In vivo evolution of a β-lactamase-like activity throughout the idiotypic pathway

Biocatalysis and Biotransformation

Volumn 21, Issue 2 SPEC. ISS., 2003, Pages 79-85

  Padiolleau Lefevre, Séverine ^a   Debat, Hélène ^a   Thomas, Daniel ^a   Friboulet, Alain ^a   Avalle, Bérangère ^a  

^a UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

Author keywords

lactamase; Abzyme; Anti idiotypic antibody; Catalytic antibody; Molecular evolution; Penicillin binding protein

Indexed keywords

CHEMICAL MODIFICATION; ENZYME KINETICS; GENES; PROTEINS;

BINDING PROTEINS;

BIOCATALYSTS;

7 (THIENYL 2 ACETAMIDO) 3 [(4 NITRO 3 CARBOXYPHENYL)THIOMETHYL] 3 CEPHEM 4 CARBOXYLIC ACID; AMPICILLIN; BETA LACTAMASE; CARBOXYLIC ACID DERIVATIVE; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN G 9G4H9; METICILLIN; PADAC; PENICILLIN BINDING PROTEIN; PENICILLIN G; UNCLASSIFIED DRUG;

ANTIBODY ENGINEERING; CATALYSIS; CHEMICAL MODIFICATION; CONFERENCE PAPER; DRUG STRUCTURE; ELECTROPHORESIS; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME SUBSTRATE; IN VIVO STUDY; KINETICS; MOLECULAR EVOLUTION; NONBIOLOGICAL MODEL; NONHUMAN; PURIFICATION;

EID: 0041813133     PISSN: 10242422     EISSN: None     Source Type: Journal    
DOI: 10.1080/1024242031000121386     Document Type: Conference Paper

References (27)

