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Volumn 84, Issue 1, 1999, Pages 151-169

Dangerous dogmas in medicine: The nonthyroidal illness syndrome

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; LIOTHYRONINE; THYROID HORMONE; THYROTROPIN; THYROXINE;

EID: 0032933702     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.1.151     Document Type: Article
Times cited : (413)

References (107)
  • 1
    • 0030944473 scopus 로고    scopus 로고
    • Euthyroid sick syndrome: An overview
    • 1. McIver B, Gorman CA. 1997 Euthyroid sick syndrome: an overview. Thyroid. 7:125-132.
    • (1997) Thyroid , vol.7 , pp. 125-132
    • McIver, B.1    Gorman, C.A.2
  • 2
    • 0023923914 scopus 로고
    • 3 syndrome during caloric deprivation and non-thyroidal illness: An overview
    • 3 syndrome during caloric deprivation and non-thyroidal illness: an overview. Acta Med Kaust. 15:42-45.
    • (1988) Acta Med Kaust , vol.15 , pp. 42-45
    • Hennemann, G.1    Docter, R.2    Krenning, E.P.3
  • 3
    • 0029053434 scopus 로고
    • Euthyroid sick syndrome in tuberculosis before and after treatment
    • 3. Chow CC, Mak TW, Chan CH, Cockram CS. 1995 Euthyroid sick syndrome in tuberculosis before and after treatment. Ann Clin Biochem. 32:385-391.
    • (1995) Ann Clin Biochem , vol.32 , pp. 385-391
    • Chow, C.C.1    Mak, T.W.2    Chan, C.H.3    Cockram, C.S.4
  • 4
    • 0021358350 scopus 로고
    • Circulating thyroid hormone changes in acute trauma: Prognostic implications for clinical outcome
    • 4. Phillips RH, Valente WA, Caplan ES, Connor TB, Wiswell JG. 1984 Circulating thyroid hormone changes in acute trauma: prognostic implications for clinical outcome. J Trauma. 24:116-119.
    • (1984) J Trauma , vol.24 , pp. 116-119
    • Phillips, R.H.1    Valente, W.A.2    Caplan, E.S.3    Connor, T.B.4    Wiswell, J.G.5
  • 7
    • 0028878176 scopus 로고
    • Changes in thyroid hormone parameters after acute myocardial infarction
    • 7. Eber B, Schumacher M, Langsteger W, et al. 1995 Changes in thyroid hormone parameters after acute myocardial infarction. Cardiology. 86:152-156.
    • (1995) Cardiology , vol.86 , pp. 152-156
    • Eber, B.1    Schumacher, M.2    Langsteger, W.3
  • 8
    • 0025819632 scopus 로고
    • Cardiopulmonary bypass and thyroid function: A "euthyroid sick syndrome."
    • 8. Holland FW, Brown PS, Weintraub BD, Clark RE. 1991 Cardiopulmonary bypass and thyroid function: a "euthyroid sick syndrome." Ann Thorac Surg. 52:46-50.
    • (1991) Ann Thorac Surg , vol.52 , pp. 46-50
    • Holland, F.W.1    Brown, P.S.2    Weintraub, B.D.3    Clark, R.E.4
  • 9
    • 0027134866 scopus 로고
    • The 'euthyroid sick syndrome:' Incidence, risk factors and prognostic value soon after allogeneic bone marrow transplantation
    • 9. Vexiau P, Perez-Castiglioni P, Socie G, et al. 1993 The 'euthyroid sick syndrome:' incidence, risk factors and prognostic value soon after allogeneic bone marrow transplantation. Br J Hematol. 85:778-782.
    • (1993) Br J Hematol , vol.85 , pp. 778-782
    • Vexiau, P.1    Perez-Castiglioni, P.2    Socie, G.3
  • 11
    • 0022491864 scopus 로고
    • Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment
    • 11. Welle SL, Campbell RG. 1986 Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment. Metabolism. 35:289-291.
    • (1986) Metabolism , vol.35 , pp. 289-291
    • Welle, S.L.1    Campbell, R.G.2
  • 12
    • 0026718612 scopus 로고
    • Do thyroid function tests independently predict survival in the critically ill?
    • 12. Maldonado LS, Murata GH, Hershman JM, Braunstein GD. 1992 Do thyroid function tests independently predict survival in the critically ill? Thyroid 2:119.
    • (1992) Thyroid , vol.2 , pp. 119
    • Maldonado, L.S.1    Murata, G.H.2    Hershman, J.M.3    Braunstein, G.D.4
  • 15
    • 0020110358 scopus 로고
    • Alterations in thyroid function in patients with systemic illnesses: The "euthyroid sick syndrome."
    • 15. Wartofsky L, Burman KD. 1982 Alterations in thyroid function in patients with systemic illnesses: the "euthyroid sick syndrome." Endocr Rev. 3:164-217.
    • (1982) Endocr Rev , vol.3 , pp. 164-217
    • Wartofsky, L.1    Burman, K.D.2
  • 16
    • 0002954970 scopus 로고    scopus 로고
    • Clinical relevance of thyroid hormone alterations in nonthyroidal illness
    • 16. Kaptein EM. 1997 Clinical relevance of thyroid hormone alterations in nonthyroidal illness. Thyroid Int. 4:22-25.
    • (1997) Thyroid Int , vol.4 , pp. 22-25
    • Kaptein, E.M.1
  • 17
    • 0027430770 scopus 로고
    • The sick euthyroid syndrome: Changes in thyroid hormone serum parameters and hormone metabolism
    • 17. Docter R, Krenning EP, de Jong M, Hennemann G. 1993 The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism. Clin Endocrinol (Oxf). 39:499-518.
