Interleukin-7 is a direct inhibitor of in vitro osteoclastogenesis

Endocrinology

Volumn 144, Issue 8, 2003, Pages 3524-3531

  Lee, Sun Kyeong ^a   Kalinowski, Judith F ^a   Jastrzebski, Sandra L ^a   Puddington, Lynn ^a   Lorenzo, Joseph A ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID PHOSPHATASE; COLECALCIFEROL; COLONY STIMULATING FACTOR 1; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; TARTARIC ACID;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BONE DEVELOPMENT; BONE MARROW CELL; CELL CULTURE; CELL STIMULATION; CONTROLLED STUDY; IN VITRO STUDY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OSTEOCLAST; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

EID: 0041814592     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2002-221057     Document Type: Article

References (73)

1. Chambers TJ, Hall TJ 1991 Cellular and molecular mechanisms in the regulation and function of osteoclasts. Vitam Horm 46:41-86
2. Roodman GD 1996 Advances in bone biology: the osteoclast. Endocr Rev 17:308-332
3. Suda T, Takahashi N, Martin TJ 1992 Modulation of osteoclast differentiation. Endocr Rev 13:66-79
4. Mundy GR, Roodman GD 1987 Osteoclast ontogeny and function. In: Peck WA, ed. Bone and mineral research annual. New York: Elsevier; vol 5:209-279
5. Manabe N, Kawaguchi H, Chikuda H, Miyaura C, Inada M, Nagai R, Nabeshima Y-I, Nakamura K, Sinclair AM, Scheuermann RH, Kuro-o M 2001 Connection between B lymphocyte and osteoclast differentiation pathways. J Immunol 167:2625-2631
6. + cells: its role in accelerated osteoclastogenesis due to estrogen deficiency. J Bone Miner Res 16:2215-2221
7. Quinn JMW, Whitty GA, Byrne RJ, Gillespie MT, Hamilton JA 2002 The generation of highly enriched osteoclast-lineage cell populations. Bone 30:164-170
8. 2 cooperates with TRANCE in osteoclast induction from hemopoietic precursors: synergistic activation of differentiation, cell spreading and fusion. Endocrinology 140:1927-1935
9. Katazawa R, Kimble RB, Vannice JL, Kung VT, Pacifici R 1994 Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest 94:2397-2406
10. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T 1990 IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303
11. Girasole G, Passeri G, Jilka RL, Manolagas SC 1994 Interleukin-11: a new cytokine critical for osteoclast development. J Clin Invest 93:1516-1524
12. Onoe Y, Miyaura T, Kaminakayashiki Y, Nagai K, Noguchi K, Chen Q-R, Sep H, Ohta H, Nozawa S, Kudo I, Suda T 1996 IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts. J Immunol 156:758-764
13. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 90:11924-11928
14. Kincade PW 1987 Experimental models for understanding B lymphocyte formation. Adv Immunol 41:181-267
15. Namen AE, Lupton S, Hjerrid K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March C, Urdal D, Gillis S 1988 Stimulation of B cell progenitors by cloned murine interleukin 7. Nature 33:571-573
16. Namen AE, Schmierer AE, March CJ, Overell RW, Park LS, Urdal DL, Mochizuki DY 1988 B cell precursor growth-promoting activity. Purification and characterization of a growth factor active on lymphocyte precursors. J Exp Med 167:988-1002
17. Era T, Nishikawa S, Sudo T, Wang FH, Ogawa M, Kunisada T, Hayashi S 1994 How B-precursor cells are driven to cycle. Immunol Rev 137:35-51
18. Grabstein KH, Waldschmidt TJ, Finkelman FD, Hess BW, Alpert AR, Boiani NE, Namen AE, Morrissey PJ 1993 Inhibition of murine B and T lymphopoiesis in vivo by an anti-interleukin 7 monoclonal antibody. J Exp Med 178:257-264
19. Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R 2002 Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest 110:1643-1650
20. Maki K, Sunaga S, Komagata Y, Kodaira Y, Mabuchi A, Karasuyama H, Yokomuro K, Miyazaki J, Ikuta K 1996 Interleukin-7 receptor-deficient mice lack γδT cells. Proc Natl Acad Sci USA 93:7172-7177
21. Peschon JJ, Morrissey PJ, Grabstein KH, Ramsdell FJ, Maraskovsky E, Gliniak BC, Park LS, Ziegler SF, Williams DE, Ware CB, Meyer JD, Davidson BL 1994 Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J Exp Med 180:1955-1960
22. Von Freeden-Jeffry U, Vieira P, Lucian LA, McNeil T, Burdach SEG, Murray R 1995 Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. J Exp Med 181:1519-1526
23. Rich BE 1997 Autocrine expression of interleukin-7 rescues lymphoid expansion in interleukin-7-deficient mice. Immunology 92:374-380
24. Maeurer MJ, Lotze MT 1998 Interleukin-7 (IL-7) knockout mice: implications for lymphopoiesis and organ-specific immunity. Int Rev Immunol 16:309-322
