IL-4 addition during differentiation of CD34 progenitors delays maturation of dendritic cells while promoting their survival

European Journal of Cell Biology

Volumn 75, Issue 3, 1998, Pages 287-293

  Rougier, Nathalie ^a   Schmitt, Daniel ^a   Vincent, Claude ^a  

^a EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

CD34+ progenitors; Dendritic cells; Dermic dendrocytes; IL 4; Maturation

Indexed keywords

CD1 ANTIGEN; CD14 ANTIGEN; CD34 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LANGERHANS CELL; PRIORITY JOURNAL; STEM CELL; UMBILICAL CORD BLOOD;

EID: 0031943296     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0171-9335(98)80124-6     Document Type: Article

References (25)

1. Bender, A., M. Sapp, G. Schuler, R. M. Steinman, N. Bhardwaj: Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 196, 121-135 (1996).
2. Caux, C., C. Dezutter-Dambuyant, D. Schmitt, J. Banchereau: GM-CSF and TNFα cooperate in the generation of dendritic Langerhans cells. Nature 360, 258-261 (1992).
3. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNFα. J. Exp. Med. 184, 695-706 (1996).
4. Caux, C., J. Banchereau: In vitro regulation of dendritic cell development and function. In: A. D. Whetton, J. Gordon (eds.): Blood Cell Biochemistry: hematopoietic cell growth factors and their receptors. Vol. 7. pp. 263-301. Plenum Press. New York 1996.
5. Chapuis, F., M. Rosenzwajg, M. Yagello, M. Ekman, P. Biberfeldand, J. C. Gluckman: Differentiation of human dendritic cells from monocytes in vitro. Eur. J. Immunol. 27, 431-441 (1997).
6. Jansen, J. H., G.-J. H. M. Wientjens, W. E. Fibbe, R. Willemze, H. C. Klui-Nelemans: Inhibition of human macrophage colony formation by interleukin 4. J. Exp. Med. 170, 577-582 (1989).
7. + leukocytes acquire the phenotype and function of antigen-presenting dendritic cells when cultured in GM-CSF and IL-4. J. Leukocyte Biol. 59, 208-218 (1996).
8. Kock, A., T. Schwartz, R. Kirnbauer, A. Urbanski, P. Perry, J. C. Ansel, T. A. Luger: Human keratinocytes are a source for tumor necrosis factor-α: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J. Exp. Med. 172, 1609-1614 (1990).
9. Kupper, T. S., F. Lee, D. Coleman, J. Chodakewitz, P. Flood, M. Horowitz: Keratinocyte derived T-cell growth factor (KTGF) is identical to granulocyte macrophage colony stimulating factor (GM-CSF). J. Investig. Dermatol. 91, 185-188 (1988).
10. Lauener, R. P., S. M. Goyert, R. S. Geha, D. Vercelli: Interleukin-4 down-regulates the expression of CD14 in normal human monocytes. Eur. J. Immunol. 20, 2375-2381 (1990).
11. Liu, L. M., G. G. MacPherson: Antigen processing: cultured lymph-borne dendritic cells can process and present native protein antigens. Immunology 84, 241-246 (1995).
12. Lutz, M. B., G. Girolomoni, P. Ricciardi-Castagnoli: The role of cytokines in functional regulation and differentiation of dendritic cells. Immunobiology 195, 431-455 (1996).
13. Reid, C. D. L., P. R. Fryer, C. Clifford, A. Kirk, J. Tikerpae, S. C. Knight: Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood. Blood 76, 1139-1149 (1990).
14. + progenitors in human bone marrow. J. Immunol. 149, 2681-2688 (1992).
15. Reid, C. D. L.: The dendritic cell lineage in haemopoiesis. Br. J. Haematol. 96, 217-223 (1997).
16. Romani, N., S. Koide, M. Crowley, M. Witmer-Pack, A. M. Livingstone, C. Garrison Fathman, K. Inaba, R. M. Steinman: Presentation of exogenous protein antigens by dendritic cells to T cell clones. J. Exp. Med. 169, 1169-1178 (1989).
17. Romani, N., S. Gruner, D. Brang, E. Kämpgen, A. Lenz, B. Trockenbacher, G. Konwalinka, P. O. Fritsch, R. M. Steinman, G. Schuler: Proliferating dendritic cell progenitors in human blood. J. Exp. Med. 180, 83-93 (1994).
18. + hematopoietic precursor cells. Blood 87, 535-544 (1996).
19. Ruppert, J., D. Friedrichs, H. Xu, J. H. Peters: IL-4 decreases the expression of the monocyte differentiation marker CD14, paralleled by an increasing accessory potency. Immunobiol. 182, 449-464 (1991).
20. Sallusto, F., A. Lanzavecchia: Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and down-regulated by tumor necrosis factor alpha. J. Exp. Med. 179, 1109-1118 (1994).
21. Steinman, R. M.: The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9, 271-296 (1991).
22. Steinman, R. M., L. Huffman, M. Pope: Maturation and migration of cutaneous dendritic cells. J. Investig. Dermatol. 105, 2S-7S (1995).
23. + hematopoietic progenitor cells. Blood 87, 1292-1302 (1996).
24. Teunissen, M. B. M.: Dynamic nature and function of epidermal Langerhans cells in vivo and in vitro: a review, with emphasis on human Langerhans cells. Histochem. J. 24, 697-716 (1992).
25. Young, J. W., R. M. Steinman: The hematopoietic development of dendritic cells: a distinct pathway for myeloid differentiation. Stem cells 14, 376-387 (1996).