Ubiquitinated deiodinase: Not dead yet

Journal of Clinical Investigation

Volumn 112, Issue 2, 2003, Pages 145-147

  Koenig, Ronald J ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE PRECURSOR; LIOTHYRONINE; THYROID HORMONE; THYROXINE; IODIDE PEROXIDASE; IODOTHYRONINE DEIODINASE TYPE II; UBIQUITIN;

BRAIN DEVELOPMENT; BRAIN GROWTH; BRAIN METABOLISM; DEIODINATION; ENZYME ACTIVITY; ENZYME REACTIVATION; HORMONE SYNTHESIS; PRIORITY JOURNAL; REVIEW; THERMOGENESIS; UBIQUITINATION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; HUMAN; METABOLISM; NOTE; PHYSIOLOGY; TEMPERATURE;

ANIMALS; HUMANS; IODIDE PEROXIDASE; MODELS, BIOLOGICAL; TEMPERATURE; THYROID HORMONES; UBIQUITIN;

EID: 0041742424     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200319157     Document Type: Review

References (16)

1. Berry, M.J., Banu, L., and Larsen, P.R. 1991. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 349:438-440.
2. Davey, J.C., Becker, K.B., Schneider, M.J., St. Germain, D.L., and Galton, V.A. 1995. Cloning of a cDNA for the type II iodothyronine deiodinase. J. Biol. Chem. 270:26786-26789.
3. Bianco, A.C., Salvatore, D., Gereben, B., Berry, M.J., and Larsen, P.R. 2002. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr. Rev. 23:38-89.
4. Baqui, M.M.A., Gereben, B., Harney, J.W., Larsen, P.R., and Bianco, A.C. 2000. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 141:4309-4312.
5. Bianco, A.C., and Silva, J.E. 1987. Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J. Clin. Invest. 79:295-300.
6. Gereben, B., Goncalves, C., Harney, J.W., Larsen, P.R., and Bianco, A.C. 2000. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol. Endocrinol. 14:1697-1708.
7. Ravid, T., Doolman, R., Avner, R., Harats, D., and Roitelman, R. 2000. The ubiquitin-proteasome pathway mediates the regulated degradation of mammalian 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J. Biol. Chem. 275:35840-35847.
8. Curcio-Morelli, C., et al. 2003. Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein interacting deubiquitinating enzymes regulates thyroid hormone activation. J. Clin. Invest. 112:189-196. doi:10.1172/JCI200318348.
9. Berry, M.J., Maia, A.L., Kieffer, J.D., Harney, J.W., and Larsen, P.R. 1992. Substitution of cysteine for selenocysteine in type 1 iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology. 131:1848-1882.
10. Latif, F., et al. 1993. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science. 260:1317-1320.
11. Ohh, M., and Kaelin, W.G., Jr. 1999. The von Hippel-Lindau tumour suppressor protein: new perspectives. Mol. Med. Today. 5:257-263.
12. Li, Z., et al. 2002. Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppresor protein. J. Biol. Chem. 277:4656-4662.
13. Li, Z., et al. 2002. Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor. Biochem. Biophys. Res. Commun. 294:700-709.
14. De Groot, L.J. 1999. Dangerous dogmas in medicine: the nonthyroidal illness syndrome. J. Clin. Endocrinol. Metab. 84:151-164.
15. Crantz, F.R., Silva, J.E., and Larsen, P.R. 1982. An analysis of the sources and quantity of 3,5,3′-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology. 110:367-375.
16. Campos-Barros, A., et al. 1996. Phenolic and tyrosyl ring iodothyronine deiodination and thyroid hormone concentrations in the human central nervous system. J. Clin. Endocrinol. Metab. 81:2179-2185.