    • (1993) Clin Endocrinol (Oxf) , vol.39 , pp. 499-518
    • Docter, R.1    Krenning, E.P.2    De Jong, M.3    Hennemann, G.4
  • 18
    • 0023608154 scopus 로고
    • Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: Studies using turpentine oil-injected rat
    • 18. Chopra IJ, Huang TS, Boado R, Solomon DH, Chua Teco GN. 1987 Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: studies using turpentine oil-injected rat. J Endocrinol Invest. 10:559-564.
    • (1987) J Endocrinol Invest , vol.10 , pp. 559-564
    • Chopra, I.J.1    Huang, T.S.2    Boado, R.3    Solomon, D.H.4    Chua Teco, G.N.5
  • 19
    • 0023743945 scopus 로고
    • Normal free thyroxine in critical nonthyroidal illnesses measured by ultra filtration of undiluted serum and equilibrium dialysis
    • 19. Surks MI, Hupart KH, Pan C, Shapiro LE. 1988 Normal free thyroxine in critical nonthyroidal illnesses measured by ultra filtration of undiluted serum and equilibrium dialysis. J Clin Endocrinol Mctab. 67:1031-1039.
    • (1988) J Clin Endocrinol Mctab , vol.67 , pp. 1031-1039
    • Surks, M.I.1    Hupart, K.H.2    Pan, C.3    Shapiro, L.E.4
  • 22
    • 0018422190 scopus 로고
    • Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses
    • 22. Chopra IJ, Solomon DH, Hepner GW, Morgenstein AA. 1979 Misleadingly low free thyroxine index and usefulness of reverse triiodothyronine measurement in nonthyroidal illnesses. Ann Intern Med. 90:905-912.
    • (1979) Ann Intern Med , vol.90 , pp. 905-912
    • Chopra, I.J.1    Solomon, D.H.2    Hepner, G.W.3    Morgenstein, A.A.4
  • 23
    • 0020466330 scopus 로고
    • The relationship between serum triiodothyronine and thyrotropin during systemic illness
    • 23. Bacci V, Schussler GC, Kaplan TB. 1982 The relationship between serum triiodothyronine and thyrotropin during systemic illness. J Clin Endocrinol Metab. 54:1229-1235.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 1229-1235
    • Bacci, V.1    Schussler, G.C.2    Kaplan, T.B.3
  • 24
    • 0029054303 scopus 로고
    • Determination of free triiodothyronine by six different methods in patients with nonthyroidal illness and in patients treated with amiodarone
    • 24. Sapin R, Schlienger JL, Kaltenbach G, et al. 1995 Determination of free triiodothyronine by six different methods in patients with nonthyroidal illness and in patients treated with amiodarone. Ann Clin Biochem. 32:314-324.
    • (1995) Ann Clin Biochem , vol.32 , pp. 314-324
    • Sapin, R.1    Schlienger, J.L.2    Kaltenbach, G.3
  • 25
    • 0029744156 scopus 로고    scopus 로고
    • 3) in undiluted serum by equilibrium dialysis/radioimmunoassay
    • 3) in undiluted serum by equilibrium dialysis/radioimmunoassay. Thyroid. 6:255-259.
    • (1996) Thyroid , vol.6 , pp. 255-259
    • Chopra, I.J.1    Taing, P.2    Mikus, L.3
  • 26
    • 13144306082 scopus 로고    scopus 로고
    • Simultaneous measurement of free thyroxine and free 3,5,3′-triiodothyronine in undiluted serum by direct equilibrium dialysis/radioimmunoassay: Evidence that free triiodothyronine and free thyroxine are normal in many patients with the low triiodothyronine syndrome
    • 26. Chopra IJ. 1998 Simultaneous measurement of free thyroxine and free 3,5,3′-triiodothyronine in undiluted serum by direct equilibrium dialysis/radioimmunoassay: evidence that free triiodothyronine and free thyroxine are normal in many patients with the low triiodothyronine syndrome. Thyroid. 8:249-257.
    • (1998) Thyroid , vol.8 , pp. 249-257
    • Chopra, I.J.1
  • 27
    • 0028808234 scopus 로고
    • Thyroid hormone treatment after coronary-artery bypass surgery
    • 27. Klemperer JD, Klein I, Gomez M, et al. 1995 Thyroid hormone treatment after coronary-artery bypass surgery. N Engl J Med. 333:1522-1527.
    • (1995) N Engl J Med. , vol.333 , pp. 1522-1527
    • Klemperer, J.D.1    Klein, I.2    Gomez, M.3
  • 29
    • 0030051476 scopus 로고    scopus 로고
    • Thyroid hormone metabolism and thyroid diseases in chronic renal failure
    • 29. Kaptein EM. 1996 Thyroid hormone metabolism and thyroid diseases in chronic renal failure. Endocr Rev. 17:45-63.
    • (1996) Endocr Rev , vol.17 , pp. 45-63
    • Kaptein, E.M.1
  • 30
    • 0026750453 scopus 로고
    • Fatty acid-induced increase in serum dialyzable free thyroxine after physical exercise: Implication for nonthyroidal illness
    • 30. Liewendahl K, Helenius T, Naveri H, Tikkanen H. 1992 Fatty acid-induced increase in serum dialyzable free thyroxine after physical exercise: implication for nonthyroidal illness. J Clin Endocrinol Metab. 74:1361-1365.
