A novel disintegrin-like domain of a high molecular weight metalloprotease inhibits platelet aggregation

Biochemical and Biophysical Research Communications

Volumn 309, Issue 3, 2003, Pages 637-642

  You, Weon Kyoo ^a   Jang, Yoon Jung ^a   Chung, Kwang Hoe ^a   Kim, Doo Sik ^a  

^a Yonsei University   (South Korea)

Author keywords

DECD sequence; Disintegrin like protein; Integrin; Platelet aggregation

Indexed keywords

ASPARAGINE; COLLAGEN; COMPLEMENTARY DNA; CYSTEINE; DISINTEGRIN; FIBRINOGEN; GLUTAMINE; GLYCOPROTEIN IIB; GLYCOPROTEIN IIIA; HALYDIN; METALLOPROTEINASE; RECOMBINANT PROTEIN; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; DNA SEQUENCE; ENZYME INHIBITION; EVIDENCE BASED MEDICINE; EXPERIMENTAL TEST; GENETIC CODE; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE MEMBRANE;

PICHIA; PICHIA PASTORIS; SERPENTES;

EID: 0041829403     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2003.08.049     Document Type: Article

References (26)

1. Pytela R., Pierschbacher M.D., Ginsberg M.H., Plow E.F., Rouslathi E. Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp-specific adhesion receptors. Science. 231:1986;1559-1562.
2. Savage B., Cattaneo M., Ruggeri Z.M. Mechanism of platelet aggregation. Curr. Opin. Hematol. 8:2001;270-276.
3. Niewiarowski S., McLane M.A., Kloczewiak M., Stewart G.J. Disintegrins and other naturally occurring antagonists of platelet fibrinogen receptors. Semin. Hematol. 31:1994;289-300.
4. Kang I.C., Chung K.H., Lee S.J., Yun Y.D., Moon H.M., Kim D.S. Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb. Res. 91:1998;65-73.
5. Brooks P.C., Montgomery A.M., Rosenfeld M., Reisfeld R.A., Hu T., Klier G., Cheresh D.A. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell. 79:1994;1157-1164.
6. Kang I.C., Lee Y.D., Kim D.S. A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 59:1999;3754-3760.
7. Matsui T., Fujimura Y., Titani K. Snake venom proteases affecting hemostasis and thrombosis. Biochim. Biophys. Acta. 1477:2000;146-156.
8. Schlondorff J., Blobel C.P. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J. Cell Sci. 112:1999;3603-3617.
9. Evans J.P. Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization. BioEssays. 23:2001;628-639.
10. Jeon O.H., Kim D.S. Molecular cloning and functional characterization of a snake venom metalloprotease. Eur. J. Biochem. 263:1999;526-533.
11. Bellavite P., Andrioli G., Guzzo P., Arigliano P., Chirumbolo S., Manzato F., Santonastaso C. A colorimetric method for the measurement of platelet adhesion in microtiter plates. Anal. Biochem. 216:1994;444-450.
12. Hong S.Y., Sohn Y.D., Chung K.H., Kim D.S. Structural and functional significance of disulfide bonds in saxatilin, a 7.7. kDa disintegrin Biochem. Biophys. Res. Commun. 293:2002;530-536.
13. Clemetson K.J., Clemetson J.M. Platelet collagen receptors. Thromb. Haemost. 86:2001;189-197.
14. Alberio L., Dale G.L. Review article: platelet-collagen interactions: membrane receptors and intracellular signalling pathways. Eur. J. Clin. Invest. 29:1999;1066-1076.
15. Leclerc J.R. Platelet glycoprotein IIb/IIIa antagonists: lessons learned from clinical trials and future directions. Crit. Care Med. 30:2002;S332-S340.
16. Shattil S.J., Kashiwagi H., Pampori N. Integrin signaling: the platelet paradigm. Blood. 91:1998;2645-2657.
17. Kam P.C., Egan M.K. Platelet glycoprotein IIb/IIIa antagonists: pharmacology and clinical developments. Anesthesiology. 96:2002;1237-1249.
18. Hong S.Y., Koh Y.S., Chung K.H., Kim D.S. Snake venom disintegrin, saxatilin, inhibits platelet aggregation, human umbilical vein endothelial cell proliferation, and smooth muscle cell migration. Thromb. Res. 105:2002;79-86.
19. Ni H., Freedman J. Platelets in hemostasis and thrombosis: role of integrins and their ligands. Transfus. Apheresis Sci. 28:2003;257-264.
20. Kamiguti A.S., Hay C.R., Zuzel M. Inhibition of collagen-induced platelet aggregation as the result of cleavage of alpha 2 beta 1-integrin by the snake venom metalloproteinase jararhagin. Biochem. J. 320:1996;635-641.
21. Zigrino P., Kamiguti A.S., Eble J., Drescher C., Nischt R., Fox J.W., Mauch C. The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling. J. Biol. Chem. 277:2002;40528-40535.
22. Blobel C.P., White J.M. Structure, function and evolutionary relationship of proteins containing a disintegrin domain. Curr. Opin. Cell. Biol. 4:1992;760-765.
23. Wu W.B., Peng H.C., Huang T.F. Disintegrin causes proteolysis of beta-catenin and apoptosis of endothelial cells. Involvement of cell-cell and cell-ECM interactions in regulating cell viability. Exp. Cell Res. 286:2003;115-127.
24. Kaku S., Umemura K., Mizuno A., Kawasaki T., Nakashima M. Evaluation of the disintegrin, triflavin, in a rat middle cerebral artery thrombosis model. Eur. J. Pharmacol. 321:1997;301-305.
25. Yeh C.H., Peng H.C., Yang R.S., Huang T.F. Rhodostomin, a snake venom disintegrin, inhibits angiogenesis elicited by basic fibroblast growth factor and suppresses tumor growth by a selective alpha(v)beta(3) blockade of endothelial cells. Mol. Pharmacol. 59:2001;1333-1342.
26. Morris V.L., Schmidt E.E., Koop S., MacDonald I.C., Grattan M., Khokha R., McLane M.A., Niewiarowski S., Chambers A.F., Groom A.C. Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis. Exp. Cell Res. 219:1995;571-578.