Protein tyrosine phosphatase alpha (PTPα) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety

Brain Research

Volumn 984, Issue 1-2, 2003, Pages 1-10

  Skelton, Matthew R ^a   Ponniah, Sathivel ^b   Wang, Dennis Z M ^b   Doetschman, Thomas ^c   Vorhees, Charles V ^a   Pallen, Catherine J ^b,d  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Anxiety; Hypoactivity; PTP ; Spatial learning

Indexed keywords

METHAMPHETAMINE; PROTEIN KINASE; PROTEIN TYROSINE PHOSPHATASE; RECEPTOR PROTEIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANXIETY; ARTICLE; CONTROLLED STUDY; KNOCKOUT MOUSE; LATENT PERIOD; LEARNING; LOCOMOTION; MAZE TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECOGNITION; REGULATORY MECHANISM; SWIMMING; WILD TYPE;

EID: 0041655974     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(03)02839-7     Document Type: Article

References (39)

1. Ali D.W., Salter M.W. NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr. Opin. Neurobiol. 11:2001;336-342.
2. Berglund E.O., Murai K.K., Fredette B., Sekerkova G., Marturano B., Weber L., Mugnaini E., Ranscht B. Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. Neuron. 24:1999;739-750.
3. Bhandari V., Lim K.L., Pallen C.J. Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn. J. Biol. Chem. 273:1998;8691-8698.
4. Boyle M.E., Berglund E.O., Murai K.K., Weber L., Peles E., Ranscht B. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve. Neuron. 30:2001;385-397.
5. Brummendorf T., Hubert M., Treubert U., Leuschner R., Tarnok A., Rathjen F.G. The axonal recognition molecule F11 is a multifunctional protein: specific domains mediate interactions with Ng-CAM and restrictin. Neuron. 10:1993;711-727.
6. den Hertog J., Overvoorde J., de Laat S.W. Expression of receptor protein-tyrosine phosphatase alpha mRNA and protein during mouse embryogenesis. Mech. Dev. 58:1996;89-101.
7. den Hertog J., Pals C.E., Peppelenbosch M.P., Tertoolen L.G., de Laat S.W., Kruijer W. Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. EMBO J. 12:1993;3789-3798.
8. Fang K.S., Martins-Green M., Williams L.T., Hanafusa H. Characterization of chicken protein tyrosine phosphatase alpha and its expression in the central nervous system. Brain Res. Mol. Brain Res. 37:1996;1-14.
9. Gennarini G., Durbec P., Boned A., Rougon G., Goridis C. Transfected F3/F11 neuronal cell surface protein mediates intercellular adhesion and promotes neurite outgrowth. Neuron. 6:1991;595-606.
10. Grant S.G., O'Dell T.J., Karl K.A., Stein P.L., Soriano P., Kandel E.R. Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science. 258:1992;1903-1910.
11. Harder K.W., Moller N.P., Peacock J.W., Jirik F.R. Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion. J. Biol. Chem. 273:1998;31890-31900.
12. Husi H., Ward M.A., Choudhary J.S., Blackstock W.P., Grant S.G. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nat. Neurosci. 3:2000;661-669.
13. Izquierdo I., Medina J.H. Memory formation: the sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol. Learn. Mem. 68:1997;285-316.
14. Kaplan R., Morse B., Huebner K., Croce C., Howk R., Ravera M., Ricca G., Jaye M., Schlessinger J. Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc. Natl. Acad. Sci. USA. 87:1990;7000-7004.
15. Krueger N.X., Streuli M., Saito H. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 9:1990;3241-3252.
16. Lei G., Xue S., Chery N., Liu Q., Xu J., Kwan C.L., Fu Y.P., Lu Y.M., Liu M., Harder K.W., Yu X.M. Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. EMBO J. 21:2002;2977-2989.
17. Maness P.F., Beggs H.E., Klinz S.G., Morse W.R. Selective neural cell adhesion molecule signaling by Src family tyrosine kinases and tyrosine phosphatases. Perspect. Dev. Neurobiol. 4:1996;169-181.