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 1361-1365
    • Liewendahl, K.1    Helenius, T.2    Naveri, H.3    Tikkanen, H.4
  • 31
    • 0022999002 scopus 로고
    • Effect of free fatty acids on the concentration of free thyroxine in human serum: The role of albumin
    • 31. Mendel CM, Frost PH, Cavalieri RR. 1986 Effect of free fatty acids on the concentration of free thyroxine in human serum: the role of albumin. J Clin Endocrinol Metab. 63:1394-1399.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1394-1399
    • Mendel, C.M.1    Frost, P.H.2    Cavalieri, R.R.3
  • 32
    • 0029879190 scopus 로고    scopus 로고
    • Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis
    • 32. Jaume JC, Mendel CM, Frost PH, Greenspan FS, Laughton CW. 1996 Extremely low doses of heparin release lipase activity into the plasma and can thereby cause artifactual elevations in the serum-free thyroxine concentration as measured by equilibrium dialysis. Thyroid. 6:79.
    • (1996) Thyroid , vol.6 , pp. 79
    • Jaume, J.C.1    Mendel, C.M.2    Frost, P.H.3    Greenspan, F.S.4    Laughton, C.W.5
  • 33
    • 0017249631 scopus 로고
    • Measurements of free thyroxine: Comparison of percent of free thyroxine in diluted and undiluted sera
    • 33. Uchimura H, Nagataki S, Tabuchi T, Mizuno M, Ingbar SH. 1976 Measurements of free thyroxine: comparison of percent of free thyroxine in diluted and undiluted sera. J Clin Endocrinol Metab. 42:561-566.
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 561-566
    • Uchimura, H.1    Nagataki, S.2    Tabuchi, T.3    Mizuno, M.4    Ingbar, S.H.5
  • 35
    • 0022371113 scopus 로고
    • Improved ultarfiltration method for simultaneous measurement of free thyroxine and free triiodothyronine in serum
    • 35. Wang Y-S, Hershman JM, Pekary AE. 1985 Improved ultarfiltration method for simultaneous measurement of free thyroxine and free triiodothyronine in serum. Clin Chem. 31:517-522.
    • (1985) Clin Chem , vol.31 , pp. 517-522
    • Wang, Y.-S.1    Hershman, J.M.2    Pekary, A.E.3
  • 36
    • 0021939804 scopus 로고
    • Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3′-triiodothyronine in sera of patients with nonthyroidal illnesses
    • 36. Chopra IJ, Huang T-S, Beredo A, Solomon DH, Chua Teco GN, Mead JF. 1985 Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3′-triiodothyronine in sera of patients with nonthyroidal illnesses. J Clin Endocrinol Metab. 60:666.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 666
    • Chopra, I.J.1    Huang, T.-S.2    Beredo, A.3    Solomon, D.H.4    Chua Teco, G.N.5    Mead, J.F.6
  • 37
    • 0025802811 scopus 로고
    • Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with nonthyroidal illness
    • 37. Mendel CM, Laughton CW, McMahon FA, Cavalieri RR. 1991 Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with nonthyroidal illness. Metabolism. 40:491-502.
    • (1991) Metabolism , vol.40 , pp. 491-502
    • Mendel, C.M.1    Laughton, C.W.2    McMahon, F.A.3    Cavalieri, R.R.4
  • 38
    • 0023226994 scopus 로고
    • On the albumin-dependence of the measurement of free thyroxine. II. Patients with nonthyroidal illness
    • 38. Csako G, Zweig MH, Benson C, Ruddel M. 1987 On the albumin-dependence of the measurement of free thyroxine. II. Patients with nonthyroidal illness. Clin Chem. 33:87-92.
    • (1987) Clin Chem , vol.33 , pp. 87-92
    • Csako, G.1    Zweig, M.H.2    Benson, C.3    Ruddel, M.4
  • 39
    • 0021815040 scopus 로고
    • Relationship between serum free fatty acids and thyroid hormone binding inhibitor in nonthyroid illnesses
    • 39. Chopra IJ, Chua Teco GN, Mead JF, et al. 1985 Relationship between serum free fatty acids and thyroid hormone binding inhibitor in nonthyroid illnesses. J Clin Endocrinol Metab. 60:980-984.
    • (1985) J Clin Endocrinol Metab , vol.60 , pp. 980-984
    • Chopra, I.J.1    Chua Teco, G.N.2    Mead, J.F.3
  • 40
    • 0022576606 scopus 로고
    • Thyroxine therapy in patients with severe nonthyroidal illnesses and lower serum thyroxine concentration
    • 40. Brent GA, Hershman JM. 1986 Thyroxine therapy in patients with severe nonthyroidal illnesses and lower serum thyroxine concentration. J Clin Endocrinol Metab. 63:1-8.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 1-8
    • Brent, G.A.1    Hershman, J.M.2
  • 41
    • 0001843041 scopus 로고    scopus 로고
    • Nonthyroidal illness syndrome or euthyroid sick syndrome?
    • 41. Chopra IJ. 1996 Nonthyroidal illness syndrome or euthyroid sick syndrome? Endocr Prac. 2:45-52.
    • (1996) Endocr Prac. , vol.2 , pp. 45-52
    • Chopra, I.J.1
  • 42
    • 0028221214 scopus 로고
    • Comparison of second and third generation methods for measurement of serum thyrotropin in patients with overt hyperthyroidism, patients receiving thyroxine therapy, and those with nonthyroidal illness
    • 42. Franklyn JA, Black EG, Betteridge J, Sheppard MC. 1994 Comparison of second and third generation methods for measurement of serum thyrotropin in patients with overt hyperthyroidism, patients receiving thyroxine therapy, and those with nonthyroidal illness. J Clin Endocrinol Metab. 78:1368-1371.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1368-1371
    • Franklyn, J.A.1    Black, E.G.2    Betteridge, J.3    Sheppard, M.C.4
  • 45
    • 0025373320 scopus 로고
    • Fatal nonthyroidal illness may impair nocturnal thyrotropin levels
    • 45. Arem R, Deppe S. 1990 Fatal nonthyroidal illness may impair nocturnal thyrotropin levels. Am J Med. 88:258-262.
