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Volumn 107, Issue 1, 2003, Pages 30-37

Negative regulatory role of PI3-kinase in TNF-induced tumor necrosis

Author keywords

Anti tumor therapy; PI3 kinase; Tissue factor; Tumor necrosis factor; Vascular targeting

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; THROMBOPLASTIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; WORTMANNIN;

EID: 0041914316     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.11345     Document Type: Article
Times cited : (7)

References (52)
  • 1
    • 0028030125 scopus 로고
    • Vascular targeting: A new approach to the therapy of solid tumors
    • Burrows FJ, Thorpe PE. Vascular targeting: a new approach to the therapy of solid tumors. Pharmacol Ther 1994;64:155-74.
    • (1994) Pharmacol Ther , vol.64 , pp. 155-174
    • Burrows, F.J.1    Thorpe, P.E.2
  • 2
    • 0025717523 scopus 로고
    • Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents
    • Kerbel RS. Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti-cancer therapeutic agents. Bioessays 1991;13:31-6.
    • (1991) Bioessays , vol.13 , pp. 31-36
    • Kerbel, R.S.1
  • 3
    • 0035254648 scopus 로고    scopus 로고
    • Angiogenesis: Regulators and clinical applications
    • Liekens S, De Clercq E, Neyts J. Angiogenesis: regulators and clinical applications. Biochem Pharmacol 2001;61:253-70.
    • (2001) Biochem Pharmacol , vol.61 , pp. 253-270
    • Liekens, S.1    De Clercq, E.2    Neyts, J.3
  • 5
    • 0023130601 scopus 로고
    • Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo
    • Asher A, Mule JJ, Reichert CM, Shiloni E, Rosenberg SA. Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo. J Immunol 1987;138:963-74.
    • (1987) J Immunol , vol.138 , pp. 963-974
    • Asher, A.1    Mule, J.J.2    Reichert, C.M.3    Shiloni, E.4    Rosenberg, S.A.5
  • 7
    • 0023931308 scopus 로고
    • Recombinant human tumor necrosis factor-alpha: Thrombus formation is a cause of anti-tumor activity
    • Shimomura K, Manda T, Mukumoto S, Kobayashi K, Nakano K, Mori J. Recombinant human tumor necrosis factor-alpha: thrombus formation is a cause of anti-tumor activity. Int J Cancer 1988;41: 243-7.
    • (1988) Int J Cancer , vol.41 , pp. 243-247
    • Shimomura, K.1    Manda, T.2    Mukumoto, S.3    Kobayashi, K.4    Nakano, K.5    Mori, J.6
  • 9
    • 0023009932 scopus 로고
    • In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma
    • Brouckaert PG, Leroux-Roels GG, Guisez Y, Tavernier J, Fiers W. In vivo anti-tumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-gamma, on a syngeneic murine melanoma. Int J Cancer 1986;38:763-9.
    • (1986) Int J Cancer , vol.38 , pp. 763-769
    • Brouckaert, P.G.1    Leroux-Roels, G.G.2    Guisez, Y.3    Tavernier, J.4    Fiers, W.5
  • 10
    • 9344242921 scopus 로고    scopus 로고
    • Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma
    • Zhang Y, Deng Y, Wendt T, Liliensiek B, Bierhaus A, Greten J, He W, Chen B, Hach-Wunderle V, Waldherr R, Ziegler R, Mannel D, et al. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced tissue factor expression and fibrin deposition in mouse meth-A sarcoma. J Clin Invest 1996;97:2213-24.
    • (1996) J Clin Invest , vol.97 , pp. 2213-2224
    • Zhang, Y.1    Deng, Y.2    Wendt, T.3    Liliensiek, B.4    Bierhaus, A.5    Greten, J.6    He, W.7    Chen, B.8    Hach-Wunderle, V.9    Waldherr, R.10    Ziegler, R.11    Mannel, D.12
  • 11
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Huang X, Molema G, King S, Watkins L, Edgington TS, Thorpe PE. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 1997;275:547-50.
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3    Watkins, L.4    Edgington, T.S.5    Thorpe, P.E.6
  • 12
    • 0032532656 scopus 로고    scopus 로고
    • Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • Ran S, Gao B, Duffy S, Watkins L, Rote N, Thorpe PE. Infarction of solid Hodgkin's tumors in mice by antibody-directed targeting of tissue factor to tumor vasculature. Cancer Res 1998;58:4646-53.
    • (1998) Cancer Res , vol.58 , pp. 4646-4653
