Withdrawal of TNF-α after the fifth day of differentiation of CD34+ cord blood progenitors generates a homogeneous population of Langerhans cells and delays their maturation

Experimental Dermatology

Volumn 12, Issue 1, 2003, Pages 96-105

  Noirey, N ^a   Staquet, M J ^a   Gariazzo, M J ^a   Serres, M ^a   Dezutter Dambuyant, C ^a   Andre C ^b   Schmitt, D ^a   Vincent, Claude ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

^b Stallergenes SA   (France)

Author keywords

Internalization; Langerhans cells; Migration; MLR; Morphology

Indexed keywords

ANTIGEN; CD34 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CYTOKINE; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; HLA DR ANTIGEN; MATRIX METALLOPROTEINASE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; ENDOCYTOSIS; HUMAN; HUMAN CELL; IMMATURITY; IN VITRO STUDY; LANGERHANS CELL; PROTEIN SYNTHESIS; STEM CELL; T LYMPHOCYTE ACTIVATION; UMBILICAL CORD BLOOD;

ANTIGENS, CD34; CELL AGING; CELL DIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; DRUG ADMINISTRATION SCHEDULE; GELATINASES; HEMATOPOIETIC STEM CELLS; HUMANS; LANGERHANS CELLS; LYMPHOCYTE CULTURE TEST, MIXED; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0041672320     PISSN: 09066705     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0625.2003.00043.x     Document Type: Article

References (34)