1. Avalle, B., Vanwetswinkel, S. and Fastrez, J. (1997) "In vitro selection for catalytic turnover from a library of β-lactamase mutants and penicillin binding proteins", Bioorg. Med. Chem. Lett. 7, 479-484.
2. Avalle, B., Thomas, D. and Friboulet, A. (1998) "Functional mimicry: Elicitation of a monoclonal anti-idiotypic antibody hydrolysing β-lactams", FASEB J. 12, 1055-1060.
3. Avalle, B., Débat, H., Friboulet, A. and Thomas, D. (2000) "Catalytic mechanism of an abzyme displaying a β-lactamase like activity", Appl. Biochem. Biotechnol. 83, 163-171.
4. Awdeh, Z.L., Williamson, R. and Askonas, B.A. (1970) "One cell - One immunoglobulin. Origin of limited heterogeneity of myeloma proteins", Biochem. J. 116, 241-248.
5. Banfield, M.J., King, D.J., Mountain, A. and Brady, R.L. (1997) "VL:VH domain rotations in engineered antibodies: Crystal structures of Fab fragments from two murine anti-tumour antibodies and their engineered human constructs", Proteins 29, 161-171.
6. Blackburn, G.M. and Garçon, A. (2000) "Catalytic antibodies", In: Rehm, H.J. and Reed, G., eds, Biotechnology, Vol. 8b (Wiley VCH, Sheffield, UK), pp 404-490.
7. Clezardin, P., Mc Gregor, J.L., Manach, M., Boerkenche, H. and Dechavanne, M. (1985) "One step procedure for the rapid isolation of mouse monoclonal antibodies and their antigen binding fragments by Fast Protein Liquid Chromatography on a Mono Q anion-exchange column", J. Chromatogr. 319, 67-77.
8. Davies, C., Whites, S.W. and Nicholas, R.A. (2001) "Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3 A resolution", J. Biol. Chem. 276, 616-623.
9. Débat, H., Avalle, B., Friboulet, A. and Thomas, D. (2000) "Structure-function studies of a new generation of catalytic protein: An abzyme with a beta-lactamase activity", Int. J. Biochromatogr. 5, 91-96.
10. Débat, H., Avalle, B., Chose, O., Sarde, C.O., Friboulet, A. and Thomas, D. (2001) "Overpassing an aberrant VK gene to sequence an anti-idiotypic abzyme with β-lactamase like activity that could have a possible linkage with auto-immune disease", FASEB J. 15, 815-822.
11. Dideberg, O., Charlier, P., Wéry, J.P., Dehottay, P., Dusart, J., Erpicum, T., Frère, J.M. and Ghuysen, J.M. (1987) "The crystal structure of the beta-lactamase of Streptomyces albus G at 0.3 nm resolution", Biochem. J. 245, 911-919.
12. Galleni, M., Raquet, X., Lamotte-Brasseur, J., Fonze, E., Amicosnte, G. and Frère, J.M. (1995) "DD-peptidases and β-lactamases: Catalytic mechanisms and specificities", J. Chemotherapy 7, 3-7.
13. Izadyar, L., Friboulet, A., Remy, M.H., Roseto, A. and Thomas, D. (1993) "Monoclonal anti-idiotypic antibodies as functional internal images of enzyme active sites: Production of a catalytic antibody with a cholinesterase activity", Proc. Natl. Acad. Sci. USA 90, 8876-8880.
14. Janda, K.D., Schloeder, D., Benkovic, S.J. and Lerner, R.A. (1998) "Induction of an antibody that catalyses the hydrolysis of an amide bond", Science 244, 1188-1191.
15. Jerne, N.K. (1974) "Toward a network theory of the immune system", Ann. Immunol. 125c, 373-389.
16. Kirby, R. (1992) "Evolutionary origin of the class A and class C β-lactamases", J. Mol. Evol. 34, 345-350.
17. Laemmli, U.K. (1970) "Cleavage of structural proteins during the assembly of the head of bacteriophage T4", Nature 227, 680-685.
18. Lamotte-Brasseur, J., Dive, G., Dideberg, O., Charlier, P., Frère, J.M. and Ghuysen, J.M. (1991) "Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G", Biochem. J. 279, 231-221.
19. Lefèvre, S., Débat, H., Thomas, D., Friboulet, A. and Avalle, B. (2001) "A suicide substrate mechanism for hydrolysis of β-lactams by an anti-idiotypic catalytic antibody", FEBS Lett. 489, 25-28.
20. Matagne, A. and Frère, J.M. (1995) "Contribution of mutant analysis to the understanding catalysis: The case of class A β-lactamases", Biochim. Biophys. Acta. 1246, 109-127.
21. Neoh, S.H., Gordon, C., Potter, A. and Zola, H. (1986) "The purification of mouse monoclonal antibodies from ascitic fluid", J. Immunol. Meth. 91, 231-235.
22. Ostler, E.L., Resmini, M., Boucher, G., Romanov, N., Brocklehurst, K. and Gallacher, G. (2002) "Polyclonal antibody-catalysed hydrolysis of a β-lactam", Chem. Commun. 3, 226-227.
23. Pillet, D., Paon, M., Vorobiev, I.I., Gabibov, A.G., Thomas, D. and Friboulet, A. (2002) "Idiotypic network mimicry and antibody catalysis: Lessons for the elicitation of efficient anti-idiotypic protease antibodies", J. Immunol. Meth. 269, 5-12.
24. Raznikov, A.V., Egorov, Ts.A., Mirgorodskaia, O.V., Skliankina, V.A. and Avaeva, S.M. (1992) "Functionally important residues of glutamic acid residue in E. coli pyrophosphatase: A chemical modification and localisation within the primary structure", Biochemistry (Moscow) 57, 1902-1912.
25. Strynadka, N.C.J., Adachi, H., Jensen, S.E., Johns, K., Sielecki, A., Betzel, C., Sutoh, K. and James, M.N.G. (1992) "Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution", Nature 359, 700-705.
26. Tanaka, F., Almer, H., Lerner, R.A. and Barbas III, C.F. (1999) "Catalytic single-chain antibodies processing β-lactamase activity selected from a phage displayed combinatorial library using a mechanism-based inhibitor", Tetrahedron Lett. 40, 8063-8066.
27. Vanwetswinkel, S., Avalle, B. and Fastrez, J. (2000) "Selection of beta-lactamases and penicillin binding mutants from a library of phage displayed TEM-1 beta-lactamase randomly mutated in the active site omega-loop", J. Mol. Biol. 295, 527-567.