Critical role of JC virus-specific CD4 T-cell responses in preventing progressive multifocal leukoencephalopathy

AIDS

Volumn 17, Issue 10, 2003, Pages 1443-1449

  Gasnault, Jacques ^a,b   Kahraman, Mufide ^a   De Herve, Marie Ghislaine De Goër ^a   Durali, Deniz ^a   Delfraissy, Jean François ^a,b   Taoufik, Yassine ^a,c  

^a INSERM   (France)

^b Department of Internal Medicine ^*  (France)

^c BICÊTRE HOSPITAL   (France)

Author keywords

CD4 T cell; Central nervous system; HIV; Immune restoration; JC virus; Progressive multifocal leukoencephalopathy; Proliferation assay

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN;

ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CEREBROSPINAL FLUID ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; JC VIRUS; LYMPHOCYTE PROLIFERATION; MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; SEROLOGY; SURVIVAL; URINALYSIS; VIRUS EXCRETION; VIRUS PURIFICATION;

ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CELL DIVISION; GENES, VIRAL; HIV INFECTIONS; HUMANS; JC VIRUS; LEUKOENCEPHALOPATHY, PROGRESSIVE MULTIFOCAL; POLYMERASE CHAIN REACTION; VIRUS SHEDDING;

EID: 0041867853     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200307040-00004     Document Type: Article

References (36)