1. Banchereau J, Briere F, Caux C et al. Immunobiology of dendritic cells. Annu Rev Immunol 2000: 18: 767-811.
2. Valladeau J, Duvert-Frances V, Pin J J et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol 1999: 29: 2695-2704.
3. Steinman R M, Hoffman L, Pope M. Maturation and migration of cutaneous dendritic cells. J Invest Dermatol 1995: 105: 2S-7S.
4. Teunissen M B M. Dynamic nature and function of epidermal Langerhans cells in vitro and in vivo: A review, with emphasis on human Langerhans cells. Histochem J 1992: 24: 697-716.
5. Rougier N, Redziniak G, Schmitt D, Vincent C. Evaluatin of the capacity of dendritic cells derived from cord blood CD34+ precursors to presents haptens to unsensitized autologous T cells in vitro. J Invest Dermatol 1998: 110: 348-352.
6. Chapuis F, Rosenzwajg M, Yagello M, et al. Differentiation of human dendritic cells from monocytes in vitro. Eur J Immunol 1997: 27: 431-441.
7. Sallustro F, Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor α. J Exp Med 1994: 179: 1109-1118.
8. Lutz M B, Girolomoni G, Ricciardi-Castagnoli P. The role of cytokines in functional regulation and differentiation of dendritic cells. Immunobiol 1996: 195: 431-455.
9. Reid C D L. The dendritic cell lineage in haemopoiesis. Br J Haematol 1997: 96: 217-223.
10. Strunk D, Rappersberger K Egger C et al. Generation of human dendritic cells/Langerhans cells from circulating CD34+ hematopoietic progenitor cells. Blood 1996: 87: 1292-1302.
11. Caux C, Dezutter C, Schmitt D, Banchereau J. GM-CSF and TNFα cooperate in the generation of dendritic Langerhans cell. Nature 1992: 360: 258-261.
12. Reid C D L, Stackpoole A, Meager A, Tikerpae J. Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 1992: 149: 2681-2688.
13. Rosenzwajg M, Canque B, Gluckman J C. Human dendritic cell differentiation pathway from CD34+ hematopoietic precursor cells. Blood 1996: 87: 535-544.
14. Heussen C, Dowdle E B. Electrophoretic analysis of plasminogen activators in polyacrylamide gels containing sodium dodecyl sulfate and copolymerized substrates. Anal Biochem 1980: 102: 196-202.
15. Noirey N, Rougier N, André C, Schmitt D, Vincent C. Langerhans-like dendritic cells generated from cord blood progenitors internalize pollen allergens by macropinocytosis, and part of the molecules are processed and can activate autologous naïve T lymphocytes. J Allergy Clin Immunol 2000: 105: 1194-1201.
16. Kobayashi Y, Staquet M J, Dezutter-Dambuyant C, Schmitt D. Development of motility of Langerhans cell through extracellular matrix by in vitro hapten contact. Eur J Immunol 1994: 24: 2254-2257.
17. Siegel S. Non Parametric Statistics for the Behavioral Sciences. New York: McGraw-Hill, 1956.
18. + hemopoietic progenitors. J Immunol 1996: 157: 1499-1507.
19. + progenitors. J Leukoc Biol 1999: 66: 781-791.
20. + precursor cells develop into Langerhans cells in a TGF-β1-dependent manner. J Immunol 1999: 163: 4869-4877.
21. Caux C, Durand I, Moreau I, Duvert V, Saeland S, Banchereau J. Tumor necrosis factor α cooperates with interleukin-3 in the recruitment of a primitive subset of human CD34+ progenitors. J Exp Med 1993: 177: 1815-1820.
22. Jacobsen S E, Ruscetti F W, Dubois C M, Keller J R. Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: Role of colony-stimulating factor receptor modulation. J Exp Med 1992: 175: 1759-1772.
23. Young J W, Szabolcs P, Moore M A. Identification of dendritic cell colony-forming units among normal human CD34+ bone marrow progenitors that are expanded by c-kit-ligand and yield pure dendritic cell colonies in the presence of granulocyte/macrophage colony-stimulating factor and tumor necrosis factor alpha. J Exp Med 1995: 182: 1111-1119.
24. Santiago-Schwarz F, McCarthy M, Tucci J, Carsons S E. Neutralization of tumor necrosis factor activity shortly after the onset of dendritic cell hematopoiesis reveals a novel mechanism for the selective expansion of the CD14-dependent dendritic cell pathway. Blood 1998: 92: 745-755.
25. Rougier N, Schmitt D, Vincent C. IL-4 addition during differentiation of CD34 progenitors delays maturation of dendritic cells while promoting their survival. Eur J Cell Biol 1998: 75: 287-293.
26. Rougier N, Redziniak G, Mougin D, Schmitt D, Vincent C. In vitro evaluation of the sensitization potential of weak contact allergens using Langerhans-like dendritic cells and autologous T cells. Toxicology 2000: 145: 73-82.
27. Cumberbatch M, Kimber I. Tumor necrosis factor-α is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization. Immunology 1995: 84: 31-35.
28. Cumberbatch M, Griffiths C E M, Tucker S C, Dearman R J, Kimber I. Tumor necrosis factor-α induces Langerhans cell migration in humans. Br J Dermatol 1999: 141: 192-200.
29. Koch F, Heufler C, Kampgen E, Schneeweiss D, Bock G, Schuler G. Tumor necrosis factor alpha maintains the viability of murine epidermal Langerhans cells in culture, but in contrast to granulocyte/macrophage colony-stimulating factor, without inducing their functional maturation. J Exp Med 1990: 171: 159-171.
30. Riedl E, Strobl H, Majdic O, Knapp W. TGF-β1 promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis. J Immunol 1997: 158: 1591-1597.
31. Kobayashi Y, Matsumoto M, Kotani M, Makino T. Possible involvement of matrix metalloproteinase-9 in Langerhans cell migration and maturation. J Immunol 1999: 163: 5989-5993.
32. Kobayashi Y. Langerhans' cells produce type IV collagenase (MMP-9) following epicutaneous stimulation with haptens. Immunology 1997: 90: 496-501.
33. Noirey N, Staquet M J, Gariazzo M J et al. Relationship between expression of matrix metalloproteinases and migration of epidermal and in vitro generated Langerhans cells. Eur J Cell Biol 2002: 81: 383-389.
34. + progenitors. J Immunol 2000: 164: 3600-3607.