    • (1990) Am J Med , vol.88 , pp. 258-262
    • Arem, R.1    Deppe, S.2
  • 46
    • 0023620127 scopus 로고
    • Secretion of thyrotropin with reduced concanavalin-A-binding activity in patients with severe nonthyroid illness
    • 46. Lee H-Y, Suhl J, Pekary AE, Hershman JM. 1987 Secretion of thyrotropin with reduced concanavalin-A-binding activity in patients with severe nonthyroid illness. J Clin Endocrinol Metab. 65:942.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 942
    • Lee, H.-Y.1    Suhl, J.2    Pekary, A.E.3    Hershman, J.M.4
  • 47
    • 0026620244 scopus 로고
    • Both hyperand hypogonadotropic hypogonadism occur transiently in acute illness: Bio- and immunoactive gonadorropins
    • 47. Spratt DI, Bigos ST, Beitins I, Cox F, Longcope C, Orav J. 1992 Both hyperand hypogonadotropic hypogonadism occur transiently in acute illness: bio- and immunoactive gonadorropins. J Clin Endocrinol Metab. 75:1562-1570.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 1562-1570
    • Spratt, D.I.1    Bigos, S.T.2    Beitins, I.3    Cox, F.4    Longcope, C.5    Orav, J.6
  • 48
    • 0027167672 scopus 로고
    • Reproductive axis suppression in acute illness is related to disease severity
    • 48. Spratt DI, Cox F, Orav J, Moloney J, Bigos T. 1993 Reproductive axis suppression in acute illness is related to disease severity. J Clin Endocrinol Metab. 76:1548-1554.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1548-1554
    • Spratt, D.I.1    Cox, F.2    Orav, J.3    Moloney, J.4    Bigos, T.5
  • 50
    • 0020042131 scopus 로고
    • Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses. A noncompartmental analysis
    • 50. Kaptein EM, Robinson WJ, Grieb DA, Nicoloff JT. 1982 Peripheral serum thyroxine, triiodothyronine and reverse triiodothyronine kinetics in the low thyroxine state of acute nonthyroidal illnesses. A noncompartmental analysis. J Clin Invest. 69:526-535.
    • (1982) J Clin Invest , vol.69 , pp. 526-535
    • Kaptein, E.M.1    Robinson, W.J.2    Grieb, D.A.3    Nicoloff, J.T.4
  • 51
    • 0017671137 scopus 로고
    • Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodo-thyronine
    • 51. Lim VS, Fang VS, Katz AI, Refetoff S. 1977 Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodo-thyronine. J Clin Invest. 60:522-534.
    • (1977) J Clin Invest , vol.60 , pp. 522-534
    • Lim, V.S.1    Fang, V.S.2    Katz, A.I.3    Refetoff, S.4
  • 52
    • 0027153559 scopus 로고
    • Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: Effects of bilirubin and nonesterified fatty acids
    • 52. Lim C-F, Docter R, Visser TJ, et al. 1993 Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids. J Clin Endocrinol Metab. 76:1165-1172.
    • (1993) J Clin Endocrinol Metab , vol.76 , pp. 1165-1172
    • Lim, C.-F.1    Docter, R.2    Visser, T.J.3
  • 53
    • 0029150952 scopus 로고
    • Impaired thyroxine and 3,5,3′-triiodothyronine handling by rat hepatocytes in the presence of serum of patients with nonthyroidal illness
    • 53. Vos RA, de Jong M, Bernard BF, Docter R, Krenning EP, Hennemann G. 1995 Impaired thyroxine and 3,5,3′-triiodothyronine handling by rat hepatocytes in the presence of serum of patients with nonthyroidal illness. J Clin Endocrinol Metab. 80:2364-2370.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 2364-2370
    • Vos, R.A.1    De Jong, M.2    Bernard, B.F.3    Docter, R.4    Krenning, E.P.5    Hennemann, G.6
  • 54
    • 0028283716 scopus 로고
    • Transport of thyroxine into cultured hepatocytes: Effects of mild nonthyroidal illness and calorie restriction in obese subjects
    • 54. Lim C-F, Docter R, Krenning EP, van Toor H, Bernard B, de Jong M, Hennemann G. 1994 Transport of thyroxine into cultured hepatocytes: effects of mild nonthyroidal illness and calorie restriction in obese subjects. Clin Endocrinol (Oxf). 40:79-85.
    • (1994) Clin Endocrinol (Oxf) , vol.40 , pp. 79-85
    • Lim, C.-F.1    Docter, R.2    Krenning, E.P.3    Van Toor, H.4    Bernard, B.5    De Jong, M.H.G.6
  • 55
    • 0022411903 scopus 로고
    • Measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: Reduced thyroxine uptake from serum of patients with nonthyroidal illness
    • 55. Sarne DH, Refetoff S. 1985 Measurement of thyroxine uptake from serum by cultured human hepatocytes as an index of thyroid status: reduced thyroxine uptake from serum of patients with nonthyroidal illness. J Clin Endocrinol Metab. 61:1046-1052.
    • (1985) J Clin Endocrinol Metab , vol.61 , pp. 1046-1052
    • Sarne, D.H.1    Refetoff, S.2
  • 57
    • 0345896851 scopus 로고    scopus 로고
    • Differential end organ responsiveness to suboptimal thyroid hormone concentrations as assessed by short-term withdrawal of levothyroxine sodium in athyreotic patients
    • 57. DeGroot LJ, Manowitz N, Chait L, Mayor G. Differential end organ responsiveness to suboptimal thyroid hormone concentrations as assessed by short-term withdrawal of levothyroxine sodium in athyreotic patients [Abstract]. Proc of the 70th Annual Meet of the Am Thyroid Assoc. 1997.