25. Wei C, Zeff R, Goldschneider I 2000 Murine pro-B cells require IL-7 and its receptor complex to up-regulate IL-7Rα, terminal deoxynucleotidyltransferase and cμ expression. J Immunol 164:1961-1970
26. Miyaura C, Onoe Y, Inada M, Maki K, Ikuta K, Ito M, Suda T 1997 Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: similarity to estrogen deficiency. Proc Natl Acad Sci USA 94:9360-9365
27. Takeda S, Gillis S, Palacios R 1989 In vitro effects of recombinant interleukin 7 on growth and differentiation of bone marrow pro-B and pro-T-lymphocyte clones and fetal thymocyte clone. Proc Natl Acad Sci USA 86:1634-1638
28. Morrissey PJ, Conlon P, Charrier K, Braddy S, Alpert A, Williams D, Namen AE, Mochizuki D 1991 Administration of IL-7 to normal mice. J Immunol 147:561-568
29. Mertsching E, Grawunder U, Meyer V, Rolink T, Ceredig R 1996 Phenotypic and functional analysis of B lymphopoiesis in interleukin-7-transgenic mice: expansion of pro/pre-B cell number and persistence of B lymphocyte development in lymph nodes and spleen. Eur J Immunol 26:28-33
30. Mertsching E, Meyer V, Linares J, Lombard-Platet S, Ceredig R 1998 Interleukin-7, a non-redundant potent cytokine whose over-expression massively perturbs B-lymphopoiesis. Int Rev Immunol 16:285-308
31. Valenzona HO, Pointer R, Ceredig R, Osmond DG 1996 Prelymphomatous B cell hyperplasia in the bone marrow of interleukin-7 transgenic mice: precursor B cell dynamics, microenvironmental organization and osteolysis. Exp Hematol 24:1521-1529
32. Weitzmann MN, Cenci S, Rifas L, Brown C, Pacifici R 2000 Interleukin-7 stimulates osteoclast formation by up-regulating the T-cell production of soluble osteoclastogenic cytokines. Blood 96:1873-1878
33. Toraldo G, Roggia C, Qian WP, Pacifici R, Weitzmann MN 2003 IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor κB ligand and tumor necrosis factor α from T cells. Proc Natl Acad Sci USA 100:125-130
34. Borzillo GV, Endo K, Tsujimoto Y 1992 Bcl-2 confers growth and survival advantage interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene 7:869-876
35. Griffiths SD, Goodhead DT, Marsden SJ, Wright EG, Krajewski S, Reed JC, Korsmeyer SJ, Greaves M 1994 Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis. J Exp Med 179:1789-1797
36. Borghesi LA, Smithson G, Kincade PW 1997 Stromal cell modulation of negative regulatory signals that influence apoptosis and proliferation of B lineage lymphocytes. J Immunol 159:4171-4179
37. Lu L, Osmond DG 1997 Apoptosis during B lymphopoiesis in mouse bone marrow. J Immunol 158:5136-5145
38. Lu L, Chaudhury P, Osmond DG 1999 Regulation of cell survival during B lymphopoiesis: apoptosis and Bcl-2/Bax content of precursor B cells in bone marrow of mice with altered expression of IL-7 and recombinase-activating gene-2. J Immunology 162:1931-1940
39. Baird AM, Gerstein RM, Berg LJ 1999 The role of cytokine receptor signaling in lymphocyte development. Curr Opin Immunol 11:157-166
40. 3 in osteoclast-like multinucleated cells formed from mouse bone marrow cells. Endocrinology 123:1504-1510
41. Udagawa N, Takahashi N, Akatsu T, Sasaki T, Yamaguchi A, Kodama H, Martin TJ, Suda T 1989 The bone marrow-derived stromal cell lines MC3T3-G2/PA6 and ST2 support osteoclast-like cell differentiation in cocultures with mouse spleen cells. Endocrinology 125:1805-1813
42. Lee SK, Goldring SR, Lorenzo JA 1995 Expression of the calcitonin receptor in bone marrow cell cultures and in bone: a specific marker of the differentiated osteoclast that is regulated by calcitonin. Endocrinology 136:4572-4581
43. Lee SK, Lorenzo JA 1999 Parathyroid hormone stimulated TRANCE and inhibits osteoprotegerin messenger ribonucleic acid expression in murine bone marrow cultures: correlation with osteoclast-like cell formation. Endocrinology 140:3552-3561
44. Takahashi N, Yamana H, Yoshiki S, Roodman GD, Mundy GR, Jones SJ, Boyde A, Suda T 1988 Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 122:1373-1382
45. Akatsu T, Tamura T, Takahashi N, Udagawa N, Tanaka S, Sasaki T, Yamaguchi A, Nagata N, Suda T 1992 Preparation and characterization of a mouse osteoclast-like multinucleated cell population. J Bone Miner Res 7:1297-1306
46. Akatsu T, Takahashi N, Debari K, Morita I, Nagata N, Takatani O, Suda T 1989 Prostaglandins promote osteoclast-like cell formation by a mechanism involving cyclic adenosine 3′, 5′-monophosphate in mouse bone marrow cell cultures. J Bone Miner Res 4:29-35