1. Weber T, Trebst C, Frye S, Cinque P, Vago L, Sindic CJ, et al. Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy. J Infect Dis 1997, 176:250-254.
2. Berger JR, Major EO. Progressive multifocal leukoencephalopathy. Semin Neurol 1999, 19:193-200.
3. Ellison GW. Progressive multifocal leukoencephalopathy (PML). I. Investigation of the immunologic status of a patient with lymphosarcoma and PML. J Neuropathol Exp Neurol 1969, 28:501-506.
4. Willoughby E, Price RW, Padgett BL, Walker DL, Dupont B. Progressive multifocal leukoencephalopathy (PML): in vitro cell-mediated immune responses to mitogens and JC virus. Neurology 1980, 30:256-262.
5. Knowles WA, Pillay D, Johnson MA, Hand JF, Brown DW. Prevalence of long-term BK and JC excretion in HIV-infected adults and lack of correlation with serological markers. J Med Virol 1999, 59:474-479.
6. Guillaume B, Sindic CJ, Weber T. Progressive multifocal leukoencephalopathy: simultaneous detection of JCV DNA and anti-JCV antibodies in the cerebrospinal fluid. Eur J Neurol 2000, 7:101-106.
7. Knight A, O'Brien P, Osoba D. 'Spontaneous' progressive multi-focal leukoencephalopathy. Immunologic aspects. Ann Intern Med 1972, 77:229-233.
8. Marriott PJ, O'Brien MD, Mackenzie IC, Janota I. Progressive multifocal leucoencephalopathy: remission with cytarabine. J Neurol Neurosurg Psychiatry 1975, 38:205-209.
9. Weber F, Goldmann C, Kramer M, Kaup FJ, Pickhardt M, Young P, et al. Cellular and humoral immune response in progressive multifocal leukoencephalopathy. Ann Neurol 2001, 49:636-642.
10. Koralnik IJ, Du Pasquier RA, Letvin NL. JC virus-specific cytotoxic T lymphocytes in individuals with progressive multifocal leukoencephalopathy. J Virol 2001, 75:3483-3487.
11. Du Pasquier RA, Clark KW, Smith PS, Joseph JT, Mazullo JM, De Girolami U, et al. JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy. J Neurovirol 2001, 7:318-322.
12. Keene JA, Forman J. Helper activity is required for the in vivo generation of cytotoxic T lymphocytes. J Exp Med 1982, 155:768-782.
13. Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998, 188:2199-2204.
14. Gasnault J, Taoufik Y, Goujard C, Kousignian P, Abbed K, Boue F, et al. Prolonged survival without neurological improvement in patients with AIDS-related progressive multifocal leukoencephalopathy on potent combined antiretroviral therapy. J Neurovirol 1999, 5:421-429.
15. Taoufik Y, Delfraissy JF, Gasnault J. Highly active antiretroviral therapy does not improve survival of patients with high JC virus load in the cerebrospinal fluid at progressive multifocal leukoencephalopathy diagnosis [letter]. AIDS 2000, 14:758-759.
16. Major EO, Miller AE, Mourrain P, Traub RG, de Widt E, Sever J. Establishment of a line of human fetal glial cells that supports JC virus multiplication. Proc Natl Acad Sci USA 1985, 82:1257-1261.
17. Major EO, Vacante DA, Traub RG, London WT, Sever JL. Owl monkey astrocytoma cells in culture spontaneously produce infectious JC virus which demonstrates altered biological properties. J Virol 1987, 61:1435-1441.
18. Frye S, Trebst C, Dittmer U, Petry H, Bodemer M, Hunsmann G, et al. Efficient production of JC virus in SVG cells and the use of purified viral antigens for analysis of specific humoral and cellular immune response. J Virol Methods 1997, 63:81-92.
19. Taoufik Y, Gasnault J, Karaterki A, Ferey MP, Marchadier E, Gousard C. Prognostic value of JC virus load in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. J Infect Dis 1998, 178:1816-1820.
20. th edn. Edited by Mandell GL, Bennett JE, Dolin R. New York: Churchill Livingstone; 1995:1400-1406.
21. Moret H, Guichard M, Matheron S, Katlama C, Sazdovitch V, Huraux JM, et al. Virological diagnosis of progressive multifocal leukoencephalopathy: detection of JC virus DNA in cerebrospinal fluid and brain tissue of AIDS patients. J Clin Microbiol 1993, 31:3310-3313.
22. Cinque P, Scarpellini P, Vago L, Linde A, Lazzarin A. Diagnosis of central nervous system complications in HIV-infected patients: cerebrospinal fluid analysis by the polymerase chain reaction. AIDS 1997, 11:1-1 7.
23. Clifford DB. Opportunistic viral infections in the setting of human immunodeficiency virus. Semin Neurol 1999, 19:185-192.
24. Berger JR, Pall L, Lanska D, Whiteman M. Progressive multifocal leukoencephalopathy in patients with HIV infection. J Neurovirol 1998, 4:59-68.
25. Tassie JM, Gasnault J, Bentata M, Deloumeaux J, Boué F, Billaud E, et al. Survival improvement of AIDS-related progressive multi-focal leukoencephalopathy in the era of protease inhibitors. AIDS 1999, 13:1881-1887.
26. Agostini HT, Ryschkewitsch CF, Mory R, Singer EJ, Stoner GL. JC virus (JCV) genotypes in brain tissue from patients with progressive multifocal leukoencephalopathy (PML) and in urine from controls without PML: increased frequency of JCV type 2 in PML. J Infect Dis 1997, 176:1-8.
27. Dubois V, Moret H, Lafon ME, Brodard V, Icart J, Ruffault A, et al. JC virus genotypes in France: molecular epidemiology and potential significance for progressive multifocal leukoencephalopathy. J Infect Dis 2001, 183:213-217.
28. Dorries K. Latent and persistent polyomavirus infection. In Human Polyomaviruses: Molecular and Clinical Perspectives. Edited by Khalili K, Stoner GL. New York: Wiley-Liss; 2001: 197-235.
29. Gee GV, Atwood WJ. Genetic identification of factors controlling JCV tropism [abstract]. J Neurovirol 2002, 8:109.
30. De Luca A, Giancola ML, Ammassari A, Grisetti S, Paglia MG, Gentile M. The effect of potent antiretroviral therapy and JC virus load in cerebrospinal fluid on clinical outcome of patients with AIDS-associated progressive multifocal leukoencephalopathy. J Infect Dis 2000, 182:1077-1083.
31. Giudici B, Vaz B, Bossolasco S, Casari S, Brambilla AM, Lüke W, et al. Highly active antiretroviral therapy and progressive multi-focal leukoencephalopathy: effects on cerebrospinal fluid markers of JC virus replication and immune response. Clin Infect Dis 2000, 30:95-99.
32. Matloubian M, Concepcion RJ, Ahmed R. CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection. J Virol 1994, 68:8056-8063.
33. Sarawar SR, Lee BJ, Reiter SK, Schoenberger SP. Stimulation via CD40 can substitute for CD4 T cell function in preventing reactivation of a latent herpesvirus. Proc Natl Acad Sci USA 2001, 98:6325-6329.
34. Albert ML, Jegathesan M, Darnell RB. Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells. Nature Immunol 2001, 2:1010-1017.
35. Schoenberger SP, Toes RE, van der Voort El, Offringa R, Melief CJ. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998, 393:480-483.
36. Ridge JP, Di Rosa F, Matzinger P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 1998, 393:474-478.