    • (1997) Proc of the 70th Annual Meet of the Am Thyroid Assoc
    • DeGroot, L.J.1    Manowitz, N.2    Chait, L.3    Mayor, G.4
  • 58
    • 0021357326 scopus 로고
    • Serum angiotensin converting enzyme in severe nonthyroidal illness associated with low serum thyroxine concentration
    • 58. Brent GA, Hershman JM, Reed AW, Sastre A, Lieberman J. 1986 Serum angiotensin converting enzyme in severe nonthyroidal illness associated with low serum thyroxine concentration. Ann Intern Med. 100:680-683.
    • (1986) Ann Intern Med , vol.100 , pp. 680-683
    • Brent, G.A.1    Hershman, J.M.2    Reed, A.W.3    Sastre, A.4    Lieberman, J.5
  • 59
    • 0029970303 scopus 로고    scopus 로고
    • Serum sex hormone-binding globulin and osteocalcin in systemic nonthyroidal illness associated with low thyroid hormone concentrations
    • 59. Seppel T, Becker A, Lippert F, Schlaghecke R. 1996 Serum sex hormone-binding globulin and osteocalcin in systemic nonthyroidal illness associated with low thyroid hormone concentrations. J Clin Endocrinol Metab. 81:1663-1665.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1663-1665
    • Seppel, T.1    Becker, A.2    Lippert, F.3    Schlaghecke, R.4
  • 60
    • 0018758389 scopus 로고
    • Subcellular alterations causing reduced hepatic thyroxine-5′-monodeiodinase activity in fasted rats
    • 60. Kaplan MM. 1979 Subcellular alterations causing reduced hepatic thyroxine-5′-monodeiodinase activity in fasted rats. Endocrinology. 104:58-64.
    • (1979) Endocrinology , vol.104 , pp. 58-64
    • Kaplan, M.M.1
  • 62
    • 0025788413 scopus 로고
    • Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation
    • 62. Blake NG, Eckland JA, Foster OJF, Lightman SL. 1991 Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. Endocrinology. 129:2714-2718.
    • (1991) Endocrinology , vol.129 , pp. 2714-2718
    • Blake, N.G.1    Eckland, J.A.2    Foster, O.J.F.3    Lightman, S.L.4
  • 63
    • 0030734631 scopus 로고    scopus 로고
    • Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness
    • 63. Fliers E, Guldenaar SEF, Wiersinga WM, Swaab DF. 1997 Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab. 82:4032-4036.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 4032-4036
    • Fliers, E.1    Guldenaar, S.E.F.2    Wiersinga, W.M.3    Swaab, D.F.4
  • 64
    • 15644365769 scopus 로고    scopus 로고
    • Neuroendocrinology of prolonged critical illness: Effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues
    • 64. Van den Berghe G, De Zegher F, Baxter RC, et al. 1998 Neuroendocrinology of prolonged critical illness: effects of exogenous thyrotropin-releasing hormone and its combination with growth hormone secretagogues. J Clin Endocrinol Metab. 83:309-319.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 309-319
    • Van Den Berghe, G.1    De Zegher, F.2    Baxter, R.C.3
  • 65
    • 0014864243 scopus 로고
    • The role of glucocorticoids in the regulation of thyroid function in man
    • 65. Nicoloff JT, Fisher DA, Appleman Jr MD. 1970 The role of glucocorticoids in the regulation of thyroid function in man. J Clin Invest. 49:1922.
    • (1970) J Clin Invest , vol.49 , pp. 1922
    • Nicoloff, J.T.1    Fisher, D.A.2    Appleman M.D., Jr.3
  • 66
    • 0023250411 scopus 로고
    • Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration
    • 66. Brabant G, Brabant A, Ranft U. 1987 Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration. J Clin Endocrinol Metab. 65:83.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 83
    • Brabant, G.1    Brabant, A.2    Ranft, U.3
  • 67
    • 0025204578 scopus 로고
    • TSH secretion in Cushing's syndrome: Relation to glucocorticoid excess, diabetes, goiter, and the 'sick euthyroid syndrome.'
    • 67. Benker G, Raida M, Olbricht T, Wagner R, Reinhardt W, Reinwein D. 1990 TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goiter, and the 'sick euthyroid syndrome.' Clin Endocrinol (Oxf). 33:777-786.
    • (1990) Clin Endocrinol (Oxf) , vol.33 , pp. 777-786
    • Benker, G.1    Raida, M.2    Olbricht, T.3    Wagner, R.4    Reinhardt, W.5    Reinwein, D.6
  • 68
    • 0023154510 scopus 로고
    • The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3′-triiodothyronine generation in rats
    • 68. Bianco AC, Nunes MT, Hell NS, Maciel RMB. 1987 The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3′-triiodothyronine generation in rats. Endocrinology. 120:1033-1038.
    • (1987) Endocrinology , vol.120 , pp. 1033-1038
    • Bianco, A.C.1    Nunes, M.T.2    Hell, N.S.3    Maciel, R.M.B.4
  • 69
    • 0021369879 scopus 로고
    • Reduced triiodothyronine content in liver but not pituitary of the uremic rat model: Demonstration of changes compatible with thyroid hormone deficiency in liver only
    • 69. Lim VS, Passo C, Murata Y, Ferrari E, Nakamura H, Refetoff S. 1984 Reduced triiodothyronine content in liver but not pituitary of the uremic rat model: demonstration of changes compatible with thyroid hormone deficiency in liver only. Endocrinology. 114:280-286.
