Blood-brain barrier and general anesthetics

Japanese Journal of Anesthesiology

Volumn 52, Issue 8, 2003, Pages 840-845

  Tanobe, Kyoko ^a   Nishikawa, Koichi ^a   Hinohara, Hiroshi ^a   Okamoto, Tomonori ^a   Saito, Shigeru ^a   Goto, Fumio ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Morphine; P glycoprotein; Propofol; Tight junction; Transporter

Indexed keywords

ANESTHETIC AGENT; CARRIER PROTEIN; GLYCOPROTEIN P; ISOFLURANE; MEMBRANE RECEPTOR; PENTOBARBITAL;

ACTIVE TRANSPORT; BLOOD BRAIN BARRIER; BRAIN EDEMA; BRAIN HYPOXIA; BRAIN ISCHEMIA; CONFERENCE PAPER; DRUG DIFFUSION; DRUG TRANSPORT; ENCEPHALITIS; ENDOTHELIUM CELL; GENERAL ANESTHESIA; HUMAN; LIPID SOLUBILITY; MEMBRANE STRUCTURE; MEMBRANE TRANSPORT; MOLECULAR WEIGHT; NERVE CELL LESION; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN ISOLATION; TIGHT JUNCTION; TRANSCYTOSIS; VERTEBRATE;

ANESTHETICS, GENERAL; ANIMALS; BLOOD-BRAIN BARRIER; HUMANS; MOLECULAR WEIGHT; MORPHINE; P-GLYCOPROTEIN; PROPOFOL; TIGHT JUNCTIONS;

EID: 0041821416     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (35)

1. Pollay M, Roberts PA. Blood-brain barrier: a definition of normal and altered function. Neurosurgery 1980; 6: 675-85.
2. Bradbury MW. The structure and function of the blood-brain barrier. Fed Proc 1984; 43: 186-90.
3. Pardridge WM. Brain metabolism: a perspective from the blood-brain barrier. Physiol Rev 1983; 63: 1481-535.
4. Pardridge WM. CNS drug design based on principles of blood-brain barrier transport. J Neurochem 1988; 70: 1781-92.
5. Simpson IA, Appel NM, Hokari M, Oki J, Holman GD, Maher F, et al. Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. J Neurochem 1999; 72: 238-47.
6. Sugiyama Y, Kusuhara H, Suzuki H. Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood-brain and blood-cerebrospinal fluid barriers: importance in the drug delivery to the brain. J Control Release 1999; 62: 179-86.
7. Riordan JR, Deuchars K, Kartner N, Alon N, Trent J, Ling V. Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines. Nature 1985; 316: 817-9.
8. Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 1994; 77: 491-502.
9. Neuwelt EA, Maravilla KR, Frenkel EP, Rapaport SI, Hill SA, Barnett PA. Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. J Clin Invest 1979; 64: 684-8.
10. Neuwelt EA, Maravilla KR, Frenkel EP, Barnett P, Hill S, Moore RJ. Use of enhanced computerized tomography to evaluate osmotic blood-brain barrier disruption. Neurosurgery 1980; 6: 49-56.
11. 2+ exchange blocker on osmotic blood-brain barrier disruption. Brain Res 2001; 900: 157-62.
12. Sokrab TE, Johansson BB, Kalimo H, Olsson Y. A transient hypertensive opening of the blood-brain barrier can lead to brain damage. Extravasation of serum proteins and cellular changes in rats subjected to aortic compression. Acta Neuropathol (Berl) 1988; 75: 557-65.
13. Mayhan WG. Disruption of blood-brain barrier during acute hypertension in adult and aged rats. Am J Physiol 1990; 258: H 1735-8.
14. Johansson BB, Linder LE. Do nitrous oxide and lidocaine modify the blood-brain barrier in acute hypertension in the rat? Acta Anaesthesiol Scand 1980; 24: 65-8.
15. Forster A, Van Horn K, Marshall LE, Shapiro HM. Anesthetic effects on blood-brain barrier function during acute arterial hypertension. Anesthesiology 1978; 49: 26-30.
16. Ishikawa T, Funatsu N, Okamoto K, Takeshita H, McDowall DG. Blood-brain barrier function following drug-induced hypotension in the dog. Anesthesiology 1983; 59: 526-31.
17. Karibe H, Zarow GJ, Graham SH, Weinstein PR. Mild intraischemic hypothermia reduces postischemic hyperperfusion, delayed postischemic hypoperfusion, blood-brain barrier disruption, brain edema, and neuronal damage volume after temporary focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1994; 14: 620-7.
18. Smith SL, Hall ED. Mild pre- and post-traumatic hypothermia attenuates blood-brain barrier damage following controlled cortical impact injury in the rat. J Neurotrauma 1996; 13: 1-9.
19. Chi OZ, Liu X, Weiss HR. Effects of mild hypothermia on blood-brain barrier disruption during isoflurane or pentobarbital anesthesia. Anesthesiology 2001; 95: 933-8.
20. Estrada C, Bready J, Berliner J, Cancilla PA. Choline uptake by cerebral capillary endothelial cells in culture. J Neurochem 1990; 54: 1467-73.
21. Murakami K, Kondo T, Chan PH. Blood-brain barrier disruption, edema formation, and apoptotic neuronal death following cold injury. Acta Neurochir Suppl (Wien) 1997; 70: 234-6.
22. Angel C, Bounds HM, Perry A. A comparison of the effects of halothane on blood-brain barrier and memory consolidation. Dis Nerv Syst 1972; 33: 87-93.
23. Anderson RE, Michenfelder JD, Sundt TM. Brain intracellular pH, blood flow, and blood-brain barrier differences with barbiturate and halothane anesthesia in the cat. Anesthesiology 1980; 52: 201-6.
24. Chi OZ, Anwar M, Sinha AK, Wei HM, Klein SL, Weiss HR. Effects of isoflurane on transport across the blood-brain barrier. Anesthesiology 1992; 76: 426-31.
25. Chi OZ, Wei HM, Anwar M, Sinha AK, Klein SL, Weiss HR. Effects of fentanyl on alpha-aminoisobutyric acid transfer across the blood-brain barrier. Anesth Analg 1992; 75: 31-6.
26. Saija A, Princi P, De Pasquale R, Costa G. Modifications of the permeability of the blood-brain barrier and local cerebral metabolism in pentobarbital- and ketamine-anaesthetized rats. Neuropharmacology 1989; 28: 997-1002.
27. Chi OZ, Chun TW, Liu X, Weiss HR. The effects of pentobarbital on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth Analg 1998; 86: 1230-5.
28. Chi OZ, Lee DI, Liu X, Weiss HR. The effects of morphine on blood-brain barrier disruption caused by intracarotid injection of hyperosmolar mannitol in rats. Anesth Analg 2000; 90: 603-8.
29. Regev R, Assaraf YG, Eytan GD. Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug-resistant cells. Eur J Biochem 1999; 259:18-24.
30. Henthorn TK, Liu Y, Mahapatro M, Ng KY. Active transport of fentanyl by the blood-brain barrier. J Pharmacol Exp Ther 1999; 289: 1084-9.
31. Callaghan R, Riordan JR. Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. J Biol Chem 1993; 268: 16059-64.
32. Thompson SJ, Koszdin K, Bernards CM. Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein. Anesthesiology 2000; 92: 1392-9.
33. Pardridge WM. Brain drug targeting and gene technologies. Jpn J Pharmacol 2001; 87: 97-103.
34. Li JY, Boado RJ, Pardridge WM. Blood-brain barrier genomics. J Cereb Blood Flow Metab 2001; 21: 61-8.