    • Ran, S.1    Gao, B.2    Duffy, S.3    Watkins, L.4    Rote, N.5    Thorpe, P.E.6
  • 13
    • 0035863566 scopus 로고    scopus 로고
    • Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
    • Nilsson F, Kosmehl hr, Zardi L, Neri D. Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice. Cancer Res 2001;61: 711-6.
    • (2001) Cancer Res , vol.61 , pp. 711-716
    • Nilsson, F.1    Kosmehl, H.R.2    Zardi, L.3    Neri, D.4
  • 14
    • 0023692996 scopus 로고
    • Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas
    • Nawroth P, Handley D, Matsueda G, De Waal R, Gerlach hr, Blohm D, Stern D. Tumor necrosis factor/cachectin-induced intravascular fibrin formation in meth A fibrosarcomas. J Exp Med 1988;168:637-47.
    • (1988) J Exp Med , vol.168 , pp. 637-647
    • Nawroth, P.1    Handley, D.2    Matsueda, G.3    De Waal, R.4    Gerlach, H.R.5    Blohm, D.6    Stern, D.7
  • 15
    • 0025688912 scopus 로고
    • Vascular permeability factor: A tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration
    • Clauss M, Gerlach M, Gerlach hr, Brett J, Wang F, Familletti PC, Pan YC, Olander JV, Connolly DT, Stern D. Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration. J Exp Med 1990;172:1535-45.
    • (1990) J Exp Med , vol.172 , pp. 1535-1545
    • Clauss, M.1    Gerlach, M.2    Gerlach, H.R.3    Brett, J.4    Wang, F.5    Familletti, P.C.6    Pan, Y.C.7    Olander, J.V.8    Connolly, D.T.9    Stern, D.10
  • 16
    • 0025218720 scopus 로고
    • A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin
    • Clauss M, Murray JC, Vianna M, de Waal R, Thurston G, Nawroth P, Gerlach hr, Bach R, Familletti PC, Stern D. A polypeptide factor produced by fibrosarcoma cells that induces endothelial tissue factor and enhances the procoagulant response to tumor necrosis factor/cachectin. J Biol Chem 1990;265:7078-83.
    • (1990) J Biol Chem , vol.265 , pp. 7078-7083
    • Clauss, M.1    Murray, J.C.2    Vianna, M.3    De Waal, R.4    Thurston, G.5    Nawroth, P.6    Gerlach, H.R.7    Bach, R.8    Familletti, P.C.9    Stern, D.10
  • 18
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-4.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 19
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, Perruzzi CA, Harvey VS, Dvorak HF. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-5.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harvey, V.S.5    Dvorak, H.F.6
  • 21
    • 0030020590 scopus 로고    scopus 로고
    • In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease
    • Contrino J, Hair G, Kreutzer DL, Rickles FR. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 1996;2:209-15.
    • (1996) Nat Med , vol.2 , pp. 209-215
    • Contrino, J.1    Hair, G.2    Kreutzer, D.L.3    Rickles, F.R.4
  • 22
    • 0027725139 scopus 로고
    • Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis
    • Drake TA, Cheng J, Chang A, Taylor FB, Jr. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol 1993;142:1458-70.
    • (1993) Am J Pathol , vol.142 , pp. 1458-1470
    • Drake, T.A.1    Cheng, J.2    Chang, A.3    Taylor F.B., Jr.4
  • 23
    • 2442724586 scopus 로고
    • Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity
    • Nawroth PP, Handley DA, Esmon CT, Stern DM. Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci USA 1986;83:3460-4.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 3460-3464
    • Nawroth, P.P.1    Handley, D.A.2    Esmon, C.T.3    Stern, D.M.4
  • 24
    • 0024421453 scopus 로고
    • Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils
    • Baggiolini M, Walz A, Kunkel SL. Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 1989;84:1045-9.
    • (1989) J Clin Invest , vol.84 , pp. 1045-1049
    • Baggiolini, M.1    Walz, A.2    Kunkel, S.L.3
  • 26
    • 0028926427 scopus 로고
    • Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors
    • Moll T, Czyz M, Holzmuller hr, Hofer-Warbinek R, Wagner E, Winkler hr, Bach FH, Hofer E. Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors. J Biol Chem 1995;270:3849-57.
    • (1995) J Biol Chem , vol.270 , pp. 3849-3857