    • (1984) Endocrinology , vol.114 , pp. 280-286
    • Lim, V.S.1    Passo, C.2    Murata, Y.3    Ferrari, E.4    Nakamura, H.5    Refetoff, S.6
  • 71
    • 0026484283 scopus 로고
    • Continuous infusion of interleukin-1β induces a nonthyroidal illness syndrome in the rat
    • 71. Hermus ARMM, Sweep CGJ, van der Meer MJM, et al. 1992 Continuous infusion of interleukin-1β induces a nonthyroidal illness syndrome in the rat. Endocrinology. 131:2139-2146.
    • (1992) Endocrinology , vol.131 , pp. 2139-2146
    • Hermus, A.R.M.M.1    Sweep, C.G.J.2    Van Der Meer, M.J.M.3
  • 72
    • 0025193674 scopus 로고
    • Inhibition of 125-I organification and thyroid hormone release by interleukin-1, tumor necrosis factor-α, and interferon-γ in human thyrocytes in suspension culture
    • 72. Sato K, Satoh T, Shizume K, et al. 1990 Inhibition of 125-I organification and thyroid hormone release by interleukin-1, tumor necrosis factor-α, and interferon-γ in human thyrocytes in suspension culture. J Clin Endocrinol Metab. 70:1735-1743.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 1735-1743
    • Sato, K.1    Satoh, T.2    Shizume, K.3
  • 73
    • 0025017232 scopus 로고
    • Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever
    • 73. Cannon JG, Tompkins RG, Gelfand JA, et al. 1990 Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever. J Infect Dis. 161:79-84.
    • (1990) J Infect Dis , vol.161 , pp. 79-84
    • Cannon, J.G.1    Tompkins, R.G.2    Gelfand, J.A.3
  • 74
    • 0028919859 scopus 로고
    • Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man
    • 74. van der Poll T, Van Zee KJ, Endert E, et al. 1995 Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man. J Clin Endocrinol Metab. 80:1341-1346.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1341-1346
    • Van Der Poll, T.1    Van Zee, K.J.2    Endert, E.3
  • 76
    • 0025849738 scopus 로고
    • A study of the serum concentration of tumor necrosis factor-α in thyroidal and nonthyroidal illnesses
    • 76. Chopra IJ, Sakane S, Chua Teco GN. 1991 A study of the serum concentration of tumor necrosis factor-α in thyroidal and nonthyroidal illnesses. J Clin Endocrinol Metab. 72:1113-1116.
    • (1991) J Clin Endocrinol Metab , vol.72 , pp. 1113-1116
    • Chopra, I.J.1    Sakane, S.2    Chua Teco, G.N.3
  • 77
    • 0028673303 scopus 로고
    • Relationship of the increased serum interleukin-6 concentration to changes of thyroid function in nonthyroidal illness
    • 77. Bartalena L, Brogioni S, Grasso L, Velluzzi F, Martino E. 1994 Relationship of the increased serum interleukin-6 concentration to changes of thyroid function in nonthyroidal illness. J Endocrinol Invest. 17:269-274.
    • (1994) J Endocrinol Invest , vol.17 , pp. 269-274
    • Bartalena, L.1    Brogioni, S.2    Grasso, L.3    Velluzzi, F.4    Martino, E.5
  • 78
    • 0027131203 scopus 로고
    • Association between serum interleukin-6 and serum 3,5,3′-triiodothyronine in nonthyroidal illness
    • 78. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. 1993 Association between serum interleukin-6 and serum 3,5,3′-triiodothyronine in nonthyroidal illness. J Clin Endocrinol Metab. 77:1695-1699.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 1695-1699
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 79
    • 0028033128 scopus 로고
    • Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans
    • 79. Stouthard JML, van der Poll T, Endert E, et al. 1994 Effects of acute and chronic interleukin-6 administration on thyroid hormone metabolism in humans. J Clin Endocrinol Metab. 79:1342-1346.
    • (1994) J Clin Endocrinol Metab , vol.79 , pp. 1342-1346
    • Stouthard, J.M.L.1    Van Der Poll, T.2    Endert, E.3
  • 80
    • 0030944073 scopus 로고    scopus 로고
    • Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice
    • 80. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. 1997 Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice. J Endocrinol. 153:115-122.
    • (1997) J Endocrinol , vol.153 , pp. 115-122
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 81
    • 0030179447 scopus 로고    scopus 로고
    • Relationship between serum 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon-γ in patients with nonthyroidal illness
    • 81. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. 1996 Relationship between serum 3,5,3′-triiodothyronine and serum interleukin-8, interleukin-10 or interferon-γ in patients with nonthyroidal illness. J Endocrinol Invest. 19:480-483.
    • (1996) J Endocrinol Invest , vol.19 , pp. 480-483
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 82
    • 0028956194 scopus 로고
    • Soluble cytokine receptors and the low 3,5,3′-triiodothyronine syndrome in patients with nonthyroidal disease
    • 82. Boelen A, Platvoet-ter Schiphorst MC, Wiersinga WM. 1995 Soluble cytokine receptors and the low 3,5,3′-triiodothyronine syndrome in patients with nonthyroidal disease. J Clin Endocrinol Metab. 80:971-976.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 971-976
    • Boelen, A.1    Platvoet-ter Schiphorst, M.C.2    Wiersinga, W.M.3
  • 83
    • 0024743465 scopus 로고
    • Role of high blood glucagon in the reduction of serum levels of triiodothyronine in severe nonthyroid diseases
    • 83. Custro N, Scafidi V, Costanzo G, Calanni S. 1989 Role of high blood glucagon in the reduction of serum levels of triiodothyronine in severe nonthyroid diseases. Minerva Endocrinol. 14:221-226.
