Boucher, F.2
Mouhieddine, S.3
Leiris, J.D.4
-
48
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167-1174.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
|