18. Matthews R.J., Cahir E.D., Thomas M.L. Identification of an additional member of the protein-tyrosine-phosphatase family: evidence for alternative splicing in the tyrosine phosphatase domain. Proc. Natl. Acad. Sci. USA. 87:1990;4444-4448.
19. Miyakawa T., Yagi T., Kagiyama A., Niki H. Radial maze performance, open-field and elevated plus-maze behaviors in Fyn-kinase deficient mice: further evidence for increased fearfulness. Brain Res. Mol. Brain Res. 37:1996;145-150.
20. Miyakawa T., Yagi T., Watanabe S., Niki H. Increased fearfulness of Fyn tyrosine kinase deficient mice. Brain Res. Mol. Brain Res. 27:1994;179-182.
21. A.R. Mohn, R.R. Gainetdinov, M.G. Caron, B.H. Koller, Mice with reduced NMDA receptor expression display behaviors related to schizophrenia.
22. Murai K.K., Misner D., Ranscht B. Contactin supports synaptic plasticity associated with hippocampal long-term depression but not potentiation. Curr. Biol. 12:2002;181-190.
23. Peles E., Nativ M., Campbell P.L., Sakurai T., Martinez R., Lev S., Clary D.O., Schilling J., Barnea G., Plowman G.D. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Cell. 82:1995;251-260.
24. Pesheva P., Gennarini G., Goridis C., Schachner M. The F3/11 cell adhesion molecule mediates the repulsion of neurons by the extracellular matrix glycoprotein J1-160/180. Neuron. 10:1993;69-82.
25. Ponniah S., Wang D.Z., Lim K.L., Pallen C.J. Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn. Curr. Biol. 9:1999;535-538.
26. Reed T.M., Repaske D.R., Snyder G.L., Greengard P., Vorhees C.V. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. J. Neurosci. 22:2002;5188-5197.
27. Rios J.C., Melendez-Vasquez C.V., Einheber S., Lustig M., Grumet M., Hemperly J., Peles E., Salzer J.L. Contactin-associated protein (Caspr) and contactin form a complex that is targeted to the paranodal junctions during myelination. J. Neurosci. 20:2000;8354-8364.
28. Sahin M., Dowling J.J., Hockfield S. Seven protein tyrosine phosphatases are differentially expressed in the developing rat brain. J. Comp. Neurol. 351:1995;617-631.
29. Sap J., D'Eustachio P., Givol D., Schlessinger J. Cloning and expression of a widely expressed receptor tyrosine phosphatase. Proc. Natl. Acad. Sci. USA. 87:1990;6112-6116.
30. Su J., Muranjan M., Sap J. Receptor protein tyrosine phosphatase alpha activates Src-family kinases and controls integrin-mediated responses in fibroblasts. Curr. Biol. 9:1999;505-511.
31. Su J., Yang L.T., Sap J. Association between receptor protein-tyrosine phosphatase RPTPalpha and the Grb2 adaptor. J. Biol. Chem. 271:1996;28086-28096.
32. Tezuka T., Umemori H., Akiyama T., Nakanishi S., Yamamoto T. PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc. Natl. Acad. Sci. USA. 96:1999;435-440.
33. Tsai W., Morielli A.D., Peralta E.G. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. EMBO J. 16:1997;4597-4605.
34. Umemori H., Sato S., Yagi T., Aizawa S., Yamamoto T. Initial events of myelination involve Fyn tyrosine kinase signalling. Nature. 367:1994;572-576.
35. Upchurch M., Wehner J.M. Differences between inbred strains of mice in Morris water maze performance. Behav. Genet. 18:1988;55-68.
36. Yang C.Q., Friesel R. Identification of a receptor-like protein tyrosine phosphatase expressed during Xenopus development. Dev. Dyn. 212:1998;403-412.
37. Yang L.T., Alexandropoulos K., Sap J. c-SRC mediates neurite outgrowth through recruitment of Crk to the scaffolding protein Sin/Efs without altering the kinetics of ERK activation. J. Biol. Chem. 277:2002;17406-17414.
38. Yu X.M., Askalan R., Keil G.J., Salter M.W. NMDA channel regulation by channel-associated protein tyrosine kinase Src. Science. 275:1997;674-678.
39. Zheng X.M., Wang Y., Pallen C.J. Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. Nature. 359:1992;336-339.