    • (1989) Minerva Endocrinol , vol.14 , pp. 221-226
    • Custro, N.1    Scafidi, V.2    Costanzo, G.3    Calanni, S.4
  • 85
    • 0018388472 scopus 로고
    • Serum triiodothyronine and other clinical and laboratory indices of alcoholic liver disease
    • 85. Walfish PG, Orrego H, Israel Y, Blake J, Kalant H. 1979 Serum triiodothyronine and other clinical and laboratory indices of alcoholic liver disease Ann Intern Med. 91:13-16.
    • (1979) Ann Intern Med , vol.91 , pp. 13-16
    • Walfish, P.G.1    Orrego, H.2    Israel, Y.3    Blake, J.4    Kalant, H.5
  • 86
    • 0020652519 scopus 로고
    • Serum free thyroid hormone concentrations and indices in alcoholic liver cirrhosis, primary biliary cirrhosis and chronic active hepatitis
    • 86. Liewendahl K, Helenius T, Tanner P, Salaspuro M. 1983 Serum free thyroid hormone concentrations and indices in alcoholic liver cirrhosis, primary biliary cirrhosis and chronic active hepatitis. Acta Endocrinol (Copenh). 251:21-26.
    • (1983) Acta Endocrinol (Copenh) , vol.251 , pp. 21-26
    • Liewendahl, K.1    Helenius, T.2    Tanner, P.3    Salaspuro, M.4
  • 87
    • 0016139784 scopus 로고
    • Alterations in circulating thyroid hormones and thyrotropin in hepatic cirrhosis: Evidence for euthyroidism despite subnormal serum triiodothyronine
    • 87. Chopra IJ, Solomon DH, Chopra U, Young RT, Chua Teco GN. 1974 Alterations in circulating thyroid hormones and thyrotropin in hepatic cirrhosis: evidence for euthyroidism despite subnormal serum triiodothyronine. J Clin Endocrinol Metab. 39:501-511.
    • (1974) J Clin Endocrinol Metab , vol.39 , pp. 501-511
    • Chopra, I.J.1    Solomon, D.H.2    Chopra, U.3    Young, R.T.4    Chua Teco, G.N.5
  • 88
    • 0019811418 scopus 로고
    • Alterations of thyroid hormone indices in acute renal failure and in acute critical illness with and without acute renal failure
    • 88. Kaptein EM, Levitan D, Feinstein EI, Nicoloff JT, Massry SG. 1981 Alterations of thyroid hormone indices in acute renal failure and in acute critical illness with and without acute renal failure. Am J Nephrol. 1:138-143.
    • (1981) Am J Nephrol , vol.1 , pp. 138-143
    • Kaptein, E.M.1    Levitan, D.2    Feinstein, E.I.3    Nicoloff, J.T.4    Massry, S.G.5
  • 89
    • 0015841817 scopus 로고
    • Thyroid abnormalities in renal failure. A study of 53 patients on chronic hemodialysis
    • 89. Ramirez G, Jubiz W, Gutch CF, Bloomer HA, Siegler R, Kolff WJ. 1973 Thyroid abnormalities in renal failure. A study of 53 patients on chronic hemodialysis. Ann Intern Med. 79:500-504.
    • (1973) Ann Intern Med , vol.79 , pp. 500-504
    • Ramirez, G.1    Jubiz, W.2    Gutch, C.F.3    Bloomer, H.A.4    Siegler, R.5    Kolff, W.J.6
  • 90
    • 0019185753 scopus 로고
    • Thyroid function in a uremic rat model. Evidence suggesting tissue hypothyroidism
    • 90. Lim VS, Henriquez C, Seo H, Refetoff S, Martino E. 1980 Thyroid function in a uremic rat model. Evidence suggesting tissue hypothyroidism. J Clin Invest. 66:946-954.
    • (1980) J Clin Invest , vol.66 , pp. 946-954
    • Lim, V.S.1    Henriquez, C.2    Seo, H.3    Refetoff, S.4    Martino, E.5
  • 91
    • 0024818803 scopus 로고
    • Augmentation of protein degradation by L-triiodothyronine in uremia
    • 91. Lim VS, Tsalikian E, Flanigan MJ. 1989 Augmentation of protein degradation by L-triiodothyronine in uremia. Metabolism. 38:1210-1215.
    • (1989) Metabolism , vol.38 , pp. 1210-1215
    • Lim, V.S.1    Tsalikian, E.2    Flanigan, M.J.3
  • 92
    • 0021149614 scopus 로고
    • Decreased free fraction of serum thyroid hormones during carbohydrate overfeeding
    • 92. Welle S, O'Connell M, Danforth E, Campbell R. 1984 Decreased free fraction of serum thyroid hormones during carbohydrate overfeeding. Metabolism. 33:837.
    • (1984) Metabolism , vol.33 , pp. 837
    • Welle, S.1    O'Connell, M.2    Danforth, E.3    Campbell, R.4
  • 93
    • 0022491864 scopus 로고
    • Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment
    • 93. Welle SL, Campbell RG. 1986 Decrease in resting metabolic rate during rapid weight loss is reversed by low dose thyroid hormone treatment. Metabolism. 35:289-291.
