Cutting edge: H-2DM is responsible for the large differences in presentation among peptides selected by I-Ak during antigen processing

Journal of Immunology

Volumn 171, Issue 5, 2003, Pages 2183-2186

  Lovitch, Scott B ^a   Petzold, Shirley J ^a   Unanue, Emil R ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DM ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; T LYMPHOCYTE;

EID: 0041929599     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.5.2183     Document Type: Article

References (39)

1. Velazquez, C., R. DiPaolo, and E. R. Unanue. 2001. Quantitation oflysozyme peptides bound to class II MHC molecules indicates very large differences in levels of presentation. J. Immunol. 166:5488.
2. k class II molecule. Immunol. Rev. 172:209.
3. k class II molecules in human APC containing deleted or mutated HLA-DM genes. J. Immunol. 153:5382.
4. Karz, J. F., C. Stebbins, E. Appella, and A. J. Sant. 1996. Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules. J. Exp. Med. 184:1747.
5. Kropshofer, H., A. B. Vogt, G. Moldenhauer, J. Hammer, J. S. Blum, and G. J. Hämmerling. 1996. Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 15:6144.
6. Van Ham, S. M., U. Gruneberg, G. Malcherek, I. Broker, A. Melms, and J. Trowsdale. 1996. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs. J. Exp. Med. 184:2019.
7. Peterson, M., and A. J. Sant. 1998. The inability of the NOD class II molecule to form stale peptide complexes does not reflect a failure to interact productively with DM. J. Immunol. 161:2961.
8. Nanda, N. K., and A. J. Sant. 2000. DM determines the cryptic and immunodominant fate of T cell epitopes. J. Exp. Med. 192:781.
9. Nadimi, F., J. Moreno, F. Momburg, A. Heuser, S. Fuchs, L. Adorini, and G. J. Hämmerling. 1991. Antigen presentation of hen egg-white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II-associated invariant chain. Eur. J. Immunol. 21:1255.
10. Momburg, F., S. Fuchs, J. Drexler, R. Busch, M. Post, G. J. Hämmerling, and L. Adorini. 1993. Epitope-specific enhancement of antigen presentation by invariant chain. J. Exp. Med. 178:1453.
11. Zhong, G., P. Romagnoli, and R. N. Germain. 1997. Related leucine-based cytoplasmic targeting signals in invariant chain and major histocompatibility complex class II molecules control endocytic presentation of distinct determinants in a single protein. J. Exp. Med. 185:429.
12. Wolf, P. R., S. Tourne, T. Miyazaki, C. Benoist, D. Mathis, and H. L. Ploegh. 1998. The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed. Eur. J. Immunol. 28:2605.
13. Koonce, C. H., G. Wutz, E. J. Robertson, A. B. Vogt, H. Kropshofer, and E. K. Bikoff. 2003. DM loss in k haplotype mice reveals isotype-specific chaperone requirements. J. Immunol. 170:3751.
14. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. M. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLADR. Nature 375:802.
15. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
16. Sherman, M. A., D. A. Weber, and P. Jensen. 1995. DM enhances binding to class II MHC by release of invariant chain-derived peptides. Immunity 3:197.
17. Weber, D. A., B. D. Evavold, and P. E. Jensen. 1996. Enhanced dissociation of HLADR-bound peptides in the presence of HLA-DM. Science 274:618.
18. Vogt, A. B., H. Kropshofer, G. Moldenhauer, and G. J. Hämmerling. 1996. Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM. Proc. Natl. Acad. Sci. USA 93:9724.
19. Sanderson, F., C. Thomas, J. Neefjes, and J. Trowsdale. 1996. Association between HLA-DM and HLA-DR in vivo. Immunity 4:87.
20. Denzin, L. K., C. Hammond, and P. Cresswell. 1996. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules. J. Exp. Med. 184:2153.
21. Kropshofer, H., S. O. Arndt, G. Moldenhauer, G. J. Hämmerling, and A. B. Vogt. 1997. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH. Immunity 6;297.
22. Riberdy, J., and P. Cresswell. 1992. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation. J. Immunol. 148:2586.
23. Allen, P. M., and E. R. Unanue. 1984. Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas. J. Immunol. 132:1077.
24. Allen, P. M., D. J. McKean, B. N. Beck, J. Sheffield, and L. H. Glimcher. 1985. Direct evidence that a class II molecule and a simple globular protein generate multiple determinants. J. Exp. Med. 162:1264.
25. Pu, Z., J. A. Carrero, and E. R. Unanue. 2002. Distinct recognition by two subsets of T cells of a class II MHC-peptide complex. Proc. Natl. Acad. Sci. USA 99:8844.
26. k-derived peptides that are autoantigenic to type B T cells. J. Immunol. 170:4155.
27. k. Proc. Natl. Acad. Sci. USA 89:7380.
28. k by using peptide-specific immunoaffinity. J. Immunol. 161:6074.
29. k molecules analyzed with 35 monoclonal alloantibodies. Immunogenetics 14:481.
30. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B.J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:76.
31. k cells. J. Immunol. 157:2247.
32. Lindner, R., and E. R. Unanue. 1996. Distinct antigen-MHC class II complexes generated by separate processing pathways. EMBO J. 15:6910.
33. Germain, R. N., and L R. Hendrix. 1991. MHC class II structure, occupancy, and surface expression determined by post-endoplasmic reticulum antigen binding. Nature 353:134.
34. Nelson, C. A., S. J. Perzold, and E. R. Unanue. 1993. Identification of two distinct properties ofclass II major histocompatibility complex-associated peptides. Proc. Natl. Acad. Sci. USA 90:1227.
35. Karlsson, L., A. Pèléraux, R. Lindstedt, M. Liljedahl, and P. A. Peterson. 1994. Reconstitution of an operational class II MHC compartment in nonantigen-presenting cells. Science 266:1569.
36. Stebbins, C. C., G. E. Loss, C. G. Elias, A. Chervonsky, and A. J. Sant. 1995. The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent. J. Exp. Med. 181:223.
37. Ghosh, P., M. Amaya, E. Mellins, and D. C. Wiley. 1995. The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3. Nature 378:457
38. Sette, A., S. Southwood, J. Miller, and E. Appella. 1995. Binding of major histocompatibility complex class II to the invariant-chain derived peptide, CLIP, is regulated by allelic polymorphism in class II. J. Exp. Med 181:677.
39. Bangia, N. B., and T. H. Watts. 1995. Evidence for invatiant chain 85-101 (CLIP) binding in the antigen binding site of MHC class II molecules. Int. Immunol. 7:1585.