47. Shuto T, Kukita T, Hirata M, Jimi E, Koga T 1994 Dexamethasone stimulates osteoclast-like cell formation by inhibiting granulocyte-macrophage colony-stimulating factor production in mouse bone marrow cultures. Endocrinology 134:1121-1126
48. Menaa C, Kurihara N, Roodman GD 2000 CFU-GM-derived cells form osteoclasts at a very high efficiency. Biochem Biophys Res Commun 267:943-946
49. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ 1979 Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299
50. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, Timms E, Tan H-L, Elliott G, Kelley MJ, Sarosi I, Wang L, Xia X-Z, Elliott R, Chiu L, Black T, Scully S, Capparelli C, Morony S, Shimamoto G, Bass MB, Boyle WJ 1999 Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96:3540-3545
51. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Amgen EST Program, Boyle WJ 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309-319
52. Namen AE, Lupton S, Hjerrild K, Wingnall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S, Cosman D, Goodwin RG 1988 Stimulation of B-cell progenitors by cloned murine interleukin-7. Nature 333:571-573
53. Alonso S, Minty A, Bourlet Y, Buckingham M 1986 Comparison of the three actin-coding sequences in the mouse: evolutionary relationships between the actin genes of warm-blooded vertebrates. J Mol Evol 23:11-22
54. Sabath DE, Broome HE, Prystowsky MB 1990 Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte. Gene 91:185-191
55. Lee G, Namen AE, Gillis S, Ellingsworth LR, Kincade PW 1989 Normal B cell precursors responsive to recombinant murine IL-7 and inhibition of IL-7 activity by transforming growth factor-β. J Immunol 142:3875-3883
56. Park LS, Friend DJ, Schmierer AE, Dower SK, Namen AE 1990 Murine interleukin-7 (IL-7) receptor. Characterization on an IL-7-dependent cell line. J Exp Med 171:1073-1089
57. Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS, McBride OW, Leonard WJ 1993 Interelukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans. Cell 73:147-157
58. Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ 1993 Interleukin-2 receptor γ chain: a functional component of the interleukin-7 receptor. Science 262:1877-1880
59. Kondo M, Takeshita T, Higuchi M, Nakamura M, Sudo T, Nishikawa S, Sugamura K 1994 Functional participation of the IL-2 receptor γ chain in IL-7 receptor complexes. Science 263:1453-1454
60. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K 1992 Cloning of the γ chain of the human IL-2 receptor. Science 257:379-382
61. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K 1993 Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 262:1874-1877
62. Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland PF, Friedmann MC, Miyajima A, Puri RK, Paul WE, Warren J 1993 Interleukin-2 receptor γ chain: a functional component of the interleukin-4 receptor. Science 262:1880-1883
63. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, Goldman AS, Schmalstieg FC, Ihle JN, O'Shea JJ, Leonard WJ 1994 Interaction of IL-2R β and γ chains with Jak1 and Jak3: implications for XSCID and XCID. Science 266:1042-1045
64. Giri JG, Ahdieh M, Eisenman J, Shanebeck K, Grabstein K, Kumaki S, Namen A, Park LS, Cosman D, Anderson D 1994 Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13:2822-2830
65. + B cells in vitro and signals via a novel mechanism. J Immunol 162:677-683
66. Habib T, Senadheera S, Weinberg K, Kaushansky K 2002 The common γ chain (γc) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry 41:8725-8731
67. Hardy RR, Hayakawa K 2001 B cell development pathways. Annu Rev Immunol 19:308-332
68. Scott EW, Simon MC, Anastasi J, Singh H 1994 Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265:1573-1677
69. McKercher SR, Torbett BE, Anderson KL, Henkel GW, Vestal DJ, Baribault H, Klemsz M, Feeney AJ, Wu GE, Paige CJ, Maki RA 1996 Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities. EMBO J 15:5647-5658
70. DeKoter RP, Singh H 2000 Regulation of B lymphocytes and macrophage development by graded expression of PU.1. Science 288:1439-1441
71. DeKoter RP, Lee H-J, Singh H 2002 PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity 16:297-309
72. Nutt SL, Heavey B, Rolink AG, Busslinger M 1999 Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401:556-562
73. Katavic V, Grcevic D, Lee SK, Jastrzebski S, Dougall W, Anderson D, Puddington L, Aguila HL, Lorenzo JA, The surface antigen CD45R identifies a population of estrogen-regulated murine marrow cells that contain osteoclast precursors. Bone, in press