    • (1986) Metabolism , vol.35 , pp. 289-291
    • Welle, S.L.1    Campbell, R.G.2
  • 95
    • 0025916433 scopus 로고
    • Triiodothyronine-receptor complex in rat brain: Effects of thyroidectomy, fasting, food restriction, and diabetes
    • 95. Sanchez B, Jolin T. 1991 Triiodothyronine-receptor complex in rat brain: effects of thyroidectomy, fasting, food restriction, and diabetes. Endocrinology. 129:361-367.
    • (1991) Endocrinology , vol.129 , pp. 361-367
    • Sanchez, B.1    Jolin, T.2
  • 97
    • 0018415335 scopus 로고
    • Effect of triiodothyronine replacement on the metabolic and pituitary responses to starvation
    • 97. Gardner DF, Kaplan MM, Stanley CA, Utiger RD. 1979 Effect of triiodothyronine replacement on the metabolic and pituitary responses to starvation. N Engl J Med. 300:579-584.
    • (1979) N Engl J Med , vol.300 , pp. 579-584
    • Gardner, D.F.1    Kaplan, M.M.2    Stanley, C.A.3    Utiger, R.D.4
  • 98
    • 0018647139 scopus 로고
    • 3 and reverse T3 administration on muscle protein catabolism during fasting as measured by 3-methyl-histidine excretion
    • 3 and reverse T3 administration on muscle protein catabolism during fasting as measured by 3-methyl-histidine excretion. Metabolism. 28:805-813.
    • (1979) Metabolism , vol.28 , pp. 805-813
    • Burman, K.D.1    Wartofsky, L.2    Dinterman, R.E.3    Kesler, P.4    Wannemacher, R.W.5
  • 99
    • 0029862748 scopus 로고    scopus 로고
    • Metabolic effects of triodothyronine replacement during fasting in obese subjects
    • 99. Byerley LO, Heber D. 1996 Metabolic effects of triodothyronine replacement during fasting in obese subjects. J Clin Endocrinol Metab. 81:968-976.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 968-976
    • Byerley, L.O.1    Heber, D.2
  • 100
    • 0020348719 scopus 로고
    • Hypermetabolic low triiodothyronine syndrome of burn injury
    • 100. Becker RA, Vaughan GM, Ziegler MG, et al. 1982 Hypermetabolic low triiodothyronine syndrome of burn injury. Crit Care Med. 10:870-875.
    • (1982) Crit Care Med , vol.10 , pp. 870-875
    • Becker, R.A.1    Vaughan, G.M.2    Ziegler, M.G.3
  • 101
    • 0021948077 scopus 로고
    • Effect of thyroid hormone supplementation on survival after bacterial infection
    • 101. Little JS. 1985 Effect of thyroid hormone supplementation on survival after bacterial infection. Endocrinology. 117:1431-1435.
    • (1985) Endocrinology , vol.117 , pp. 1431-1435
    • Little, J.S.1
  • 102
    • 0023608154 scopus 로고
    • Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: Studies using turpentine oil-injected rat
    • 102. Chopra IJ, Huang TS, Boado R, Solomon DH, Chua Teco GN. 1987 Evidence against benefit from replacement doses of thyroid hormones in nonthyroidal illness: studies using turpentine oil-injected rat. J Endocrinol Invest. 10:559.
    • (1987) J Endocrinol Invest , vol.10 , pp. 559
    • Chopra, I.J.1    Huang, T.S.2    Boado, R.3    Solomon, D.H.4    Chua Teco, G.N.5
  • 103
    • 0029558312 scopus 로고
    • Effect of triiodothyronine administration in experimental myocardial injury
    • 103. Hsu R-B, Huang T-S, Chen Y-S, Chu S-H. 1995 Effect of triiodothyronine administration in experimental myocardial injury. J Endocrinol Invest. 18:702-709.
    • (1995) J Endocrinol Invest , vol.18 , pp. 702-709
    • Hsu, R.-B.1    Huang, T.-S.2    Chen, Y.-S.3    Chu, S.-H.4
  • 104
    • 0018734783 scopus 로고
    • Thyroid administration lowers mortality in premature infants
    • 104. Schoenberger W, Grimm W, Emmrich P, Gempp W. 1979 Thyroid administration lowers mortality in premature infants. Lancet. 2:1181.
    • (1979) Lancet , vol.2 , pp. 1181
    • Schoenberger, W.1    Grimm, W.2    Emmrich, P.3    Gempp, W.4
  • 105
    • 0024100405 scopus 로고
    • The effect of triiodothyronine and reverse triiodothyronine on canine hemorrhagic shock
    • 105. Shigematsu H, Shatney CH. 1988 The effect of triiodothyronine and reverse triiodothyronine on canine hemorrhagic shock. Nippon Geka Gakkai Zasshi. 89:1587-1593.
    • (1988) Nippon Geka Gakkai Zasshi , vol.89 , pp. 1587-1593
    • Shigematsu, H.1    Shatney, C.H.2
  • 106
    • 0027521607 scopus 로고
    • Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs
    • 106. Facktor MA, Mayor GH, Nachreiner RF, D'Alecy LG. 1993 Thyroid hormone loss and replacement during resuscitation from cardiac arrest in dogs. Resuscitation. 26:141-162.
    • (1993) Resuscitation , vol.26 , pp. 141-162
    • Facktor, M.A.1    Mayor, G.H.2    Nachreiner, R.F.3    D'Alecy, L.G.4
  • 107
    • 0029859011 scopus 로고    scopus 로고
    • Thyroid hormone abnormalities in heart failure: Possibilities for therapy
    • 107. Hamilton MA, Stevenson LW. 1996 Thyroid hormone abnormalities in heart failure: possibilities for therapy. Thyroid. 6:527-529.
    • (1996) Thyroid , vol.6 , pp. 527-529
    • Hamilton, M.A.1    Stevenson, L.W.2


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