    • Moll, T.1    Czyz, M.2    Holzmuller, H.R.3    Hofer-Warbinek, R.4    Wagner, E.5    Winkler, H.R.6    Bach, F.H.7    Hofer, E.8
  • 27
    • 0035174972 scopus 로고    scopus 로고
    • Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor upregulation vía EGR-1 in endothelial cells
    • Mechtcheriakova D, Schabbauer G, Lucerna M, Clauss M, De Martin R, Binder BR, Hofer E. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor upregulation vía EGR-1 in endothelial cells. Faseb J 2001;15:230-42.
    • (2001) Faseb J , vol.15 , pp. 230-242
    • Mechtcheriakova, D.1    Schabbauer, G.2    Lucerna, M.3    Clauss, M.4    De Martin, R.5    Binder, B.R.6    Hofer, E.7
  • 28
    • 0033152286 scopus 로고    scopus 로고
    • Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1
    • Mechtcheriakova D, Wlachos A, Holzmuller hr, Binder BR, Hofer E. Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1. Blood 1999;93:3811-23.
    • (1999) Blood , vol.93 , pp. 3811-3823
    • Mechtcheriakova, D.1    Wlachos, A.2    Holzmuller, H.R.3    Binder, B.R.4    Hofer, E.5
  • 29
    • 0030605839 scopus 로고    scopus 로고
    • Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: Functional analysis of the tumor necrosis factor receptors
    • Clauss M, Grell M, Fangmann C, Fiers W, Scheurich P, Risau W. Synergistic induction of endothelial tissue factor by tumor necrosis factor and vascular endothelial growth factor: functional analysis of the tumor necrosis factor receptors. FEBS Lett 1996;390:334-8.
    • (1996) FEBS Lett , vol.390 , pp. 334-338
    • Clauss, M.1    Grell, M.2    Fangmann, C.3    Fiers, W.4    Scheurich, P.5    Risau, W.6
  • 30
    • 0035895879 scopus 로고    scopus 로고
    • Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells
    • Shen BQ, Lee DY, Cortopassi KM, Damico LA, Zioncheck TF. Vascular endothelial growth factor KDR receptor signaling potentiates tumor necrosis factor-induced tissue factor expression in endothelial cells. J Biol Chem 2001;276:5281-6.
    • (2001) J Biol Chem , vol.276 , pp. 5281-5286
    • Shen, B.Q.1    Lee, D.Y.2    Cortopassi, K.M.3    Damico, L.A.4    Zioncheck, T.F.5
  • 32
    • 0032987731 scopus 로고    scopus 로고
    • Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability
    • Wu HM, Yuan Y, Zawieja DC, Tinsley J, Granger HJ. Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability. Am J Physiol 1999;276:H535-42.
    • (1999) Am J Physiol , vol.276
    • Wu, H.M.1    Yuan, Y.2    Zawieja, D.C.3    Tinsley, J.4    Granger, H.J.5
  • 33
    • 0027410497 scopus 로고
    • The MAP kinase cascade is essential for diverse signal transduction pathways
    • Nishida E, Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 1993;18:128-31.
    • (1993) Trends Biochem Sci , vol.18 , pp. 128-131
    • Nishida, E.1    Gotoh, Y.2
  • 34
    • 0035066383 scopus 로고    scopus 로고
    • Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
    • Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol Rev 2001;81:807-69.
    • (2001) Physiol Rev , vol.81 , pp. 807-869
    • Kyriakis, J.M.1    Avruch, J.2
  • 35
    • 0030734010 scopus 로고    scopus 로고
    • p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells
    • Rousseau S, Houle F, Landry J, Huot J. p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells. Oncogene 1997;15:2169-77.
    • (1997) Oncogene , vol.15 , pp. 2169-2177
    • Rousseau, S.1    Houle, F.2    Landry, J.3    Huot, J.4
  • 37
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    • Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-5.
    • (1999) Nature , vol.399 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 38
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio Y, Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 1999;274:16349-54.
    • (1999) J Biol Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 39
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-10.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6    Sessa, W.C.7    Walsh, K.8
  • 40
  • 41
    • 0035942232 scopus 로고    scopus 로고
    • Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway
    • Chavakis E, Dernbach E, Hermann C, Mondorf UF, Zeiher AM, Dimmeler S. Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway. Circulation 2001; 103: 2102-7.
    • (2001) Circulation , vol.103 , pp. 2102-2107
    • Chavakis, E.1    Dernbach, E.2    Hermann, C.3    Mondorf, U.F.4    Zeiher, A.M.5    Dimmeler, S.6
  • 42
    • 0034685915 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells
    • Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells. J Biol Chem 2000;275:15458-65.
    • (2000) J Biol Chem , vol.275 , pp. 15458-15465
    • Madge, L.A.1    Pober, J.S.2
  • 43
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999;11:219-25.
    • (1999) Curr Opin Cell Biol , vol.11 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 44
    • 0015822275 scopus 로고
    • Culture of human endothelial cells derived from umbilical veins: Identification by morphologic and immunologic criteria
    • Jaffe EA, Nachman RL, Becker CG, Minick CR. Culture of human endothelial cells derived from umbilical veins: identification by morphologic and immunologic criteria. J Clin Invest 1973;52:2745-56.
    • (1973) J Clin Invest , vol.52 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, R.L.2    Becker, C.G.3    Minick, C.R.4
  • 45
    • 0026045094 scopus 로고
    • An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma
    • Ruf W, Edgington TS. An anti-tissue factor monoclonal antibody which inhibits TF.VIIa complex is a potent anticoagulant in plasma. Thromb Haemost 1991;66:529-33.
    • (1991) Thromb Haemost , vol.66 , pp. 529-533
    • Ruf, W.1    Edgington, T.S.2
  • 47
    • 0033607633 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Raf by Akt (protein kinase B)
    • Zimmermann S, Moelling K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 1999;286:1741-4.
    • (1999) Science , vol.286 , pp. 1741-1744
    • Zimmermann, S.1    Moelling, K.2
  • 48
    • 0035839556 scopus 로고    scopus 로고
    • Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells
    • Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 2001;276:30359-65.
    • (2001) J Biol Chem , vol.276 , pp. 30359-30365
    • Gratton, J.P.1    Morales-Ruiz, M.2    Kureishi, Y.3    Fulton, D.4    Walsh, K.5    Sessa, W.C.6
  • 49
    • 0031018424 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen-activated protein kinase pathways
    • Read MA, Whitley MZ, Gupta S, Pierce JW, Best J, Davis RJ, Collins T. Tumor necrosis factor alpha-induced E-selectin expression is activated by the nuclear factor-kappaB and c-JUN N-terminal kinase/p38 mitogen- activated protein kinase pathways. J Biol Chem 1997;272: 2753-61.
    • (1997) J Biol Chem , vol.272 , pp. 2753-2761
    • Read, M.A.1    Whitley, M.Z.2    Gupta, S.3    Pierce, J.W.4    Best, J.5    Davis, R.J.6    Collins, T.7
  • 50
    • 0032515047 scopus 로고    scopus 로고
    • Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: Requirement for Flk-1/KDR activation
    • Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway: requirement for Flk-1/KDR activation. J Biol Chem 1998;273:30336-43.
    • (1998) J Biol Chem , vol.273 , pp. 30336-30343
    • Gerber, H.P.1    McMurtrey, A.2    Kowalski, J.3    Yan, M.4    Keyt, B.A.5    Dixit, V.6    Ferrara, N.7
  • 51
    • 0029767998 scopus 로고    scopus 로고
    • Apoptosis is associated with increased cell surface tissue factor procoagulant activity
    • Greeno EW, Bach RR, Moldow CF. Apoptosis is associated with increased cell surface tissue factor procoagulant activity. Lab Invest 1996;75:281-9.
    • (1996) Lab Invest , vol.75 , pp. 281-289
    • Greeno, E.W.1    Bach, R.R.2    Moldow, C.F.3
  • 52
    • 0030956584 scopus 로고    scopus 로고
    • Apoptotic vascular endothelial cells become procoagulant
    • Bombeli T, Karsan A, Tait JF, Harlan JM. Apoptotic vascular endothelial cells become procoagulant. Blood 1997;89:2429-42.
    • (1997) Blood , vol.89 , pp. 2429-2442
    • Bombeli, T.1    Karsan, A.2    Tait, J.F.3    Harlan, J.M.4


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