Colorectal cancer cell adhesion attenuates Ad-E2F-1 mediated apoptosis

Journal of Surgical Research

Volumn 113, Issue 1, 2003, Pages 81-87

  Chao, Celia ^a,b   Jamshidi Parsian, Azemat ^a   Wang, Warner W ^a   McMasters, Kelly M ^a  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

Author keywords

Cellular survival; Colorectal cancer cells; Extracellular matrix; Gene therapy resistance

Indexed keywords

ADENOVIRUS VECTOR; ANTIBODY; BETA GALACTOSIDASE; BETA1 INTEGRIN; MATRIGEL; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BASEMENT MEMBRANE; CANCER CELL DESTRUCTION; CELL ADHESION; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL CANCER; CONTROLLED STUDY; CYTOMEGALOVIRUS; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; NICK END LABELING; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TISSUE CULTURE; TRANSGENE; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 0041734710     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-4804(03)00137-9     Document Type: Article

References (14)

1. Meredith J.E. Jr, Fazell B., Schwartz M.A. The extracellular matrix as a cell survival factor. Mol. Biol. Cell. 4:1993;953.
2. Stupack D.G., Cheresh D.A. Get a ligand, get a life Integrin, signaling and cell survival. J. Cell. Sci. 115:2002;3729.
3. Elliott M.J., Dong Y.B., Yang H.L., McMasters K.M. E2F-1 up-regulates c-Myc and p14(ARF) and induces apoptosis in colon cancer cells. Clin. Cancer Res. 7:2001;3590.
4. Yang H.L., Dong Y.B., Elliott M.J., Lius T.J., Atienza C. Jr, Stilwell A., McMasters K.M. Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells. Clin. Cancer Res. 5:1999;2242.
5. Chao C., Lotz M.M., Clarke A.C., Mercurio A.M. A function for the integrin alpha6beta4 in the invasive properties of colorectal carcinoma cells. Cancer Res. 56:1996;4811.
6. Hunt K.K., Deng J., Liu T.-J., Wilson-Heiner M., Swisher S.G., Clayman G., Hung M.C. Adenovirus-mediated overexpression of the transcription factor E2F-1 induces apoptosis in human breast and ovarian carcinoma cell lines and does not require p53. Cancer Res. 57:1997;4722.
7. Martin-Padura I., Bazzoni G., Zanetti A., Bernasoni S., Elices M.J., Mantovani A., Dejana E. A novel mechanism of colon carcinoma cell adhesion to the endothelium triggered by beta 1 integrin chain. J. Biol. Chem. 269:1994;6124.
8. Weaver V., Lelievre S., Lakins J., Chrenek M., Jones J., Giancotti F., Werb Z., Bissell M. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2:2002;205.
9. Sethi T., Rintoul R.C., Moore S.M., MacKinnon A.S., Salter D., Choo C., Chilvers E.R., Dransfield I., Donnelly S.C., Strieter R., Haslett C. Extracellular matrix proteins protect small cell lung cancer against apoptosis A mechanism for small cell lung cancer growth and drug resistance in vivo. Nat. Med. 5:1999;662.
10. Damiano J.S. Integrins as novel drug targets for overcoming innate drug resistance. Curr. Cancer Drug Targets. 2:2002;37.
11. Gottesman M.M. Mechanisms of cancer drug resistance. Ann. Rev. Med. 53:2002;615.
12. Bergelson J.M., Cunningham J.A., Droguett E.A., Kurt-Jones E.A., Krithivas A., Hong J.S., Horwitz M.S., Crowell R.L., Finberg R.W. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 275:1997;1320.
13. Pearson A.S., Koch P.E., Atkinson N., Xiong M., Finberg R.W., Roth J.A., Fang B. Factors limiting adenovirus-mediated gene transfer into human lung and pancreatic cancer cell lines. Clin. Cancer Res. 5:1999;4208.
14. Zhang L., Gu J., Lin T., Huang X., Roth J.A., Fang B. Mechanisms involved in development of resistance to adenovirus-mediated pro-apoptotic gene therapy in DLD1 human colon cancer cell line. Gene Ther. 9:2002;1262.