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Volumn 13, Issue 4, 2003, Pages 452-458

The afferent synapse of cochlear hair cells

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER;

EID: 0041878310     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-4388(03)00098-9     Document Type: Review
Times cited : (133)

References (50)
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    • + channels to auditory neurotransmission in the guinea pig cochlea. J Neurophysiol 2003, in press. Published online: http://jn.physiology.org/cgi/reprint/01155.2002v1.pdf The authors perfused specific toxins into the guinea pig cochlea to examine the role of BK channels (calcium-sensitive, voltage-gated potassium channels) in synaptic transmission in vivo. Charybdotoxin or iberiotoxin reversibly blocked the compound action potential but had no effect on signals generated by outer hair cells. As BK channels appear to be expressed by inner hair cells and by the afferent neurons, the effects of toxin on sound evoked afferent signals could occur presynaptically, postsynaptically, or both.
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    • 2+ release
    • The authors used voltage-clamp recording and calcium imaging dyes to characterize the calcium transients arising during depolarization of inner hair cells. Application of ryanodine (to block calcium-induced calcium release from internal stores), reduced the amplitude and rate of rise of the calcium transient evoked by depolarization.
    • 2+ release. J. Physiol. 539:2002;15-23 The authors used voltage-clamp recording and calcium imaging dyes to characterize the calcium transients arising during depolarization of inner hair cells. Application of ryanodine (to block calcium-induced calcium release from internal stores), reduced the amplitude and rate of rise of the calcium transient evoked by depolarization.
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    • Synaptic ribbon. Conveyor belt or safety belt?
    • The authors present a recent review comparing synaptic ribbon function in hair cells and retinal cells. They describe the hypothesis of compound vesicle fusion.
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    • Distribution of the glutamate/aspartate transporter GLAST in relation to the afferent synapses of outer hair cells in the guinea pig cochlea
    • The authors used immunogold electron microscopy to chart the disposition of GLAST reactivity in Deiter's cells. These cells surround outer hair cells and express GLAST in a manner analogous to the supporting cells that surround inner hair cells.
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    • The authors used RT-PCR cloning, in situ hybridization and immunohistology to map the expression of various glutamate transporters in the guinea-pig cochlea. In addition to GLAST expression in supporting cells, GLT-1 (glutamate transporter-1) and EAAC1 were detected in spiral ganglion neurons, the cochlear afferents.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.