Continuous in vitro evolution of ribozymes that operate under conditions of extreme pH

Journal of Molecular Evolution

Volumn 57, Issue 3, 2003, Pages 292-298

  Kühne, Henriette ^a,b   Joyce, Gerald F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Cardinal Health   (United States)

Author keywords

Catalytic RNA; Continuous evolution; In vitro selection; pH extremes; Ribozyme; RNA ligase

Indexed keywords

RIBOZYME; RNA LIGASE;

ARTICLE; CATALYSIS; ENZYME ACTIVITY; EVOLUTION; IN VITRO SELECTION; MUTATION; PH; RNA STRUCTURE; SEQUENCE ANALYSIS;

BASE SEQUENCE; DIRECTED MOLECULAR EVOLUTION; ENZYME STABILITY; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA STABILITY; RNA, CATALYTIC; THERMODYNAMICS;

EID: 0041832313     PISSN: 00222844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00239-003-2480-z     Document Type: Article

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