Analysis of the systemic and intrathecal humoral immune response in progressive multifocal leukoencephalopathy

Journal of Infectious Diseases

Volumn 176, Issue 1, 1997, Pages 250-254

  Weber, Thomas ^a   Trebst, Corinna ^b   Frye, Stephan ^b   Cinque, Paola ^b   Vago, Luca ^b   Sindic, Christian J M ^b   Schulz Schaeffer, Walter Joachim ^b   Kretzschmar, Hans Arthur ^b   Enzensberger, Wolfgang ^b   Hunsmann, Gerhard ^b   Luke, Wolfgang ^b  

^a Marienkrankenhaus Hamburg   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; RECOMBINANT PROTEIN; STRUCTURAL PROTEIN; VIRUS ANTIGEN; VIRUS PROTEIN;

ADULT; AGED; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; JC VIRUS; MAJOR CLINICAL STUDY; MALE; OLIGODENDROGLIA; PRIORITY JOURNAL; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; STRUCTURAL GENE;

EID: 16944363426     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/514032     Document Type: Article

References (15)

1. Berger JR, Concha M. Progressive multifocal leukoencephalopathy: the evolution of a disease once considered rare. J Neurovirol 1995;1:5-18.
2. Major EO, Amemiya K, Tornatore CS, Houff SA, Berger JR. Pathogenesis and molecular biology of progressive niultifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev 1992;5:49-73.
3. Padgett BL, Walker DL, Zu Rhein GM, Eckroade RJ, Dessel BH. Cultivation of papova-like virus from human brain with progressive multifocal leucoencephalopathy. Lancet 1971;1:1257-60.
4. Weber T, Frye S, Bodemer M, Otto M, Luke W. Clinical implications of nucleic acid amplification methods for the diagnosis of viral infections of the nervous system. J Neurovirol 1996;2:175-90.
5. Andersson M, Alvarez Cermeno J, Bernardi G, et al. Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report. J Neurol Neurosurg Psychiatry 1994;57:897-902.
6. Heide W, Kömpf D, Reusche E, Bodemer M, Weber T. Failure of cytarabine/interferon therapy in progressive multifocal leukoencephalopathy [letter]. Ann Neurol 1995;37:412-3.
7. Weber T, Turner RW, Frye S, et al. Progressive multifocal leukoencephalopathy diagnosed by amplification of JC virus-specific DNA from cerebrospinal fluid. AIDS 1994;8:49-57.
8. Reiber H, Lange P. Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 1991;37:1153-60.
9. Cutler SJ, Wright DJ. Comparison of immunofluorescence and enzyme linked immunosorbent assays for diagnosing Lyme disease. J Clin Pathol 1989;42:869-71.
10. Padgett BL, Walker DL. Virologie and serologic studies of progressive multifocal leukoencephalopathy. Prog Clin Biol Res 1983;105:107-17.
11. Knowles WA, Luxton RW, Hand JF, Gardner SD, Brown DWG. The JC virus antibody response in serum and cerebrospinal fluid in progressive multifocal leucoencephalopathy. Clin Diagn Virol 1995;4:183-94.
12. Kuchelmeister K, Gullotta F, Bergmann M, Angeli G, Masini T. Progressive multifocal leukoencephalopathy (PML) in the acquired immunodeficiency syndrome (AIDS). A neuropathological autopsy study of 21 cases. Pathol Res Pract 1993;189:163-73.
13. Sindic CJM, Cambasio CL, Depré A, Laterre EC, Masson PL. Immune complexes in cerebrospinal fluid and serum of neurological patients. Possible intrathecal formation in bacterial meningitis and herpetic encephalitis. J Neuroimmunol 1984;6:9-18.
14. Neel JV, Major EO, Awa AA, et al. Hypothesis: "rogue cell"-type chromosomal damage in lymphocytes is associated with infection with the JC human polyoma virus and has implications for oncogenesis. Proc Natl Acad Sci USA 1996;93:2690-5.
15. Achim CL, Wiley CA. Expression of major histocompatibility complex antigens in the brains of patients with progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol 1992;51: 257-63.